AU8617691A - Inhibition of herpesviridae infection by antisense oligonucleotides - Google Patents

Inhibition of herpesviridae infection by antisense oligonucleotides

Info

Publication number
AU8617691A
AU8617691A AU86176/91A AU8617691A AU8617691A AU 8617691 A AU8617691 A AU 8617691A AU 86176/91 A AU86176/91 A AU 86176/91A AU 8617691 A AU8617691 A AU 8617691A AU 8617691 A AU8617691 A AU 8617691A
Authority
AU
Australia
Prior art keywords
oligomer
virus
gene
target sequence
complementary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU86176/91A
Other languages
English (en)
Inventor
Kameron W. Maxwell
Bernard Roizman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genta Inc
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Publication of AU8617691A publication Critical patent/AU8617691A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1133—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against herpetoviridae, e.g. HSV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU86176/91A 1990-08-15 1991-08-13 Inhibition of herpesviridae infection by antisense oligonucleotides Abandoned AU8617691A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56850190A 1990-08-15 1990-08-15
US568501 1990-08-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU37763/95A Division AU3776395A (en) 1990-08-15 1995-11-09 Inhibition of herpesviridae infection by antisense oligonucleotides

Publications (1)

Publication Number Publication Date
AU8617691A true AU8617691A (en) 1992-03-17

Family

ID=24271562

Family Applications (2)

Application Number Title Priority Date Filing Date
AU86176/91A Abandoned AU8617691A (en) 1990-08-15 1991-08-13 Inhibition of herpesviridae infection by antisense oligonucleotides
AU37763/95A Abandoned AU3776395A (en) 1990-08-15 1995-11-09 Inhibition of herpesviridae infection by antisense oligonucleotides

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU37763/95A Abandoned AU3776395A (en) 1990-08-15 1995-11-09 Inhibition of herpesviridae infection by antisense oligonucleotides

Country Status (10)

Country Link
EP (1) EP0547149A4 (ko)
JP (1) JPH06500469A (ko)
KR (1) KR930701105A (ko)
AU (2) AU8617691A (ko)
CA (1) CA2089476A1 (ko)
IE (1) IE912883A1 (ko)
IL (1) IL99172A (ko)
NZ (1) NZ239372A (ko)
TW (1) TW226408B (ko)
WO (1) WO1992003051A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2105595A1 (en) * 1992-09-23 1994-03-24 Ramaswamy Narayanan Antisense polynucleotides
WO1995032986A1 (en) * 1994-06-01 1995-12-07 Hybridon, Inc. Branched oligonucleotides as pathogen-inhibitory agents
AU713611B2 (en) 1994-10-28 1999-12-09 Delft Diagnostic Laboratory B.V. New polynucleic acid sequences for use in the detection and differentiation of prokaryotic organisms
CA2223032A1 (en) * 1997-02-21 1998-08-21 Smithkline Beecham Corporation Use of hsv-1 ul-15 and vp5 in identifying anti-viral agents
EP2330194A3 (en) 2002-09-13 2011-10-12 Replicor, Inc. Non-sequence complementary antiviral oligonucleotides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ209840A (en) * 1983-10-17 1988-11-29 Kaji Akira A method of inhibiting viral propagation by hybridising dna with the viral rna thus blocking its action
US5248670A (en) * 1990-02-26 1993-09-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotides for inhibiting herpesviruses
CA2092711A1 (en) * 1990-09-21 1992-03-22 Laure Aurelian Compositions and methods for inhibiting growth or replication of viruses

Also Published As

Publication number Publication date
WO1992003051A1 (en) 1992-03-05
EP0547149A4 (en) 1993-09-01
CA2089476A1 (en) 1992-02-16
IL99172A (en) 1999-03-12
TW226408B (ko) 1994-07-11
JPH06500469A (ja) 1994-01-20
IE912883A1 (en) 1992-02-26
KR930701105A (ko) 1993-06-11
NZ239372A (en) 1997-06-24
AU3776395A (en) 1996-02-29
IL99172A0 (en) 1992-07-15
EP0547149A1 (en) 1993-06-23

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