AU760967B2 - Herbal composition for the prophylaxis and treatment of AIDS - Google Patents

Herbal composition for the prophylaxis and treatment of AIDS Download PDF

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Publication number
AU760967B2
AU760967B2 AU68125/98A AU6812598A AU760967B2 AU 760967 B2 AU760967 B2 AU 760967B2 AU 68125/98 A AU68125/98 A AU 68125/98A AU 6812598 A AU6812598 A AU 6812598A AU 760967 B2 AU760967 B2 AU 760967B2
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Prior art keywords
stephania
aids
composition
menispermaceae
zingiberaceae
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AU6812598A (en
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Somchok Kongpitak
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Schulze Howard Kenneth
V THAI HERBS Co Ltd
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THAI HERBS Co Ltd V
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

WO 99/51249 PCT/AU98/00236 1 Herbal Composition for the Prophylaxis and Treatment of AIDS The present invention is in the fields of medicine and pharmacology. In particular the present invention relates to herbal composition for the prophylaxis and treatment of human immunodeficiency virus (HIV) disease and Acquired Immune Deficiency Syndrome (AIDS) and AIDS related complex.
TECHNICAL FIELD Acquired Immune Deficiency Syndrome (AIDS) is a pandemic immunosuppressive disease which results in life threatening opportunistic infection and malignancies. The disease kills the helper cells of the immune system which play a crucial role in cell mediated immunity. The progressive loss of the helper cells in the blood leads to a stage where the body is rendered incapable of resisting many bacterial, viral and parasitical invasions resulting in the AIDS patient dying from opportunistic infections. A retrovirus, designated human immunodeficiency virus (HIV-1), has been isolated and identified as the etiologic agent of this disease.
It was estimated that there were about 23 millions HIV infected patients all over the world in 1997. Of these patients, 90% live in developing countries with Asia having the highest numbers of newly infected patients.
Several agents have been reported to inhibit the growth of the human immunodeficiency virus. These include nucleoside analog reverse Transcriptase inhibitors (NRTIs) e.g. zidovudine, lamivudine, d4T (trade names) and protease inhibitors e.g. indinavir, ritonavir, nelfinavir (trade names). A combination of drugs may be used, for example 3 drug regimens that usually include 2 nucleoside analog reverse transcriptase inhibitors and a protease inhibitor, but they are complex and costly. Furthermore these compounds appear to be too toxic for prolonged use or only have a limited capability of minimising or eliminating HIV infections from the human host.
Accordingly the currently known anti-HIV drugs now available are costly and potentially toxic and inaccessible to the majority of HIV infected patients in SUBSTITUTE SHEET (RULE 26) 2 developing countries. Therefore all patients need less expensive, less toxic and effective anti-HIV drugs.
Herbal preparations/ treatments and medicines have been used for the treatment of various diseases in Thailand and South East Asia for several hundred years. Recent interest in natural treatment for health problems has resulted in herbal drugs being researched as to their chemical constituents, toxicity and activities.
The object of the present invention is to provide a herbal composition for the prophylaxis and treatment of AIDS and/or a method for the prophylaxis and treatment of AIDS patients using that herbal composition.
By the terms HIV and AIDS related virus is meant the commonly designated HIV series (human immunodeficiency virus) formerly called HTLV, LAV and ARV, and species thereof.
DISCLOSURE OF THE INVENTION In one form of this invention there is proposed a method for the prophylaxis and treatment of AIDS and AIDS related complex comprising the step of administering to an animal or person a therapeutically effective amount of a preparation including an extract of one or more of the following plants; Stephania venosa Spreng, Stephania suberosa Forman, Stephania glabra 20 Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada.
In a further form of the invention there is proposed a composition for the prophylaxis and treatment of AIDS and AIDS related complex including an extract of one or more of the following plants; Stephania venosa Spreng, 25 Stephania suberosa Forman, Stephania glabra Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada.
In a further form of the invention there is proposed a method of inhibiting in "i vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV with a preparation consisting essentially of an extract from the following Stephania venosa Spreng, Stephania WO 99/51249 PCT/AU98/00236 3 suberosa Forman, Stephania glabra Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada.
In a yet further form of the invention there is proposed a composition for the prophylaxis and treatment of AIDS and AIDS related complex comprising a therapeutically acceptable composition of herbs comprising 18.0 to 19.0% of the total weight of the following formulated by weight of each of Stephania venosa Spreng, Hedychium coronarium Roem, 16.0 to 17.0% by weight of each of Stephania suberosa Forman, Stephania glabra Roxb. Miers and 14.5 to 15.5% by weight of each of Zingiber officinalis Roscoe, Curcurma Amada.
