BE2013C065I2 - - Google Patents

Download PDF

Info

Publication number
BE2013C065I2
BE2013C065I2 BE2013C065C BE2013C065C BE2013C065I2 BE 2013C065 I2 BE2013C065 I2 BE 2013C065I2 BE 2013C065 C BE2013C065 C BE 2013C065C BE 2013C065 C BE2013C065 C BE 2013C065C BE 2013C065 I2 BE2013C065 I2 BE 2013C065I2
Authority
BE
Belgium
Prior art keywords
virus
patients
vaccine
derived
recombinants
Prior art date
Application number
BE2013C065C
Other languages
French (fr)
Original Assignee
Bavarian Nordic As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159864&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2013C065(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bavarian Nordic As filed Critical Bavarian Nordic As
Publication of BE2013C065I2 publication Critical patent/BE2013C065I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A61K39/285—Vaccinia virus or variola virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and which is characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus or its recombinants as medicament or vaccine. Additionally, a method for inducing an immune response even in immuno-compromised patients, patients with pre-existing immunity to the vaccine virus or patients undergoing antiviral therapies is provided.
BE2013C065C 2000-11-23 2013-11-21 BE2013C065I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001764 2000-11-23
PCT/EP2001/013628 WO2002042480A2 (en) 2000-11-23 2001-11-22 Modified vaccinia ankara virus variant

Publications (1)

Publication Number Publication Date
BE2013C065I2 true BE2013C065I2 (en) 2021-01-29

Family

ID=8159864

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2013C065C BE2013C065I2 (en) 2000-11-23 2013-11-21

Country Status (29)

