AU744003B2 - Use of neonicodinoids on transgenic plants - Google Patents

Use of neonicodinoids on transgenic plants Download PDF

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AU744003B2
AU744003B2 AU25176/99A AU2517699A AU744003B2 AU 744003 B2 AU744003 B2 AU 744003B2 AU 25176/99 A AU25176/99 A AU 25176/99A AU 2517699 A AU2517699 A AU 2517699A AU 744003 B2 AU744003 B2 AU 744003B2
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crop
bacterial
fungal pathogens
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Hubert Buholzer
Bruce Lee
Marius Sutter
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Syngenta Participations AG
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring

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  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Health & Medical Sciences (AREA)
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  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
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Description

WO 99/35913 PCTfEP99/00183 -1- USE OF NEONICODINOIDS ON TRANSGENIC PLANTS The present invention relates to a method of controlling pests with a nitroimino- or nitroguanidino-compound, especially thiamethoxam; more specifically to a novel method of controlling pests in and on transgenic crops of useful plants with a nitroimino- or nitroguanidino-compound.
Certain pest control methods are proposed in the iiterature. However, these methods are not fully satisfactory in the field of pest control, which is why there is a demand for providing further methods for controlling and combating pests, in particular insects and representatives of the order Acarina, or for protecting plants, especially crop plants. This object is achieved according to the invention by providing the present method.
The present invention therefore relates to a method of controlling pests in crops of transgenic useful plants, such as, for example, in crops of maize, cereals, soya beans, tomatoes, cotton, potatoes, rice and mustard, characterized in that a pesticidal composition comprising a nitroimino- or nitroguanidino-compound, especially thiamethoxam, imidacloprid, Ti-435 or thiacloprid in free form or in agrochemically useful salt form and at least one auxiliary is applied to the pests or their environment, in particular to the crop plant itself; to the use of the composition in question and to propagation material of transgenic plants which has been treated with it.
Surprisingly, it has now emerged that the use of a nitroimino- or nitroguanidino-compound compound for controlling pests on transgenic useful plants which contain for instance one or more genes expressing a pesticidally, particularly insecticidally, acaricidally, nematocidally or fugicidally active ingredient, or which are tolerant against herbicides or resistent against the attack of fungi, has a synergistic effect. It is highly surprising that the use of a nitroimino- or nitroguanidino-compound in combination with a transgenic plant exceeds the additive effect, to be expected in principle, on the pests to be controlled and thus extends the range of action of the nitroimino- or nitroguanidino-compound and of the active principle expressed by the transgenic plant in particular in two respects: In particular, it has been found, surprisingly, that within the scope of invention the pesticidal activity of a nitroimino- or nitroguanidino-compound in combination with the effect expressed by the transgenic useful plant, is not only additive in comparison with the pesticidal activities of the nitroimino- or nitroguanidino-compound alone and of the WO 99/35913 PCT[EP99/00183 -2transgenic crop plant alone, as can generally be expected, but that a synergistic effect is present. The term "synergistic", however, is in no way to be understood in this connection as being restricted to the pesticidal activity, but the term also refers to other advantageous S properties of the method according to the invention compared with the nitroimino- or nitroguanidino-compound and the transgenic useful plant alone. Examples of such advantageous properties which may be mentioned are: extension of the pesticidal spectrum of action to other pests, for example to resistant strains; reduction in the application rate of the nitroimino- or nitroguanidino-compound, or sufficient control of the pests with the aid of the compositions according to the invention even at an application rate of the nitroimino- or nitroguanidino-compound alone and the transgenic useful plant alone are entirely ineffective; enhanced crop safety; improved quality of produce such as higher content of nutrient or oil, better fiber quality, enhanced shelf life, reduced content of toxic products such as mycotoxins, reduced content of residues or unfavorable constituents of any kind or better digestability; improved tolerance to unfavorable temperatures, draughts or salt content of water; enhanced assimilation rates such as nutrient uptake, water uptake and photosynthesis; favorable crop properties such as altered leaf aerea, reduced vegetative growth, increased yields, favorable seed shape/seed thickness or germination properties, altered colonialisation by saprophytes or epiphytes, reduction of senescense, improved phytoalexin production, improved of accelerated ripening, flower set increase, reduced boll fall and shattering, better attraction to beneficials and predators, increased pollination, reduced attraction to birds; or other advantages known to those skilled in the art.
Nitroimino- and nitroguanidino-cpmpounds, such as thiamethoxam (5-(2-Chlorthiazol-5ylmethyl)-3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazin), are known from EP-A-0'580'553.
Within the scope of invention thiamethoxam is preferred.
