FR3109084A1 - PERKYNINE, phytotherapeutic composition with antiasthenic effect - Google Patents
PERKYNINE, phytotherapeutic composition with antiasthenic effect Download PDFInfo
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- FR3109084A1 FR3109084A1 FR2010168A FR2010168A FR3109084A1 FR 3109084 A1 FR3109084 A1 FR 3109084A1 FR 2010168 A FR2010168 A FR 2010168A FR 2010168 A FR2010168 A FR 2010168A FR 3109084 A1 FR3109084 A1 FR 3109084A1
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- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 230000000694 effects Effects 0.000 title abstract description 6
- 239000000284 extract Substances 0.000 claims abstract description 33
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims abstract description 14
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 13
- 241001071795 Gentiana Species 0.000 claims abstract description 11
- 230000001580 bacterial effect Effects 0.000 claims abstract description 8
- 230000003612 virological effect Effects 0.000 claims abstract description 8
- 244000183685 Citrus aurantium Species 0.000 claims abstract description 7
- 235000007716 Citrus aurantium Nutrition 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 208000034657 Convalescence Diseases 0.000 claims abstract description 3
- 235000007164 Oryza sativa Nutrition 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 235000009566 rice Nutrition 0.000 claims description 12
- 241001632410 Eleutherococcus senticosus Species 0.000 claims description 10
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 7
- 229960002216 methylparaben Drugs 0.000 claims description 7
- 235000010234 sodium benzoate Nutrition 0.000 claims description 7
- 239000004299 sodium benzoate Substances 0.000 claims description 7
- 229960004016 sucrose syrup Drugs 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000013736 caramel Nutrition 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 239000001268 cinchona succirubra pav. Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004290 sodium methyl p-hydroxybenzoate Substances 0.000 claims description 4
- 244000182633 Cinchona succirubra Species 0.000 claims description 3
- 235000006768 Cinchona succirubra Nutrition 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 206010003549 asthenia Diseases 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 2
- 238000009160 phytotherapy Methods 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 abstract description 11
- 239000006188 syrup Substances 0.000 abstract description 11
- 229920002729 Cinchotannic acid Polymers 0.000 abstract description 4
- 241000411851 herbal medicine Species 0.000 abstract description 3
- 230000001766 physiological effect Effects 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 abstract 1
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract 1
- 235000008434 ginseng Nutrition 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 241000209094 Oryza Species 0.000 description 10
- 239000000243 solution Substances 0.000 description 7
- 238000003306 harvesting Methods 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 235000021513 Cinchona Nutrition 0.000 description 2
- 241000157855 Cinchona Species 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 229940107147 siberian ginseng root Drugs 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 241000489438 Cinchona pubescens Species 0.000 description 1
- 235000004310 Cinnamomum zeylanicum Nutrition 0.000 description 1
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 1
- 235000016646 Citrus taiwanica Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000021329 brown rice Nutrition 0.000 description 1
- 235000021310 complex sugar Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000009329 organic farming Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
Abstract
Composition liquide, sous forme de sirop, en administration orale, à base d’extrait sec de plantes : Orange amère, Cannelle de Madagascar, Gentiane, Quinquina rouge et optionnellement Ginseng de Sibérie, et son procédé de fabrication. La composition est destinée à une utilisation en phytothérapie, pour l’obtention d’un effet physiologique sur l’organisme, plus particulièrement un effet antiasthénique, en convalescence, et un effet de prévention des rechutes virales et/ou bactériennes . Liquid composition, in syrup form, for oral administration, based on dry extract of plants: Bitter Orange, Cinnamon from Madagascar, Gentian, Cinchona red and optionally Ginseng from Siberia, and process for its manufacture. The composition is intended for use in herbal medicine, for obtaining a physiological effect on the body, more particularly an antiasthenic effect, in convalescence, and an effect of preventing viral and/or bacterial relapses.
Description
L’objet de l’invention concerne une composition liquide, formulée pour une administration orale, à base d’extraits secs de plantes.The subject of the invention relates to a liquid composition, formulated for oral administration, based on dry plant extracts.
