BE1019113A3 - COMPOSITION CONTAINING GRANADO POLYPHENOLS, D VITAMINS AND OLIGOELEMENTS. - Google Patents
COMPOSITION CONTAINING GRANADO POLYPHENOLS, D VITAMINS AND OLIGOELEMENTS. Download PDFInfo
- Publication number
- BE1019113A3 BE1019113A3 BE2009/0794A BE200900794A BE1019113A3 BE 1019113 A3 BE1019113 A3 BE 1019113A3 BE 2009/0794 A BE2009/0794 A BE 2009/0794A BE 200900794 A BE200900794 A BE 200900794A BE 1019113 A3 BE1019113 A3 BE 1019113A3
- Authority
- BE
- Belgium
- Prior art keywords
- mcg
- composition
- composition according
- polyphenols
- elderberry
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 235000013824 polyphenols Nutrition 0.000 title claims description 28
- 150000008442 polyphenolic compounds Chemical class 0.000 title claims description 27
- 244000294611 Punica granatum Species 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 241000219991 Lythraceae Species 0.000 claims abstract description 21
- 235000014360 Punica granatum Nutrition 0.000 claims abstract description 21
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 14
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 10
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract description 8
- 235000013305 food Nutrition 0.000 claims abstract description 6
- 230000007969 cellular immunity Effects 0.000 claims abstract description 3
- 230000004727 humoral immunity Effects 0.000 claims abstract description 3
- 230000009993 protective function Effects 0.000 claims abstract description 3
- 230000002035 prolonged effect Effects 0.000 claims abstract 2
- 241000208829 Sambucus Species 0.000 claims description 12
- 235000018735 Sambucus canadensis Nutrition 0.000 claims description 12
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 12
- 235000007123 blue elder Nutrition 0.000 claims description 12
- 235000007124 elderberry Nutrition 0.000 claims description 12
- 235000008995 european elder Nutrition 0.000 claims description 12
- 229910052711 selenium Inorganic materials 0.000 claims description 12
- 239000011669 selenium Substances 0.000 claims description 12
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 9
- 239000011701 zinc Substances 0.000 claims description 7
- 229910052725 zinc Inorganic materials 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 235000005282 vitamin D3 Nutrition 0.000 claims description 6
- 239000011647 vitamin D3 Substances 0.000 claims description 6
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 6
- 229940021056 vitamin d3 Drugs 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 235000013311 vegetables Nutrition 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 230000004682 mucosal barrier function Effects 0.000 claims description 2
- 239000008247 solid mixture Substances 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 3
- 230000006870 function Effects 0.000 claims 1
- 235000021579 juice concentrates Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 abstract description 9
- 210000000987 immune system Anatomy 0.000 abstract description 9
- 229930003316 Vitamin D Natural products 0.000 abstract description 8
- 235000019166 vitamin D Nutrition 0.000 abstract description 8
- 239000011710 vitamin D Substances 0.000 abstract description 8
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract description 8
- 229940046008 vitamin d Drugs 0.000 abstract description 8
- 235000015872 dietary supplement Nutrition 0.000 abstract description 4
- 210000001519 tissue Anatomy 0.000 abstract description 4
- 230000004888 barrier function Effects 0.000 abstract description 3
- 230000001413 cellular effect Effects 0.000 abstract description 3
- 210000004400 mucous membrane Anatomy 0.000 abstract description 3
- 239000011573 trace mineral Substances 0.000 abstract description 3
- 235000013619 trace mineral Nutrition 0.000 abstract description 3
- 238000012423 maintenance Methods 0.000 abstract description 2
- 230000001932 seasonal effect Effects 0.000 abstract description 2
- 235000011649 selenium Nutrition 0.000 description 9
- 229940091258 selenium supplement Drugs 0.000 description 9
- 235000006708 antioxidants Nutrition 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 6
- 235000016804 zinc Nutrition 0.000 description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010048259 Zinc deficiency Diseases 0.000 description 3
- 235000010208 anthocyanin Nutrition 0.000 description 3
- 229930002877 anthocyanin Natural products 0.000 description 3
- 239000004410 anthocyanin Substances 0.000 description 3
- 150000004636 anthocyanins Chemical class 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229920001864 tannin Polymers 0.000 description 3
- 235000018553 tannin Nutrition 0.000 description 3
- 239000001648 tannin Substances 0.000 description 3