Also preferred within the scope of invention is imidacloprid of the formula
CI
N*Ny N'H known from The Pesticide Manual, 10tEd. (1991), The N 0
NO
2 British Crop Protection Council, London, page 591; WO 99/35913 PCT/EP99/00183 -3- Cl also preferred is Thiacloprid of the formula N N S known from
II
N'CN
EP-A-235'725;
CI
S
SH CH also preferred is the compound of the formula N I known as N NH N
NO
2 Ti-435 (Clothiamidin) from EP-A-376'279 The agrochemically compatible salts of the nitroimino- or nitroguanidino-compounds are, for example, acid addition salts of inorganic and organic acids, in particular of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, perchloric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, malonic acid, toluenesulfonic acid or benzoic acid. Preferred within the scope of the present invention is a composition known per se which comprises, as active ingredient, thiamethoxam and imidacloprid, each in the free form, especially thiamethoxam.
The transgenic plants used according to the invention are plants, or propagation material thereof, which are transformed by means of recombinant DNA technology in such a way that they are for instance capable of synthesizing selectively acting toxins as are known, for example, from toxin-producinginvertebrates, especially of the phylum Arthropoda, as can be obtained from Bacillus thuringiensis strains; or as are known from plants, such as lectins; or in the alternative capable of expressing a herbicidal or fungicidal resistance. Examples of such toxins, or transgenic plants which are capable of synthesizing such toxins, have been disclosed, for example, in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529 and EP-A-451 878 and are incorporated by reference in the present application.
The methods for generating such transgenic plants are widely known to those skilled in the art and described, for example, in the publications mentioned above.
WO 99/35913 PCT/EP99/00183 -4- The toxins which can be expressed by such transgenic plants include, for example, toxins, such as proteins which have insecticidal properties and which are expressed by transgenic plants, for example Bacillus cereus proteins or Bacillus popliae proteins; or Bacillus S thuringiensis endotoxins such as CrylA(a), CrylA(b), CrylA(c), CryllA, CrylllA, CrylllB2 orCytA; VIP1; VIP2; VIP3; or insecticidal proteins of bacteria colonising nematodes like Photorhabdusspp or Xenorhabdus spp such as Photorhabdus luminescens, Xenorhabdus nematophilus etc.; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin, papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize RIP, abrin, luffin, saporin or bryodin; plant lectins such as pea lectins, barley lectins or snowdrop lectins; or agglutinins; toxins produced by animals, such as scorpion toxins, spider venoms, wasp venoms and other insect-specific neurotoxins; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid UDP-glycosyl transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COAreductase, ion channel blockers such as sodium and calcium, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases.
Examples of known transgenic plants which comprise one or more genes which encode insecticidal resistance and express one or more toxins are the following: KnockOut® (maize), YieldGard® (maize); NuCOTN 33B® (cotton), Bollgard® (cotton), NewLeaf® (potatoes), NatureGard® and Protecta®.
The following tables comprise further examples of targets and principles and crop phenotypes of transgenic crops which show tolerance against pests mainly insects, mites, nematodes, virus, bacteria and diseases or are tolerant to specific herbicides or classes of herbicides.
Table Al: Crop: Maize Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones WO 99/35913 WO 9935913PCT/EP99/O1 83 Effected target or expressed principle(s) Crop phenotype Tolerance to Hydroxyphenylpyruvate, dioxygenase
(HPPD)
Phosphinothnicin acetyl transferdse 0-Methyl transf erase GGlutarnine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enoipyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl Dimboa biosynthesis (Bxl gene) CMIII (small basic maize seed peptide Corn- SAFP (zeamatin) Isoxazoles such as Isoxaflutol or Isoxachiortol, Triones such as mesotnione or sulcotnione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or suit osate Glyphosate or suft osate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulf onylureas Helminthosporium turcicum, Rhopalosiphumn maydis, Diplodia maydis, Ostrinia nubilalis, lepidoptera sp.
plant pathogenes eg. fusanium, altemnaria, sclerotina plant pathogenes eg. fusarium, altemaria, sclerotina, rhizoctonia, chaetomium,phycomyces Cochliobulus plant pathogenes plant pathogenes viruses such as maize dwarf mosaic Hml gene Chitinases Glucanases Coat proteins WO 99/35913 WO 9935913PCT/EP99/OO1 83 -6- Effected target or expressed principle(s) Crop phenotype Tolerance to Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor (LAPI) Limonene synthase Lectines virus, maize chlorotic dwarf virus lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodoptera frugiperda, corn rootworms, sesarnia sp., black cutworm, asian corn borer,weevils lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodoptera frugiperda, corn rootworms, sesarnia sp., black cutworm, asian corn borer, weevils corn rootworrns lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodoptera frugiperda, corn rootworms, sesarnia sp., black cutworm, asian corn borer, weevils WO 99/35913 WO 9935913PCTIEP99/001 83 -7- Effected target or expressed principle(s) Crop phenotype Tolerance to i Protease Inhibitors eg. cystatin, patatin, virgiferin, OPTI ribosomne inactivating protein maize 5C9 polypeptide HMVG-CoA reductase weevils, corn rootworrn lepidoptera, coleoptera, diptera, nematodes, eg. ostninia nubilalis, heliothis zea, armyworrns eg.
spodloptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodloptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils lepidloptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils Table A2: Crop Wheat Effected target or expressed principle(s) ICrop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione WO 99/35913 PCT/EP99/00183 -8- Effected target or expressed principle(s) Crop phenotype Tolerance to i Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Ar.4hranilate Synthae- Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU Antifungal polypeptide AlyAFP glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glucanases double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas plant pathogenes eg septoria and fusarioum plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria and other diseases plant pathogenes eg. fusarium, septoria and other diseases viral, bacterial, fungal, nematodal pathogens plant pathogenes plant pathogenes viruses such as BYDV and MSMV viruses such as BYDV and MSMV lepidoptera, coleoptera, diptera, WO 99/35913 PCT/EP99/00183 -9- Effected target or expressed principle(s) I Crop phenotype Tolerance to Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg. cystatin, patatin, virgiferin, CPTI ribosorne inactivating protein HMG-CoA reductase nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.
spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils Table A3: Crop Barley Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione WO 99/35913 PCT/EP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to Phosphinothricin acetyl transferase 0-Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Arithrani:ate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl Antifungal polypeptide AIyAFP glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glucanases double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas plant pathogenes eg septoria and fusarioum plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria and other diseases plant pathogenes eg. fusarium, septoria and other diseases viral, bacterial, fungal, nematodal pathogens plant pathogenes plant pathogenes viruses such as BYDV and MSMV viruses such as BYDV and MSMV lepidoptera, coleoptera, diptera, WO 99/35913 WO 9935913PCT/EP99/O1 83 11 Effected target or expressed principle(s) Crop phenotype Tolerance to.
Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidlase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg. cystatin, patatin, virgiferin, CPTI ribosome inactivating protein HMG-CoA reductase nematodes, lepidloptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nemnatodes, lepidloptera, coleoptera, diptera, nematodes, lepidloptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids Table A4: Crop Rice Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transf erase O -Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotnione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis WO 99/35913 PCT/EP99/00183 -12- Effected target or expressed principle(s) SCrop phenotype Tolerance to Adenylosuccinate Synthase Anthranilate Synthase Nitrilase Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 Antifungal polypeptide AlyAFP glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Phenylalanine ammonia lyase (PAL) phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas plant pathogenes plant pathogenes plant pathogenes plant pathogenes plant pathogenes eg bacterial leaf blight and rice blast, inducible plant pathogenes eg bacterial leaf blight and rice blast plant pathogenes eg bacterial leaf blight and rice blast plant pathogenes eg bacterial leaf blight and rice blast plant pathogenes viral, bacterial, fungal, nematodal pathogens plant pathogenes eg bacterial leaf blight and rice blast plant pathogenes Glucanases WO 99/35913 PCT/EP99/00183 -13- Effected target or expressed principle(s) Crop phenotype /Tolerance to double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydrcxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors, ribosome inactivating protein HMG-CoA reductase viruses such as BYDV and MSMV viruses such as BYDV and MSMV lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper Table A5: Crop Soya Effected target or expressed principle(s) Crop phenotype Tolerance to WO 99/35913 WO 9935913PCT/EP99/OO1 83 -14- Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxcyps'-enylpyruvate dioxyge.ase
(HPPD)
Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase olpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Antifungal polypeptide AIyAFP oxalate oxidase glucose oxidase Sulfonylureas, imidazolinones, Triazolopynimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotnione Phosphinothricin altered lignin levels G lufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sult osate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as pyrrolnitrin synthesis genes WO 99/35913 PCTIEP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to i serine/threonine kinases Phenylalanine ammonia lyase (PAL) phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glucanases double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot plant pathogenes eg bacterial leaf blight and rice blast plant pathogenes eg bacterial leaf blight and rice blast bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot plant pathogenes viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot viruses such as BPMV and SbMV viruses such as BYDV and MSMV lepidoptera, coleoptera, aphids lepidoptera, lepidoptera, lepidoptera, coleoptera, aphids coleoptera, aphids coleoptera, aphids lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids Protease Inhibitors eg virgiferin WO 99/35913 WO 9935913PCTEP99/O1 83 -16- Effected target or expressed principle(s) Crop phenotype Tolerance to i ribosome inactivating protein HMG-CoA reductase Barnase Cyst nematode hatching stimulus Antiieeding principles lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids nematodes eg root knot nematodes and cyst nematodes cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A6: Crop Potatoes Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphe nylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sult osate WO 99/35913 WO 9935913PCT/EP99/O1 83 17.
