BE1016566A4 - Preparation in the form of pill, tablet, dragee, lozenge or capsule containing calcium, vitamin D and vitamin K to satisfy all human daily requirements e.g. for pregnant and breast feeding women and old people - Google Patents
Preparation in the form of pill, tablet, dragee, lozenge or capsule containing calcium, vitamin D and vitamin K to satisfy all human daily requirements e.g. for pregnant and breast feeding women and old people Download PDFInfo
- Publication number
- BE1016566A4 BE1016566A4 BE2004/0257A BE200400257A BE1016566A4 BE 1016566 A4 BE1016566 A4 BE 1016566A4 BE 2004/0257 A BE2004/0257 A BE 2004/0257A BE 200400257 A BE200400257 A BE 200400257A BE 1016566 A4 BE1016566 A4 BE 1016566A4
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- Prior art keywords
- vitamin
- calcium
- pill
- emi
- pills
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- 239000011575 calcium Substances 0.000 title claims abstract description 40
- 229960005069 calcium Drugs 0.000 title claims abstract description 36
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 36
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 239000006187 pill Substances 0.000 title claims abstract description 20
- 239000003826 tablet Substances 0.000 title claims abstract description 13
- 239000002775 capsule Substances 0.000 title claims abstract description 12
- 239000008298 dragée Substances 0.000 title claims abstract description 10
- 239000007937 lozenge Substances 0.000 title claims abstract 4
- 235000001465 calcium Nutrition 0.000 title abstract description 31
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract description 13
- 229930003316 Vitamin D Natural products 0.000 title abstract description 12
- 235000019166 vitamin D Nutrition 0.000 title abstract description 12
- 239000011710 vitamin D Substances 0.000 title abstract description 12
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract description 12
- 229940046008 vitamin d Drugs 0.000 title abstract description 12
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 title abstract description 8
- 229930003448 Vitamin K Natural products 0.000 title abstract description 7
- 235000019168 vitamin K Nutrition 0.000 title abstract description 7
- 239000011712 vitamin K Substances 0.000 title abstract description 7
- 150000003721 vitamin K derivatives Chemical class 0.000 title abstract description 7
- 229940046010 vitamin k Drugs 0.000 title abstract description 7
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 210000000481 breast Anatomy 0.000 title abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 14
- 208000001132 Osteoporosis Diseases 0.000 claims abstract description 11
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 7
- 229940088594 vitamin Drugs 0.000 claims description 22
- 229930003231 vitamin Natural products 0.000 claims description 22
- 235000013343 vitamin Nutrition 0.000 claims description 22
- 239000011782 vitamin Substances 0.000 claims description 22
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 19
- 210000000988 bone and bone Anatomy 0.000 claims description 15
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 3
- 230000009245 menopause Effects 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 150000001669 calcium Chemical class 0.000 claims 1
- 239000001527 calcium lactate Substances 0.000 abstract description 2
- 229960002401 calcium lactate Drugs 0.000 abstract description 2
- 235000011086 calcium lactate Nutrition 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 abstract 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 235000019175 phylloquinone Nutrition 0.000 abstract 1
- 239000011772 phylloquinone Substances 0.000 abstract 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 abstract 1
- 229960001898 phytomenadione Drugs 0.000 abstract 1
- 235000005282 vitamin D3 Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 3
- 230000035935 pregnancy Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 1
- -1 CALCIUM VITAMIN Chemical class 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 206010016454 Femur fracture Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010041541 Spinal compression fracture Diseases 0.000 description 1
- 206010047626 Vitamin D Deficiency Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002364 anti-haemorrhagic effect Effects 0.000 description 1
- 230000001749 antrachitic effect Effects 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Preparation in the form of pill, tablet, dragee, lozenge or capsule containing calcium, vitamin D and vitamin K, in sufficient quantities to satisfy all daily human requirements i.e. two to three pills, tablets, dragees, lozenges or capsules containing calcium carbonate and/or calcium lactate (100-12000 mg) and vitamin D3 (1-50 mu g) and vitamin K1 (10-5000 mu g) sufficient to provide all the daily requirements of women who are pregnant or breast feeding children, and of people more than 50 years old, and to protect them from osteoporosis. ACTIVITY : Osteopathic. MECHANISM OF ACTION : None given.
Description
Procédé pour fournir les besoins quotidiens de l'être humain en CALCIUM (Ca), en VITAMINE " D " et en VITAMINE " K " sous forme de pilule à croquer ou à avaler.
