AU8680598A - Alpha 1a adrenergic receptor antagonist - Google Patents

Alpha 1a adrenergic receptor antagonist Download PDF

Info

Publication number
AU8680598A
AU8680598A AU86805/98A AU8680598A AU8680598A AU 8680598 A AU8680598 A AU 8680598A AU 86805/98 A AU86805/98 A AU 86805/98A AU 8680598 A AU8680598 A AU 8680598A AU 8680598 A AU8680598 A AU 8680598A
Authority
AU
Australia
Prior art keywords
alkyl
halogen
compound
substituted
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU86805/98A
Other languages
English (en)
Inventor
Gerald F. Bills
Michel Chartrain
Norihiro Ikemoto
Robert D Larsen
Wenjie Li
Christopher M. Roberge
Daniel R Sidler
Colleen S. Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719706.5A external-priority patent/GB9719706D0/en
Priority claimed from GBGB9719708.1A external-priority patent/GB9719708D0/en
Priority claimed from US09/122,301 external-priority patent/US6207444B1/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU8680598A publication Critical patent/AU8680598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU86805/98A 1997-08-05 1998-07-31 Alpha 1a adrenergic receptor antagonist Abandoned AU8680598A (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US5490297P 1997-08-05 1997-08-05
US5481597P 1997-08-05 1997-08-05
US60054815 1997-08-05
US60054902 1997-08-05
GBGB9719706.5A GB9719706D0 (en) 1997-09-16 1997-09-16 Alpha 1a adrenergic receptor antagonist
GB9719706 1997-09-16
GB9719708 1997-09-16
GBGB9719708.1A GB9719708D0 (en) 1997-09-16 1997-09-16 Enzymatic resolution of a dihydropyrimidinone
US09122301 1998-07-24
US09/122,301 US6207444B1 (en) 1997-08-05 1998-07-24 Enzymatic process of making alpha 1a adrenergic receptor antagonists using protease
PCT/US1998/016011 WO1999007695A2 (fr) 1997-08-05 1998-07-31 ANTAGONISTE DE RECEPTEUR ADRENERGIQUE ALPHA 1a

Publications (1)

Publication Number Publication Date
AU8680598A true AU8680598A (en) 1999-03-01

Family

ID=27517427

Family Applications (1)

Application Number Title Priority Date Filing Date
AU86805/98A Abandoned AU8680598A (en) 1997-08-05 1998-07-31 Alpha 1a adrenergic receptor antagonist

Country Status (5)

Country Link
EP (1) EP1003734A2 (fr)
JP (1) JP2001512724A (fr)
AU (1) AU8680598A (fr)
CA (1) CA2297889A1 (fr)
WO (1) WO1999007695A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ297278A (en) 1994-11-16 1999-06-29 Synaptic Pharma Corp 4-aryl dihydropyrimidine derivatives end medicaments
US6268369B1 (en) 1994-11-16 2001-07-31 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6228861B1 (en) 1995-11-16 2001-05-08 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
US6245773B1 (en) 1996-05-16 2001-06-12 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6172066B1 (en) 1996-05-16 2001-01-09 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
AU2386800A (en) * 1998-12-23 2000-07-12 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6680323B2 (en) 1998-12-23 2004-01-20 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6274585B1 (en) * 1998-12-23 2001-08-14 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6720324B2 (en) 2000-07-05 2004-04-13 Synaptic Pharmaceutical Corporation Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
NZ531033A (en) 2001-07-13 2005-07-29 Astrazeneca Uk Ltd Preparation of a 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound or analogous aminopyrimidine compounds
EP2088142A3 (fr) 2002-12-16 2010-04-21 AstraZeneca UK Limited Dihydropyrimidines, leur procédé de préparation et leur utilisation.
WO2005016910A1 (fr) 2003-08-18 2005-02-24 Sankio Chemical Co., Ltd. Pyridyltetrahydropyridines, pyridylpiperidines et leur methode de preparation
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ297278A (en) * 1994-11-16 1999-06-29 Synaptic Pharma Corp 4-aryl dihydropyrimidine derivatives end medicaments
BR9611933A (pt) * 1995-12-14 1999-03-02 Merc & Co Processo para formar um composto

Also Published As

Publication number Publication date
WO1999007695A3 (fr) 1999-06-17
WO1999007695A2 (fr) 1999-02-18
JP2001512724A (ja) 2001-08-28
CA2297889A1 (fr) 1999-02-18
EP1003734A2 (fr) 2000-05-31

Similar Documents

Publication Publication Date Title
US5629322A (en) Cyclic amidine analogs as inhibitors of nitric oxide synthase
US5705640A (en) O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same
US8044080B2 (en) Isoxazoline derivative and novel process for its preparation
AU8680598A (en) Alpha 1a adrenergic receptor antagonist
EP1682135B1 (fr) sel d'un dérivé de tétrahydropyranyl cyclopentyl tétrahydropyridopyridine comme antagoniste de CCR-2
FR2945531A1 (fr) Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
US20110021558A1 (en) Thieno-pyridine derivatives as mek inhibitors
US20180258054A1 (en) Process for making hydroxylated cyclopentylpyrimidine compounds
JP2023551110A (ja) Ｉｌ‐１７モジュレーターとしてのジシクロプロピルメチル誘導体
US20050245535A1 (en) Sulfonyl amide inhibitors of calcium channel function
TWI491607B (zh) ４，４’-（１-甲基-１，２-乙二基）-雙-（２，６-哌二酮）之新製法
SK285909B6 (sk) Deriváty a analógy galantamínu, spôsob ich výroby, ich použitie na výrobu liečiva, spôsob výroby tohto liečiva a spôsob separácie (+) a (-) izomérov racemických derivátov a analógov galantamínu
KR20000005505A (ko) 피페리딘 및 피롤리딘
JP3044055B2 (ja) １，２―エタンジオール誘導体およびその塩
WO2000043374A1 (fr) Derives de polyazanaphthalenone en tant qu'antagonistes du recepteur adrenergique alpha 1a
EP0420883A1 (fr) Derives de 3-oxo-propane-nitrile tricycliques et procede servant a leur preparation.
US5258383A (en) DC-89 derivatives
US20110124867A1 (en) Process and intermediates for the Synthesis of heterocyclic Substituted Piperazines with CXCR3 Antagonist Activity
US6320049B1 (en) Alpha 1a adrenergic receptor antagonists
JPH10500106A (ja) 治療物質としての置換された縮合および橋かけ二環式化合物
US7423152B2 (en) Process for the manufacture of intermediates in camptothecin production
AU596927B2 (en) Pyrido (1,8) naphthyridinones and their use as pharmaceuticals
US5214065A (en) Dc-89 derivatives
US20050070554A1 (en) Substituted heterocyclic compounds and methods of use
JP3376479B2 (ja) 縮合ピリミジン誘導体、その製造法および用途

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period