Effected target or expressed principle(s) Crop phenotype Tolerance to- Giypnosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SWl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrotnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) phytoalexins B-i ,3-glucanase antisense receptor kinase Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pynidin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sultonylureas blackspot bruise bacterial and fungal pathogens such as phytophtora Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as phytophtora bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacteria such as corynebacterium sepedonicum, Erwinia carotovora bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia WO 99/35913 PCT/EP99/00183 -18- Effected target or expressed principle(s) Crop phenotype Tolerance to i Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Barase Disease resistance response gene 49 trans aldolase antisense Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor stilbene synthase bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens such as Phytophtora, Vericiilium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia blackspots bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids WO 99/35913 PCTIEP99/00183 -19- Effected target or expressed principle(s) I Crop phenotype Tolerance to Lectines Protease Inhibitors eg cystatin, patatin ribosome inactivating protein HMG-CoA reductase Cyst nematode hatching stimulus Barnase Antifeeding principles coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A7: Crop Tomatoes Effected target or expressed principle(s) Crop phenotype Tolerance to
I
Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and WO 99/35913 PCTIEP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to i Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate ox;idoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or suliosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas blackspot bruise bacterial and fungal pathogens such as phytophtora Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould WO 99/35913 PCT/EP99/00183 -21- Effected target or expressed principle(s) Crop phenotype Tolerance to serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene 12 Fusarium resistance locus phytoalexins etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
leaf mould altemaria solani bacteria bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
fusarium bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould WO 99/35913 PCT/EP99/00183 -22- Effected target or expressed principle(s) Crop phenotype Tolerance to B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bactenal and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV WO 99/35913 PCT/EP99/00183 -23.
Effected target or expressed principle(s) Crop phenotype Tolerance to
I
Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase Antifeeding principles
TRV
viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A8: Crop Peppers Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) SSulfonylureas, Imidazolinones, WO 99/35913 WO 9935913PCTEP99/0O1 83 -24- Effected target or expressed principle(s) Crop phenotype Tolerance to i AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate
(HPPD)
dioxygenase Phosphinothricin acetyl transf erase 0-Methyl transf erase Glutamnine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes Triazolopyrimidines, Pynimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachiortol, Triones such as mesotnione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromnoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pynidin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics; and herbicides such as Sulfonylureas, bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens WO 99/35913 PCT/EP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Ct5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene 12 Fusarium resistance locus phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Bamase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins bacterial and fungal pathogens bacterial and fungal pathogens rot, leaf mould etc.
bacterial and fungal pathogens bacterial and fungai pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens fusarium bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV lepidoptera, whiteflies aphids WO 99/35913 PCT/EP99/00183 -26- Effected target or expressed principle(s) Crop phenotype Tolerance to 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease inhibitors eg cystatin, patatin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase Antifeeding principles lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A9: Crop Grapes Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and WO 99/35913 PCTIEP99/00183 -27- Effected target or expressed principle(s) Crop phenotype Tolerance to Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or suffosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Cf genes eg. Cf 9 Cf5 Cf4 Cf2 WO 99/35913 PCT/EP99/00183 -28- Effected target or expressed principle(s) Crop phenotype Tolerance to I Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew viruses viruses viruses viruses WO 99/35913 PCT/EP99/00183 -29- Effected target or expressed principle(s) Crop phenotype Tolerance to
I
Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase
CBI
Antifeeding principles viruses viruses lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids, diseases lepidoptera, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes or general diseases root knot nematodes nematodes eg root knot nematodes or root cyst nematodes Table A10: crop Oil Seed rape Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as WO 99/35913 WO 9935913PCT/EP99/OO1 83 Effected target or expressed principle(s) ICrop phenotype Tolerance to Phosphinothricin acetyl transf erase 0-Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SWl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnithn synthesis genes mesotnione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromnoxynil and loxinyl Glyphosate or sult osate Glyphosate or sult osate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosponium, Phomna, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosponium, Phomna, Sclerotinia WO 99/35913 PCT/EP99/00183 -31- Effected target or expressed principle(s) Crop phenotype Tolerance to serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4-Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Barnase bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Scierotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, WO 99/35913 PCT/EP99/00183 -32- Effected target or expressed principle(s) Crop phenotype Tolerance to Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin,
CPTI
ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Bamase
CBI
Antifeeding principles induced at a nematode feeding site Sclerotinia, nematodes bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia viruses viruses viruses viruses viruses viruses lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids, diseases lepidoptera, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table Al 1: Crop Brassica vegetable (cabbage, brussel sprouts, broccoli etc.) WO 99/35913 WO 9935913PCT/EP99/OO1 83 -33.
Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transf erase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidlase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase Sulfonylureas, tmidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones lsoxazo'es such as Isoxaflutol or Isoxachiortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glut osinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromnoxynil and loxinyl Glyphosate or sult osate Glyphosate or suft osate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens WO 99/35913 PCT/EP99/00183 -34- Effected target or expressed principle(s) Crop phenotype /Tolerance to pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens viruses viruses viruses viruses viruses viruses lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids WO 99/35913 PCT/EP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to i Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin,
CPTI
ribosomne inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase
CBI
Antifeeding principles induced at a nematode feeding site lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids, diseases lepidoptera, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A12: Crop Pome fruits eg apples, pears Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate
(HPPD)
dioxygenase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis inhibitors of tryptophan synthesis and Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase WO 99/35913 PCT/EP99/00183 -36- Effected target or expressed principle(s) Crop phenotype /Tolerance to
I
Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sultosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like Cf genes eg. Cf 9 Cf5 Cf4 Cf2 WO 99/35913 PCT/EP99/00183 -37- Effected target or expressed principle(s) Crop phenotype Tolerance to Osmotin Alpha Hordothionin Systemir Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barase Glucanases apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and tungal pathogens liKe apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight WO 99/35913 PCT/EP99/00183 -38- Effected target or expressed principle(s) Crop phenotype Tolerance to double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin,
CPTI
ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Bamase
CBI
Antifeeding principles induced at a nematode feeding site viruses viruses viruses viruses viruses viruses lepidoptera, aphids, mites lepidoptera, lepidoptera, lepidoptera, lepidoptera, lepidoptera, aphids, mites aphids, mites aphids, mites aphids, mites aphids, mites lepidoptera, aphids, mites lepidoptera, aphids, diseases, mites lepidoptera, aphids, mites cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A13: Crop Melons Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) Sulfonylureas, Imidazolinones, Triazolopyrimidines, WO 99/35913 WO 9935913PCT/EP99/OOI 83 39.
Effected target or expressed principle(s) Crop phenotype Tolerance to AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transf erase 0-Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromnoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora WO 99/35913 PCT/EP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora WO 99/35913 PCT/EP99/00183 -41 Effected target or expressed principle(s) Crop phenotype Tolerance to 4.
Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora viruses as CMV,, PRSV, WMV2, SMV,
ZYMV
viruses as CMV,, PRSV, WMV2, SMV,
ZYMV
viruses as CMV,, PRSV, WMV2, SMV,
ZYMV
viruses as CMV,, PRSV, WMV2, SMV,
ZYMV
viruses as CMV,, PRSV, WMV2, SMV,
ZYMV
viruses as CMV,, PRSV, WMV2, SMV,
ZYMV
lepidoptera, aphids, mites lepidoptera, aphids, mites, whitefly lepidoptera, aphids, mites, whitefly lepidoptera, aphids, mites, whitefly WO 99/35913 PCT/EP99/00183 -42- Effected target or expressed principle(s) ICrop phenotype Tolerance to Lectines Protease Inhibitors eg cystatin, patatin, S CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Bamase
CBI
Antifeeding principles induced at a nematode feeding site lepidoptera, aphids, lepidoptera, aphids, mites, whitefly mites, whitefly lepidoptera, aphids, mites, whitefly lepidoptera, aphids, mites, whitefly lepidoptera, aphids, mites, wnitefly cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A14: Crop Banana Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase S Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such Nitrilase WO 99/35913 PCT/EP99/00183 -43- Effected target or expressed principle(s) Crop phenotype Tolerance to i 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin denvatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal WO 99/35913 PCT/EP99/00183 -44- Effected target or expressed principle(s) Crop phenotype Tolerance to genes Lytic protein S Lysozym Chitinases Bamase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as Banana bunchy top virus
(BBTV)
viruses as Banana bunchy top virus
(BBTV)
viruses as Banana bunchy top virus
(BBTV)
viruses as Banana bunchy top virus
(BBTV)
viruses as Banana bunchy top virus
(BBTV)
viruses as Banana bunchy top virus
(BBTV)
lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes cyst nematodes WO 99/35913 PCTEP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to
I
Bamase
CBI
Antifeeding principles induced at a nematode feeding site nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A 15: Crop Cotton Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transferase 0-Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachiortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
WO 99/35913 PCT/EP99/00183 -46- Effected target or expressed principle(s) Crop phenotype Tolerance to I Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Bamase Glucanases double stranded ribonuclease Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as wound tumor virus (WTV) WO 99/35913 PCT/EP99/00183 -47- Effected target or expressed principle(s) Crop phenotype Tolerance to Coat proteins 17kDa or 60 kDa protein S Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase
CBI