La présente invention concerne l'apport des besoins quotidiens en CALCIUM en VITAMINE "D" et en VITAMINE "K" sous forme de pilule, de comprimé, de dragé, de cachet, de capsule, ou de gélule, à avaler ou a croquer, qui peuvent être aussi revêtus d'un enduit lisse et imperméable pour leur permettre d'être avalées facilement.
Cette combinaison de CALCIUM, de VITAMINE "D" et de vitamine "K" n'existe pas sous aucune forme, ni solide, ni liquide. Cette invention combine le Calcium, la Vitamine D et la Vitamine K dans une petite pilule revêtue d'un enduite lisse et imperméable lui permettant d'être avalé facilement. Cette pilule remplacerait : Les préparations liquides calcaires et crayeuses, ou les comprimés crayeux a croquer et les préparations huileuses pour la vitamine "D" et la vitamine " K " qui sont liposolubles.
L'enrichissement en Calcium (Ca) se fait par le Carbonate de Calcium (CaC03) ou le Lactate
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40% du poids du squelette humain est composé de calcium, 99% du calcium ce trouvant dans le corps humain est stocké dans les os et les dents, le restant 1% se trouve dans le sang et les tissus. Ce calcium libre qui se trouve dans le sang, permet au sang de se coaguler, aux muscles de se contracter et aux nerfs de fonctionner correctement et transmettre les messages. Les os sont des organes vivants dans lesquelles sont stockées les réserves de calcium.
La relation des os avec le reste du corps est dynamique, ce qui veut dire que lorsque la quantité de calcium se trouvant dans le sang, les muscles et les nerfs diminue, ces organes iront chercher le calcium dans les os, ce phénomène s'appelle la " résorption " et lorsque le calcium est remplacé par l'alimentation il retournera dans les os, ce phénomène s'appelle la
" formation ". La " résorption " c'est l'affaiblissement des os et la " formation " c'est la reconstruction des os. Si l'apport en calcium est insuffisant, la résorption continuerait et aurait des effets catastrophiques pour le squelette.
Les besoins en calcium de l'être humain sont estimés a 1000 à 1200 mg par jour, équivalent à quatre grands verres de lait. C'est dans son alimentation et en particulier dans les produits laitiers que la personne trouvera le calcium qui lui est nécessaire, chose qui n'est pas possible surtout chez les personnes plus âgées soufrant d'hypercholestérolémie.
La vitamine D (dite antirachitique) est produite dans le corps par l'exposition de la peau au soleil. Pour que le corps produise assez de vitamine D afin d'assimiler le calcium qu'il a puisé dans les aliments il faudrait qu'au moins les bras et les jambes soient exposés au soleil pendant quelques longes minutes par jour, chose qui ne peut pas se faire dans les pays froids, qui ont aussi peu d'ensoleillement. En conséquence sans la présence de vitamine D le calcium que la personne a cherché dans sa nourriture ne pourra être assimilé que très partiellement. Le calcium seul, même si il est consommé par l'être humain en grandes quantités, sans vitamine D, ne pourra pas être absorbé ni utilisé par l'organisme. Une déficience en vitamine D aura des effets néfastes : les os seront affaiblies et fragilisés.
La Vitamine "K" (dite antihémorragique) non seulement elle protège l'intégrité du squelette, mais elle est nécessaire pour l'ossification du calcium et pour la formation des os sains.
Le CALCIUM se trouve en pharmacie sous sa forme minéral, poudreuse ou granuleuse sèche, par contre, la vitamine D et la vitamine K étant liposolubles, (soluble dans une matière grasse) elles se trouvent en pharmacie sous forme huileuse. Le mélange de calcium et de vitamine D sans la vitamine K existe déjà sous forme de préparations très désagréable à consommer. Le mélange de ces produits dans leur état naturel, aboutirait en une boue calcaire huileuse, dégoûtante pour le consommateur.
Au contraire un mélange de carbonate ou lactate de calcium, enrichis de vitamine " D " et de vitamine " K " faisant partie d'une petite pilule, d'un comprimé d'un dragé , d'un cachet ou d'une gélule revêtue d'un enduit lisse et imperméable pourront être consommées facilement. Deux à trois pilules, enrichis de calcium, de vitamine D et de vitamine K par jour, suffisent pour couvrir tous les besoins de l'être humain, pour optimiser la formation d'os et de dents solides chez l'enfant, ainsi que pour couvrir, sans danger, tous les besoins de la femme enceinte, qui augmentent de 50% pendant la grossesse et la période de l'allaitement. Ainsi que pour protéger les personnes, agés surtout le femmes de plus de 50 ans contre la perte de calcium et l'ostéoporose,qui est une maladie très grave.
