BE612912A - - Google Patents
Info
- Publication number
- BE612912A BE612912A BE612912DA BE612912A BE 612912 A BE612912 A BE 612912A BE 612912D A BE612912D A BE 612912DA BE 612912 A BE612912 A BE 612912A
- Authority
- BE
- Belgium
- Prior art keywords
- sep
- atropine
- dimethyl
- phosphonate
- trichloro
- Prior art date
Links
- 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 claims description 236
- RKUNBYITZUJHSG-SPUOUPEWSA-N Atropine Chemical group O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 69
- 229930006677 A03BA01 - Atropine Natural products 0.000 claims description 64
- 229960000396 Atropine Drugs 0.000 claims description 63
- 244000045947 parasites Species 0.000 claims description 37
- 239000000243 solution Substances 0.000 claims description 33
- 241001465754 Metazoa Species 0.000 claims description 32
- 239000007924 injection Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 30
- 238000002347 injection Methods 0.000 claims description 27
- NJRWNWYFPOFDFN-UHFFFAOYSA-L phosphonate(2-) Chemical compound [O-][P]([O-])=O NJRWNWYFPOFDFN-UHFFFAOYSA-L 0.000 claims description 23
- 241000282472 Canis lupus familiaris Species 0.000 claims description 20
- 230000001078 anti-cholinergic Effects 0.000 claims description 18
- 239000011780 sodium chloride Substances 0.000 claims description 16
- 230000002605 anti-dotal Effects 0.000 claims description 15
- 239000000729 antidote Substances 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 14
- 230000002588 toxic Effects 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 13
- WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- -1 hydroxyethyl Chemical group 0.000 claims description 12
- 231100000331 toxic Toxicity 0.000 claims description 12
- 241000282887 Suidae Species 0.000 claims description 10
- 229960002028 Atropine Sulfate Drugs 0.000 claims description 9
- JPKKQJKQTPNWTR-CHYDPLAESA-N CHEMBL3182372 Chemical group O.OS(O)(=O)=O.O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1.O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 JPKKQJKQTPNWTR-CHYDPLAESA-N 0.000 claims description 9
- 241000283707 Capra Species 0.000 claims description 9
- OSASVXMJTNOKOY-UHFFFAOYSA-N Chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims description 7
- 229960004926 Chlorobutanol Drugs 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
- 241000282326 Felis catus Species 0.000 claims description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000003379 elimination reaction Methods 0.000 claims description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 5
- 229960003260 Chlorhexidine Drugs 0.000 claims description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Exidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 4
- 241000607479 Yersinia pestis Species 0.000 claims description 4
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 230000002335 preservative Effects 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- RLSSMJSEOOYNOY-UHFFFAOYSA-N M-Cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims description 3
- 239000000812 cholinergic antagonist Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 229940100630 metacresol Drugs 0.000 claims description 3
- 231100000486 side effect Toxicity 0.000 claims description 3
- 239000008174 sterile solution Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N Methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 description 44
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 41
- 239000010452 phosphate Substances 0.000 description 41
- 230000035492 administration Effects 0.000 description 14
- 230000000694 effects Effects 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 241001465677 Ancylostomatoidea Species 0.000 description 5
- 241000283690 Bos taurus Species 0.000 description 5
- 241000283898 Ovis Species 0.000 description 5
- 239000003760 tallow Substances 0.000 description 5
- 241000244206 Nematoda Species 0.000 description 4
- 230000002141 anti-parasite Effects 0.000 description 4
- 230000001713 cholinergic Effects 0.000 description 4
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 229940079593 drugs Drugs 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- 206010070863 Toxicity to various agents Diseases 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000000295 complement Effects 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- GZUXJHMPEANEGY-UHFFFAOYSA-N Bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 210000003608 Feces Anatomy 0.000 description 2
- CYHOMWAPJJPNMW-JIGDXULJSA-N Tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 238000009877 rendering Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 231100000563 toxic property Toxicity 0.000 description 2
- VZDNSFSBCMCXSK-UHFFFAOYSA-N (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;hydrobromide Chemical compound Br.CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 VZDNSFSBCMCXSK-UHFFFAOYSA-N 0.000 description 1
- 229940006211 Anticholinergic mydriatics and cycloplegics Drugs 0.000 description 1
- 229940065524 Anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 241000132092 Aster Species 0.000 description 1
- 241000931178 Bunostomum Species 0.000 description 1
- 210000000805 Cytoplasm Anatomy 0.000 description 1
- 206010011906 Death Diseases 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Ethylene tetrachloride Chemical compound ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- 230000036826 Excretion Effects 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000257176 Hypoderma <fly> Species 0.000 description 1
- 229940102223 Injectable Solution Drugs 0.000 description 1
- 210000003205 Muscles Anatomy 0.000 description 1
- 241000510960 Oesophagostomum Species 0.000 description 1
- 241000543819 Oestrus ovis Species 0.000 description 1
- 241000243795 Ostertagia Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- QIZDQFOVGFDBKW-DHBOJHSNSA-N Pseudotropine Natural products OC1C[C@@H]2[N+](C)[C@H](C1)CC2 QIZDQFOVGFDBKW-DHBOJHSNSA-N 0.000 description 1
- 241000190070 Sarracenia purpurea Species 0.000 description 1
- 241000294518 Todea Species 0.000 description 1
- 241000607216 Toxascaris Species 0.000 description 1
- 241000244031 Toxocara Species 0.000 description 1
- 241000243797 Trichostrongylus Species 0.000 description 1
- 241001489151 Trichuris Species 0.000 description 1
- OJIPQOWZZMSBGY-ZZJGABIISA-N [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;hydrochloride Chemical compound Cl.C([C@H]1CC[C@@H](C2)N1C)C2OC(=O)C(CO)C1=CC=CC=C1 OJIPQOWZZMSBGY-ZZJGABIISA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000000507 anthelmentic Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000002939 deleterious Effects 0.000 description 1
- DKMROQRQHGEIOW-UHFFFAOYSA-N diethyl butanedioate Chemical compound CCOC(=O)CCC(=O)OCC DKMROQRQHGEIOW-UHFFFAOYSA-N 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- CIMFXUNKOJVRNC-UHFFFAOYSA-L disodium;(4-nonylphenyl)-dioxido-oxo-$l^{5}-phosphane Chemical compound [Na+].[Na+].CCCCCCCCCC1=CC=C(P([O-])([O-])=O)C=C1 CIMFXUNKOJVRNC-UHFFFAOYSA-L 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008079 hexane Substances 0.000 description 1
- 230000001771 impaired Effects 0.000 description 1
- 230000000749 insecticidal Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000000968 intestinal Effects 0.000 description 1
- 230000002147 killing Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- UPQNPBHYPACBSK-UHFFFAOYSA-N methylsulfinylmethane;sodium Chemical compound [Na].CS(C)=O UPQNPBHYPACBSK-UHFFFAOYSA-N 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 150000002903 organophosphorus compounds Chemical class 0.000 description 1
- 230000003071 parasitic Effects 0.000 description 1
- 239000003186 pharmaceutical solution Substances 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-M valerate Chemical compound CCCCC([O-])=O NQPDZGIKBAWPEJ-UHFFFAOYSA-M 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE612912A true BE612912A (zh) |
Family
ID=193232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE612912D BE612912A (zh) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE612912A (zh) |
-
0
- BE BE612912D patent/BE612912A/fr unknown
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