Antifeeding principles induced at a nematode feeding site viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes WO 99/35913 WO 9935913PCT/EP99/OOI 83 -48- Table A 16: Crop Sugarcane Effected target or expressed principle(s) Acetolactate synthase (ALS) Acelty!CcA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transf erase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidloreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SWl or selection Polyphenol oxidlase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP Crop phenotype Tolerance to Sulfonylureas, Imidazolinones, Tiazolopyrimidlines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3 ,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sult osate Diphenylethers, cyclic imides, phenylpyrazoles, pynidin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens WO 99/35913 PCT/EP99/00183 -49- Effected target or expressed principle(s) oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylatanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Bamase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Crop phenotype Tolerance to bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens eg clavibacter bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV WO 99/35913 PCT/EP99/00183 Effected target or expressed principle(s) Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Bamase
CBI
Antifeeding principles induced at a nematode feeding site Crop phenotype Tolerance to lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites. nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A 17: Crop Sunflower Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) Sulfonylureas, Imidazolinones, WO 99/35913 WO 9935913PCT/EP99/OO1 83 -51 Effected target or expressed principle(s) ICrop phenotype Tolerance to AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transf erase 0-Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidase or Polyphenol oxidlase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase Triazolopyrimidlines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or tsoxacniortol, Triones suich as mesotnione or sulcotnione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromnoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulf onylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens eg sclerotinia bacterial or fungal pathogens glucose oxidlase WO 99/35913 PCT/EP99/00183 -52- Effected target or expressed principle(s) Crop phenotype Tolerance to i pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or tunga! pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV lepidoptera, aphids, mites, nematodes, whitefly, beetles WO 99/35913 PCT/EP99/00183 -53- Effected target or expressed principle(s) Crop phenotype Tolerance to 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase
CBI
Antifeeding principles induced at a nematode feeding site lepidoptera, aphids, whitefly, beetles lepidoptera, aphids, whitefly, beetles lepidoptera, aphids, whitefly, beetles lepidoptera, aphids, whitefly, beetles lepidoptera, aphids, whitefly, beetles lepidoptera, aphids, whitefly, beetles lepidoptera, aphids, whitefly, beetles lepidoptera, aphids, whitefly, beetles cyst nematodes mites, nematodes, mites, nematodes, mites, nematodes, mites, nematodes, mites, nematodes, mites, nematodes, mites, nematodes, mites, nematodes, nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A 18: Crop Sugarbeet, Beet root Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, AcetylCoA Carboxylase (ACCase) WO 99/35913 PCT/EP99/00183 -54- Effected target or expressed principle(s) Crop phenotype Tolerance to Hydroxyphenylpyruvate dioxygenase
(HPPD)
Phosphinothricin acetyl transferase 0-Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AIyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hyd roxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens eg sclerotinia bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens WO 99/35913 PCT/EP99/00183 Effected target or expressed principle(s) Crop phenotype Tolerance to Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense AX WIN proteins receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or funga! pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens like Cercospora beticola bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as BNYVV viruses as BNYVV viruses as BNYVV viruses as BNYVV viruses as BNYVV viruses as BNYVV lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, WO 99/35913 PCT/EP99/00183 -56- Effected target or expressed principle(s) Crop phenotype Tolerance to Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase Beet cyst nematode resistance locus
CBI
Antifeeding principles induced at a nematode feeding site whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies cyst nematodes nematodes eg root knot nematodes and cyst nematodes cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes The abovementioned animal pests which can be controlled by the method according to the invention include: for example, insects, representatives of the order acarina and representatives of the class nematoda; especially from the order Lepidoptera Acleris spp., Adoxophyes spp., especially Adoxophyes reticulana; Aegeria spp., Agrotis spp., especially Agrotis spinifera; Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyrotaenia spp., Autographa spp., Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Crocidolomia binotalis, Cryptophlebia leucotreta, Cydia spp., especially Cydia pomonella; WO 99/35913 PCT/EP99/00183 57 Diatraea spp., Diparopsis castanea, Eanias spp., Ephestia Spp., especially E. Khuniella; Eucosma spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Grapholita spp., Hedya nubiferana, Heliothis spp., especially H. Virescens und H. zea; Hellula undalis, Hyphantria cunea, Keiferia lycopersicella, Leucoptera scitella, Lithocollethis spp., Lobesiaspp., Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca sexta, Operophtera spp., Ostrinia nubilalis, Pammene spp., Pandemis spp., Panolis flammea, Pectinophora spp.. Phthorimaea operculella, Pieris rapac, Pienis spp., Plutefla xylostella, Prays spp., Scirpophaga spp., Sesamia spp., Sparganothis spp., Spodopteralittoralis, Synanthedon spp., Thaumetopoea spp., Tortrix spp., Trichoplusia ni and Yponomeuta spp.; from the order Coleoptera, for example Agriotes spp., Anthonomus spp., Atomaria linearis, Chaetocnema