Physiologiquement chez l'être humain, le capital osseux est maximal a l'age de 30 ans.
A partir de cet age, la perte annuelle est de 0,5%. A la ménopause, la perte s'accélère pendant une dizaine d'années et peut atteindre 2%. A 80 ans la femme a perdu plus que la moitié de son capital osseux, chez les hommes cette perte est plus progressive.
L'ostéoporose a atteint des proportions épidémiques dans le monde, dans certains pays Européens, au delà de l'age de 50 ans, une femme sur trois et un home sur 8 souffrent de cette maladie. On appelle l'ostéoporose, " le voleur silencieux du calcium des os " parce que sauf pour le tassement vertébral, la perte osseuse se produit sans douleurs et sans signes évidents. Souvent, le diagnostique de la maladie ne se fait q'après une fracture du fémur, douloureuse et handicapante.
Dans l'union européenne l'ostéoporose constitue un problème majeur de santé publique, le coût s'élève à plusieurs milliards d'euro par an, et se problème ne fait que s'accentuer avec le doublement de la population de plus de 60 ans.
Description
Procédé pour fournir les besoins quotidiens de l'être humain en CALCIUM (Ca), en VITAMINE " D " et en VITAMINE " K " sous forme de pilule à croquer ou à avaler.
Procédé sous forme d'une pilule, le mot pilule dénomine aussi un comprimé, un dragé , un cachet, ou une gélule qui pourront être enrobés d'un enduit lisse et imperméable pour pouvoir être avalés facilement et pour fournir tous les besoins quotidiens de l'être humain en CALCIUM (Ca), en VITAMINE " D " et en VITAMINE " K ", ainsi que pour prévenir les carences en calcium et en vitamine D, en particulier chez les enfants, chez les femmes enceintes et pendant la période d'allaitement, ainsi que pour la prévention de l'ostéoporose chez les personnes âgés de plus de 50 ans
Dans certains cas, d'autres minéraux tels que le fer, la magnésie, le magnésium, et le zinc et d'autres vitamines telles que la vitamine " A " la vitamine " C ", ou la vitamine " E " pourraient être ajoutés aux pilules.
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transformé en granules. Les granules de calcium enrichi sont ensuite comprimés et transformés en pilules, en comprimés, en dragés en cachets ou en gélules, qui seront enrobés d'un enduit lisse et imperméable pour leur permettre d'être facilement avalés.. Deux à trois pilules, enrichis de calcium, de vitamine D et de vitamine K par jour, suffisent pour couvrir tous les besoins de l'être humain, pour optimiser la formation d'os et de dents solides chez l'enfant, ainsi que pour couvrir, sans danger, tous les besoins de la femme enceinte, qui augmentent de 50% pendant la grossesse et la période de l'allaitement, ainsi que pour protéger les personnes et surtout les femmes au delà de 50 ans contre l'ostéoporose, maladie très grave.
Process for providing daily human needs for CALCIUM (Ca), VITAMIN "D" and VITAMIN "K" as a chewable or swallowing pill.
The present invention relates to the provision of the daily requirements of CALCIUM VITAMIN "D" and VITAMIN "K" in the form of pill, tablet, candy, cachet, capsule, or capsule, to swallow or chew, which can also be coated with a smooth and impervious coating to allow them to be swallowed easily.
This combination of CALCIUM, VITAMIN "D" and vitamin "K" does not exist in any form, neither solid nor liquid. This invention combines Calcium, Vitamin D and Vitamin K in a small pill coated with a smooth, impermeable coating that allows it to be swallowed easily. This pill would replace: Chalky and chalky liquid preparations, or chalky chewable tablets and oily preparations for vitamin "D" and vitamin "K" which are fat soluble.
The enrichment in Calcium (Ca) is done by Calcium Carbonate (CaCO3) or Lactate
<EMI ID = 1.1>
40% of the weight of the human skeleton is composed of calcium, 99% of the calcium found in the human body is stored in the bones and teeth, the remaining 1% is in the blood and tissues. This free calcium found in the blood allows the blood to clot, the muscles to contract and the nerves to function properly and transmit the messages. Bones are living organs in which calcium stores are stored.
