BE1003256A5 - BUTYNYLAMINE DERIVATIVES. - Google Patents

BUTYNYLAMINE DERIVATIVES. Download PDF

Info

Publication number
BE1003256A5
BE1003256A5 BE8900977A BE8900977A BE1003256A5 BE 1003256 A5 BE1003256 A5 BE 1003256A5 BE 8900977 A BE8900977 A BE 8900977A BE 8900977 A BE8900977 A BE 8900977A BE 1003256 A5 BE1003256 A5 BE 1003256A5
Authority
BE
Belgium
Prior art keywords
alkyl group
hydrogen atom
group
butynylamine
different
Prior art date
Application number
BE8900977A
Other languages
French (fr)
Inventor
Kimura Kiyoshi
Kise Masahiro
Morita Iwao
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Application granted granted Critical
Publication of BE1003256A5 publication Critical patent/BE1003256A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Dérivés de la butynylamine représentés par la formule générale (I) suivante et leurs sels pharmacologiquement acceptables, dans laquelle R1 et R2 sont des groupes cycloalkyle, phényle ou 2-thiényle identiques ou différents; R3 et R4 sont un atome d'hydrogène ou un groupe alkyle identiques ou différents ou forment ensemble un groupe cycloalkyle conjointement avec l'atome de carbone adjecent;R5 et R6 sont un atome d'hydrogène ou un groupe alkyle identiques ou différents, ou forment ensemble un groupe amino cyclique conjointement avec l'atome d'azote adjacent, et A désigne O ou NR (où R est un atome d'hydrogène ou un groupe alkyle), à l'exclusion du cas où R3 et R4 sont tous deux des atomes d'hydrogène, A est O et, au moins l'un ou l'outre des symboles R1 et R2 est un groupe phényle.Butynylamine derivatives represented by the following general formula (I) and their pharmacologically acceptable salts, in which R1 and R2 are identical or different cycloalkyl, phenyl or 2-thienyl groups; R3 and R4 are the same or different hydrogen atom or alkyl group or together form a cycloalkyl group together with the adjacent carbon atom; R5 and R6 are the same or different hydrogen atom or alkyl group, or form together a cyclic amino group together with the adjacent nitrogen atom, and A denotes O or NR (where R is a hydrogen atom or an alkyl group), excluding the case where R3 and R4 are both hydrogen atoms, A is O and at least one or more of the symbols R1 and R2 is a phenyl group.

BE8900977A 1988-09-14 1989-09-14 BUTYNYLAMINE DERIVATIVES. BE1003256A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23127288 1988-09-14

Publications (1)

Publication Number Publication Date
BE1003256A5 true BE1003256A5 (en) 1992-02-11

Family

ID=16921002

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900977A BE1003256A5 (en) 1988-09-14 1989-09-14 BUTYNYLAMINE DERIVATIVES.

Country Status (13)

Country Link
US (1) US5036098B1 (en)
EP (1) EP0359311B1 (en)
KR (1) KR0154325B1 (en)
CN (1) CN1038410C (en)
BE (1) BE1003256A5 (en)
CA (1) CA1317943C (en)
CH (1) CH680440A5 (en)
DE (1) DE68927657T2 (en)
ES (1) ES2016060A6 (en)
FR (1) FR2639044B1 (en)
GB (2) GB8919320D0 (en)
HU (2) HUT58045A (en)
IL (1) IL91377A (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066680A (en) * 1989-02-14 1991-11-19 Fujisawa Pharmaceutical Co., Ltd. Novel substituted-acetamide compound and a process for the preparation thereof
US5192779A (en) * 1989-02-14 1993-03-09 Fujisawa Pharmaceutical Co., Ltd. Substituted-acetamide compound and a process for the preparation thereof
CA2259316A1 (en) * 1996-07-01 1998-01-08 Bridge Pharma, Inc. Smooth muscle spasmolytic agents, compositions and methods of use thereof
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US6013830A (en) * 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
US6140529A (en) * 1998-10-22 2000-10-31 Sepracor Inc. Synthesis of optically active cyclohexylphenylglycolate esters
WO2003035599A1 (en) * 2001-10-26 2003-05-01 Pharmacia & Upjohn Company Quarternary ammonium compounds and their use as antimuscarinic agents
CA2464217A1 (en) * 2001-11-05 2003-05-15 Pharmacia & Upjohn Company Antimuscarinic aerosol
TW200412945A (en) * 2002-10-25 2004-08-01 Upjohn Co Quaternary ammonium compounds
BR0315784A (en) * 2002-10-29 2005-09-20 Pharmacia & Upjohn Co Llc Quaternary ammonium compounds
WO2004039374A1 (en) * 2002-10-29 2004-05-13 Pharmacia & Upjohn Company Llc Quaternary ammonium compounds as muscarinic receptor antagonists
US8025587B2 (en) * 2008-05-16 2011-09-27 Taylor Made Golf Company, Inc. Golf club
WO2004091597A2 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Method of treating irritable bowel syndrome (ibs)
CA2522102A1 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Quaternary ammonium compounds and their use as antimuscarinic agents
US8748433B2 (en) 2010-04-30 2014-06-10 Merck Sharp & Dohme Corp. β3 adrenergic receptor agonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940540A (en) * 1960-07-26 1963-10-30 Mead Johnson & Co Aminoacetylenes and process for preparing the same
EP0383256A2 (en) * 1989-02-14 1990-08-22 Fujisawa Pharmaceutical Co., Ltd. A novel substituted-acetamide compound and a process for the preparation thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL122610C (en) * 1959-02-18
JPH0755904B2 (en) * 1986-05-14 1995-06-14 小玉株式会社 Bladder disease treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940540A (en) * 1960-07-26 1963-10-30 Mead Johnson & Co Aminoacetylenes and process for preparing the same
EP0383256A2 (en) * 1989-02-14 1990-08-22 Fujisawa Pharmaceutical Co., Ltd. A novel substituted-acetamide compound and a process for the preparation thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACTA PHARM. SUECICA, vol. 6, 1969, pages 349-358, Stockholm, SE; R. DAHLBOM et al.: "Acetylene compounds of potential pharmacological value" *