tibialis, Cosmopolites spp., Curculio, spp., Dermestes spp., Diabrotica spp., Epilachna spp., Eremnus spp., Leptinotarsa decemlineata, Lissorhoptrus spp., Melolontha spp., Oryzaephilus app., Otiorhynchus spp., Phlyctinus spp., Popillia app., Psylliodes spp., Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga spp., Tenebrio app., Tribolium spp. and Trogoderma spp.; from the order Orthoptera, for example Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Periplaneta spp. and Schistocerca spp.; from the order Isoptera, for example Reticulitermes spp.; from the order Psocoptera, for example Liposcelis spp.; from the order Anoplura, for example Haemnatopinus spp., Linognathus app., Pediculus spp., Pemphigus spp. and Phylloxera spp.; from the order Mallophaga, for example Damalinea spp. and Trichodectes spp.; from the order Thysanoptera, for example Frankliniella app., Hercinothrips spp., Taeniothrips app., Thrips palmi, Thrips tabaci and Scirtothrips aurantii; from theobrder Heteroptera, for example Cimex app., Distantiella theobroma, Dysdercus spp., Euchistus app. Eurygaster spp. Leptocorisa app., Nezara spp., Piesma app., Rhodnius spp., Sahibergella singutaris, Scotinophara app. *and Triatoma app.; from the order Homoptera, for example Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella aurantii, Aphididae, Aphis craccivora, A. fabae, A. gosypii; Aspidiotus spp., Bemisia tabaci, Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccus hesperidumn, Empoasca app., Eriosoma lanigerum, Erythroneura spp., Gascardia WO 99/35913 PCT/EP99/00183 58 spp., Laodelphax spp., Lecanium comi, Lepidosaphes spp., Macrosiphus spp., Myzus spp., especially M.persicae; Nephotettix spp., especially N. cincticeps; Nilaparvata spp., especially N. lugens; Paratoria spp., Pemphigus spp., Planococcus spp., Pseudaulacaspis spp., Pseudococcus spp., especially P. Fragilis, P. citriculus and P. comstocki; Psylla spp., especially P. pyri; Pulvinania aethiopica, Quadraspidiotus spp., Rhopalosiphumn spp., Saissetia spp., Scaphoideus spp., Schizaphis spp., Sitobion spp., Trialeurodes vaporariorum, Trioza ervtreae and Unaspis citrn; from the order Hymenoptera, for example Acromyrmnex, Atta spp., Cephus spp., Dipnion spp., Diprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomonumr pharaonis, Neodiprion spp., Solenopsis spp. and Vespa spp.; from the order Diptera, for example Aedes spp., Antherigona soccata, Bibio, hortulanus, Calliphora erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cuterebra. spp., Dacus spp., Drosophila melanogaster, Fannia spp., Gastrophilus spp., Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseolia spp., Oscinella. frt, Pegomyia hyoscyami, Phorbia spp., Rhagoletis pomnonella, Sciara spp., Stomoxys spp., Tabanus spp., Tannia spp. and Tipula spp.; from the order Siphonaptera, for example Ceratophyllus spp. and Xenopsylla cheopis; from the order Thysanura, for example Lepisma saccharina and from the order Acarina, for example Acarus siro, Aceria sheldoni; Aculus spp., especially A.
schlechtendali; Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., especially B. californicus and B. phoenicis; Bryobia praetiosa, Calipitrimerus spp., Chorioptes spp., Derrnanyssus gallinae, Eotetranychus spp., especially E.carpini and E. orientalis; Eriophyes spp., especially E. vitis; Hyalomma spp., Nxodes spp., Olygonychus pratensis, Omnithodoros spp., Panonychus spp., especially P. ulmi and P. citri; Phyllocoptruta spp., especially P.
oleivora; Polyp hagotarsonemnus spp., especially P. latus; Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus spp. and Tetranychus spp., in particular T. urticae, T. cinnabarinus and T. Kanzawai; representatives of the class Nematoda; nematodes selected from the group consisting of root knot nematodes, cyst-forming nematodes, stem eelworms and foliar nematodes; WO 99/35913 PCT/EP99/00183 -59nematodes selected from the group consisting of Anguina spp.; Aphelenchoides spp.; Ditylenchus spp.; Globodera spp., for example Globodera rostochiensis; Heterodera spp., for example Heterodera avenae, Heterodera glycines, Heterodera schachtii or Heterodera S trifolii; Longidorus spp.; Meloidogyne spp., for example Meloidogyne incognita or Meloidogyne javanica; Pratylenchus, for example Pratylenchus neglectans or Pratylenchus penetrans; Radopholus spp., for example Radopholus similis; Trichodorus spp.; Tylenchulus, for example Tylenchulus semipenetrans; and Xiphinema spp.; or nematodes selected from the group consisting of Heterodera spp., for example Heterodera glycines; and Meloidogyne spp., for example Meloidogyne incognita.
The method according to the invention allows pests of the abovementioned type to be controlled, i.e. contained or destroyed, which occur, in particular, on transgenic plants, mainly useful plants and ornamentals in agriculture, in horticulture and in forests, or on parts, such as fruits, flowers, foliage, stalks, tubers or roots, of such plants, the protection against these pests in some cases even extending to plant parts which form at a later point in time.
The method according to the invention can be employed advantageously for controlling pests in rice, cereals such as maize or sorghum; in fruit, for example stone fruit, pome fruit and soft fruit such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries and blackberries; in legumes such as beans, lentils, peas or soya beans; in oil crops such as oilseed rape, mustard, poppies, olives, sunflowers, coconuts, castor-oil plants, cacao or peanuts; in the marrow family such as pumpkins, cucumbers or melons; in fibre plants such as cotton, flax, hemp or jute; in citrus fruit such as oranges, lemons, grapefruit or tangerines; in vegetables such as spinach, lettuce, asparagus, cabbage species, carrots, onions, tomatoes, potatoes, beet or capsicum; in the laurel family such as avocado, Cinnamonium or camphor; or in tobacco, nuts, coffee, egg plants, sugar cane, tea, pepper, grapevines, hops, the banana family, latex plants or ornamentals, mainly in maize, rice, cereals, soya beans, tomatoes, cotton, potatoes, sugar beet, rice and mustard; in particular in cotton, rice, soya beans, potatoes and maize.