La composition est destinée à une utilisation en phytothérapie, pour l’obtention d’un effet physiologique sur l’organisme, plus particulièrement un effet antiasthénique en convalescence post infectieuse virale et/ou bactérienne.The composition is intended for use in herbal medicine, for obtaining a physiological effect on the body, more particularly an antiasthenic effect in post infectious viral and/or bacterial convalescence.
La composition, appelée PERKYNINE, est formulée sous forme d’un sirop pour une administration orale.The composition, called PERKYNINE, is formulated as a syrup for oral administration.
Le sirop étant choisi parmi le sirop de saccharose (ou éventuellement de riz) .The syrup being chosen from sucrose (or optionally rice) syrup.
La dite composition comprenant en outre des principes actifs, des excipients, de l’eau et un alcool.Said composition further comprising active principles, excipients, water and an alcohol.
L’objet de l’invention, concerne une composition comprenant, en masse, par rapport à la masse totale de la composition :The object of the invention relates to a composition comprising, by mass, relative to the total mass of the composition:
- Un sirop de saccharose (ou éventuellement de riz, issu de l’agriculture biologique) .en une teneur entre 29,05 % et 30,85 % en masse.- A sucrose syrup (or possibly rice syrup, from organic farming) with a content between 29.05% and 30.85% by mass.
- Un extrait sec d’écorce deQuinquina rouge, (Cinchona succirubra) broyée pour une teneur de 7,685 à 11, 685 % en masse- A dry extract of red cinchona bark ( Cinchona succirubra ) crushed for a content of 7.685 to 11.685% by mass
- Un extrait sec d’écorce d’ O range amère ( Citrus aurantium) broyée pour une teneur de 12, 375 à 16,375 % en masse- A dry extract of bark of O range bitter ( Citrus aurantium ) crushed for a content of 12.375 to 16.375% by mass
- Un extrait sec de racine deGentianebroyée pour une teneur de 1,39 à 2,54 % en masse- A dry extract of ground Gentian root for a content of 1.39 to 2.54% by mass
- Un extrait sec de l’écorce du Cannelier roulée ouC annelle de Madagascar ( Cinnamomum zeylanicum) broyée pour une teneur de 7,55 % en masse- A dry extract of the bark of the rolled Cinnamon or Cinnamon from Madagascar ( Cinnamomum zeylanicum ) crushed for a content of 7.55% by mass
- Optionnellement, un extrait sec de la racine deGinseng de Sibérie(Eleutherococcus senticosus) broyée pour une teneur de 0 à 1% en masse.- Optionally, a dry extract of Siberian Ginseng root ( Eleutherococcus senticosus ) ground for a content of 0 to 1% by mass.
- De l’eau purifiée pour une teneur de 25 % en masse.- Purified water for a content of 25% by mass.
- De l’alcool à 60 ° pour une teneur de 10 % en masse.- Alcohol at 60° for a content of 10% by mass.
La composition pouvant comprendre en outre un agent conservateur et/ou un arôme caramel.The composition may additionally comprise a preservative and/or a caramel flavoring.
Afin que la préparation reste homogène dans le temps, le sirop de saccharose (ou éventuellement de riz) est utilisé comme support des extraits sec de plantes et permet d’éviter la sédimentation et la formation de plusieurs phases dans le temps.In order for the preparation to remain homogeneous over time, sucrose syrup (or possibly rice syrup) is used as a support for the dry plant extracts and prevents sedimentation and the formation of several phases over time.
Afin que la préparation se conserve dans le temps, la composition pourra comprendre un agent conservateur tel queIn order for the preparation to be preserved over time, the composition may comprise a preservative such as
- Le Benzoate de Sodium (ou le Parahydroxybenzoate de Méthyle) à une teneur de 0 à 0, 15 % en masse- Sodium Benzoate (or Methyl Parahydroxybenzoate) at a content of 0 to 0.15% by mass
- Et de l’Acide Citrique, pour maintenir un ph adéquat, à une teneur entre 0 et 0,8 % en masse.- And Citric Acid, to maintain an adequate pH, at a content between 0 and 0.8% by mass.
Les masses étant données par rapport à la masse totale de la composition.The masses being given relative to the total mass of the composition.