In a yet still further form of the invention there is proposed a composition for the prophylaxis and treatment of AIDS and AIDS related complex comprising each of the following of selected dried plant material in the proportions selected hereafter: Name of herb Classification Weight (mg) minimum Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers.
Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada
(MENISPERMACEAE)
(MENISPERMACEAE)
(MENISPERMACEAE)
(ZINGIBERACEAE)
(ZINGIBERACEAE)
(ZINGIBERACEAE)
It is to be understood though that the particular weight of each plant may depending on the potency of each plant.
In a further still form of the invention there is proposed a composition for the prophylaxis and treatment of AIDS and AIDS related complex comprising the following, as dried plant materials Name of herb Classification Weight (mg) Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers.
(MENISPERMACEAE)
(MENISPERMACEAE)
(MENISPERMACEAE)
SUBSTITUTE SHEET (RULE 26) WO 99/51249 PCT/AU98/00236 Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada
(ZINGIBERACEAE)
(ZINGIBERACEAE)
(ZINGIBERACEAE)
In preference the composition is in the form of a capsule, said capsule being preferentially a gelatin capsule.
In preference the composition is in the form of a liquid mixed with a syrup.
In a still further form of the invention there is proposed a process for preparing a composition for the prophylaxis and treatment of AIDS and AIDS related complex including: 0 pulverising into powder the following amounts of dried plant material consisting essentially of: Name of herb Classification Weight(mg) range Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers.
Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada
(MENISPERMACEAE)
(MENISPERMACEAE)
(MENISPERMACEAE)
(ZINGIBERACEAE)
(ZINGIBERACEAE)
(ZINGIBERACEAE)
40-60 40-60 40-60 40-60 30-50 30-50 preparing a pharmaceutical formulation comprising the powder of step (a) In preference the total weight of the composition of Stephania venosa Spreng, Stephania suberosa Forman, Stephania glabra Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada is no more than 300 mgs.
In preference the method includes giving the composition in the quantities stated twice a day before meals to a patient (human adult) who weighs 60 kg or less.
SUBSTITUTE SHEET (RULE 26) WO 99/51249 PCT/AU98/00236 In preference the method includes giving the composition three times a day before meals to a patient (human adult) who weighs 60-100 kg.
BEST MODE OF THE INVENTION The following detailed description and procedures are provided to illustrate the principles of the invention. They are not, however, intended to limit this invention.
After a significant period of trial and modification a mixture of the following herbs was found to be successful for treating AIDS patients.
Name of Herb Classification Stephania venosa Spreng (MENISPERMACEAE) Stephania suberosa Forman (MENISPERMACEAE) Stephania glabra Roxb. Miers. (MENISPERMACEAE) Hedychium coronarium Roem (ZINGIBERACEAE) Zingiber officinalis Roscoe (ZINGIBERACEAE) Curcurma Amada (ZINGIBERACEAE) Each herb was collected fresh, was washed with water, cut into small pieces, dried and separated from all extraneous material. Each herb was weighed according to predetermined proportions and pulverised together into a powder of about 40-100 mesh, and dried again. However, it is to be understood that the extracts from each subject herb can be used and prepared by known organic extraction procedures.
The resulting herbal powder composition is then filled into hard gelatin capsules. The combination of the herbal composition with an appropriate solid carrier, such as lactose, starch, and lubricants magnesium stearate, calcium stearate) or the like can be used. Each capsule contained approximately 300 mg of the herbal powder composition.
The dosage for oral use chosen for trials is one capsule, twice a day before meals for a patient who weighs 60 kg or lower, and for a patient who weighs 60 to 100 kg, one capsule is administered three times a day before meals.
SUBSTITUTE SHEET (RULE 26) WO 99/51249 PCT/AU98/00236 6 From experiments conducted so far, a therapeutically effective quantify of the referred to composition for an average human adult is at least as follows Name of herb Classification Min wt (mg) Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers.
Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada
(MENISPERMACEAE)
(MENISPERMACEAE)
(MENISPERMACEAE)
(ZINGIBERACEAE)
(ZINGIBERACEAE)
(ZINGIBERACEAE)
It has also been found that the above minimum weights can be some 20 mg for each herb.
In a first example the composition comprises the following increased by Name of herb Classification Weight (mg) Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers.
Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada (MENISPERMACEAE) (MENISPERMACEAE) (MENISPERMACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE) Total 300 Over one hundred patients with confirmed cases of full blown AIDS or HIV infected were treated with the composition of this invention in AIDS treatment hospitals. Both before treatment and periodically after treatment all patients were tested for the following hemoglobin (Hb) white blood cells (WBC) platelet (Pit) polymorphonuclear (PMN) basophol (Bas) lymphocyte (Lymph) monocyte (Mono) SUBSTITUTE SHEET (RULE 26) WO 99/51249 PCT/AU98/00236 7 CD4, CD8, CD4/CD8 ratio as well as other physical conditions. It was found that most of the patients showed improved physical conditions and the symptoms of most opportunistic infections either reduced or significantly disappeared. Thus, approximately equal quantities of the herbs in the composition were found to give a therapeutic advantage.
SUBSTITUTE SHEET (RULE 26)

Claims (6)