- PMYDPQQPEAYXKD-UHFFFAOYSA-N 3-hydroxy-n-naphthalen-2-ylnaphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(NC(=O)C3=CC4=CC=CC=C4C=C3O)=CC=C21 PMYDPQQPEAYXKD-UHFFFAOYSA-N 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 240000006024 Lactobacillus plantarum Species 0.000 description 2
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 229940072205 lactobacillus plantarum Drugs 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 229960002181 saccharomyces boulardii Drugs 0.000 description 2
- 229960001881 sodium selenate Drugs 0.000 description 2
- 235000018716 sodium selenate Nutrition 0.000 description 2
- 239000011655 sodium selenate Substances 0.000 description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 2
- 235000006076 zinc citrate Nutrition 0.000 description 2
- 239000011746 zinc citrate Substances 0.000 description 2
- 229940068475 zinc citrate Drugs 0.000 description 2
- CUCUKLJLRRAKFN-UHFFFAOYSA-N 7-Hydroxy-(S)-usnate Chemical compound CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O CUCUKLJLRRAKFN-UHFFFAOYSA-N 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 241000985694 Polypodiopsida Species 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229930014669 anthocyanidin Natural products 0.000 description 1
- 150000001452 anthocyanidin derivatives Chemical class 0.000 description 1
- 235000008758 anthocyanidins Nutrition 0.000 description 1
- 230000003217 anti-cancerogenic effect Effects 0.000 description 1
- 230000002790 anti-mutagenic effect Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- VWPUAXALDFFXJW-UHFFFAOYSA-N benzenehexol Chemical compound OC1=C(O)C(O)=C(O)C(O)=C1O VWPUAXALDFFXJW-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001968 ellagitannin Polymers 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013575 mashed potatoes Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 239000003016 pheromone Substances 0.000 description 1
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical compound OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 description 1
- 229960001553 phloroglucinol Drugs 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000019525 primary metabolic process Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229940004858 usnic acid Drugs 0.000 description 1
- ICTZCAHDGHPRQR-UHFFFAOYSA-N usnic acid Natural products OC1=C(C)C(O)=C(C(C)=O)C2=C1C1(C)C(O)=C(C(=O)C)C(=O)C=C1O2 ICTZCAHDGHPRQR-UHFFFAOYSA-N 0.000 description 1
- WEYVVCKOOFYHRW-UHFFFAOYSA-N usninic acid Natural products CC12C(=O)C(C(=O)C)=C(O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O WEYVVCKOOFYHRW-UHFFFAOYSA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
La découverte présente concerne une composition contenant des polyhénols de grenado, de la vitamine D et des oligoéléments qui convient particulièrement bien comme complément alimentaire dans le cas d'un manque de micro aliments, d'antioxydants végétaux et de régulateurs de la cellule dû à l'alimentation et/ou saisonnier. La découverte représente un complément alimentaire efficace destiné à favoriser le fonctionnement sain et naturel du système immunitaire local au niveau de la muqueuse et de tout le système immunitaire cellulaire et humoral. En résumé, on a pu établir de façon inattendue que la composition résultant de la découverte garantit un séjour prolongé des substances végétales et des micro aliments dans la bouche, favorise le maintien de la fonction protectrice naturelle de la barrière muqueuse dans l'espace bucco pharyngien, améliore et équilibre le fonctionnement naturel de l'immunité cellulaire et humorale et renforce les systèmes de protection antioxydants dans le corps et en particulier dans les tissus de l'espace bucco pharyngien ...The present discovery relates to a composition containing pomegranate polyhenols, vitamin D and trace elements which is particularly suitable as a food supplement in the case of a lack of micro foods, plant antioxidants and cell regulators due to the 'food and / or seasonal. The discovery represents an effective food supplement intended to promote the healthy and natural functioning of the local immune system at the level of the mucous membrane and of the entire cellular and humoral immune system. In summary, it was unexpectedly established that the composition resulting from the discovery guarantees a prolonged stay of plant substances and micro-foods in the mouth, promotes the maintenance of the natural protective function of the mucous barrier in the bucco-pharyngeal space. , improves and balances the natural functioning of cellular and humoral immunity and strengthens antioxidant protection systems in the body and in particular in the tissues of the oral pharyngeal space ...