L’invention a également pour objet un procédé de préparation de la composition liquide formulée pour une administration orale.The invention also relates to a method for preparing the liquid composition formulated for oral administration.
Ce procédé comprend les étapes suivantes :This process includes the following steps:
- Une étape de préparation d’une solution hydroalcoolique dans laquelle on fait infuser dans l’eau purifiée, et l’alcool, l’extrait sec d’écorce deQuinquina rouge, broyée, l’extrait sec d’écorced ’O range amèrebroyée, l’extrait sec de racinede Gentianebroyée et l’extrait sec deCannelle de Madagascarbroyée, et optionnellement l’extrait sec deGinseng de Sibérie, à une température de 20 °C, dans laquelle on ajoute, après refroidissement, l’agent conservateur le Benzoate de Sodium (ou le Parahydroxybenzoate de Méthyle).A step for the preparation of a hydroalcoholic solution in which the dry extract of red Cinchona bark, crushed, the dry extract of bark of O range bitter is infused in purified water and alcohol. ground, the dry extract of ground gentian root and the dry extract of ground cinnamon from Madagascar , and optionally the dry extract of Siberian ginseng , at a temperature of 20°C, to which is added, after cooling, the preservative Sodium Benzoate (or Methyl Parahydroxybenzoate).
- Une étape de filtration de la solution aqueuse obtenue à l’étape a.A stage of filtration of the aqueous solution obtained in stage a.
- Une étape d’incorporation sous agitation à la solution hydroalcoolique obtenue b, le sirop de riz (ou le sirop de saccharose) à une température de 40 °C,A step of incorporation with stirring into the hydroalcoholic solution obtained b, rice syrup (or sucrose syrup) at a temperature of 40°C,
- Une étape d’homogénéisation de la composition obtenue à l’étape c.A step of homogenizing the composition obtained in step c.
La composition orale ainsi décrite correspond à une phytothérapie à effet antiasthénique post infectieuse bactérienne ou virale.The oral composition thus described corresponds to a herbal medicine with a bacterial or viral post-infectious antiasthenic effect.
Etape a de la préparation aqueuse d’extrait secStep a of the aqueous preparation of dry extract deof Quinquina rougeCinchona red ,, dd ’' OO range amère,bitter range, deof GentianeGentian ,, deof Cannelle de MadagascaMadagascan cinnamon rr et optionnellemand optional ee nt dunt of Ginseng de SibérieSiberian ginseng ,,
L’extrait sec d’écorce deQuinquina rouge, est préparé après récolte de l’écorce des arbustes, qui sera découpée en morceaux, séchée, puis broyée pour obtenir un extrait sec.The dry extract of Cinchona red bark is prepared after harvesting the bark of the shrubs, which will be cut into pieces, dried, then ground to obtain a dry extract.
L’extrait sec d’écorce coupée d’Orange amère est réalisé selon la même méthode que pour le Quinquina.The dry extract of cut bark of Bitter Orange is produced using the same method as for Cinchona.
L’extrait sec de racine deGentianeest préparé après récolte des racines deGentiane, qui seront découpées en fines lamelles, séchées, pasteurisées, puis broyées pour obtenir un extrait sec. Gentian root dry extract is prepared after harvesting Gentian roots, which are cut into thin strips, dried, pasteurized and then ground to obtain a dry extract.
L’extrait sec deCannelle de M adagascarest préparé après récolte de l’écorce des canneliers qui est ensuite roulée, puis séchée, et broyée pour obtenir un extrait sec Madagascar Cinnamon dry extract is prepared after harvesting the bark of cinnamon trees which is then rolled, then dried, and ground to obtain a dry extract .
L’extrait sec de racine deGinseng de Sibérieest préparé après récolte des racines deGinseng de Sibérie, qui seront découpées en fines lamelles, séchées, pasteurisées, puis broyées pour obtenir un extrait sec. Siberian Ginseng root dry extract is prepared after harvesting Siberian Ginseng roots, which will be cut into thin strips, dried, pasteurized and then ground to obtain a dry extract.
