AU8108998A - Aprotinin variants with improved properties and bikunins of aprotinin variants - Google Patents
Aprotinin variants with improved properties and bikunins of aprotinin variantsInfo
- Publication number
- AU8108998A AU8108998A AU81089/98A AU8108998A AU8108998A AU 8108998 A AU8108998 A AU 8108998A AU 81089/98 A AU81089/98 A AU 81089/98A AU 8108998 A AU8108998 A AU 8108998A AU 8108998 A AU8108998 A AU 8108998A
- Authority
- AU
- Australia
- Prior art keywords
- aprotinin variants
- bikunins
- improved properties
- aprotinin
- variants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19725014 | 1997-06-13 | ||
DE19725014A DE19725014A1 (en) | 1997-06-13 | 1997-06-13 | Aprotinin variants with improved properties and bikunins of aprotinin variants |
PCT/EP1998/003259 WO1998056916A1 (en) | 1997-06-13 | 1998-06-02 | Aprotinin variants with improved properties and bikunins of aprotinin variants |
Publications (1)
Publication Number | Publication Date |
---|---|
AU8108998A true AU8108998A (en) | 1998-12-30 |
Family
ID=7832381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU81089/98A Abandoned AU8108998A (en) | 1997-06-13 | 1998-06-02 | Aprotinin variants with improved properties and bikunins of aprotinin variants |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1002083A1 (en) |
JP (1) | JP2002503958A (en) |
AU (1) | AU8108998A (en) |
DE (1) | DE19725014A1 (en) |
WO (1) | WO1998056916A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4565531B2 (en) * | 2000-09-01 | 2010-10-20 | 生化学工業株式会社 | DNA for targeting the bikunin gene |
GB0411145D0 (en) * | 2004-05-19 | 2004-06-23 | Imp College Innovations Ltd | Protease inhibitors and their therapeutic applications |
BRPI0519349A8 (en) * | 2004-12-23 | 2017-09-12 | Csl Behring Gmbh | PREVENTION OF THROMBO FORMATION AND/OR STABILIZATION |
WO2008086858A1 (en) * | 2006-12-22 | 2008-07-24 | Bayer Schering Pharma Aktiengesellschaft | Production and use of non-native variants of domain 2 of human placental bikunin designed by directed molecular evolution |
WO2008110301A1 (en) * | 2007-03-13 | 2008-09-18 | Bayer Schering Pharma Aktiengesellschaft | Aprotinin variants with improved properties |
ES2700149T3 (en) | 2014-02-24 | 2019-02-14 | Takeda Gmbh | UTI fusion proteins |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
DK225488D0 (en) * | 1988-04-26 | 1988-04-26 | Novo Industri As | POLYPEPTIDE |
DE3930522A1 (en) * | 1989-09-13 | 1991-03-21 | Bayer Ag | RECOMBINANT APROTININ VARIANTS - GENETIC METHOD FOR MICROBIAL PRODUCTION OF HOMOGENEOUS APROTININ VARIANTS, AND THE THERAPEUTIC APPLICATION THEREOF |
IL99585A0 (en) * | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
JPH07509229A (en) * | 1992-07-13 | 1995-10-12 | コルバス・インターナショナル、インコーポレイテッド | Inhibitor of factor Xa derived from bovine pancreatic trypsin inhibitor |
WO1994007528A1 (en) * | 1992-09-25 | 1994-04-14 | Corvas International, Inc. | Bovine pancreatic trypsin inhibitor derived inhibitors of factor viia-tissue factor complex |
JP3805785B2 (en) * | 1994-01-11 | 2006-08-09 | ダイアックス コープ. | Kallikrein-inhibiting Kunitz domain protein and its homologues |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
DE19629982A1 (en) * | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin variants with improved properties |
-
1997
- 1997-06-13 DE DE19725014A patent/DE19725014A1/en not_active Withdrawn
-
1998
- 1998-06-02 EP EP98930775A patent/EP1002083A1/en not_active Withdrawn
- 1998-06-02 AU AU81089/98A patent/AU8108998A/en not_active Abandoned
- 1998-06-02 WO PCT/EP1998/003259 patent/WO1998056916A1/en not_active Application Discontinuation
- 1998-06-02 JP JP50147199A patent/JP2002503958A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE19725014A1 (en) | 1998-12-17 |
WO1998056916A1 (en) | 1998-12-17 |
EP1002083A1 (en) | 2000-05-24 |
JP2002503958A (en) | 2002-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |