AU746656B2 - Complex formation between dsDNA and oligomer of heterocycles - Google Patents

Complex formation between dsDNA and oligomer of heterocycles Download PDF

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Publication number
AU746656B2
AU746656B2 AU41450/97A AU4145097A AU746656B2 AU 746656 B2 AU746656 B2 AU 746656B2 AU 41450/97 A AU41450/97 A AU 41450/97A AU 4145097 A AU4145097 A AU 4145097A AU 746656 B2 AU746656 B2 AU 746656B2
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AU
Australia
Prior art keywords
heterocycles
oligomers
oligomer
dsdna
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU41450/97A
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English (en)
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AU4145097A (en
Inventor
Peter Dervan
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California Institute of Technology
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California Institute of Technology
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Filing date
Publication date
Application filed by California Institute of Technology filed Critical California Institute of Technology
Publication of AU4145097A publication Critical patent/AU4145097A/en
Application granted granted Critical
Publication of AU746656B2 publication Critical patent/AU746656B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU41450/97A 1997-05-08 1997-07-21 Complex formation between dsDNA and oligomer of heterocycles Ceased AU746656B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/853522 1997-05-08
US08/853,522 US6635417B1 (en) 1996-07-31 1997-05-08 Complex formation between DSDNA and oligomer of cyclic heterocycles
PCT/US1997/012722 WO1998050582A1 (en) 1997-05-08 1997-07-21 COMPLEX FORMATION BETWEEN dsDNA AND OLIGOMER OF HETEROCYCLES

Publications (2)

Publication Number Publication Date
AU4145097A AU4145097A (en) 1998-11-27
AU746656B2 true AU746656B2 (en) 2002-05-02

Family

ID=25316259

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41450/97A Ceased AU746656B2 (en) 1997-05-08 1997-07-21 Complex formation between dsDNA and oligomer of heterocycles

Country Status (7)

Country Link
US (1) US6635417B1 (université)
EP (1) EP1007729A4 (université)
JP (1) JP2002514082A (université)
AU (1) AU746656B2 (université)
CA (1) CA2288806A1 (université)
IL (1) IL132740A0 (université)
WO (1) WO1998050582A1 (université)

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WO1998037067A1 (en) 1996-02-26 1998-08-27 California Institute Of Technology Design, synthesis and use of specific polyamide dna-binding ligands
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
CA2403537A1 (en) 2000-03-16 2001-10-11 Genesoft, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7078536B2 (en) 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0011938D0 (en) * 2000-05-17 2000-07-05 Angeletti P Ist Richerche Bio Improvements relating to gene delivery systems
WO2002100852A1 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
AU2002312371A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Aryl-benzimidazole compounds having antiinfective activity
EP1401817A4 (en) 2001-06-13 2005-11-02 Genesoft Pharmaceuticals Inc ISOQUINOLINE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY
AU2002312370A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Antipathogenic benzamide compounds
EP1572072A4 (en) * 2001-09-13 2009-04-01 Genesoft Inc PROCESS FOR TREATING INFECTIONS WITH PHARMACORESISTANT BACTERIA
CA2494139A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
CA2531869A1 (en) * 2003-04-30 2004-11-18 Pharmacia Corporation Compounds having a fused, bicyclic moiety for binding to the minor groove of dsdna
US20060174364A1 (en) * 2004-03-01 2006-08-03 Avigenics, Inc. Artificial chromosomes and transchromosomic avians
WO2005112924A2 (en) * 2004-04-27 2005-12-01 California Institute Of Technology Methods of treating cancer by inhibiting histone gene expression
WO2005120582A2 (en) * 2004-06-07 2005-12-22 California Institute Of Technology Compositions and methods for inhibiting expression of hypoxia-inducible genes
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US7935530B2 (en) * 2006-11-29 2011-05-03 California Institute Of Technology Polyamides with tail structures capable of binding DNA
US8835480B2 (en) * 2007-04-23 2014-09-16 California Institute Of Technology Inhibitors for steroid response elements and related methods
US9630950B2 (en) 2007-04-23 2017-04-25 California Institute Of Technology Inhibitors for steroid response elements and RNA polymerase II and related methods
US9650421B2 (en) 2011-09-02 2017-05-16 Northwestern University Self-assembled nanostructures
AU2017321322A1 (en) 2016-08-29 2019-02-28 California Institute Of Technology Compositions and methods for treatment of prostate cancer

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US4795700A (en) * 1985-01-25 1989-01-03 California Institute Of Technology Nucleic acid probes and methods of using same
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
CA1308516C (en) * 1987-07-06 1992-10-06 J. William Lown Oligopeptide anticancer and antiviral agents
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
CA2005039A1 (en) 1989-12-08 1991-06-08 Randell L. Mills Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
CA2103665C (en) 1991-02-06 2003-04-15 J. William Lown Oligopeptide antiretroviral agents
IT1247878B (it) 1991-02-15 1995-01-05 Menarini Farma Ind Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono
US5578444A (en) 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
US5726014A (en) 1991-06-27 1998-03-10 Genelabs Technologies, Inc. Screening assay for the detection of DNA-binding molecules
EP0593618B1 (en) 1991-06-27 1998-04-22 Genelabs Technologies, Inc. Screening assay for the detection of dna-binding molecules
GB2261661A (en) 1991-11-21 1993-05-26 Erba Carlo Spa Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles
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IT1271456B (it) 1993-03-01 1997-05-28 Menarini Farma Ind Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono
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Non-Patent Citations (1)

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WADE ET AL. J AAN CHEM SOC. 1992 112:8783-99 *

Also Published As

Publication number Publication date
EP1007729A4 (en) 2006-05-17
CA2288806A1 (en) 1998-11-12
IL132740A0 (en) 2001-03-19
US6635417B1 (en) 2003-10-21
EP1007729A1 (en) 2000-06-14
WO1998050582A1 (en) 1998-11-12
AU4145097A (en) 1998-11-27
JP2002514082A (ja) 2002-05-14

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