EP1089750A4 - Compositions et procedes permettant d'inhiber la resorption d'un os - Google Patents

Compositions et procedes permettant d'inhiber la resorption d'un os

Info

Publication number
EP1089750A4
EP1089750A4 EP99930491A EP99930491A EP1089750A4 EP 1089750 A4 EP1089750 A4 EP 1089750A4 EP 99930491 A EP99930491 A EP 99930491A EP 99930491 A EP99930491 A EP 99930491A EP 1089750 A4 EP1089750 A4 EP 1089750A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
bone resorption
inhibiting bone
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99930491A
Other languages
German (de)
English (en)
Other versions
EP1089750A1 (fr
Inventor
Alfred A Reszka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817170.5A external-priority patent/GB9817170D0/en
Priority claimed from GBGB9819126.5A external-priority patent/GB9819126D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1089750A1 publication Critical patent/EP1089750A1/fr
Publication of EP1089750A4 publication Critical patent/EP1089750A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99930491A 1998-06-24 1999-06-21 Compositions et procedes permettant d'inhiber la resorption d'un os Withdrawn EP1089750A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US9049798P 1998-06-24 1998-06-24
US90497P 1998-06-24
US9291798P 1998-07-15 1998-07-15
US92917P 1998-07-15
GB9817170 1998-08-06
GBGB9817170.5A GB9817170D0 (en) 1998-08-06 1998-08-06 Compositions and methods for inhibiting bone resorption
GBGB9819126.5A GB9819126D0 (en) 1998-09-02 1998-09-02 Compositions and methods for inhibiting bone resorption
GB9819126 1998-09-02
PCT/US1999/013961 WO1999066945A1 (fr) 1998-06-24 1999-06-21 Compositions et procedes permettant d'inhiber la resorption d'un os

Publications (2)

Publication Number Publication Date
EP1089750A1 EP1089750A1 (fr) 2001-04-11
EP1089750A4 true EP1089750A4 (fr) 2001-10-04

Family

ID=27451814

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99930491A Withdrawn EP1089750A4 (fr) 1998-06-24 1999-06-21 Compositions et procedes permettant d'inhiber la resorption d'un os

Country Status (5)

Country Link
EP (1) EP1089750A4 (fr)
JP (1) JP2002518457A (fr)
AU (1) AU761138B2 (fr)
CA (1) CA2335471A1 (fr)
WO (1) WO1999066945A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492170B1 (en) 2000-09-11 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 9 expression
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US6410520B2 (en) * 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAMILTON R ET AL: "Synthesis and proteinase inhibitory properties of diphenyl phosphonate analogues of aspartic and glutamic acids", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 13, 7 July 1998 (1998-07-07), pages 1655 - 1660, XP004137102, ISSN: 0960-894X *
See also references of WO9966945A1 *

Also Published As

Publication number Publication date
AU4702499A (en) 2000-01-10
AU761138B2 (en) 2003-05-29
CA2335471A1 (fr) 1999-12-29
EP1089750A1 (fr) 2001-04-11
JP2002518457A (ja) 2002-06-25
WO1999066945A1 (fr) 1999-12-29

Similar Documents

Publication Publication Date Title
EP1088333A4 (fr) Compositions et procedes inhibant la resorption osseuse
GB9820457D0 (en) Methods for sterilizing cyanoacrylate compositions
IL138430A0 (en) Methods and compositions for treating and preventing mucositis
HUP0104836A3 (en) Bone fixation system
AUPQ127399A0 (en) Compositions and methods for treating or preventing osteoporosis
AU3359697A (en) Bone resorption inhibitors
GB9812103D0 (en) Surgical implant
BG105437A (en) REFLECTIVELY MODIFIED COMPOSITIONS AND METHODS FOR OBTAINING THEM
EP1056456A4 (fr) Compositions et procedes d'utilisation du r-lansoprazole
EP1148877A4 (fr) Inhibition de la resorption osseuse
GB9819979D0 (en) Sanitising compositions and methods
EP1056457A4 (fr) Compositions de s-lansoprazole et procedes d'utilisation
EP1106181A4 (fr) Compositions a finalite nutritionnelle pour prevenir ou traiter l'hyperlipoproteinemie
EP1073333A4 (fr) Compositions a base de s-rabeprazole et procedes
GB9819243D0 (en) Method for inhibiting bone resorption
EP1043963A4 (fr) Compositions a base d'osteopontine activant la reparation osseuse
EP1089750A4 (fr) Compositions et procedes permettant d'inhiber la resorption d'un os
GB9828084D0 (en) Femoral component
GB9828085D0 (en) Femoral component
GB9824450D0 (en) Malodour counteractant compositions
GB9822330D0 (en) Compositions and methods for inhibiting bone resorption
GB9819126D0 (en) Compositions and methods for inhibiting bone resorption
GB9817170D0 (en) Compositions and methods for inhibiting bone resorption
EP1073332A4 (fr) Compositions a base de r-rabeprazole et procedes
EP1397146A4 (fr) Compositions et methodes d'inhibition de la resorption osseuse

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010124

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20010124;LT PAYMENT 20010124;LV PAYMENT 20010124;MK PAYMENT 20010124;RO PAYMENT 20010124;SI PAYMENT 20010124

A4 Supplementary search report drawn up and despatched

Effective date: 20010817

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 38/00 A, 7A 61K 38/07 B, 7A 61K 31/66 B, 7C 07K 5/00 B, 7A 61K 38/08 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20040212