BE637271A - - Google Patents
Info
- Publication number
- BE637271A BE637271A BE637271DA BE637271A BE 637271 A BE637271 A BE 637271A BE 637271D A BE637271D A BE 637271DA BE 637271 A BE637271 A BE 637271A
- Authority
- BE
- Belgium
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B43/00—Preparation of azo dyes from other azo compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27053463A | 1963-04-04 | 1963-04-04 | |
| US27053763A | 1963-04-04 | 1963-04-04 | |
| US27053663A | 1963-04-04 | 1963-04-04 | |
| US37971464A | 1964-07-01 | 1964-07-01 | |
| US468142A US3331843A (en) | 1963-04-04 | 1965-06-29 | 1-substituted-4-substituted aminoalkylene piperazines |
| US468143A US3331830A (en) | 1963-04-04 | 1965-06-29 | 1-substituted-4-substituted aminoalkylene piperazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE637271A true BE637271A (ar) | 1900-01-01 |
Family
ID=27559486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE637271D BE637271A (ar) | 1963-04-04 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US3331830A (ar) |
| BE (1) | BE637271A (ar) |
| BR (1) | BR6352303D0 (ar) |
| CH (1) | CH482691A (ar) |
| DE (1) | DE1445425A1 (ar) |
| FI (2) | FI41280C (ar) |
| FR (1) | FR3708M (ar) |
| GB (1) | GB1047935A (ar) |
| LU (1) | LU44424A1 (ar) |
| MC (1) | MC435A1 (ar) |
| NL (1) | NL297170A (ar) |
| NO (1) | NO117694B (ar) |
| SE (2) | SE320667B (ar) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1165283A (en) * | 1967-01-17 | 1969-09-24 | Science Union & Cie | New Purine Derivatives and processes for prepararing them |
| US3491098A (en) * | 1967-05-29 | 1970-01-20 | Sterling Drug Inc | 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines |
| GB1279843A (en) * | 1969-05-23 | 1972-06-28 | Science Union & Cie | Benzamidoethyl-piperazines and process for their preparation |
| US4081542A (en) * | 1975-04-21 | 1978-03-28 | Merck & Co., Inc. | Piperazinylpyrazines |
| CH653021A5 (fr) * | 1981-04-24 | 1985-12-13 | Delalande Sa | Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant. |
| US4457931A (en) * | 1982-09-27 | 1984-07-03 | Selvi & C. S.P.A. | Piperazine derivatives with anticholinergic and/or antihistaminic activity |
| NL8601494A (nl) * | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
| US5057517A (en) * | 1987-07-20 | 1991-10-15 | Merck & Co., Inc. | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents |
| US4977156A (en) * | 1988-07-26 | 1990-12-11 | The Dow Chemical Company | Amino piperazine esters showing biocidal activity |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| JP3193560B2 (ja) * | 1993-04-16 | 2001-07-30 | 明治製菓株式会社 | 新規ベンゾオキサゾール誘導体 |
| JP2002538120A (ja) * | 1999-03-03 | 2002-11-12 | メルク エンド カムパニー インコーポレーテッド | プレニルタンパク質トランスフェラーゼの阻害剤 |
| CA2362493A1 (en) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| KR20010085555A (ko) | 1999-06-24 | 2001-09-07 | 히라이 가쯔히꼬 | 아드레날린 알파1비 수용체 길항약 |
| AU6936500A (en) * | 1999-08-24 | 2001-03-19 | Regents Of The University Of California, The | Non-quinoline inhibitors of malaria parasites |
| ATE398105T1 (de) * | 2002-03-13 | 2008-07-15 | Janssen Pharmaceutica Nv | Carbonylamino- derivativate als neue inhibitoren von histone deacetylase |
| MXPA04007776A (es) | 2002-03-13 | 2004-10-15 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como nuevos inhibidores de histona deacetilasa. |
| BR0307606A (pt) * | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivados de piperazinila, piperidinila e morfolinila como inibidores de histona desacetilase |
| EA007272B1 (ru) * | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н. В. | Новые ингибиторы гистондеацетилазы |
| SG156687A1 (en) * | 2004-07-28 | 2009-11-26 | Janssen Pharmaceutica Nv | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
| UY29177A1 (es) * | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| WO2006089076A2 (en) | 2005-02-18 | 2006-08-24 | Neurogen Corporation | Thiazole amides, imidazole amides and related analogues |
| EP1885710B1 (en) | 2005-05-18 | 2015-08-19 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| CN101370803B (zh) * | 2006-01-19 | 2012-12-12 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶抑制剂的取代的吲哚基-烷基-氨基衍生物 |
| JP5247470B2 (ja) | 2006-01-19 | 2013-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| JP5225104B2 (ja) * | 2006-01-19 | 2013-07-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体 |
| US8101616B2 (en) * | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| AU2008277796A1 (en) | 2007-07-19 | 2009-01-22 | F. Hoffmann-La Roche Ag | Novel heterocyclyl compounds and their use as chemokine antagonists |
| PL2195293T3 (pl) | 2007-08-22 | 2014-03-31 | Astrazeneca Ab | Pochodne cyklopropyloamidu |
