BE445131A - - Google Patents
Info
- Publication number
- BE445131A BE445131A BE445131DA BE445131A BE 445131 A BE445131 A BE 445131A BE 445131D A BE445131D A BE 445131DA BE 445131 A BE445131 A BE 445131A
- Authority
- BE
- Belgium
- Prior art keywords
- extraction
- insulin
- enzymes
- glands
- trypsin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 50
- 238000000605 extraction Methods 0.000 claims description 35
- 102000004877 Insulin Human genes 0.000 claims description 25
- 108090001061 Insulin Proteins 0.000 claims description 25
- 229940125396 insulin Drugs 0.000 claims description 25
- 102000004190 Enzymes Human genes 0.000 claims description 23
- 108090000790 Enzymes Proteins 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 10
- 210000000496 pancreas Anatomy 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 description 20
- 210000004907 gland Anatomy 0.000 description 12
- 102000004142 Trypsin Human genes 0.000 description 10
- 108090000631 Trypsin Proteins 0.000 description 10
- 239000012588 trypsin Substances 0.000 description 10
- 239000002994 raw material Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000284 extract Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001066 destructive effect Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 229940079919 digestives enzyme preparation Drugs 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE445131A true BE445131A (d) |
Family
ID=101594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE445131D BE445131A (d) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE445131A (d) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2571126A (en) * | 1943-06-04 | 1951-10-16 | Novo Terapeutisk Labor As | Hot aqueous extraction of enzymes from insulin-free pancreas |
| US2573099A (en) * | 1946-10-23 | 1951-10-30 | Novo Terapeutisk Labor As | Method of recovering proteolytic enzymes from mammalian pancreas glands with urea |
| US2637680A (en) * | 1943-03-31 | 1953-05-05 | Danske Andelsslagteriers Konse | Method for the extraction of insulin as well as enzymes from pancreas |
| US2803585A (en) * | 1946-10-23 | 1957-08-20 | Novo Terapeutisk Labor As | Method of recovering broteolytic pancreas enzymes from mammalian pancreas glands subsequent to insulin removal |
-
0
- BE BE445131D patent/BE445131A/fr unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2637680A (en) * | 1943-03-31 | 1953-05-05 | Danske Andelsslagteriers Konse | Method for the extraction of insulin as well as enzymes from pancreas |
| US2571126A (en) * | 1943-06-04 | 1951-10-16 | Novo Terapeutisk Labor As | Hot aqueous extraction of enzymes from insulin-free pancreas |
| US2573099A (en) * | 1946-10-23 | 1951-10-30 | Novo Terapeutisk Labor As | Method of recovering proteolytic enzymes from mammalian pancreas glands with urea |
| US2803585A (en) * | 1946-10-23 | 1957-08-20 | Novo Terapeutisk Labor As | Method of recovering broteolytic pancreas enzymes from mammalian pancreas glands subsequent to insulin removal |
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