Description
Composition contenant des polyphénols de grenade, de la vitamine DComposition containing pomegranate polyphenols, vitamin D
et des oligoélémentsand trace elements
La découverte présente concerne une composition contenant des polyphénols de grenade, de la vitamine D et des oligoéléments qui convient particulièrement bien comme complément alimentaire dans le cas d’un manque de micro aliments, d’antioxydants végétaux et de régulateurs de la cellule dû à l’alimentation ou/et saisonnier.The present discovery relates to a composition containing pomegranate polyphenols, vitamin D and trace elements which is particularly suitable as a dietary supplement in the case of a lack of micro-foods, plant antioxidants and cell regulators due to food and / or seasonal.
On sait par expérience que le nombre des maladies infectieuses augmente nettement en hiver. C’est après le passage de l’été à l’hiver que les épidémies de grippe sont les plus fréquentes et que des complications peuvent apparaître. La concentration en vitamine D dépend surtout de la lumière solaire. En hiver, les niveaux de vitamine D dans le sang baissent nettement. La vitamine D jour un rôle essentiel pour le système immunitaire et la régulation de celui-ci.It is known from experience that the number of infectious diseases increases markedly in winter. It is after the passage from summer to winter that influenza epidemics are the most frequent and complications can occur. The concentration of vitamin D depends mainly on sunlight. In winter, vitamin D levels in the blood drop dramatically. Vitamin D plays a vital role for the immune system and the regulation of it.
Le zinc et le sélénium aussi sont essentiels pour le fonctionnement naturel du système immunitaire humoral et cellulaire. Ils sont surutilisés lors d’infections plus fréquentes, c’est pourquoi nous en avons plus besoin en hiver et en cas d’infections.Zinc and selenium are also essential for the natural functioning of the humoral and cellular immune system. They are overused during more frequent infections, which is why we need it more in winter and in case of infections.
Le zinc est un composant de plus de 300 enzymes. Au moins un tiers de la population est sous-alimenté en zinc. C’est surtout chez les personnes d’un certain âge que la carence en zinc (plus ou moins 50%) semble être fréquente. Les groupes à risque, surtout les enfants, les personnes d’un certain âge ou malades et les diabétiques souffrent souvent des conséquences d’une carence en zinc: faibles défenses immunitaires, refroidissements fréquents, épuisement, mauvaise cicatrisation, maladies de la peau et problèmes de cheveux et d’ongles. Au cours de la vieillesse, on note souvent une carence latente en zinc et de l’inflammation rampante. Cela fait baisser la performance immunitaire et favorise les infections et les maladies auto-immunes.Zinc is a component of more than 300 enzymes. At least a third of the population is undernourished in zinc. It is especially among older people that zinc deficiency (more or less 50%) seems to be common. Groups at risk, especially children, elderly or sick people, and diabetics often suffer from the consequences of zinc deficiency: low immune defenses, frequent colds, exhaustion, poor scarring, skin diseases and problems hair and nails. In old age, there is often latent zinc deficiency and creeping inflammation. This lowers immune performance and promotes infections and autoimmune diseases.
Il existe souvent une carence en sélénium nocive pour les défenses immunitaires, chez les fumeurs surtout. Les nutritionnistes pensent que la dose de sélénium assimilée naturellement doit être fondamentalement améliorée. Elle est tout simplement insuffisante pour une défense contre les refroidissements, car ceux-ci augmentent le besoin en sélénium. En cas de manque de sélénium, la résistance aux infections est beaucoup plus faible et des complications peuvent apparaître.There is often a deficiency of selenium harmful to the immune system, especially among smokers. Nutritionists believe that the naturally assimilated dose of selenium needs to be fundamentally improved. It is simply not enough for a defense against colds, because they increase the need for selenium. In case of lack of selenium, resistance to infection is much lower and complications may occur.
