BE415573A - - Google Patents
Info
- Publication number
- BE415573A BE415573A BE415573DA BE415573A BE 415573 A BE415573 A BE 415573A BE 415573D A BE415573D A BE 415573DA BE 415573 A BE415573 A BE 415573A
- Authority
- BE
- Belgium
- Prior art keywords
- sep
- provitamin
- cholesterin
- alcohol
- invertebrates
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 66
- 229930193551 sterin Natural products 0.000 claims description 37
- HVYWMOMLDIMFJA-UHFFFAOYSA-N 3-cholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 HVYWMOMLDIMFJA-UHFFFAOYSA-N 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 20
- 229930003316 Vitamin D Natural products 0.000 claims description 19
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 19
- 235000019166 vitamin D Nutrition 0.000 claims description 19
- 239000011710 vitamin D Substances 0.000 claims description 19
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 19
- 229940046008 vitamin d Drugs 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 13
- 230000008569 process Effects 0.000 claims description 9
- 239000000470 constituent Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- YUGCAAVRZWBXEQ-UHFFFAOYSA-N Precholecalciferol Natural products C=1CCC2(C)C(C(C)CCCC(C)C)CCC2C=1C=CC1=C(C)CCC(O)C1 YUGCAAVRZWBXEQ-UHFFFAOYSA-N 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 208000010201 Exanthema Diseases 0.000 claims description 3
- 201000005884 exanthem Diseases 0.000 claims description 3
- 206010037844 rash Diseases 0.000 claims description 3
- 230000002035 prolonged effect Effects 0.000 claims description 2
- 239000007858 starting material Substances 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 62
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 30
- 239000000243 solution Substances 0.000 description 25
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
- 239000003208 petroleum Substances 0.000 description 16
- 239000000126 substance Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 241000700159 Rattus Species 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 14
- 238000009835 boiling Methods 0.000 description 12
- 239000003026 cod liver oil Substances 0.000 description 9
- 235000012716 cod liver oil Nutrition 0.000 description 9
- 230000009466 transformation Effects 0.000 description 9
- 241000243142 Porifera Species 0.000 description 8
- 230000001749 antrachitic effect Effects 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 241000237536 Mytilus edulis Species 0.000 description 7
- 235000019483 Peanut oil Nutrition 0.000 description 7
- 238000000862 absorption spectrum Methods 0.000 description 7
- 235000013372 meat Nutrition 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000312 peanut oil Substances 0.000 description 7
- 238000001953 recrystallisation Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- QSVJYFLQYMVBDR-UHFFFAOYSA-N Ergosterin Natural products C1C(O)CCC2(C)C3=CCC4(C)C(C(C)C=CC(C)C(C)C)CCC4C3=CC=C21 QSVJYFLQYMVBDR-UHFFFAOYSA-N 0.000 description 6
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 6
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 238000004821 distillation Methods 0.000 description 6
- DNVPQKQSNYMLRS-APGDWVJJSA-N ergosterol Chemical group C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-APGDWVJJSA-N 0.000 description 6
- 235000020638 mussel Nutrition 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 239000008149 soap solution Substances 0.000 description 6
- 241000257469 Asterias Species 0.000 description 5
- 241000545744 Hirudinea Species 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 241000243818 Annelida Species 0.000 description 3
- 241000238421 Arthropoda Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241000237852 Mollusca Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241001233061 earthworms Species 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 150000002978 peroxides Chemical class 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 241000254032 Acrididae Species 0.000 description 2