Country Link
US (11) US7189536B2 (en)
EP (4) EP2202315A1 (en)
JP (1) JP4421188B2 (en)
KR (3) KR100830295B1 (en)
CN (2) CN100537773C (en)
AT (1) ATE314483T2 (en)
AU (2) AU2002231639B2 (en)
BE (1) BE2013C065I2 (en)
BR (1) BRPI0115533B8 (en)
CA (1) CA2421151C (en)
CY (2) CY1105594T1 (en)
CZ (1) CZ295808B6 (en)
DE (2) DE60116371T3 (en)
DK (1) DK1335987T4 (en)
EE (1) EE05680B1 (en)
ES (1) ES2256323T5 (en)
FR (1) FR13C0070I2 (en)
HU (2) HU230198B1 (en)
IL (2) IL154712A0 (en)
LU (1) LU92311I2 (en)
MX (1) MXPA03002513A (en)
NO (1) NO337867B1 (en)
NZ (1) NZ524661A (en)
PL (1) PL212047B1 (en)
PT (1) PT1335987E (en)
RU (1) RU2290438C2 (en)
SI (1) SI1335987T2 (en)
UA (1) UA76731C2 (en)
WO (1) WO2002042480A2 (en)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL154712A0 (en) 2000-11-23 2003-10-31 Bavarian Nordic As Modified vaccinia ankara virus variant
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
US7097842B2 (en) 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7628980B2 (en) 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
UA82466C2 (en) * 2001-07-18 2008-04-25 Бавариан Нордика А/С Method for intensification of chordopoxvirus amplification
WO2003048184A2 (en) 2001-12-04 2003-06-12 Bavarian Nordic A/S Flavivirus ns1 subunit vaccine
AU2003239805B2 (en) * 2002-04-19 2009-09-10 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7501127B2 (en) 2002-05-16 2009-03-10 Bavarian Nordic A/S Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara
DK1404852T3 (en) * 2002-05-16 2006-05-08 Bavarian Nordic As Expression of genes in modified vaccinia virus Ankara using the coccyx ATI promoter
KR101041691B1 (en) 2002-05-16 2011-06-14 버베리안 노딕 에이/에스 Intrageneous region as an intra-genome insertion site of modified vaccinia virus Ankara (MBA)
SI1434858T2 (en) 2002-09-05 2019-05-31 Bavarian Nordic A/S Method for the amplification of a poxvirus under serum free conditions
ATE377088T1 (en) * 2003-11-24 2007-11-15 Bavarian Nordic As PROMOTORS FOR EXPRESSION IN MODIFIED VACCINIA VIRUS ANKARA
WO2005120579A1 (en) * 2004-06-14 2005-12-22 Ishihara Sangyo Kaisha, Ltd. Freeze-dried composition of inactivated virus envelope with membrane fusion activity
CN1295339C (en) * 2005-01-11 2007-01-17 武汉大学 Attenuated vaccinia virus Tiantan strain vector and its preparation and application
UA100836C2 (en) * 2005-02-23 2013-02-11 Бавариан Нордик А/С Normal;heading 1;heading 2;heading 3;USE OF A MODIFIED VACCINIA VIRUS ANKARA FOR THE RAPID INDUCTION OF IMMUNITY AGAINST A POXVIRUS OR OTHER INFECTIOUS AGENTS
WO2006113927A2 (en) * 2005-04-20 2006-10-26 University Of Washington Immunogenic vaccinia peptides and methods of using same
KR100717279B1 (en) * 2005-08-08 2007-05-15 삼성전자주식회사 Mask ROM Device and Formation Method
US7913477B2 (en) * 2006-01-27 2011-03-29 William Anthony Harper Insert registration in packets
EP1826264A1 (en) * 2006-02-24 2007-08-29 Deutsches Primatenzentrum GmbH Primate model for orthopox virus infections
EP1835031A1 (en) 2006-03-14 2007-09-19 Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe Use of a recombinant modified vaccinia virus Ankara (MVA) for the treatment of type I hypersensitivity in a living animal including humans
MX2008016036A (en) 2006-06-20 2009-04-07 Transgene Sa Recombinant viral vaccine.
EP2029756B1 (en) * 2006-06-20 2016-11-09 Transgene S.A. Process for producing poxviruses and poxvirus compositions
CA2662730A1 (en) * 2006-09-08 2008-03-13 Bavarian Nordic A/S Phenotypic and genotypic differences of mva strains
EP2073837B1 (en) * 2006-10-06 2014-06-25 Bavarian Nordic Inc. Recombinant modified vaccinia ankara virus encoding a her-2 antigen in combination with a taxane for use in treating cancer
US8268327B2 (en) 2007-04-27 2012-09-18 Bavarian Nordic A/S Immediate protection against pathogens via MVA
AU2008250596C1 (en) 2007-05-14 2010-11-25 Bavarian Nordic A/S Purification of Vaccinia virus- and recombinant Vaccinia virus-based vaccines
US8003364B2 (en) * 2007-05-14 2011-08-23 Bavarian Nordic A/S Purification of vaccinia viruses using hydrophobic interaction chromatography
NZ584042A (en) * 2007-10-18 2012-09-28 Bn Immunotherapeutics Inc Use of mva to treat prostate cancer
KR100970449B1 (en) * 2007-12-21 2010-07-16 (주)이지아이 Rubber flooring and installation method for children's playground with safety
EP2303322A1 (en) * 2008-06-20 2011-04-06 Bavarian Nordic A/S Recombinant modified vaccinia virus measles vaccine
HRP20150470T1 (en) 2009-01-20 2015-06-05 Transgene Sa ICAM-1 SOLUBLE AS A BIOMARKER FOR PREDICTION OF THERAPY RESPONSE
US8613936B2 (en) 2009-03-13 2013-12-24 Bavarian Nordic A/S Replication deficient recombinant viruses expressing antigens regulated by transcriptional control elements comprising multiple elements
US8394385B2 (en) * 2009-03-13 2013-03-12 Bavarian Nordic A/S Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines
CN102362184B (en) 2009-03-24 2015-04-08 特朗斯吉有限公司 Biomarkers for monitoring patients