On mange moins d’antioxydants végétaux en hiver puisqu’on les trouve surtout dans la nourriture végétale. Les polyphénols forment un groupe des composants végétaux secondaires. Dans le règne végétal, ils sont présents partout avec plus de 8000 composés et dérivent dans leur structure de base du phénol (hydroxybenzol). La structure de base des polyphénols consiste en un anneau ou un système d’anneaux aromatique avec deux ou plusieurs groupes d’hydroxyles qui y sont directement liés. Par polyphénols, on entend donc des liaisons aromatiques dont la molécule renferme au moins deux groupes d’hydroxyles phénoliques. Dans la nature, on trouve les polyphénols libres et éthérifiés dans les colorants de fleurs (par ex. anthocyane, anthocyanidine, flavine, flavonoïde), dans les tannins (par ex. catéchine, tanins), comme composants des lichens ou des fougères (par ex. acide usnique, acylpolyphénols) dans les lignines comme les dérivés de l’acide gallique, la phloroglucine, le pyrogallol ou Γ hexahydroxybenzolWe eat fewer plant antioxidants in the winter because they are found mainly in vegetable food. Polyphenols form a group of secondary plant components. In the vegetable kingdom, they are present everywhere with more than 8000 compounds and derive in their basic structure of phenol (hydroxybenzol). The basic structure of polyphenols consists of an aromatic ring or ring system with two or more groups of hydroxyls directly attached to it. By polyphenols is meant aromatic bonds whose molecule contains at least two phenolic hydroxyl groups. In nature, free and etherified polyphenols are found in flower dyes (eg anthocyanin, anthocyanidin, flavin, flavonoid), in tannins (eg catechins, tannins), as components of lichens or ferns (eg eg, usnic acid, acylpolyphenols) in lignins such as gallic acid derivatives, phloroglucin, pyrogallol or hexahydroxybenzol
Compte tenu de leur structure chimique, les polyphénols englobent les groupes des acides carboniques de phénols et leurs polymères (tanins), des flavonoïdes et des dérivés de stilbène. Les polyphénols peuvent se présenter sous forme de liaisons hautement moléculaires par ex. comme glucosides ou esters. Très souvent, les ployphénols sont présents dans les plantes sous forme de glucosides (liés à un ou plusieurs monomères de sucre semblables ou différents) ou comme polymères.Given their chemical structure, polyphenols include the groups of phenolic carbons and their polymers (tannins), flavonoids and stilbene derivatives. The polyphenols can be in the form of highly molecular bonds e.g. as glucosides or esters. Very often, phenphenols are present in plants in the form of glucosides (bound to one or more similar or different sugar monomers) or as polymers.
Les polyphénols sont classés parmi les soi-disant „composants végétaux secondaires“ puisqu’ils ne sont pas synthétisés ou métabolisés dans le métabolisme primaire de la plante. Il est prouvé qu’ils possèdent des caractères hormonaux et protecteurs (substances de croissance, stéroïdes et phéromones) parmi lesquels on peut citer la protection contre les rayons UV, les ravageurs des cultures et les invasions de champignons et de bactéries. Certains des composants végétaux secondaires comme les flavonoïdes et les anthocyanes contribuent aussi de façon décisive à la couleur des fleurs et des fruits. Les baies de sureau sont très riches en une sorte particulière de polyphénols, les anthocyanes.Polyphenols are classified as so-called "secondary plant components" since they are not synthesized or metabolized in the primary metabolism of the plant. They have been shown to possess hormonal and protective characteristics (growth substances, steroids and pheromones), including protection against UV rays, crop pests and fungal and bacterial infestations. Some of the secondary plant components such as flavonoids and anthocyanins also contribute decisively to the color of flowers and fruits. Elderberries are very rich in a special kind of polyphenols, anthocyanins.
La teneur en polyphénols est déterminée selon le procédé Folin-Ciocalteu en usage dans l’industrie du vin et des jus en utilisant l’acide gallique comme substance de référence.The polyphenol content is determined by the Folin-Ciocalteu process used in the wine and juice industry using gallic acid as a reference substance.
L’intérêt grandissant pour les polyphénols est le résultat de différentes études in vivo et in vitro dans lesquelles on démontre entre autre des effets anti-cancérigènes, antimutagènes, antioxydatifs, antiviraux, anti-proliférants, anti-thrombotiques et hypolipémiants.The growing interest in polyphenols is the result of various in vivo and in vitro studies in which anti-carcinogenic, antimutagenic, anti-oxidative, antiviral, anti-proliferant, anti-thrombotic and lipid-lowering effects are demonstrated among others.
La grenade est considérée comme très riche en polyphénols particuliers comme par ex. les ellagitaninnes qui possèdent des propriétés immomodulatives et antioxydantes. L’efficacité se fait d’une part directement via leur capacité d’attraper les radicaux, d’autre part les systèmes de protection antioxydants personnels (par ex. GSH) sont renforcés durablement.Pomegranate is considered to be very rich in particular polyphenols such as e.g. ellagitannins that possess immomodulative and antioxidant properties. Efficiency is directly related to their ability to catch radicals, and personal antioxidant protection systems (eg GSH) are durably strengthened.
Les polyphénols sont essentiellement libérés de leur forme glucosidique ou polymère par les enzymes de la flore du colon. Via des processus de fermentation par des microorganismes vivants, les polyphénols de grenade sont métabolisés en liaisons moléculaires basses et plus facilement résorbables.Polyphenols are essentially released from their glucosidic or polymeric form by the enzymes of the colon flora. Through fermentation processes by living microorganisms, pomegranate polyphenols are metabolized into low molecular bonds and more easily absorbed.
Techniquement, des préparations à base de grenades, de zinc, de sélénium et de vitamine D sont connues comme substances uniques, mais pas dans cette combinaison et surtout pas sous une forme de présentation hautement concentrée et principalement liquide pour la résorption par la muqueuse de la bouche.Technically, preparations based on pomegranates, zinc, selenium and vitamin D are known as single substances, but not in this combination and especially not in a form of highly concentrated presentation and mainly liquid for resorption by the mucosa of the mouth.
La découverte présente est un complément alimentaire efficace destiné à favoriser le fonctionnement sain et naturel du système immunitaire local au niveau des muqueuses et du système immunitaire cellulaire et humoral total. En résumé, ce qui est surprenant, c’est qu’on a pu établir que la composition adaptée à la découverte garantit un séjour plus long des substances végétales et des micro aliments dans la bouche, favorise le maintien de la fonction protectrice naturelle des barrières des muqueuses dans la bouche et le pharynx, améliore et équilibre le fonctionnement naturel de l’immunité cellulaire et humorale et renforce les systèmes de protection antioxydants du corps et en particulier des tissus de l’espace bucco pharyngien.The present discovery is an effective dietary supplement intended to promote the healthy and natural functioning of the local immune system in the mucous membranes and the total cellular and humoral immune system. In summary, what is surprising is that it has been established that the composition adapted to the discovery ensures a longer stay of vegetable substances and micro foods in the mouth, promotes the maintenance of the natural protective function of the barriers mucous membranes in the mouth and pharynx, improves and balances the natural functioning of cellular and humoral immunity and strengthens antioxidant protection systems of the body and in particular the tissues of the bucco-pharyngeal space.
En l’occurrence, une composition de polyphénols de grenade, de vitamine D, de zinc et de sélénium et éventuellement de concentré de baies de sureau, s’est révélée de manière inattendue particulièrement efficace.In this case, a composition of polyphenols pomegranate, vitamin D, zinc and selenium and possibly elderberry concentrate, has unexpectedly proved particularly effective.
De façon surprenante, l’administration locale dans l’espace bucco pharyngien sous forme de gouttes de la composition décrite que l’on prend sous une forme fortement concentrée 3 à 5 fois par jour s’est révélée particulièrement efficace.Surprisingly, the local administration in the bucco-pharyngeal space in the form of drops of the composition described which is taken in a highly concentrated form 3 to 5 times per day has proved particularly effective.
