BE516402A - - Google Patents

Info

Publication number

BE516402A

BE516402A BE516402DA BE516402A BE 516402 A BE516402 A BE 516402A BE 516402D A BE516402D A BE 516402DA BE 516402 A BE516402 A BE 516402A

Authority

BE

Belgium

Prior art keywords

bromo

parts

succinimide

reaction

volume

Prior art date

Links

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• 238000000034 method Methods 0.000 claims description 10
• BHELZAPQIKSEDF-UHFFFAOYSA-N allyl bromide Chemical compound BrCC=C BHELZAPQIKSEDF-UHFFFAOYSA-N 0.000 claims description 4
• 150000001875 compounds Chemical class 0.000 claims description 4
• 150000001991 dicarboxylic acids Chemical class 0.000 claims description 4
• CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 claims description 2
• XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims description 2
• 229950011008 tetrachloroethylene Drugs 0.000 claims description 2
• -1 unsaturated aliphatic halogenated hydrocarbon Chemical class 0.000 claims description 2
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 12
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
• KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 8
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
• 238000002360 preparation method Methods 0.000 description 4
• 229960002317 succinimide Drugs 0.000 description 4
• 239000000706 filtrate Substances 0.000 description 3
• 239000000203 mixture Substances 0.000 description 3
• 239000000047 product Substances 0.000 description 3
• 229960000583 acetic acid Drugs 0.000 description 2
• 239000012362 glacial acetic acid Substances 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 239000000155 melt Substances 0.000 description 2
• 238000002844 melting Methods 0.000 description 2
• 230000008018 melting Effects 0.000 description 2
• 238000010992 reflux Methods 0.000 description 2
• AQVRUKMBZZWGLK-DOSNKVNNSA-N (8R,9S,10S,13R,14S,17R)-17-[(2R)-5,5-diphenylpent-4-en-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene Chemical compound C1(=CC=CC=C1)C(=CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C)C1=CC=CC=C1 AQVRUKMBZZWGLK-DOSNKVNNSA-N 0.000 description 1
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
• 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• 125000000950 dibromo group Chemical group Br* 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 235000019439 ethyl acetate Nutrition 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 150000004820 halides Chemical class 0.000 description 1
• 239000003208 petroleum Substances 0.000 description 1
• 230000005855 radiation Effects 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 229920002554 vinyl polymer Polymers 0.000 description 1