PT2419728E (en) 2009-04-17 2014-03-12 Transgene Sa Biomarker for monitoring patients
CA2767458A1 (en) 2009-07-10 2011-01-13 Bruce Acres Biomarker for selecting patients and related methods
EP2486138A1 (en) * 2009-10-08 2012-08-15 Bavarian Nordic A/S Generation of a broad t-cell response in humans against hiv
EP2501405A4 (en) * 2009-11-20 2013-12-04 Inviragen Inc Compositions, methods and uses for poxvirus elements in vaccine constructs
DK2529010T3 (en) 2010-01-28 2017-07-24 Bavarian Nordic As MUTANTS OF VACCINIAVIRUS CONTAINING THE MAIN GENOMIC DELETIONS OF VAT
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
NZ603620A (en) 2010-07-20 2015-01-30 Bavarian Nordic As Method for harvesting expression products
WO2012018856A2 (en) * 2010-08-02 2012-02-09 Virxsys Corporation Hiv vaccine therapy with concomitant antiviral monotherapy
AU2011316164B2 (en) * 2010-10-15 2016-01-14 Bavarian Nordic A/S Recombinant modified vaccinia virus Ankara (MVA) influenza vaccine
PL2691530T3 (en) 2011-06-10 2019-02-28 Oregon Health & Science University Glycoproteins and recombinant CMV vectors
ES2813413T3 (en) * 2011-08-05 2021-03-23 Sillajen Biotherapeutics Inc Methods and compositions for the production of vaccina virus
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en) 2011-10-27 2013-05-01 Christopher L. Parks Viral particles derived from an enveloped virus
DK2788021T3 (en) 2011-12-09 2017-04-10 Bavarian Nordic As POXVIRUS VECTOR FOR EXPRESSION OF BACTERIAL ANTIGENES CONNECTED TO TETANANOX INFRAGMENT C
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
WO2013189611A1 (en) 2012-06-22 2013-12-27 Bavarian Nordic A/S Poxviral vectors for low antibody response after a first priming immunization
ES2631608T3 (en) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Env-glycoprotein variant of HIV-1
BR112015000530A2 (en) 2012-07-10 2018-08-28 Transgene Sa mycobacterial antigen vaccine.
WO2014009433A1 (en) 2012-07-10 2014-01-16 Transgene Sa Mycobacterium resuscitation promoting factor for use as adjuvant
EA201891945A3 (en) 2012-08-01 2019-05-31 Бавариан Нордик А/С VACCINE OF THE RECOMBINANT MODIFIED ANPARA OSPOVACZINA VIRUS (MVA) RESPIRATORY-SYNCYTIAL VIRUS (RSV)
EP2892549A1 (en) 2012-09-04 2015-07-15 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
WO2014043535A1 (en) 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions for the treatment of cancer
US20150283220A1 (en) 2012-10-19 2015-10-08 Bavarian Nordic, Inc. Methods and compositions for the treatment of cancer
EA032498B1 (en) 2012-10-28 2019-06-28 Бавариан Нордик А/С Pr13.5 PROMOTER FOR ROBUST T-CELL AND ANTIBODY RESPONSES
WO2014139687A1 (en) * 2013-03-15 2014-09-18 Bavarian Nordic A/S Single high dose of mva induces a protective immune response in neonates and infants
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
AU2014340201B2 (en) 2013-10-23 2019-02-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HLA-A24 agonist epitopes of MUC1-C oncoprotein and compositions and methods of use
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
LT3074517T (en) 2013-11-28 2021-11-25 Bavarian Nordic A/S COMPOSITIONS AND METHODS FOR ELIMINATING AN ENHANCED IMMUNE RESPONSE USING THE VECTIC VIRUS VECTOR
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
MX2016009072A (en) 2014-01-09 2017-05-08 Transgene Sa Fusion of heterooligomeric mycobacterial antigens.
AU2015259516B2 (en) 2014-05-13 2020-05-28 Bavarian Nordic A/S Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against TIM-3
BR112016028816A8 (en) 2014-06-13 2021-07-20 Glaxosmithkline Biologicals Sa immunogenic combination, method of obtaining a specific immune response, use of an immunogenic combination, and, vaccination regimen for the prevention, reduction or treatment of respiratory syncytial virus infection
DK3656395T5 (en) 2014-09-03 2024-05-27 Janssen Vaccines & Prevention Bv Methods and compositions for inducing protective immunity against filovirus infection
AU2015311868B2 (en) 2014-09-03 2018-11-22 Bavarian Nordic A/S Methods and compositions for enhancing immune responses
KR101971808B1 (en) 2014-09-26 2019-04-23 베쓰 이스라엘 디코니스 메디칼 센터 인크 Methods and Compositions for Inducing Protective Immunity Against Human Immunodeficiency Virus Infection
KR101623498B1 (en) 2014-10-16 2016-05-24 대한민국 Kvacattenuated vaccinia virus kvac strain
KR101645642B1 (en) 2014-10-16 2016-08-11 대한민국 Kvac recombinant vaccinia virus derived from kvac strain
CA2965562C (en) 2014-11-04 2023-11-21 Janssen Vaccines & Prevention B.V. Therapeutic hpv16 vaccines
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
WO2016100977A1 (en) 2014-12-19 2016-06-23 The Broad Institute Inc. Methods for profiling the t-cel- receptor repertoire
CN115300622A (en) 2015-02-25 2022-11-08 纪念斯隆-凯特琳癌症中心 Use of an inactivated modified vaccinia virus Ankara as a single immunotherapy in solid tumors or in combination with immune checkpoint blockade
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