Comme la découverte le prouve, l’utilisation de polyphénols de grenade, fermentés en partie par des bactéries ou des levures probiotiques vivantes, présentes en partie sous une forme moléculaire basse, en partie sous une forme moléculaire haute, fait que les autres micro aliments restent plus longtemps dans l’espace buccal et pharyngien.As the discovery proves, the use of pomegranate polyphenols, fermented in part by bacteria or live probiotic yeasts, partly present in a low molecular form, partly in a high molecular form, makes the other micro-foods remain longer in the oral and pharyngeal space.
Ainsi, on obtient, par une administration locale, une exposition élevée et plus durable des tissus concernés, rien qu’avec des doses, que l’on trouve dans une alimentation normale.Thus, by local administration, a high and more durable exposure of the tissues concerned is obtained, with only doses, found in a normal diet.
De manière inattendue, la composition adaptée à la découverte s’est révélée particulièrement efficace dans le renforcement et le maintien de la fonction de protection naturelle des barrières de la muqueuse.Unexpectedly, the discovery-suitable composition has been found to be particularly effective in enhancing and maintaining the natural barrier function of mucosal barriers.
Lors d’infections, une multitude de cytokines (substances annonciatrices de l’inflammation), qui entraînent par la suite une réaction inflammatoire massive, peuvent être libérées à la suite d’une hyperréaction du système de défense. Dans le cas de beaucoup d’infections virales et bactériennes, il ne s’agit pas, en première ligne, d’un renforcement de l’immunité qui pourrait entraîner une avalanche encore plus violente de cytokines, mais d’une compensation du système immunitaire.During infections, a multitude of cytokines (substances that are an indication of inflammation), which subsequently cause a massive inflammatory reaction, can be released as a result of hyperreaction of the defense system. In the case of many viral and bacterial infections, it is not, in the first line, a strengthening of immunity that could lead to an even more violent avalanche of cytokines, but a compensation of the immune system .
La composition adaptée à la découverte s’est révélée de manière étonnante comme particulièrement efficace dans le maintien de l’équilibre biologique du système immunitaire.The composition suitable for discovery has surprisingly been found to be particularly effective in maintaining the biological balance of the immune system.
Dans le cadre d’infections, les systèmes de protection antioxydants du corps sont fortement mis à contribution. Un manque de substances de protection antioxydantes qui sont pourtant très importantes pour la protection de la cellule apparaît souvent momentanément. La composition adaptée à la découverte a fait ses preuves de façon surprenante dans la protection antioxydante du tissu de l’espace bucco pharyngien.In the context of infections, antioxidant protection systems of the body are heavily involved. A lack of antioxidant protective substances which are however very important for the protection of the cell often appears momentarily. The composition suitable for discovery has been surprisingly proven in the antioxidant protection of the tissue of the bucco-pharyngeal space.
La composition existe sous forme de pastilles, de liquides ou de gels. La composition sous forme liquide est déjà disponible.The composition exists in the form of pellets, liquids or gels. The composition in liquid form is already available.
On recommande la prise journalière d’au moins 3 ml répartis comme suit. 3 fois 25 gouttes ou mieux 5 fois 15 gouttes par jour, les gouttes ne doivent pas être avalées, mais gardées en bouche le plus longtemps possible.Daily intake of at least 3 ml divided as follows is recommended. 3 times 25 drops or better 5 times 15 drops a day, the drops should not be swallowed, but kept in the mouth as long as possible.