- 241000257470 Asterias rubens Species 0.000 description 2
- 241001674044 Blattodea Species 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- 241000258955 Echinodermata Species 0.000 description 2
- 241000237858 Gastropoda Species 0.000 description 2
- 241000237369 Helix pomatia Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000243684 Lumbricus Species 0.000 description 2
- 241001523579 Ostrea Species 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- YMHOBZXQZVXHBM-UHFFFAOYSA-N 2,5-dimethoxy-4-bromophenethylamine Chemical compound COC1=CC(CCN)=C(OC)C=C1Br YMHOBZXQZVXHBM-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000217381 Anodonta Species 0.000 description 1
- 241000243813 Arenicola Species 0.000 description 1
- 241000243812 Arenicola marina Species 0.000 description 1
- 241000544115 Astropecten Species 0.000 description 1
- 241000237519 Bivalvia Species 0.000 description 1
- 241000238659 Blatta Species 0.000 description 1
- 241000238662 Blatta orientalis Species 0.000 description 1
- 241000255791 Bombyx Species 0.000 description 1
- 241001521251 Buccinum Species 0.000 description 1
- 241000254001 Carausius Species 0.000 description 1
- 235000014649 Carica monoica Nutrition 0.000 description 1
- 244000132069 Carica monoica Species 0.000 description 1
- 241000238366 Cephalopoda Species 0.000 description 1
- 241001291455 Cliona Species 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 241000391124 Crangon Species 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- QRLVDLBMBULFAL-UHFFFAOYSA-N Digitonin Natural products CC1CCC2(OC1)OC3C(O)C4C5CCC6CC(OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9OC%10OC(CO)C(O)C(OC%11OC(CO)C(O)C(O)C%11O)C%10O)C8O)C(O)C7O)C(O)CC6(C)C5CCC4(C)C3C2C QRLVDLBMBULFAL-UHFFFAOYSA-N 0.000 description 1
- 241001541257 Dytiscus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000243171 Ephydatia Species 0.000 description 1
- 241000371986 Eriocheir Species 0.000 description 1
- 241000243305 Halichondria panicea Species 0.000 description 1
- 241000237903 Hirudo Species 0.000 description 1
- 241000238072 Homarus Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241000500891 Insecta Species 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- FNRXUEYLFZLOEZ-UHFFFAOYSA-N Littorin Natural products CN1C(C2)CCC1CC2OC(=O)C(O)CC1=CC=CC=C1 FNRXUEYLFZLOEZ-UHFFFAOYSA-N 0.000 description 1
- 241001441750 Littorina Species 0.000 description 1
- 241001441748 Littorina littorea Species 0.000 description 1
- 241000238383 Loligo Species 0.000 description 1
- 241000243662 Lumbricus terrestris Species 0.000 description 1
- 241000623907 Lytta Species 0.000 description 1
- 241000254071 Melolontha Species 0.000 description 1
- 241000828959 Melolontha hippocastani Species 0.000 description 1
- 241000237552 Mercenaria Species 0.000 description 1
- 241000361919 Metaphire sieboldi Species 0.000 description 1
- 241001611835 Modiola Species 0.000 description 1
- 241000257229 Musca <genus> Species 0.000 description 1
- 241000237524 Mytilus Species 0.000 description 1
- 229910004809 Na2 SO4 Inorganic materials 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241000238814 Orthoptera Species 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 241000238127 Pagurus Species 0.000 description 1
- 241001520299 Phascolarctos cinereus Species 0.000 description 1
- 241000238371 Sepiidae Species 0.000 description 1
- 241000544639 Suberites domuncula Species 0.000 description 1
- 241000254105 Tenebrio Species 0.000 description 1
- 241000254109 Tenebrio molitor Species 0.000 description 1
- 241000243653 Tubifex Species 0.000 description 1
- 241000545067 Venus Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000002050 anti-rickettsial effect Effects 0.000 description 1
