AU766923B2 - NMR spectroscopic in vitro assay using hyperpolarization - Google Patents

NMR spectroscopic in vitro assay using hyperpolarization Download PDF

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Publication number
AU766923B2
AU766923B2 AU18803/00A AU1880300A AU766923B2 AU 766923 B2 AU766923 B2 AU 766923B2 AU 18803/00 A AU18803/00 A AU 18803/00A AU 1880300 A AU1880300 A AU 1880300A AU 766923 B2 AU766923 B2 AU 766923B2
Authority
AU
Australia
Prior art keywords
assay
nmr
assay reagent
hyperpolarisation
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU18803/00A
Other languages
English (en)
Other versions
AU1880300A (en
Inventor
Jan Henrik Ardenkjaer-Larsen
Oksar Axelsson
Neil Cook
Klaes Golman
Haukur Johannesson
Peter Knox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Amersham PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9828852.5A external-priority patent/GB9828852D0/en
Priority claimed from GBGB9918096.0A external-priority patent/GB9918096D0/en
Application filed by Amersham PLC filed Critical Amersham PLC
Publication of AU1880300A publication Critical patent/AU1880300A/en
Assigned to AMERSHAM PLC reassignment AMERSHAM PLC Amend patent request/document other than specification (104) Assignors: NYCOMED AMERSHAM PLC
Application granted granted Critical
Publication of AU766923B2 publication Critical patent/AU766923B2/en
Assigned to GE HEALTHCARE LIMITED reassignment GE HEALTHCARE LIMITED Request to Amend Deed and Register Assignors: AMERSHAM PLC
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AU18803/00A 1998-12-30 1999-12-23 NMR spectroscopic in vitro assay using hyperpolarization Ceased AU766923B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9828852.5A GB9828852D0 (en) 1998-12-30 1998-12-30 Nmr spectroscopy method
GB9828852 1998-12-30
GB9918096 1999-08-02
GBGB9918096.0A GB9918096D0 (en) 1999-08-02 1999-08-02 NMR Spectroscopy method
PCT/GB1999/004410 WO2000040988A1 (en) 1998-12-30 1999-12-23 Nmr spectroscopic in vitro assay using hyperpolarization

Publications (2)

Publication Number Publication Date
AU1880300A AU1880300A (en) 2000-07-24
AU766923B2 true AU766923B2 (en) 2003-10-23

Family

ID=26314943

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18803/00A Ceased AU766923B2 (en) 1998-12-30 1999-12-23 NMR spectroscopic in vitro assay using hyperpolarization

Country Status (7)

Country Link
US (1) US7501236B1 (enExample)
EP (1) EP1141738A1 (enExample)
JP (1) JP2002534687A (enExample)
AU (1) AU766923B2 (enExample)
CA (1) CA2356442C (enExample)
IL (2) IL143927A0 (enExample)
WO (1) WO2000040988A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
GB0022341D0 (en) 2000-09-12 2000-10-25 Nycomed Imaging As Method
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
NO20023358D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Metode
GB0219953D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab An arrangement and a method for providing contrast agents
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
GB0308586D0 (en) 2003-04-14 2003-05-21 Amersham Health R & D Ab Method and arrangements in NMR spectroscopy
NO20035626D0 (no) * 2003-12-17 2003-12-17 Amersham Health As Metode
EP1555538A1 (en) * 2004-01-15 2005-07-20 Bruker BioSpin MRI GmbH Method of fast multidimensional NMR spectroscopy
US20100233096A1 (en) * 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
EP2117607A4 (en) * 2007-01-11 2012-08-08 Huntington Medical Res Inst PICTURES AND METHOD FOR THEIR USE
US20100233089A1 (en) * 2007-10-05 2010-09-16 Huntington Medical Research Institutes Imaging of genetic material with magnetic resonance
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
WO2009129265A1 (en) * 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
US9678185B2 (en) 2013-03-15 2017-06-13 Pepsico, Inc. Method and apparatus for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer
US10338052B2 (en) 2015-11-30 2019-07-02 Vanderbilt University Methods of detecting sulfur-containing compounds
US20180230182A1 (en) * 2017-02-15 2018-08-16 Cedars-Sinai Medical Center Hyperpolarization of amino acid residues for producing hyperpolarized peptides
DE102018203434B4 (de) * 2018-03-07 2019-12-05 Bernd Willi Karl-Heinz Diehl Verfahren zur heteronuklearen quantitativen Bestimmung mittels NMR-Spektroskopie, Referenzsubstanzen hierfür und Verfahren zur Bestimmung des Deuterierungsgrades einer deuterierten Verbindung
WO2022238350A1 (en) 2021-05-11 2022-11-17 Ecole Polytechnique Federale De Lausanne (Epfl) Dnp biosensor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834226A (en) * 1991-01-31 1998-11-10 Xytronyx, Inc. One-step test for aspartate aminotransferase
US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US6103492A (en) * 1993-03-08 2000-08-15 Indiana University Polynucleotide encoding mu opioid receptor
US5475304A (en) 1993-10-01 1995-12-12 The United States Of America As Represented By The Secretary Of The Navy Magnetoresistive linear displacement sensor, angular displacement sensor, and variable resistor using a moving domain wall
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5479925A (en) 1994-06-23 1996-01-02 General Electric Company Magnetic resonance (MR) angiography in a low-field imaging magnet
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
EP0904542B1 (en) * 1996-03-01 2005-06-29 Beckman Coulter, Inc. System for simultaneously conducting multiple ligand binding assays
FI982069A7 (fi) * 1996-03-29 1998-11-10 Lawrence Berkeley Nat Laboratory NMR:n ja MRI:n tehostaminen hyperpolaroitujen jalokaasujen läsnä olles sa
US6043024A (en) * 1997-04-18 2000-03-28 Abbott Laboratories Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6574496B1 (en) * 1999-05-19 2003-06-03 Amersham Health As Magnetic resonance imaging

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARDENKJAER-LARSEN ET AL JNL MAG RES JUL 98 VOL 133 NO 1, P 1-12 *
SPOONER ET AL BIOPHYS JNL DEC 98 VOL 75 NO 6 P2794-2800 *

Also Published As

Publication number Publication date
EP1141738A1 (en) 2001-10-10
JP2002534687A (ja) 2002-10-15
IL143927A0 (en) 2002-04-21
WO2000040988A1 (en) 2000-07-13
AU1880300A (en) 2000-07-24
IL143927A (en) 2007-05-15
US7501236B1 (en) 2009-03-10
CA2356442A1 (en) 2000-07-13
CA2356442C (en) 2009-03-24

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TC Change of applicant's name (sec. 104)

Owner name: AMERSHAM PLC

Free format text: FORMER NAME: NYCOMED AMERSHAM PLC

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired