BE471250A - - Google Patents
Info
- Publication number
- BE471250A BE471250A BE471250DA BE471250A BE 471250 A BE471250 A BE 471250A BE 471250D A BE471250D A BE 471250DA BE 471250 A BE471250 A BE 471250A
- Authority
- BE
- Belgium
- Prior art keywords
- energy
- less
- irradiated
- per square
- square centimeter
- Prior art date
Links
- 239000000725 suspension Substances 0.000 claims description 44
- 244000005700 microbiome Species 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 12
- 230000000890 antigenic Effects 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 3
- 229960005486 vaccines Drugs 0.000 description 60
- 239000000427 antigen Substances 0.000 description 20
- 108091007172 antigens Proteins 0.000 description 20
- 102000038129 antigens Human genes 0.000 description 20
- 239000010408 film Substances 0.000 description 17
- 229910052904 quartz Inorganic materials 0.000 description 14
- 239000010453 quartz Substances 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 9
- 241000700605 Viruses Species 0.000 description 8
- 230000002779 inactivation Effects 0.000 description 8
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 8
- 206010037742 Rabies Diseases 0.000 description 7
- 229910052753 mercury Inorganic materials 0.000 description 7
- 231100000765 Toxin Toxicity 0.000 description 6
- 230000002458 infectious Effects 0.000 description 6
- 230000003287 optical Effects 0.000 description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 6
- 230000003389 potentiating Effects 0.000 description 6
- 239000003053 toxin Substances 0.000 description 6
- 108020003112 toxins Proteins 0.000 description 6
- 210000004556 Brain Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 210000001519 tissues Anatomy 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 4
- 241000005139 Lycium andersonii Species 0.000 description 4
- 102000004965 antibodies Human genes 0.000 description 4
- 108090001123 antibodies Proteins 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000001954 sterilising Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 239000010409 thin film Substances 0.000 description 3
- 238000005429 turbidity Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 241000711798 Rabies lyssavirus Species 0.000 description 2
- 208000007089 Vaccinia Diseases 0.000 description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 description 2
- 230000003171 anti-complementary Effects 0.000 description 2
- 230000002238 attenuated Effects 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 230000000295 complement Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000002147 killing Effects 0.000 description 2
- 231100000636 lethal dose Toxicity 0.000 description 2
- 231100000668 minimum lethal dose Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000000709 Aorta Anatomy 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 210000001736 Capillaries Anatomy 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 208000001848 Dysentery Diseases 0.000 description 1
- 210000001161 Embryo, Mammalian Anatomy 0.000 description 1
- 231100000776 Exotoxin Toxicity 0.000 description 1
- 210000003608 Feces Anatomy 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 210000004185 Liver Anatomy 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 210000002966 Serum Anatomy 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229940076185 Staphylococcus aureus Drugs 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 240000008529 Triticum aestivum Species 0.000 description 1
- 241001467018 Typhis Species 0.000 description 1
- 208000001877 Whooping Cough Diseases 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000002365 anti-tubercular Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- XKRFYHLGVUSROY-UHFFFAOYSA-N argon Substances [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 101700057343 chr1 Proteins 0.000 description 1
- 238000007374 clinical diagnostic method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000000249 desinfective Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 239000002095 exotoxin Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000001771 impaired Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002045 lasting Effects 0.000 description 1
- 230000001665 lethal Effects 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- -1 merthioiate Chemical compound 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000001717 pathogenic Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002250 progressing Effects 0.000 description 1
- 230000001681 protective Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000002829 reduced Effects 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000002588 toxic Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000003313 weakening Effects 0.000 description 1
- 235000021307 wheat Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24061—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE471250A true BE471250A (da) |
Family
ID=121172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE471250D BE471250A (da) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE471250A (da) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0086071A1 (en) * | 1982-02-09 | 1983-08-17 | The Regents Of The University Of California | Ozone inactivated organisms as vaccines |
-
0
- BE BE471250D patent/BE471250A/fr unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0086071A1 (en) * | 1982-02-09 | 1983-08-17 | The Regents Of The University Of California | Ozone inactivated organisms as vaccines |
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