AU8906698A - Microstructures for the manipulation of fluid samples - Google Patents

Microstructures for the manipulation of fluid samples

Info

Publication number
AU8906698A
AU8906698A AU89066/98A AU8906698A AU8906698A AU 8906698 A AU8906698 A AU 8906698A AU 89066/98 A AU89066/98 A AU 89066/98A AU 8906698 A AU8906698 A AU 8906698A AU 8906698 A AU8906698 A AU 8906698A
Authority
AU
Australia
Prior art keywords
microstructures
manipulation
fluid samples
samples
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU89066/98A
Other versions
AU745989B2 (en
Inventor
Lee Allan Christel
Gregory T. A. Kovacs
William A. Mcmillan
M. Allen Northrup
Kurt E. Petersen
Farzad Pourahmadi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cepheid
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/910,434 external-priority patent/US6368871B1/en
Application filed by Cepheid filed Critical Cepheid
Publication of AU8906698A publication Critical patent/AU8906698A/en
Application granted granted Critical
Publication of AU745989B2 publication Critical patent/AU745989B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B01F25/4323—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
    • B01F25/43231—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors the channels or tubes crossing each other several times
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
AU89066/98A 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples Ceased AU745989B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/910,434 US6368871B1 (en) 1997-08-13 1997-08-13 Non-planar microstructures for manipulation of fluid samples
US08/910434 1997-08-13
US11545498A 1998-07-14 1998-07-14
US09/115454 1998-07-14
PCT/US1998/016870 WO1999009042A2 (en) 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU44377/02A Division AU4437702A (en) 1997-08-13 2002-05-23 Microstructures for the manipulation of fluid samples
AU44376/02A Division AU4437602A (en) 1997-08-13 2002-05-23 Microstructures for the manipulation of fluid samples

Publications (2)

Publication Number Publication Date
AU8906698A true AU8906698A (en) 1999-03-08
AU745989B2 AU745989B2 (en) 2002-04-11

Family

ID=26813216

Family Applications (1)

Application Number Title Priority Date Filing Date
AU89066/98A Ceased AU745989B2 (en) 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples

Country Status (5)

Country Link
EP (1) EP1003759A2 (en)
JP (1) JP2001515216A (en)
AU (1) AU745989B2 (en)
CA (1) CA2301309A1 (en)
WO (1) WO1999009042A2 (en)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681871A (en) * 1995-05-24 1997-10-28 Johnson & Johnson Vision Products, Inc. Method for preparing ultraviolet radiation absorbing contact lenses
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6440725B1 (en) * 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
EP1405666B1 (en) 1998-08-28 2007-03-21 febit biotech GmbH Substrate for methods to determine analytes and methods to manufacture such substrates
JP3746658B2 (en) * 1999-04-12 2006-02-15 株式会社日立製作所 Method and apparatus for producing probe array using fine particles
US20050100943A1 (en) 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
DK1181098T4 (en) * 1999-05-28 2011-09-26 Cepheid Cartridge for performing a chemical reaction
ATE278771T1 (en) * 1999-05-28 2004-10-15 Cepheid APPARATUS AND METHOD FOR ANALYZING LIQUID SAMPLES
DE19927534B4 (en) * 1999-06-16 2008-01-31 Merck Patent Gmbh Apparatus for sample application
IL147227A0 (en) 1999-07-02 2002-08-14 Clondiag Chip Tech Gmbh Microchip matrix device for duplicating and characterizing nucleic acids
US6930292B1 (en) * 1999-07-21 2005-08-16 Dako A/S Method of controlling the temperature of a specimen in or on a solid support member
CA2381361A1 (en) * 1999-08-13 2001-02-22 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
SE0001768D0 (en) * 2000-05-12 2000-05-12 Helen Andersson Microfluidic flow cell for manipulation of particles
DE10051396A1 (en) * 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh An integrated synthesis and identification of an analyte, comprises particles immobilized at a carrier to be coupled to receptors in a structured pattern to give receptor arrays for biochemical reactions
SE0004296D0 (en) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
JP3538777B2 (en) * 2001-03-26 2004-06-14 独立行政法人産業技術総合研究所 Microchemical reactor
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
WO2002086333A1 (en) * 2001-04-25 2002-10-31 President And Fellows Of Harvard College Fluidic switches and method for controlling flow in fluidic systems
WO2002087729A1 (en) * 2001-04-30 2002-11-07 Battelle Memorial Institute Apparatus and method for separation/purification of fluids utilizing rapidly cycled thermal swing
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6881315B2 (en) 2001-08-03 2005-04-19 Nec Corporation Fractionating apparatus having colonies of pillars arranged in migration passage at interval and process for fabricating pillars
DE10150549A1 (en) * 2001-10-12 2003-04-17 Roche Diagnostics Gmbh Separation module, useful for the separation of corpuscles from blood, comprises two channels from a junction with a faster flow in one channel taking most of the particles, and a slower flow with few particles through the other channel
AU2002352746A1 (en) * 2001-11-15 2003-06-10 Arryx, Inc. Sample chip
SE0202399D0 (en) * 2001-12-11 2002-08-13 Thomas Laurell Device and method usable for integrated sequential separation and enrichment of proteins
WO2003052427A1 (en) 2001-12-14 2003-06-26 Arkray, Inc. Sample measuring device
KR100408871B1 (en) * 2001-12-20 2003-12-11 삼성전자주식회사 Method of separation or filtration by carbon nanotube in biochip
DE10163476A1 (en) * 2001-12-21 2003-10-30 Siemens Ag Arrangement for separating a component from a fluid
JP2005164242A (en) * 2001-12-28 2005-06-23 Cluster Technology Co Ltd Microchip for electrophoresis
AU2002356341A1 (en) * 2001-12-28 2003-07-30 Norchip As Fluid manipulation in a microfabricated reaction chamber system
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
FR2839660B1 (en) * 2002-05-17 2005-01-21 Commissariat Energie Atomique MICROREACTOR, PROCESS FOR PREPARING THE SAME, AND METHOD FOR REALIZING BIOCHEMICAL OR BIOLOGICAL REACTION
EP1380337B1 (en) * 2002-07-12 2012-11-14 Tosoh Corporation Fine channel device and a chemically operating method for fluid using the device
US7183104B1 (en) 2002-08-23 2007-02-27 Duane Morris Llp Separator and particle detection system
FR2846957B1 (en) * 2002-11-13 2005-09-30 Commissariat Energie Atomique MICRO-SYSTEM FILLING MICROBALLS AND PROCESS FOR OBTAINING THE SAME
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
WO2004051231A1 (en) * 2002-11-29 2004-06-17 Nec Corporation Separator and separating method
JP2004354364A (en) * 2002-12-02 2004-12-16 Nec Corp Fine particle manipulating unit, chip mounted with the same and detector, and method for separating, capturing and detecting protein
WO2004051229A1 (en) * 2002-12-02 2004-06-17 Nec Corporation Liquid switch, and microchip and mass-analyzing system using the same
GB0303524D0 (en) * 2003-02-15 2003-03-19 Sec Dep For The Home Departmen Improvements in and relating to the handling of dna
JPWO2004097393A1 (en) * 2003-04-28 2006-07-13 松下電器産業株式会社 Filter and biosensor equipped with the filter
JP4348676B2 (en) 2003-06-03 2009-10-21 富士フイルム株式会社 Micro chemical equipment
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
DE10334238A1 (en) * 2003-07-28 2005-02-24 Robert Bosch Gmbh Sensor inlet channel
EP2402089A1 (en) 2003-07-31 2012-01-04 Handylab, Inc. Processing particle-containing samples
FR2865806B1 (en) * 2004-01-30 2007-02-02 Commissariat Energie Atomique ON-CHIP LABORATORY COMPRISING A MICRO-FLUIDIC NETWORK AND A COPLANAR ELECTRONEBULATING NOSE
US7932024B2 (en) * 2004-02-26 2011-04-26 Delta, Dansk Elektronik, Lys & Akustik Method, chip, device and system for collection of biological particles
ES2553097T3 (en) * 2004-05-03 2015-12-04 Handylab, Inc. Processing of samples containing polynucleotides
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
WO2005123242A1 (en) * 2004-06-15 2005-12-29 Nec Corporation Structural body, chip using the structural body, and method of controlling lyophilic/lyophobic properties
US20080023331A1 (en) * 2004-06-15 2008-01-31 Nec Corporation Electrophoretic Chip, Electrophoretic Device and Electrophoresis Method
JP4735119B2 (en) * 2004-08-09 2011-07-27 日本精工株式会社 Reactor and production method thereof
JP4591759B2 (en) * 2004-11-05 2010-12-01 横河電機株式会社 Micro electrochemical reactor