JP6936153B2 (en) 2015-04-17 2021-09-15 メモリアル スローン ケタリング キャンサー センター Use of MVA or MVAΔE3L as a solid tumor immunotherapeutic agent
CR20200476A (en) 2015-05-20 2020-12-02 Dana Farber Cancer Inst Inc Shared neoantigens
TWI750122B (en) 2015-06-09 2021-12-21 美商博德研究所有限公司 Formulations for neoplasia vaccines and methods of preparing thereof
CA2987159A1 (en) * 2015-06-15 2016-12-22 Bavarian Nordic A/S Recombinant modified vaccinia virus ankara (mva) foot and mouth disease virus (fmdv) vaccine
US9925258B2 (en) 2015-10-02 2018-03-27 International Aids Vaccine Initiative Replication-competent VSV-HIV Env vaccines
FR3042121A1 (en) 2015-10-08 2017-04-14 Jean-Marc Limacher ANTI-TUMOR COMPOSITION
CN106591361A (en) * 2015-10-20 2017-04-26 钱文斌 Recombinant pox oncolytic virus, and construction method and application thereof
EP3964569A1 (en) 2015-12-15 2022-03-09 Janssen Vaccines & Prevention B.V. Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof
HUE059343T2 (en) 2016-01-29 2022-11-28 Bavarian Nordic As Recombinant modified vaccinia virus ankara (mva) equine encephalitis virus vaccine
SG11201807051VA (en) 2016-02-25 2018-09-27 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy
WO2017147554A2 (en) 2016-02-25 2017-08-31 Memorial Sloan-Kettering Cancer Center Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors
MX391337B (en) 2016-04-13 2025-03-21 Janssen Pharmaceuticals Inc Star RECOMBINANT ARTERIVIRUS REPLICON SYSTEMS AND THEIR USES.
EP3446119A1 (en) 2016-04-18 2019-02-27 The Broad Institute Inc. Improved hla epitope prediction
SG11201808809PA (en) 2016-05-02 2018-11-29 Janssen Vaccine & Prevention B V Therapeutic hpv vaccine combinations
CN109219448B (en) 2016-06-16 2022-09-20 扬森疫苗与预防公司 HIV vaccine formulations
WO2018011768A1 (en) 2016-07-15 2018-01-18 Janssen Vaccines And Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
CN110494159A (en) 2016-09-02 2019-11-22 扬森疫苗与预防公司 Method of the induction for the immune response of HIV infection in the object of antiretroviral therapy
RS60919B1 (en) 2016-09-15 2020-11-30 Janssen Vaccines & Prevention Bv Trimer stabilizing hiv envelope protein mutations
JP7062003B2 (en) 2016-09-28 2022-05-02 バヴァリアン・ノルディック・アクティーゼルスカブ Compositions and Methods for Improving Transgene Stability in Poxvirus
BR112019007433A2 (en) 2016-10-17 2019-07-02 Synthetic Genomics Inc recombinant virus replicon systems and uses thereof
AU2017355564B2 (en) 2016-11-07 2022-04-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Development of agonist epitopes of the human papillomavirus
WO2018106615A2 (en) 2016-12-05 2018-06-14 Synthetic Genomics, Inc. Compositions and methods for enhancing gene expression
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
EP3606553A1 (en) 2017-04-06 2020-02-12 Janssen Vaccines & Prevention B.V. Mva-bn and ad26.zebov or ad26.filo prime-boost regimen
CN111107872A (en) 2017-05-12 2020-05-05 纪念斯隆-凯特林癌症中心 Vaccinia virus mutants useful for cancer immunotherapy
AU2018269319A1 (en) 2017-05-15 2019-11-07 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
US11052147B2 (en) 2017-05-15 2021-07-06 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
WO2018229711A1 (en) 2017-06-15 2018-12-20 Janssen Vaccines & Prevention B.V. Poxvirus vectors encoding hiv antigens, and methods of use thereof
EP3655032A1 (en) 2017-07-19 2020-05-27 Janssen Vaccines & Prevention B.V. Trimer stabilizing hiv envelope protein mutations
US20190022212A1 (en) 2017-07-21 2019-01-24 Beth Israel Deaconess Medical Center, Inc. Methods for safe induction of cross-clade immunity against human immunodeficiency virus infection in human
SG11202001115TA (en) 2017-08-24 2020-03-30 Bavarian Nordic As Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an antibody
WO2019055888A1 (en) 2017-09-18 2019-03-21 Janssen Vaccines & Prevention B.V. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
US11389531B2 (en) 2017-12-19 2022-07-19 Janssen Sciences Ireland Unlimited Company Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines
US11020476B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
US11021692B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Hepatitis B virus (HBV) vaccines and uses thereof
CN111741766A (en) 2017-12-19 2020-10-02 杨森科学爱尔兰无限公司 Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
CN118308379A (en) 2017-12-20 2024-07-09 葛兰素史密丝克莱恩生物有限公司 Epstein-Barr virus antigen constructs
JP7494117B2 (en) 2018-01-19 2024-06-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド Induction and enhancement of immune responses using recombinant replicon systems
US20220001001A1 (en) * 2018-07-13 2022-01-06 University Of Georgia Research Foundation Broadly reactive immunogens of dengue virus, compositions, and methods of use thereof
JP7437385B2 (en) 2018-09-06 2024-02-22 バヴァリアン・ノルディック・アクティーゼルスカブ Poxvirus composition with improved storage
CN116162654A (en) 2018-09-15 2023-05-26 纪念斯隆凯特琳癌症中心 Recombinant poxviruses for cancer immunotherapy