Ces extraits secs seront progressivement introduits dans les proportions suivantes :These dry extracts will be gradually introduced in the following proportions:
- 7,685 à 11, 685 % en masse d’écorce deQuinquina rouge 7.685 to 11.685% by mass of red cinchona bark
- 12, 375 à 16,375 % en masse d’Orange amère 12.375 to 16.375% by mass of bitter orange
- 1,39 à 2,54 % en masse deGentiane 1.39 to 2.54% by mass of Gentian
- 7,55 %en masse deCannelle de Madagascar. 7.55% by mass of Cinnamon from Madagascar.
- 0 à 1 %en masse deGinseng de Sibérie 0 to 1% by mass of Siberian Ginseng
Ces extraits secs seront introduits dans une solution constituée à 25% d’eau, et 10 % d’alcool à 60° du poids total de la composition.These dry extracts will be introduced into a solution consisting of 25% water and 10% alcohol at 60° of the total weight of the composition.
Cette incorporation sera réalisée à 20°. La solution est maintenue sous agitation mécanique pendant 90 minutes.This incorporation will be carried out at 20°. The solution is kept under mechanical stirring for 90 minutes.
Pendant cette étape a, le Benzoate de Sodium ou le Parahydroxybenzoate de Méthyle pourra être additionné optionnellement à la solution hydroalcoolique à raison de 0 à 0,15 % du poids total de la composition.During this step a, Sodium Benzoate or Methyl Parahydroxybenzoate may optionally be added to the aqueous-alcoholic solution at the rate of 0 to 0.15% of the total weight of the composition.
Au cours de cette étape un arôme caramel pourra être ajouté optionnellement, après l’addition des extraits secs, en proportion de 0 à 1% du poids total de la composition.During this step, a caramel flavor may be added optionally, after the addition of the dry extracts, in a proportion of 0 to 1% of the total weight of the composition.
Etape b de filtrationFiltration stage b
A l’issue de l’étape a, la solution est filtrée afin d’éliminer tout résidu non solubilisé, afin d’éliminer les particules supérieures à 400µm. Cette filtration est réalisée au moyen d’un tamis approprié.At the end of step a, the solution is filtered in order to eliminate any non-solubilized residue, in order to eliminate particles larger than 400 μm. This filtration is carried out using an appropriate sieve.
Etape c d’incorporation du sirop de rizStep c of incorporating the rice syrup (ou de saccharose)(or sucrose)
Le sirop de riz est obtenu par la fermentation de riz brun. Au cours de la fermentation enzymatique, le riz est transformé pour moitié en sucres complexes et en sucres simples.Rice syrup is obtained by fermenting brown rice. During the enzymatic fermentation, the rice is transformed half into complex sugars and half sugars.
Le mélange obtenu et filtré est concentré par évaporation de l’eau, jusqu’à obtention d’un sirop de riz.The mixture obtained and filtered is concentrated by evaporation of the water, until a rice syrup is obtained.
Le sirop de riz est incorporé à la solution aqueuse à une température située à 40°C. il peut être remplacé par un sirop de saccharose.The rice syrup is incorporated into the aqueous solution at a temperature of 40°C. it can be replaced by a sucrose syrup.
Au cours de l’étape c, on rajoute optionnellement l’Acide citrique, à raison de 0 à 0,8 % poids total, afin de maintenir un ph entre 3 et 5.During step c, citric acid is optionally added, at a rate of 0 to 0.8% total weight, in order to maintain a pH between 3 and 5.
Etape d’homogénéisation dHomogenization step d
Au cours de cette étape, la solution ainsi obtenue sera agitée mécaniquement pendant 30 minutes à température ambiante.During this step, the solution thus obtained will be mechanically stirred for 30 minutes at room temperature.
Toutes ces étapes seront réalisées dans des cuves en acier inoxydables, fermées, et pouvant être agitées mécaniquement.All these steps will be carried out in closed stainless steel tanks that can be mechanically stirred.