EP2194485B1 (en) 2004-11-16 2012-10-17 Illumina, Inc. Method and apparatus for reading coded microbeads
CA2588753C (en) 2004-12-03 2014-02-18 Cytonome, Inc. Unitary cartridge for particle processing
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US7560417B2 (en) 2005-01-13 2009-07-14 Wisconsin Alumni Research Foundation Method and apparatus for parallel synthesis of chain molecules such as DNA
US20090136982A1 (en) 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
EP1838442B1 (en) 2005-01-18 2013-09-11 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
JPWO2006098370A1 (en) * 2005-03-16 2008-08-28 日本電気株式会社 DELAY CIRCUIT, MICROCHIP HAVING ADJUSTING MECHANISM FOR EFFECTIVE PASSING TIME OF PATH, AND METHOD FOR MANUFACTURING THE SAME
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
EP1712284B1 (en) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Cell separation method using hydrophobic solid supports
JP2006300860A (en) * 2005-04-25 2006-11-02 Kyocera Corp Micro chemical chip
KR101306214B1 (en) * 2005-10-24 2013-09-09 미쓰이 가가쿠 가부시키가이샤 Microchip device
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
EP2001990B1 (en) 2006-03-24 2016-06-29 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
CA2646309C (en) 2006-04-21 2016-07-26 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
JP4759451B2 (en) * 2006-06-16 2011-08-31 株式会社日立ソリューションズ Pretreatment chip for biological material and pretreatment chip system
US7608399B2 (en) 2006-06-26 2009-10-27 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
WO2008009311A1 (en) * 2006-07-17 2008-01-24 Agilent Technologies, Inc. Temperature adjustment of a fluidic sample within a fluidic device
JP5173165B2 (en) * 2006-08-14 2013-03-27 東京エレクトロン株式会社 Chromatography column and method for producing the same
JP2008048735A (en) * 2006-08-21 2008-03-06 Samsung Electronics Co Ltd Method for separating microorganism with non-planar solid support and apparatus for separating the same
US8158411B2 (en) 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
JP5190571B2 (en) * 2006-08-31 2013-04-24 独立行政法人物質・材料研究機構 Manufacturing method and manufacturing apparatus of micro pillar array element
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US8999636B2 (en) 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
CN101689652A (en) * 2007-05-23 2010-03-31 安格斯公司 articles comprising wettable structured surfaces
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8357296B2 (en) 2007-09-24 2013-01-22 Emd Millipore Corporation Centrifugal filter
EP2072101A1 (en) * 2007-12-21 2009-06-24 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Multiple connected channel micro evaporator
WO2009117167A1 (en) 2008-01-02 2009-09-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
WO2009128294A1 (en) * 2008-04-19 2009-10-22 ブラザー工業株式会社 Test object receiver and test apparatus equipped with said test object receiver
KR101102532B1 (en) * 2008-07-10 2012-01-03 삼성전자주식회사 Cartridge containing reagent therein, microfluidic device having the cartridge, manufacturing method of the microfluidic device, biochemistry analysis method using microfluidic device
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
RU2009120627A (en) 2009-05-29 2010-12-10 Корнинг Инкорпорейтед (US) MICRO-LIQUID FLOW CONTROLLED DEVICES
EP2437887B1 (en) 2009-06-04 2016-05-11 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
JP5585204B2 (en) * 2010-05-18 2014-09-10 大日本印刷株式会社 Microchip and manufacturing method thereof
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
BR112013026451B1 (en) 2011-04-15 2021-02-09 Becton, Dickinson And Company system and method to perform molecular diagnostic tests on several samples in parallel and simultaneously amplification in real time in plurality of amplification reaction chambers
US8629264B2 (en) 2011-05-19 2014-01-14 Blood Cell Storage, Inc. Gravity flow fluidic device for nucleic acid extraction
US9304070B2 (en) 2011-07-13 2016-04-05 Emd Millipore Corporation All-in-one sample preparation device and method
EP2761305B1 (en) 2011-09-30 2017-08-16 Becton, Dickinson and Company Unitized reagent strip
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
HU230238B1 (en) * 2013-02-05 2015-10-28 NORMA Instruments Zártkörűen Működő Részvénytársaság Measuring unit for determining physical characteristics of liquid samples
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
SG11201703057TA (en) * 2014-10-17 2017-05-30 Water Optics Technology Pte Ltd A method and device for concentrating particles in a fluid sample
CN107779387A (en) * 2016-08-30 2018-03-09 广州康昕瑞基因健康科技有限公司 Gene sequencing reaction cell
WO2018085453A1 (en) * 2016-11-01 2018-05-11 California Institute Of Technology Microfluidic devices and methods for purifying rare antigen-specific t cell populations
WO2018183744A1 (en) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
WO2020013800A1 (en) * 2018-07-09 2020-01-16 Hewlett-Packard Development Company, L.P. Analyte capturing devices with fluidic ejection devices
CN109100525B (en) * 2018-09-08 2023-07-28 重庆科技学院 Using method of paper-based microfluidic chip for multi-channel detection
FR3097626B1 (en) * 2019-06-20 2021-07-09 Exoes Thermoregulation system with a rechargeable source of electricity
JP7310922B2 (en) 2019-12-12 2023-07-19 株式会社島津製作所 Chromatography system
CN111569962A (en) * 2020-05-21 2020-08-25 浙江大学 Protein enrichment method based on dielectrophoresis and multi-biological-probe rapid detection system
CN114590475B (en) * 2020-12-07 2023-11-17 京东方科技集团股份有限公司 Liquid storage release device
CN112452367B (en) * 2020-12-10 2022-02-22 深圳先进技术研究院 Double-layer micropore chip, preparation method of double-layer micropore chip and biological device
BE1029473B1 (en) * 2021-06-08 2023-01-16 Pharmafluidics Generic design for microfluidic device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006280A1 (en) * 1988-01-04 1989-07-13 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
CN1087960C (en) * 1994-10-22 2002-07-24 研究中心实验室(有限) Method and apparatus for diffusive transfer between immiscible fluids

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