WO2020072700A1 (en) 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
CA3113818A1 (en) 2018-10-05 2020-04-09 Bavarian Nordic A/S Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist
BR112021006614A2 (en) 2018-10-08 2021-07-20 Janssen Pharmaceuticals, Inc. alphavirus-based replicons for biotherapeutic administration
WO2020102404A1 (en) 2018-11-14 2020-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Tp5, a peptide inhibitor of aberrant and hyperactive cdk5/p25 as treatment for cancer
CA3119503A1 (en) 2018-11-20 2020-05-28 Bavarian Nordic A/S Therapy for treating cancer with an intratumoral and/or intravenous administration of a recombinant mva encoding 4-1bbl (cd137l) and/or cd40l
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
TWI852977B (en) 2019-01-10 2024-08-21 美商健生生物科技公司 Prostate neoantigens and their uses
TW202110476A (en) 2019-05-22 2021-03-16 荷蘭商傑森疫苗防護公司 Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
CN113966228A (en) 2019-06-11 2022-01-21 葛兰素史密斯克莱生物公司 mucosal vaccine formulations
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
WO2021094984A1 (en) 2019-11-14 2021-05-20 Aelix Therapeutics, S.L. Dosage regimens for vaccines
AU2020385683A1 (en) 2019-11-18 2022-06-30 Janssen Biotech, Inc. Vaccines based on mutant CALR and JAK2 and their uses
US20230190922A1 (en) 2019-11-20 2023-06-22 Bavarian Nordic A/S Recombinant MVA Viruses for Intratumoral and/or Intravenous Administration for Treating Cancer
JP7670705B2 (en) 2019-11-20 2025-04-30 バヴァリアン・ノルディック・アクティーゼルスカブ Medical Use of Recombinant Modified Vaccinia Virus Ankara (MVA) Adjuvanted with 4-1BBL
US20230287067A1 (en) 2020-01-21 2023-09-14 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Human immunogenic epitopes of hemo and hhla2 human endogenous retroviruses (hervs)
WO2021150713A2 (en) 2020-01-21 2021-07-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human immunogenic epitopes of h, k, and e human endogenous retroviruses (hervs)
WO2021180943A1 (en) 2020-03-12 2021-09-16 Bavarian Nordic A/S Compositions improving poxvirus stability
CA3181431A1 (en) 2020-06-10 2021-12-16 Jurgen Hausmann A recombinant modified vaccinia virus ankara (mva) vaccine against coronavirus disease
WO2021260065A1 (en) 2020-06-24 2021-12-30 Consejo Superior De Investigaciones Científicas (Csic) Mva-based vaccine against covid-19 expressing sars-cov-2 antigens
EP3928789A1 (en) 2020-06-24 2021-12-29 Consejo Superior de Investigaciones Científicas (CSIC) Mva-based vaccine against covid-19 expressing sars-cov-2 antigens
US12295997B2 (en) 2020-07-06 2025-05-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
CN116367854A (en) 2020-07-08 2023-06-30 杨森科学爱尔兰无限公司 RNA replicon vaccine against HBV
WO2022084333A1 (en) 2020-10-20 2022-04-28 Janssen Vaccines & Prevention B.V. Hiv vaccine regimens
EP4108257A1 (en) 2021-06-23 2022-12-28 Consejo Superior De Investigaciones Científicas Mva-based vaccine against covid-19 expressing a prefusion-stabilized sars-cov-2 s protein
EP4358999A1 (en) 2021-06-23 2024-05-01 Consejo Superior De Investigaciones Científicas Mva-based vaccine expressing a prefusion-stabilized sars-cov-2 s protein
JP2024535145A (en) 2021-09-03 2024-09-27 バヴァリアン・ノルディック・アクティーゼルスカブ Utilizing microRNAs to downregulate cytotoxic transgene expression by modified vaccinia virus Ankara (MVA)
WO2023118508A1 (en) 2021-12-23 2023-06-29 Bavarian Nordic A/S Recombinant mva viruses for intraperitoneal administration for treating cancer
CA3240596A1 (en) 2021-12-23 2023-06-29 Cigdem ATAY LANGBEIN Therapy for modulating immune response with recombinant mva encoding il-12
WO2023198815A1 (en) 2022-04-14 2023-10-19 Janssen Vaccines & Prevention B.V. Sequential administration of adenoviruses
KR20250029868A (en) 2022-06-29 2025-03-05 버베리안 노딕 에이/에스 Recombinant modified saRNA (VRP) and vaccinia virus ankara (MVA) prime-boost regimen
KR20250029119A (en) 2022-06-29 2025-03-04 버베리안 노딕 에이/에스 Epstein-Barr virus vaccine
WO2024003346A1 (en) 2022-06-30 2024-01-04 Bavarian Nordic A/S Mammalian cell line for the production of modified vaccinia virus ankara (mva)
WO2024015892A1 (en) 2022-07-13 2024-01-18 The Broad Institute, Inc. Hla-ii immunopeptidome methods and systems for antigen discovery
EP4316514A1 (en) 2022-08-03 2024-02-07 Consejo Superior de Investigaciones Científicas (CSIC) Mva-based vectors and their use as vaccine against sars-cov-2
WO2024188801A1 (en) 2023-03-10 2024-09-19 Bavarian Nordic A/S Use of quail cell lines for poxvirus production
WO2024188802A1 (en) 2023-03-10 2024-09-19 Bavarian Nordic A/S Methods of isolating poxviruses from avian cell cultures
AU2024234386A1 (en) 2023-03-10 2025-08-28 Bavarian Nordic A/S Production of poxviruses from quail cell cultures
WO2025120141A1 (en) 2023-12-08 2025-06-12 Bavarian Nordic A/S Downregulation of yield-reducing transgenes expressed by poxvirus
FR3160186A1 (en) 2024-03-13 2025-09-19 Odimma Therapeutics NON-VIRAL VECTOR FOR ENHANCED TRANSCRIPTION

