AU761138B2 - Compositions and methods for inhibiting bone resorption - Google Patents

Compositions and methods for inhibiting bone resorption Download PDF

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Publication number
AU761138B2
AU761138B2 AU47024/99A AU4702499A AU761138B2 AU 761138 B2 AU761138 B2 AU 761138B2 AU 47024/99 A AU47024/99 A AU 47024/99A AU 4702499 A AU4702499 A AU 4702499A AU 761138 B2 AU761138 B2 AU 761138B2
Authority
AU
Australia
Prior art keywords
asp
nitrogen
fmk
pharmaceutical composition
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47024/99A
Other languages
English (en)
Other versions
AU4702499A (en
Inventor
Alfred A. Reszka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817170.5A external-priority patent/GB9817170D0/en
Priority claimed from GBGB9819126.5A external-priority patent/GB9819126D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU4702499A publication Critical patent/AU4702499A/en
Application granted granted Critical
Publication of AU761138B2 publication Critical patent/AU761138B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU47024/99A 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption Ceased AU761138B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US9049798P 1998-06-24 1998-06-24
US60/090497 1998-06-24
US9291798P 1998-07-15 1998-07-15
US60/092917 1998-07-15
GBGB9817170.5A GB9817170D0 (en) 1998-08-06 1998-08-06 Compositions and methods for inhibiting bone resorption
GB9817170 1998-08-06
GB9819126 1998-09-02
GBGB9819126.5A GB9819126D0 (en) 1998-09-02 1998-09-02 Compositions and methods for inhibiting bone resorption
PCT/US1999/013961 WO1999066945A1 (fr) 1998-06-24 1999-06-21 Compositions et procedes permettant d'inhiber la resorption d'un os

Publications (2)

Publication Number Publication Date
AU4702499A AU4702499A (en) 2000-01-10
AU761138B2 true AU761138B2 (en) 2003-05-29

Family

ID=27451814

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47024/99A Ceased AU761138B2 (en) 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption

Country Status (5)

Country Link
EP (1) EP1089750A4 (fr)
JP (1) JP2002518457A (fr)
AU (1) AU761138B2 (fr)
CA (1) CA2335471A1 (fr)
WO (1) WO1999066945A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492170B1 (en) 2000-09-11 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 9 expression
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6410520B2 (en) * 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression

Also Published As

Publication number Publication date
AU4702499A (en) 2000-01-10
EP1089750A4 (fr) 2001-10-04
JP2002518457A (ja) 2002-06-25
CA2335471A1 (fr) 1999-12-29
WO1999066945A1 (fr) 1999-12-29
EP1089750A1 (fr) 2001-04-11

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)