1. A method for the prophylaxis and treatment of AIDS and AIDS related complex comprising the step of administering to an animal or a person a therapeutically effective amount of an extract of one or more of the following plants; Stephania venosa Spreng, Stephania suberosa Forman, Stephania glabra Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada.
2. A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV with a preparation consisting essentially of an extract from one or more of the following plants; Stephania venosa Spreng, Stephania suberosa Forman, Stephania glabra Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada.
3. A composition for the prophylaxis/and treatment of AIDS and AIDS related complex including an extract from each of the following plants; Stephania venosa Spreng, Stephania suberosa Forman, Stephania glabra Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada. e*
4. A composition for the prophylaxis and treatment of AIDS and AIDS related S, 20 complex comprising a therapeutically acceptable composition of herbs comprising
18.0 to 19.0% of the total weight of the following formulated by weight of each of Stephania venosa Spreng, Hedychium coronarium Roem, 16.0 to 17.0% by weight of each of Stephania suberosa Forman, Stephania glabra Roxb. Miers and 14.5 to 15.5% by weight of each of Zingiber officinalis 25 Roscoe, Curcurma Amada. 5. A composition for the prophylaxis and treatment of AIDS and AIDS related complex comprising each of the following of selected dried plant material in the proportions selected hereafter: Name of herb Classification Weight (mg) minimum WO 99/51249 PCT/AU98/00236 Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers. Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada (MENISPERMACEAE) (MENISPERMACEAE) (MENISPERMACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE) 6. A composition for the prophylaxis and treatment of AIDS and AIDS related complex comprising the following, as dried plant materials Name of herb Classification Weight (mg) Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers. Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada (MENISPERMACEAE) (MENISPERMACEAE) (MENISPERMACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE) 7. A composition as claimed in any one of claims 3 to 6 being substantially in the form of a capsule. 8. A composition as in claim 7 wherein said capsule is a gelatin capsule. 9. A composition as claimed in any one of claims 3 to 6 wherein said composition is in the form of a liquid mixed with a syrup. A composition as in any one of claims 3 to 9 wherein the total combined weight of the extracts of Stephania venosa Spreng, Stephania suberosa Forman, Stephania glabra Roxb. Miers., Hedychium coronarium Roem, Zingiber officinalis Roscoe and Curcurma Amada is no more than 300 mgs. 11. A method of prophylaxis and treatment of AIDS and AIDS related complex including administering a composition as claimed in any one of claims 3 to 10 twice a day before meals to a patient (human adult) who weighs 60 kg or less. SUBSTITUTE SHEET (RULE 26) WO 99/51249 PCT/AU98/00236 12. A method of prophylaxis and treatment of AIDS and AIDS related complex including administering a composition as claimed in any one of claims 3 to 10 three times a day before meals to a patient (human adult) who weighs 60-100 kg. 13. A process for preparing a composition for the prophylaxis and treatment of AIDS and AIDS related complex including: pulverising into powder the following amounts of dried plant material consisting essentially of: Name of herb Classification Weight(mg) range Stephania venosa Spreng Stephania suberosa Forman Stephania glabra Roxb. Miers. Hedychium coronarium Roem Zingiber officinalis Roscoe Curcurma Amada (MENISPERMACEAE) (MENISPERMACEAE) (MENISPERMACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE) (ZINGIBERACEAE)
40-60 40-60 40-60 40-60 30-50 30-50 preparing a pharmaceutical formulation comprising the powder of step SUBSTITUTE SHEET (RULE 26)
AU68125/98A 1998-04-07 1998-04-07 Herbal composition for the prophylaxis and treatment of AIDS Ceased AU760967B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/AU1998/000236 WO1999051249A1 (en) 1998-04-07 1998-04-07 Herbal composition for the prophylaxis and treatment of aids

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AU6812598A AU6812598A (en) 1999-10-25
AU760967B2 true AU760967B2 (en) 2003-05-22

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JP (1) JP2002510640A (en)
KR (1) KR20010034764A (en)
CN (1) CN1291103A (en)
AU (1) AU760967B2 (en)
WO (1) WO1999051249A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020155138A1 (en) * 2001-01-19 2002-10-24 Martin Katharine M. Composition containing Hedychium extract and use thereof
US20040052868A1 (en) 2002-09-12 2004-03-18 William Asiedu Composition treating for AIDS and associated conditions
US7160561B2 (en) 2003-05-19 2007-01-09 Amazon Biotech Inc. Herbal composition and method of treating HIV infection
EP2437766A1 (en) * 2009-03-31 2012-04-11 Erick Vidjin' Agnih Gbodossou Water-soluble antiviral product containing aframomum melegueta, for the treatment and prevention of acquired immunodeficiency syndrome (aids)
JP6198427B2 (en) * 2013-03-29 2017-09-20 小林製薬株式会社 Oral composition containing gelatin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3002700B2 (en) * 1990-08-29 2000-01-24 化研生薬株式会社 Anti-AIDS virus agent
US5683698A (en) * 1996-08-02 1997-11-04 New England Deaconess Hospital Formulation for alleviating symptoms associated with arthritis

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AU6812598A (en) 1999-10-25
CN1291103A (en) 2001-04-11
KR20010034764A (en) 2001-04-25
JP2002510640A (en) 2002-04-09
WO1999051249A1 (en) 1999-10-14

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