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072565A (en) * 1974-11-04 1978-02-07 The Dow Chemical Company Production of viruses in tissue culture without use of serum
US3914408A (en) * 1973-10-12 1975-10-21 Univ Nebraska Vaccine for neonatal calf diarrhea
DE2714665A1 (en) * 1977-04-01 1978-10-05 Mayr Anton PREPARATION FOR TREATING HERPES ZOSTER AND OTHER HERPES INFECTIONS AND METHOD FOR THE PRODUCTION THEREOF
US5155020A (en) * 1989-03-08 1992-10-13 Health Research Inc. Recombinant poxvirus host range selection system
US5338683A (en) * 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
GB8322414D0 (en) * 1983-08-19 1983-09-21 Szelke M Renin inhibitors
AU613583B2 (en) 1986-08-22 1991-08-08 Transgene S.A. Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity
FR2603040B1 (en) 1986-08-22 1990-01-26 Transgene Sa PROTEIN, DNA SEQUENCE, POXVIRUSES, CELLS AND THEIR CULTURE PROCESS, AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USEFUL IN THE PREVENTION OF SCHISTOSOMOSIS
DE3743298A1 (en) 1987-12-19 1989-06-29 Wilkinson Sword Gmbh SHAVING APPARATUS AND METHOD FOR PRODUCING A LAYER OF LOW FRICTION RESISTANCE ON A SHAVING APPARATUS
CA1341245C (en) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
US6248333B1 (en) * 1990-04-04 2001-06-19 Health Research Inc. Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD)
EP0550638A4 (en) 1990-09-25 1993-12-08 Smithkline Beecham Corporation Medium for culture of mammalian cells
AU672359B2 (en) * 1991-03-07 1996-10-03 Virogenetics Corporation Genetically engineered vaccine strain
US5843456A (en) * 1991-03-07 1998-12-01 Virogenetics Corporation Alvac poxvirus-rabies compositions and combination compositions and uses
US5403582A (en) 1993-01-21 1995-04-04 Nippon Zeon Co., Ltd. Vaccine comprising fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus
US5405772A (en) 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US5490794A (en) * 1993-11-05 1996-02-13 Sumitomo Wiring Systems, Ltd. Branch joint box
US6190655B1 (en) 1993-12-03 2001-02-20 Immunex Corporation Methods of using Flt-3 ligand for exogenous gene transfer
DE4405841C1 (en) † 1994-02-23 1995-01-05 Mayr Anton Prof Dr Med Vet Dr Multipotent non-specific immunity inducers based on combinations of poxvirus components, processes for their preparation and their use as pharmaceuticals
CA2188447C (en) * 1994-04-29 2002-10-22 Falko-Gunter Falkner Recombinant poxviruses with foreign polynucleotides in essential regions
JPH10506004A (en) * 1994-07-27 1998-06-16 ザ カウンシル オブ ザ クィーンズランド インスティテュート オブ メディカル リサーチ Polyepitope vaccine
US5676950A (en) * 1994-10-28 1997-10-14 University Of Florida Enterically administered recombinant poxvirus vaccines
US5756341A (en) 1994-11-10 1998-05-26 Immuno Ag Method for controlling the infectivity of viruses
US5753489A (en) 1994-11-10 1998-05-19 Immuno Ag Method for producing viruses and vaccines in serum-free culture
US5566011A (en) * 1994-12-08 1996-10-15 Luncent Technologies Inc. Antiflector black matrix having successively a chromium oxide layer, a molybdenum layer and a second chromium oxide layer
UA68327C2 (en) † 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
AU726623B2 (en) 1996-02-21 2000-11-16 Julianna Lisziewicz Methods and compositions for protective and therapeutic genetic immunization
WO1998004680A1 (en) 1996-07-26 1998-02-05 University Of Manitoba Serum-free medium for growth of anchorage-dependant mammalian cells
ID19548A (en) † 1996-09-24 1998-07-23 Bavarian Nordic Res Inst As RECOMBINED MVA VIRUSES EXPRESSING FEATURES ANTIGENS AND FEVER USING THEMS IN VACCINES
WO1998017283A1 (en) 1996-10-25 1998-04-30 The Wistar Institute Of Anatomy & Biology Method of vaccinating infants against infections
US6204250B1 (en) * 1996-11-22 2001-03-20 The Mount Sinai Medical Center Of The City Of New York Immunization of infants
GB9711957D0 (en) * 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
US20030138454A1 (en) * 1997-06-09 2003-07-24 Oxxon Pharmaccines, Ltd. Vaccination method
GB0023203D0 (en) 2000-09-21 2000-11-01 Isis Innovation Vaccination method