Le mécanisme d’action de cette composition concerne un effet antiasthénique, obtenu par la synergie stimulante del ’ Orange a mère, de laCannelle ,duQuinquina rougeet optionnellementdu G inseng de S i bérie. LaC annelleaméliore le goût de la préparation, et son association avec laGentiane ,(qui de plus stimule l’appétit) favorise un confort de digestion. Les propriétés particulières antibactériennes et antivirales duQuinquina rouge ,et immunostimulantes duGinseng de Sibériesont susceptibles d’accélérer le processus de guérison et de prévenir les rechutes virales et/ou bactériennes. The mechanism of action of this composition relates to an antiasthenic effect, obtained by the stimulating synergy of mother orange , cinnamon , red cinchona and optionally Siberian ginseng . C annelle improves the taste of the preparation, and its association with Gentian ( which also stimulates the appetite) promotes digestive comfort. The particular antibacterial and antiviral properties of Cinchona red , and immunostimulants of Siberian Ginseng are likely to accelerate the healing process and prevent viral and/or bacterial relapses.
La composition est indiquée dans le traitement de l’asthénie post infectieuse virale et/ou bactérienne, chez les personnes en convalescence.The composition is indicated in the treatment of viral and/or bacterial post-infectious asthenia, in convalescent persons.
La composition est également indiquée en prévention des rechutes virales et/ou bactériennes.The composition is also indicated for the prevention of viral and/or bacterial relapses.
Tableau de la composition de la PerkynineTable of the composition of Perkynine
Claims (4)
- Un sirop de riz ou de saccharose, en une teneur entre 29,05 et 30,85 % de pourcentage massique
- Des extraits secs :
- d’Orange amèreen une teneur de 12, 375 à 16,375 % de pourcentage massique,
- deCannelle de Madagascaren une teneur de 7,55 % de pourcentage massique,
- deGentianeen une teneur de 1,39 à 2,54 % de pourcentage massique
- deQuinquina rougeen une teneur de 7,685 à 11, 685 % de pourcentage massique.
- deGinseng de Sibérieen une teneur de 0 à 1 % de pourcentage massique.
- Optionnellement un agent conservateur tel que du Benzoate de Sodium ou du Parahydroxybenzoate de méthyle et un arôme caramel.
- A rice or sucrose syrup, with a content between 29.05 and 30.85% by mass percentage
- Dry extracts:
- of bitter orange in a content of 12.375 to 16.375% by mass percentage,
- Cinnamon from Madagascar with a content of 7.55% by mass percentage ,
- Gentian in a content of 1.39 to 2.54% by mass percentage
- of red Cinchona in a content of 7.685 to 11.685% by mass percentage.
- of Siberian Ginseng in a content of 0 to 1% by mass percentage.
- Optionally a preservative such as sodium benzoate or methyl parahydroxybenzoate and a caramel flavor.
• De l’eau en une teneur de 25 % de pourcentage massique
• Des extraits secs tels que définis à la revendication 1
• Du Benzoate de Sodium ou Parahydroxybenzoate de méthyle en une teneur de 0 à 0,15 % de pourcentage massique
• De l’alcool à 60° en une teneur de 10 % de pourcentage massique
• De l’Acide citrique en une teneur de 0 à 0,8 % de pourcentage massique
• Optionnellement un arôme caramel en une teneur de 0 à 1% de pourcentage massique.Composition according to Claim 1, characterized in that it comprises, in percentage by mass relative to the percentage of the total mass of the composition:
• Water in a content of 25% mass percentage
• Dry extracts as defined in claim 1
• Sodium benzoate or methyl parahydroxybenzoate in a content of 0 to 0.15% mass percentage
• Alcohol at 60° in a content of 10% mass percentage
• Citric acid in a content of 0 to 0.8% by mass percentage
• Optionally a caramel flavor in a content of 0 to 1% mass percentage.
- Une étape de préparation de la solution aqueuse dans laquelle on fait infuser dans de l’eau purifiée, et de l’alcool, l’extrait sec d’écorce broyéed ’O range amère, l’extrait sec de racinede Gentianebroyée, l’extrait sec deCannelle de Madagascarbroyée, et l’extrait sec d’écorce deQuinquina rouge, broyée, et optionnellement l’extrait sec deGinseng de Sibériebroyé, à une température de 20 °C, dans les mêmes proportions que selon la revendication 1, dans laquelle on ajoute optionnellement, après refroidissement, un agent conservateur choisi parmi le Benzoate de Sodium ou le Parahydroxybenzoate de Méthyle, optionnellement un arôme caramel pourra être ajouté, après l’addition des extraits secs, en proportion de 0 à 1% du poids total de la composition ;
- Une étape de filtration de la solution aqueuse obtenue à l’étape a.