- 230000031709 bromination Effects 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- UVYVLBIGDKGWPX-KUAJCENISA-N digitonin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O[C@H]5[C@@H]([C@@H](O)[C@@H](O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)CO7)O)[C@H](O)[C@@H](CO)O6)O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O7)O)[C@@H](O)[C@@H](CO)O6)O)[C@@H](CO)O5)O)C[C@@H]4CC[C@H]3[C@@H]2[C@@H]1O)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 UVYVLBIGDKGWPX-KUAJCENISA-N 0.000 description 1
- UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- FNRXUEYLFZLOEZ-FXUDXRNXSA-N littorine Chemical compound C([C@@H](O)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)N2C)C1=CC=CC=C1 FNRXUEYLFZLOEZ-FXUDXRNXSA-N 0.000 description 1
- 241000238565 lobster Species 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- -1 pro vitamin Chemical class 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE415573A true BE415573A (enrdf_load_html_response) |
Family
ID=78669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE415573D BE415573A (enrdf_load_html_response) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE415573A (enrdf_load_html_response) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011045243A1 (de) * | 2009-10-13 | 2011-04-21 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur inaktivierung von unerwünschten kontaminationen in blutegelextrakten |
-
0
- BE BE415573D patent/BE415573A/fr unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011045243A1 (de) * | 2009-10-13 | 2011-04-21 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur inaktivierung von unerwünschten kontaminationen in blutegelextrakten |
| US8597568B2 (en) | 2009-10-13 | 2013-12-03 | Bayer Pharma AG | Method for deactivating undesired contaminations in leech extracts |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2299149C (fr) | Procede d'isolation et de purification du paclitaxel a partir de sources naturelles | |
| Kabalak et al. | Extraction, characterization and comparison of chitins from large bodied four Coleoptera and Orthoptera species | |
| JPH04501732A (ja) | 植物、海草、細菌、オキアミ類、小エビ及びその他のザリガニ及び甲殻類からのアスタキサンチン及び関連するカロチノイド、アスタキサンチンエステル、キチン、タンパク質及び食肉の生産方法 | |
| Dorée | The occurrence and distribution of cholesterol and allied bodies in the animal kingdom | |
| EP1373176B1 (fr) | Extrait de coques de graines de lupin contenant du lupeol | |
| FR2470148A1 (fr) | Procede de preparation de fibres solubles de collagene | |
| Andersen | Cuticular sclerotization in the beetles Pachynoda epphipiata and Tenebrio molitor | |
| FR2488800A1 (fr) | Extraits d'ecorce du margousier possedant une activite antineoplastique | |
| BE415573A (enrdf_load_html_response) | ||
| Abel et al. | On the Pigment of the Negro's Skin and Hair | |
| Power et al. | XCI.—The constituents of the seeds of Hydnocarpus Wightiana and of Hydnocarpus anthelmintica. Isolation of a homologue of chaulmoogric acid | |
| CH635732A5 (fr) | Procede de desamerisation d'un extrait de fruits ou de legumes et extrait desamerise obtenu. | |
| US2216719A (en) | Vitamin | |
| Gillam | The vitamin A1 and A2 contents of mammalian and other animal livers | |
| EP0687273A1 (fr) | Inhibiteur de l'activite collagenase et composition cosmetique renfermant un tel inhibiteur | |
| RU2814085C1 (ru) | Способ получения концентрата эссенциальных элементов из морского гребешка flexopecten ponticus (варианты) | |
| RU2778480C1 (ru) | Способ получения биологически активного вещества из устрицы crassostrea gigas | |
| CH199318A (de) | Verfahren zur Herstellung eines namentlich auf Küken antirhachitisch wirkenden Präparates. | |
| BE360691A (enrdf_load_html_response) | ||
| BE416160A (enrdf_load_html_response) | ||
| Ouahiba et al. | EVALUATION DE L’ACTIVITE ANTIOXYDANTE ET L’EFFET ANTIMICROBIEN DES COMPOSES PHENOLIQUES EXTRAITS DU LICHEN «Xanthoria parietina» DE LA REGION DE BOUMERDES. | |
| BE438280A (enrdf_load_html_response) | ||
| KR20050120127A (ko) | 단백질분해효소 처리에 의한 아므르 불가사리 유래의 기능성 화장품용 조성물 | |
| EP2051720B1 (fr) | Procede de maturation ovocytaire | |
| FR3145259A1 (fr) | Procédé de traitement d’insectes et poudres obtenues |