DE19729279A1 (en) † 1997-07-09 1999-01-14 Peter Hildebrandt Urological implant, in particular vascular wall support for the urinal tract
AU3910097A (en) * 1997-08-05 1999-03-01 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Live recombinant vaccine comprising inefficiently or non-replicating vir us
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
AU776865B2 (en) 1998-11-10 2004-09-23 University Of Rochester T cells specific for target antigens and methods and vaccines based thereon
GB2370572B (en) 1998-11-18 2003-05-07 Oxford Biomedica Ltd Use of a professional antigen presenting cell
AU766954B2 (en) 1998-11-18 2003-10-30 Oxford Biomedica (Uk) Limited Polypeptide
US6173813B1 (en) 1998-12-23 2001-01-16 Otis Elevator Company Electronic control for an elevator braking system
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
CN1311871C (en) * 2000-03-02 2007-04-25 爱莫里大学 DNA expression vector and its application method
RU2280075C2 (en) * 2000-03-14 2006-07-20 Бавариан Нордик А/С Alternated strain of modified vaccinia virus ankara (mva)
KR100341030B1 (en) 2000-03-16 2002-06-20 유태욱 method for replaying caption data and audio data and a display device using the same
EP1283718A2 (en) 2000-05-24 2003-02-19 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
LU90997B1 (en) * 2000-07-11 2003-01-08 Bayer Ag Use of strains of the parapox ovis virus for producing antiviral pharmaceuticals ans anticancer pharmaceuticals
US6733993B2 (en) * 2000-09-15 2004-05-11 Merck & Co., Inc. Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications
IL154712A0 (en) 2000-11-23 2003-10-31 Bavarian Nordic As Modified vaccinia ankara virus variant
US7097842B2 (en) * 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7445924B2 (en) * 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
UA82466C2 (en) * 2001-07-18 2008-04-25 Бавариан Нордика А/С Method for intensification of chordopoxvirus amplification
WO2003048184A2 (en) * 2001-12-04 2003-06-12 Bavarian Nordic A/S Flavivirus ns1 subunit vaccine
SI1407006T1 (en) 2001-12-20 2006-04-30 Bavarian Nordic As Method for the recovery and purification of poxviruses from infected cells
AU2003219057A1 (en) 2002-03-15 2003-09-29 Baxter Healthcare S.A. Recombinant drug-sensitive vaccinia virus as smallpox vaccine
AU2003239805B2 (en) * 2002-04-19 2009-09-10 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
DK1404852T3 (en) * 2002-05-16 2006-05-08 Bavarian Nordic As Expression of genes in modified vaccinia virus Ankara using the coccyx ATI promoter
KR101041691B1 (en) * 2002-05-16 2011-06-14 버베리안 노딕 에이/에스 Intrageneous region as an intra-genome insertion site of modified vaccinia virus Ankara (MBA)
SI1434858T2 (en) * 2002-09-05 2019-05-31 Bavarian Nordic A/S Method for the amplification of a poxvirus under serum free conditions
EP1567653B1 (en) * 2002-11-25 2007-06-20 Bavarian Nordic A/S Recombinant poxvirus comprising at least two cowpox ati promoters
US6976752B2 (en) * 2003-10-28 2005-12-20 Lexmark International, Inc. Ink jet printer with resistance compensation circuit
ATE377088T1 (en) * 2003-11-24 2007-11-15 Bavarian Nordic As PROMOTORS FOR EXPRESSION IN MODIFIED VACCINIA VIRUS ANKARA
EP1586330A1 (en) * 2004-04-16 2005-10-19 Georg-August-Universität Göttingen Vaccination against malignant melanoma
US8354093B2 (en) * 2004-10-15 2013-01-15 Washington University Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
EP1835031A1 (en) 2006-03-14 2007-09-19 Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe Use of a recombinant modified vaccinia virus Ankara (MVA) for the treatment of type I hypersensitivity in a living animal including humans
EP2073837B1 (en) * 2006-10-06 2014-06-25 Bavarian Nordic Inc. Recombinant modified vaccinia ankara virus encoding a her-2 antigen in combination with a taxane for use in treating cancer
EP1925318A1 (en) 2006-11-20 2008-05-28 Paul-Ehrlich-Institut Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu
US8268327B2 (en) * 2007-04-27 2012-09-18 Bavarian Nordic A/S Immediate protection against pathogens via MVA
NZ584042A (en) * 2007-10-18 2012-09-28 Bn Immunotherapeutics Inc Use of mva to treat prostate cancer