- Une étape d’incorporation sous agitation à la solution aqueuse obtenue à l’étape b, d’un sirop de riz ou de saccharose à une température de 40 °C ;
- Une étape d’homogénéisation de la composition obtenue à l’étape c.
- A step of preparing the aqueous solution in which the dry extract of crushed bark of O range bitter , the dry extract of crushed Gentian root, is infused in purified water and alcohol, the dry extract of crushed Madagascar cinnamon , and the dry extract of crushed red Cinchona bark, and optionally the dry extract of crushed Siberian ginseng , at a temperature of 20°C, in the same proportions as according to claim 1, in which a preservative chosen from sodium benzoate or methyl parahydroxybenzoate is optionally added after cooling, optionally a caramel flavoring may be added, after the addition of the dry extracts, in a proportion of 0 to 1 % of the total weight of the composition;
- A stage of filtration of the aqueous solution obtained in stage a.
- A step of incorporating, with stirring, into the aqueous solution obtained in step b, a rice or sucrose syrup at a temperature of 40° C.;
- A step of homogenizing the composition obtained in step c.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR2003540 | 2020-04-08 | ||
| FR2003540A FR3109085A1 (en) | 2020-04-08 | 2020-04-08 | PERKYNIN |
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| FR3109084B1 FR3109084B1 (en) | 2022-05-20 |
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| FR2010168A Active FR3109084B1 (en) | 2020-04-08 | 2020-10-05 | PERKYNINE, phytotherapeutic composition with antiasthenic effect |
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| FR2003540A Pending FR3109085A1 (en) | 2020-04-08 | 2020-04-08 | PERKYNIN |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024017459A1 (en) * | 2022-07-18 | 2024-01-25 | Panteghini Vanessa | Composition based on dry extract of artemisia annua plant and siberian ginseng root |
-
2020
- 2020-04-08 FR FR2003540A patent/FR3109085A1/en active Pending
- 2020-10-05 FR FR2010168A patent/FR3109084B1/en active Active
Non-Patent Citations (3)
| Title |
|---|
| ANONYMOUS: "Randomized controlled trial of Siberian ginseng for chronic fatigue | Psychological Medicine | Cambridge Core", 1 January 2004 (2004-01-01), XP055808230, Retrieved from the Internet <URL:https://www.cambridge.org/core/journals/psychological-medicine/article/abs/randomized-controlled-trial-of-siberian-ginseng-for-chronic-fatigue/B9941CDB55F4C53FF5DB1D48B5C350A7> [retrieved on 20210527] * |
| ANONYMOUS: "Top 13 Benefits of Eleuthero Root (Siberian Ginseng)", INTERNET CITATION, 27 July 2017 (2017-07-27), XP002777749, Retrieved from the Internet <URL:https://web.archive.org/web/20170727160053/http://urbol.com/siberian-eleuthero-ginseng/> [retrieved on 20210527] * |
| M VINCENT TERRIEN ET AL: "UNIVERSITE DE NANTES FACULTE DE PHARMACIE", 1 January 2010 (2010-01-01), XP055538591, Retrieved from the Internet <URL:http://archive.bu.univ-nantes.fr/pollux/show.action?id=26848b82-b72a-42f9-ab78-e1da51521e82> [retrieved on 20190107] * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024017459A1 (en) * | 2022-07-18 | 2024-01-25 | Panteghini Vanessa | Composition based on dry extract of artemisia annua plant and siberian ginseng root |
| WO2024017485A1 (en) * | 2022-07-18 | 2024-01-25 | Panteghini Vanessa | Composition based on dry extract of red cinchona, and the antiasthenic and antiviral effect thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3109084B1 (en) | 2022-05-20 |
| FR3109085A1 (en) | 2021-10-15 |
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