The relationship of the bones with the rest of the body is dynamic, which means that when the amount of calcium in the blood, muscles and nerves decreases, these organs will seek calcium in the bones, this phenomenon is called the "resorption" and when the calcium is replaced by the food it will return to the bones, this phenomenon is called the
"training". The "resorption" is the weakening of the bones and the "formation" is the reconstruction of the bones. If calcium intake is insufficient, resorption would continue and have catastrophic effects on the skeleton.
The calcium requirements of the human being are estimated at 1000 to 1200 mg per day, equivalent to four large glasses of milk. It is in his diet and especially in dairy products that the person will find the calcium that is necessary, something that is not possible especially in older people suffering from hypercholesterolemia.
Vitamin D (called antirachitic) is produced in the body by exposure of the skin to the sun. In order for the body to produce enough vitamin D to assimilate the calcium it has been drawing from food, at least the arms and legs should be exposed to the sun for a few long minutes a day, something that can not be done. to be done in cold countries, which also have little sunshine. As a result, without the presence of vitamin D, the calcium that the person sought in his food can only be partially assimilated. Calcium alone, even if it is consumed by humans in large quantities, without vitamin D, can not be absorbed or used by the body. A deficiency in vitamin D will have harmful effects: the bones will be weakened and weakened.
Vitamin "K" (so-called anti-haemorrhagic) not only protects the integrity of the skeleton, but is necessary for calcium ossification and for the formation of healthy bones.
CALCIUM is found in pharmacy in its mineral form, powdery or granular dry, against, vitamin D and vitamin K being fat-soluble, (soluble in fat) they are in pharmacy in oily form. The mixture of calcium and vitamin D without vitamin K already exists in the form of very unpleasant preparations to consume. Mixing these products in their natural state would result in oily limestone mud, disgusting for the consumer.
On the contrary a mixture of calcium carbonate or lactate, enriched with vitamin "D" and vitamin "K" forming part of a small pill, a tablet of a dragee, a cachet or a hard capsule a smooth and waterproof coating can be easily consumed. Two to three pills, enriched with calcium, vitamin D and vitamin K a day, are enough to cover all the needs of the human being, to optimize the formation of bone and solid teeth in the child, as well as to cover, without danger, all the needs of the pregnant woman, who increase by 50% during the pregnancy and the period of the breastfeeding. As well as to protect people, especially women over 50 years old against calcium loss and osteoporosis, which is a very serious disease.
Physiologically in humans, the bone mass is maximal at the age of 30 years.
From this age, the annual loss is 0.5%. At menopause, the loss accelerates for about ten years and can reach 2%. At 80 years the woman has lost more than half of her bone capital, in men this loss is more progressive.
Osteoporosis has reached epidemic proportions worldwide, in some European countries, beyond the age of 50, one in three women and one in eight suffer from this disease. Osteoporosis, "the silent thief of bone calcium" is called because except for vertebral collapse, bone loss occurs without pain and without obvious signs. Often, the diagnosis of the disease is only after a femur fracture, painful and disabling.
In the European Union osteoporosis is a major public health problem, the cost is several billion euros per year, and the problem is only getting worse with the doubling of the population over 60 years .
Description
Process for providing daily human needs for CALCIUM (Ca), VITAMIN "D" and VITAMIN "K" as a chewable or swallowing pill.
Process in the form of a pill, the word pill also denominates a tablet, a dragee, a cachet, or a capsule which can be coated with a smooth and impermeable coating to be swallowed easily and to provide all the daily needs of the patient. CALCIUM (Ca), VITAMIN "D" and VITAMIN "K", as well as to prevent calcium and vitamin D deficiencies, particularly in children, pregnant women and during pregnancy. breastfeeding, as well as for the prevention of osteoporosis in people over 50
In some cases, other minerals such as iron, magnesia, magnesium, and zinc and other vitamins such as vitamin "A" vitamin "C", or vitamin "E" could be added to pills.