Dans les formes de présentations préférées, une dose quotidienne de la composition renferme comme composants actifs les substances suivantes • Des polyphénols de grenade (en partie fermentés) > = 10 mg à <= 1000 mg, de préférence dans une fourchette de 50 à 500 mg, ou mieux encore de 100 à <=300 mg ; et • De la vitamine D3 dans une fourchette de >=1mcg à <=50 mcg, de préférence de >= 3mcg à <= 20 mcg, ou mieux de >= 5mcg à <= 10mcg;et • Du sélénium dans une fourchette de >= 20 mcg à >= 500mcg, de préférence de >=30mcg à <= 200 mcg, ou mieux de >= 40 mcg à <= 100 mcg ; et/ou • Du zinc dans une fourchette de >= 2 mg à <= 50 mg, de préférence de >= 4 mg à <=25 mg, ou mieux de >= 8 mg à <= 12 mg ; et/ou • Du concentré de baies de sureau dans une fourchette de >= 5 mg à <= 1000 mg, de préférence de 20 mg à <= 500 mg, ou mieux de 50mg à <= 300 mgIn the preferred forms of presentation, a daily dose of the composition contains as active components the following substances: • Pomegranate polyphenols (partially fermented)> = 10 mg to <= 1000 mg, preferably in a range of 50 to 500 mg or more preferably from 100 to <= 300 mg; and • Vitamin D3 in a range of> = 1mcg to <= 50mcg, preferably from> = 3mcg to <= 20mcg, or more preferably from> = 5mcg to <= 10mcg, and • Selenium in a range of > 20 mcg at> = 500mcg, preferably from> = 30mcg to <= 200mcg, or better from> = 40mcg to <= 100mcg; and / or • zinc in a range of> = 2 mg to <= 50 mg, preferably from> = 4 mg to <= 25 mg, or more preferably from> = 8 mg to <= 12 mg; and / or • Elderberry concentrate in a range of> = 5 mg to <= 1000 mg, preferably from 20 mg to <= 500 mg, or more preferably from 50 mg to <= 300 mg
Dans les formes tout particulièrement préférées, la composition d’une dose quotidienne contient comme composants actifs : - 7,5 mcg de vtamine D3 55 mcg de sélénium 10 mg de zinc 200 mg de polyphénols de grenade (en partie fermentées) et - 25 mg de polyphénols de baies de sureauIn the most particularly preferred forms, the composition of a daily dose contains as active components: - 7.5 mcg of vetamine D3 55 mcg of selenium 10 mg of zinc 200 mg of pomegranate polyphenols (partly fermented) and - 25 mg of elderberry polyphenols
Les exemples suivants servent à illustrer la découverte présente :The following examples serve to illustrate the present discovery:
Exemple 1 : préparation des polyphénols de grenade (fermentés)Example 1 Preparation of Pomegranate Polyphenols (Fermented)
On fabrique d’abord deux inocula Inoculum 1 : Saccharomyces boulardii 1 gr de Saccharomyces boulardii (2x1010 germes lyophilisés ; disponibles dans le commerce, par ex. dans les pharmacies) est inoculé dans 1 I de purée de grenades à 36° pendant 24 hTwo Inocula Inoculum 1: Saccharomyces boulardii 1 gr of Saccharomyces boulardii (2x1010 freeze-dried organisms, commercially available, eg in pharmacies) are first inoculated into 1 I of pomegranate purée at 36 ° for 24 hours.
Inoculum 2 : Lactobacillus plantarum 0,5 gr de lactobacillus plantarum (2x1011 germes lyohilisés ; disponibles dans le commerce, par ex. chez Danisco) est inoculé dans 1 I d’un mélange de 300 ml d’eau et de 700 ml de purée de grenades à 36 pendant 24h d’une valeur ph d’environ 5.Inoculum 2: Lactobacillus plantarum 0.5 gr of Lactobacillus plantarum (2x1011 lyophilized germs, commercially available, eg from Danisco) is inoculated into 1 l of a mixture of 300 ml of water and 700 ml of mashed potatoes. grenades at 36 for 24h of a ph value of about 5.