| NZ585261A (en) | 2007-10-11 | 2011-10-28 | Astrazeneca Ab | Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors |
| WO2009050734A2 (en) * | 2007-10-15 | 2009-04-23 | Elder Pharmaceuticals Ltd. | An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| FR2945289A1 (fr) * | 2009-05-11 | 2010-11-12 | Sanofi Aventis | Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique |
| WO2011095885A1 (en) * | 2010-02-08 | 2011-08-11 | Matrix Laboratories Ltd. | An improved process for the preparation of piperaquine |
| NZ602110A (en) | 2010-02-18 | 2014-09-26 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
| KR20130034009A (ko) * | 2010-02-18 | 2013-04-04 | 아스트라제네카 아베 | 시클로프로필 아미드 유도체를 포함하는 고체 형태 |
| BR112013025410A2 (pt) | 2011-04-01 | 2016-12-20 | Astrazeneca Ab | tratamento terapêutico |
| CA2835344A1 (en) | 2011-06-06 | 2012-12-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A | Novel process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline |
| PT2785349T (pt) | 2011-11-30 | 2019-12-11 | Astrazeneca Ab | Tratamento combinado de cancro |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| MX2021001091A (es) | 2015-12-10 | 2022-04-26 | Ptc Therapeutics Inc | Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington. |
| US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| US11382918B2 (en) | 2017-06-28 | 2022-07-12 | Ptc Therapeutics, Inc. | Methods for treating Huntington's Disease |
| BR112019027719A2 (pt) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics, Inc. | métodos para tratar a doença de huntington |
| JP7399870B2 (ja) | 2018-03-27 | 2023-12-18 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| CN110606830B (zh) * | 2018-06-14 | 2022-03-18 | 珠海润都制药股份有限公司 | 一种哌嗪套用生产磷酸哌喹中间体喹啉哌嗪盐酸盐的方法 |
| EP3814360A1 (en) | 2018-06-27 | 2021-05-05 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| JP7421507B2 (ja) | 2018-06-27 | 2024-01-24 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するためのヘテロ環式およびヘテロアリール化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2513026A (en) * | 1950-06-27 | Process for preparing same | ||
| BE485737A (ar) * | 1947-11-12 | |||
| US2861072A (en) * | 1952-07-19 | 1958-11-18 | Abbott Lab | Preparation of piperazine derivatives |
| US2794804A (en) * | 1955-03-24 | 1957-06-04 | American Cyanamid Co | Substituted piperazines and method of preparing the same |
| US2949431A (en) * | 1957-07-17 | 1960-08-16 | Mobay Chemical Corp | Preparation of cellular polyurethanes using piperazine catalysts |
| US3098066A (en) * | 1960-03-04 | 1963-07-16 | Ciba Geigy Corp | Diaza-heterocyclic guanidine compounds |
| US3015657A (en) * | 1959-05-28 | 1962-01-02 | Charles F Geschickter | 1-carbalkoxy-4-(aminoalkanol) piperazines |
| US3030366A (en) * | 1961-01-25 | 1962-04-17 | Lakeside Lab Inc | Piperazinoalkyl glycolamides |
| FR1525M (fr) * | 1961-07-25 | 1962-11-16 | Ile De France | Médicaments antiémétiques nouveaux. |
| US3190883A (en) * | 1962-10-05 | 1965-06-22 | Geschickter Fund Med Res | Aminoalkanol derivatives of piperazines |
| US3184382A (en) * | 1963-08-12 | 1965-05-18 | Pure Oil Co | Method of producing tranquilization by hydroxy-loweralkyl-n-substituted carbamic acid esters |
-
0
- BE BE637271D patent/BE637271A/xx unknown
- NL NL297170D patent/NL297170A/xx unknown
-
1963
- 1963-08-06 GB GB30926/63A patent/GB1047935A/en not_active Expired
- 1963-08-28 BR BR152303/63A patent/BR6352303D0/pt unknown
- 1963-09-02 SE SE9582/63A patent/SE320667B/xx unknown
- 1963-09-02 NO NO149944A patent/NO117694B/no unknown
- 1963-09-02 DE DE19631445425 patent/DE1445425A1/de active Granted
- 1963-09-02 FI FI631675A patent/FI41280C/fi active
- 1963-09-10 MC MC453A patent/MC435A1/xx unknown
- 1963-09-11 LU LU44424D patent/LU44424A1/xx unknown
- 1963-09-16 FR FR947586A patent/FR3708M/fr not_active Expired
- 1963-09-16 CH CH1141863A patent/CH482691A/fr not_active IP Right Cessation
-
1965
- 1965-06-29 US US468143A patent/US3331830A/en not_active Expired - Lifetime
- 1965-06-29 US US468142A patent/US3331843A/en not_active Expired - Lifetime
-
1967
- 1967-05-26 SE SE7418/67A patent/SE346316B/xx unknown
-
1968
- 1968-04-04 FI FI680932A patent/FI42440C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| BR6352303D0 (pt) | 1973-07-17 |
| CH482691A (fr) | 1969-12-15 |
| FR3708M (fr) | 1965-11-29 |
| NL297170A (ar) | 1900-01-01 |
| FI41280B (ar) | 1969-06-30 |
| GB1047935A (en) | 1966-11-09 |
| US3331843A (en) | 1967-07-18 |
| SE320667B (ar) | 1970-02-16 |
| DE1445425A1 (de) | 1968-10-31 |
| FI41280C (fi) | 1969-10-10 |
| NO117694B (ar) | 1969-09-15 |
| FI42440B (ar) | 1970-04-30 |
| SE346316B (ar) | 1972-07-03 |
| LU44424A1 (ar) | 1963-11-11 |
| US3331830A (en) | 1967-07-18 |
| FI42440C (fi) | 1970-08-10 |
| MC435A1 (fr) | 1964-07-06 |