Also Published As

Publication number Publication date
US20030215466A1 (en) 2003-11-20
CZ20031366A3 (en) 2003-08-13
KR100910297B1 (en) 2009-08-03
US20110182933A1 (en) 2011-07-28
PL361459A1 (en) 2004-10-04
CA2421151C (en) 2013-07-02
DK1335987T3 (en) 2006-04-24
IL154712A (en) 2010-05-31
HUP0400685A3 (en) 2004-10-28
US7939086B2 (en) 2011-05-10
CN100537773C (en) 2009-09-09
US7384644B2 (en) 2008-06-10
DK1335987T4 (en) 2016-09-19
DE60116371D1 (en) 2006-02-02
AU3163902A (en) 2002-06-03
KR100830295B1 (en) 2008-05-16
CN101676389A (en) 2010-03-24
US20050271688A1 (en) 2005-12-08
IL154712A0 (en) 2003-10-31
US20030206926A1 (en) 2003-11-06
US6913752B2 (en) 2005-07-05
US8268329B2 (en) 2012-09-18
HUP0400685A2 (en) 2004-07-28
WO2002042480A3 (en) 2002-08-01
DE60116371T2 (en) 2006-09-07
US8268325B2 (en) 2012-09-18
US6761893B2 (en) 2004-07-13
FR13C0070I2 (en) 2019-06-21
DE20122302U1 (en) 2005-02-24
US7189536B2 (en) 2007-03-13
DE60116371T3 (en) 2016-11-17
KR20080032016A (en) 2008-04-11
RU2290438C2 (en) 2006-12-27
US20100119545A1 (en) 2010-05-13
US20120328650A1 (en) 2012-12-27
CY2013048I1 (en) 2015-12-09
HK1059453A1 (en) 2004-07-02
MXPA03002513A (en) 2004-09-10
CY1105594T1 (en) 2010-07-28
UA76731C2 (en) 2006-09-15
EP1335987A2 (en) 2003-08-20
US20090169579A1 (en) 2009-07-02
US7923017B2 (en) 2011-04-12
US20060280758A1 (en) 2006-12-14
CY2013048I2 (en) 2015-12-09
ES2256323T5 (en) 2016-11-21
EE200300173A (en) 2003-06-16
CN1476483A (en) 2004-02-18
US7335364B2 (en) 2008-02-26
EE05680B1 (en) 2013-10-15
SI1335987T1 (en) 2006-06-30
US20080089907A1 (en) 2008-04-17
NO20032309D0 (en) 2003-05-21
ES2256323T3 (en) 2006-07-16
HU230198B1 (en) 2015-10-28
EP2204452A1 (en) 2010-07-07
LU92311I2 (en) 2014-01-20
SI1335987T2 (en) 2016-10-28
ATE314483T2 (en) 2006-01-15
NO20032309L (en) 2003-05-21
JP2004514436A (en) 2004-05-20
EP1598425A1 (en) 2005-11-23
CA2421151A1 (en) 2002-05-30
AU2002231639B2 (en) 2007-01-04
EP2202315A1 (en) 2010-06-30
WO2002042480A2 (en) 2002-05-30
FR13C0070I1 (en) 2014-01-17
BR0115533B1 (en) 2017-11-14
KR20090057335A (en) 2009-06-04
KR20030081333A (en) 2003-10-17
PT1335987E (en) 2006-05-31
NO337867B1 (en) 2016-07-04
EP1335987B1 (en) 2005-12-28
NZ524661A (en) 2005-03-24
PL212047B1 (en) 2012-08-31
EP1335987B2 (en) 2016-06-15
BR0115533A (en) 2004-02-03
US20030202988A1 (en) 2003-10-30
HUS1600010I1 (en) 2020-01-28
CZ295808B6 (en) 2005-11-16
US20110182932A1 (en) 2011-07-28
JP4421188B2 (en) 2010-02-24
US7459270B2 (en) 2008-12-02
BRPI0115533B8 (en) 2021-05-25

Similar Documents

Publication Publication Date Title
HUS1600010I1 (en) Modified vaccinia ankara virus variant
NO20045480L (en) Intergenic regions such as insertion sites in the vaccinia virus ankara genome (MVA)
NZ547776A (en) Modified vaccinia virus ankara for protecting an animal against an antigen or self-protein
ATE236262T1 (en) RECOMBINANT SWINEPOX VIRUS
WO2001068117A3 (en) Immunostimulatory polynucleotide sequences for use in preventing and treating viral infections
ATE297757T1 (en) CHIMERIC VACCINES AGAINST FLAVIVIRUS
BR0316291A (en) Hcv vaccine, methods of preventing or treating an hcv infection in a mammal and vaccinating an individual, and using a hcv vaccine
EP2552490A4 (en) Ectodomains of influenza matrix 2 protein, expression system, and uses thereof
UA84667C2 (en) Vaccine directed against infection induced by herpes virus of marek's disease
EP0868522A4 (en) Recombinant poxvirus-feline infectious peritonitis virus, compositions thereof and methods for making and using them
DK0885013T3 (en) Use of multipotent paramuncture inducers from attenuated, non-immunogenic pox virus or parapox virus for the manufacture of drugs
WO2002047720A3 (en) Treatment and prevention of ebv infection and ebv-associated disorders
HK1062804A1 (en) Smallpox vaccine