Ensuite, on fabrique le ferment et on réalise la fermentation. Pour cela, on mélange les deux inocula dans un tonneau de fermentation adapté, muni d’une soupape qui laisse échapper le C02, à 10 I de purée de grenades, que l’on peut obtenir par ex. par la transformation des fruits épluchés par ex. au moyen d’un extracteur de jus de fruit de la marque Champion de la firme Plastaket Manufacturing CO. (Lodi 95240, Californie, USA ; importateur allemand : Keimling Naturkost GmbH, 21614 Buxtehude). La purée de grenades devrait avoir une teneur en sucre d’environ 14 gr/l (teneur totale de glucose et fructose). La valeur ph du ferment est amenée à 4,5 à l’aide de bicarbonate de soude et de carbonate de potassium. Le ferment fermente pendant au moins 4 à 5 jours à une température de 36° à l’abri de l’oxygène jusqu’à ce que la teneur en sucre soit tombée à plus ou moins 1% (10 gr/l) et qu’il n’y ait plus de production de C02.Then, the ferment is made and the fermentation is carried out. For this purpose, the two inocula are mixed in a suitable fermentation barrel equipped with a valve which allows CO 2 to escape, to 10 l of pomegranate mash, which can be obtained for example. by the processing of peeled fruits, e.g. using a Champion brand fruit extractor from Plastaket Manufacturing CO. (Lodi 95240, California, USA; German importer: Keimling Naturkost GmbH, 21614 Buxtehude). The pomegranate puree should have a sugar content of about 14 gr / l (total glucose and fructose content). The ph value of the ferment is brought to 4.5 with the aid of sodium bicarbonate and potassium carbonate. The ferment ferments for at least 4 to 5 days at a temperature of 36 ° in the absence of oxygen until the sugar content has fallen to plus or minus 1% (10 gr / l) and that there is no more production of CO2.
Le produit fermenté ainsi obtenu est pasteurisé.The fermented product thus obtained is pasteurized.
Exemple 2 : composition liquide pour administration dans l’espace bucco-pharyngienExample 2: liquid composition for administration in the bucco-pharyngeal space
Quantités pour une dose quotidienne de 3 ml Concentré de purée de grenades 2500 mg Purée de grenades fermentées 625mg Concentré de baies de sureau 200mg Citrate de zinc 32,26 mg Sélénate de sodium 0,133mg Cholecalciférol 7,5mcg Éthanol 395 mg vol. 16,6 %Quantities for a daily dose of 3 ml Concentrated pomegranate puree 2500 mg Fermented pomegranate puree 625mg Elderberry concentrate 200mg Zinc citrate 32.26 mg Sodium selenate 0.133mg Cholecalciferol 7.5mcg Ethanol 395mg vol. 16.6%
Exemple 3: préparation et composition d’une composition solide sous forme de tablettesExample 3 Preparation and Composition of a Solid Composition in Tablets
La pastille est fabriquée de manière traditionnelle dans la composition suivante (données pour 3 tablettes de 500 mg comme dose journalière) : 370 mg d'inuline 350mg de xylite 32,26 mg de citrate de zinc 0,133 mg de sélénate de sodium 7,5 mcg de cholecalciférol 600 mg de purée de grenades séchées à froid, fermentées 80 mg d’extrait de baies de sureau 30 mg de micro cellulose 50mg d’acide de vinThe pellet is traditionally manufactured in the following composition (data for 3 tablets of 500 mg as a daily dose): 370 mg of inulin 350 mg of xylite 32.26 mg of zinc citrate 0.133 mg of sodium selenate 7.5 mcg of cholecalciferol 600 mg of cold-dried pomegranate puree, fermented 80 mg of elderberry extract 30 mg of micro-cellulose 50 mg of wine acid
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| Title |
|---|
| ANONYMOUS: "Bio-Forme-Boutique", 21 June 2008 (2008-06-21), pages 1 - 10, XP002594585, Retrieved from the Internet <URL:http://www.bio-forme-online.com/natplusd.htm> [retrieved on 20100729] * |
| ANONYMOUS: "Dr. Jacob's Granaimun", November 2009 (2009-11-01), pages 1 - 3, XP002594586, Retrieved from the Internet <URL:http://www.pomegranate-juice.eu/?granaimun> [retrieved on 20010207] * |
| DATABASE WPI Week 200447, Derwent World Patents Index; AN 2004-495012, XP002594587 * |
| DATABASE WPI Week 200959, Derwent World Patents Index; AN 2009-M85747, XP002594588 * |
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| Date | Code | Title | Description |
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| RE | Patent lapsed |
Effective date: 20121231 |