<EMI ID = 2.1>
turned into granules. The granules of enriched calcium are then compressed and converted into pills, tablets, dragee tablets or capsules, which will be coated with a smooth and impervious coating to allow them to be easily swallowed. Two to three pills, fortified calcium, vitamin D and vitamin K a day, are sufficient to cover all human needs, to optimize the formation of bone and solid teeth in children, as well as to cover, without danger, all the needs of the pregnant woman, which increases by 50% during pregnancy and breastfeeding, as well as to protect people and especially women over 50 years against osteoporosis, a very serious disease.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE2004/0257A BE1016566A4 (en) | 2004-05-25 | 2004-05-25 | Preparation in the form of pill, tablet, dragee, lozenge or capsule containing calcium, vitamin D and vitamin K to satisfy all human daily requirements e.g. for pregnant and breast feeding women and old people |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE2004/0257A BE1016566A4 (en) | 2004-05-25 | 2004-05-25 | Preparation in the form of pill, tablet, dragee, lozenge or capsule containing calcium, vitamin D and vitamin K to satisfy all human daily requirements e.g. for pregnant and breast feeding women and old people |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1016566A4 true BE1016566A4 (en) | 2007-02-06 |
Family
ID=36649600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2004/0257A BE1016566A4 (en) | 2004-05-25 | 2004-05-25 | Preparation in the form of pill, tablet, dragee, lozenge or capsule containing calcium, vitamin D and vitamin K to satisfy all human daily requirements e.g. for pregnant and breast feeding women and old people |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE1016566A4 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010085535A1 (en) * | 2009-01-23 | 2010-07-29 | Wyeth Llc | Nutritional supplements for 50+ individuals for improving vitality, immunity, eye and bone health |
| US8846101B2 (en) | 2005-12-07 | 2014-09-30 | Takeda Nycomed As | Film-coated and/or granulated calcium-containing compounds and use thereof in pharmaceutical compositions |
| CN116617252A (en) * | 2023-03-16 | 2023-08-22 | 贵州贵国康业健康产业有限公司 | Vitamin D and vitamin K soft capsule |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999000135A1 (en) * | 1997-06-28 | 1999-01-07 | The Boots Company Plc | Composition comprising vitamin k and vitamin d, for treating or preventing osteoporosis |
| DE20306555U1 (en) * | 2003-04-26 | 2003-10-09 | Bartz Volker | Orally-administered composition for prevention or treatment of osteoporosis comprises calcium, together with vitamin D3 and vitamin K1 |
| WO2004019923A1 (en) * | 2002-08-30 | 2004-03-11 | Vitak Bv | Compositions comprising vitamin k for treating or preventing age-related stiffening of arteries |
-
2004
- 2004-05-25 BE BE2004/0257A patent/BE1016566A4/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999000135A1 (en) * | 1997-06-28 | 1999-01-07 | The Boots Company Plc | Composition comprising vitamin k and vitamin d, for treating or preventing osteoporosis |
| WO2004019923A1 (en) * | 2002-08-30 | 2004-03-11 | Vitak Bv | Compositions comprising vitamin k for treating or preventing age-related stiffening of arteries |
| DE20306555U1 (en) * | 2003-04-26 | 2003-10-09 | Bartz Volker | Orally-administered composition for prevention or treatment of osteoporosis comprises calcium, together with vitamin D3 and vitamin K1 |
Non-Patent Citations (1)
| Title |
|---|
| SCHAAFSMA ANNE ET AL: "Positive effects of a chicken eggshell powder-enriched vitamin-mineral supplement on femoral neck bone mineral density in healthy late post-menopausal Dutch women", BRITISH JOURNAL OF NUTRITION, vol. 87, no. 3, March 2002 (2002-03-01), pages 267 - 275, XP002390773, ISSN: 0007-1145 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8846101B2 (en) | 2005-12-07 | 2014-09-30 | Takeda Nycomed As | Film-coated and/or granulated calcium-containing compounds and use thereof in pharmaceutical compositions |
| US9801907B2 (en) | 2005-12-07 | 2017-10-31 | Takeda As | Film-coated and/or granulated calcium-containing compounds and use therof in pharmaceutical compositions |
| WO2010085535A1 (en) * | 2009-01-23 | 2010-07-29 | Wyeth Llc | Nutritional supplements for 50+ individuals for improving vitality, immunity, eye and bone health |
| AU2010206796B2 (en) * | 2009-01-23 | 2014-03-27 | Pf Consumer Healthcare 1 Llc | Nutritional supplements for 50+ individuals for improving vitality, immunity, eye and bone health |
| US9398776B2 (en) | 2009-01-23 | 2016-07-26 | Wyeth Llc | Nutritional supplements for 50+ individuals for improving vitality, immunity, eye and bone health |
| CN116617252A (en) * | 2023-03-16 | 2023-08-22 | 贵州贵国康业健康产业有限公司 | Vitamin D and vitamin K soft capsule |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Effective date: 20060531 |