Also Published As

Publication number Publication date
FR2639044B1 (en) 1993-08-06
KR0154325B1 (en) 1998-12-01
CN1038410C (en) 1998-05-20
CN1041582A (en) 1990-04-25
HU211134A9 (en) 1995-10-30
CA1317943C (en) 1993-05-18
KR900004728A (en) 1990-04-12
GB2222828A (en) 1990-03-21
CH680440A5 (en) 1992-08-31
EP0359311A2 (en) 1990-03-21
DE68927657D1 (en) 1997-02-27
ES2016060A6 (en) 1990-10-01
GB8919320D0 (en) 1989-10-11
IL91377A (en) 1996-09-12
GB8920766D0 (en) 1989-10-25
IL91377A0 (en) 1990-04-29
DE68927657T2 (en) 1997-07-03
EP0359311B1 (en) 1997-01-15
GB2222828B (en) 1992-04-29
EP0359311A3 (en) 1991-07-03
US5036098B1 (en) 1993-11-02
US5036098A (en) 1991-07-30
FR2639044A1 (en) 1990-05-18
HUT58045A (en) 1992-01-28

Similar Documents

Publication Publication Date Title
BE1003256A5 (en) BUTYNYLAMINE DERIVATIVES.
BE904945A (en) NOVEL THIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS.
ATE115952T1 (en) PYRIMIDINDONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIARRYTHMIC AGENTS CONTAINING SAME.
DE69415445D1 (en) Cytotoxic stilbene derivatives and pharmaceutical compositions containing them
DE3854932D1 (en) Azabicyclene derivatives substituted on the bridgehead
DK504889A (en) N-HETEROCYCLIC COMPOUNDS
DK0445731T3 (en) Azabicyclo and azacyclooxime and amine cholinergic agents and pharmaceutically acceptable salts thereof
BE1002868A4 (en) DERIVATIVES OF ACYLPHENOLS.
NO941451D0 (en) oxazoline
BE1003248A5 (en) PYROGLUTAMIDE DERIVATIVES.
AU2124992A (en) Pharmaceutically useful indole derivatives
TW333532B (en) Benzopyrans
DE69416683T2 (en) BENZOLACTAM DERIVATIVES
ATE55057T1 (en) CENTRALLY ACTING MUSCLE RELAXANTS.
YU72992A (en) DERIVATIVES OF CYCLOHEXANE AND TETRAHYDROPYRENE
ATE148128T1 (en) ANTHRACYCLINGLYCOSIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
JPS6419096A (en) Tripeptide derivative having polycyclic nitrogen-containing structure
FR2637500A1 (en) DRUGS BASED ON NEW DERIVATIVES OF CARBONYL-2 N, N'-DI- (TRIMETHOXYBENZOYLE) PIPERAZINE
DE69420514T2 (en) Cyclopropane derivatives and antiviral agents containing them
ATE215932T1 (en) INDOLE DERIVATIVES
FR2637499A1 (en) MEDICINES BASED ON NEW DERIVATIVES OF METHOXYCARBONYL-2 N, N'-DI- (TRIMETHOXYBENZOYLE) PIPERAZINE
DK0493346T3 (en) Derivatives of 1,2,3,4-tetrahydronaphthylamine with nootropic activity and pharmaceutical preparations containing the same
ATE44741T1 (en) 2-(N-SUBSTITUTED GUANIDINO)-4HETEROARYLTHIAZOLE AS ANTI-ULCER AGENTS.
TH2508EX (en) 9- aminoalkyl fluorine

Legal Events

Date Code Title Description
RE Patent lapsed

Effective date: 20070930