It has emerged that the method according to the invention is valuable preventatively and/or curatively in the field of pest control even at low use concentrations of the pesticidal composition and that a very favourable biocidal spectrum is achieved thereby. Combined with a favourable compatibility of the composition employed with warm-blooded species, WO 99/35913 PCT/EP99/00183 fish and plants, the method according to the invention can be employed against all or individual developmental stages of normally-sensitive, but also of normally-resistant, animal pests such as insects and representatives of the order Acarina, depending on the species of the transgenic crop plant to be protected from attack by pests. The insecticidal and/or acaricidal effect of the method according to the invention may become apparent directly, i.e.
in a destruction of the pests which occurs immediately or only after some time has elapsed, for example, during ecdysis. or indirectly, for example as a reduced oviposition and/or hatching rate, the good action corresponding to a destruction rate (mortality) of at least to Depending on the intended aims and the prevailing circumstances, the pesticides within the scope of invention which are known per se, are emulsifiable concentrates, suspension concentrates, directly sprayable or dilutable solutions, spreadable pastes, dilute emulsions, wettable powders, soluble powders, dispersible powders, wettable powders, dusts, granules or encapsulations in polymeric substances which comprise a nitroimino- or nitroguanidinocompound.
The active ingredients are employed in these compositions together with at least one of the auxiliaries conventionally used in art of formulation, such as extenders, for example solvents or solid carriers, or such as surface-active compounds (surfactants).
Formulation auxiliaries which are used are, for example, solid carriers, solvents, stabilizers, "slow release" auxiliaries, colourants and, if appropriate, surface-active substances (surfactants). Suitable carriers and auxiliaries are all those substances which are conventionally used for crop protection products. Suitable auxiliaries such as solvents, solid carriers, surface-active compounds, non-ionic surfactants, cationic surfactants, anionic surfactants and other auxiliaries in the compositions employed according to the invention are, for example, those which have been described in EP-A-736 252.
These compositions for controlling pests can be formulated, for example, as wettable powders, dusts, granules, solutions, emulsifiable concentrates, emulsions, suspension concentrates or aerosols. For example, the compositions are of the type described in EP- A-736 252.
The action of the compositions within the scope of invention which comprise a nitroimino- or nitroguanidino-compound can be extended substantially and adapted to prevailing circumstances by adding other insecticidally, acaricidally and/or fungicidally active WO 99/35913 PCTIEP99/00183 -61ingredients. Suitable examples of added active ingredients are representatives of the following classes of active ingredients: organophosphorous compounds, nitrophenols and derivatives, formamidines, ureas, carbamates, pyrethroids, chlorinated hydrocarbons; especially preferred components in mixtures are, for example, abamectin, emamectin, spinosad, pymetrozine, fenoxycarb, Ti-435, fipronil, pyriproxyfen, diazinon or diafenthiuron.
As a rule, the compositions within the scope of invention comprise 0.1 to 99%, in particular 0.1 to 95 of a nitroimino- or nitroguanidino-compound and 1 to 99.9 in particular 5 to 99.9 of at least one solid or liquid auxiliary, it being possible, as a rule, for 0 to 25 in particular 0.1 to 20 of the compositions to be surfactants in each case meaning per cent by weight). While concentrated compositions are more preferred as commercial products, the end user will, as a rule, use dilute compositions which have considerably lower concentrations of active ingredient.
The compositions according to the invention may also comprise other solid or liquid auxiliaries, such as stabilisers, for example epoxidized or unepoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya bean oil), antifoams, for example silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, and also fertilizers or other active ingredients for achieving specific effects, for example, bactericides, fungicides, nematicides, molluscicides or herbicides.
The compositions according to the invention are produced in a known manner, for example prior to mixing with the auxiliary/auxiliaries by grinding, screening and/or compressing the active ingredient, for example to give a particular particle size, and by intimately mixing and/or grinding the active ingredient with the auxiliary/auxiliaries.
The method according to the invention for controlling pests of the abovementioned type is carried out in a manner known per se to those skilled in the art, depending on the intended aims and prevailing circumstances, that is to say by spraying, wetting, atomizing, dusting, brushing on, seed dressing, scattering or pouring of the composition. Typical use concentrations are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm of active ingredient. The application rate may vary within wide ranges and depends on the soil constitution, the type of application (foliar application; seed dressing; application in the seed furrow), the transgenic crop plant, the pest to be controlled, the climatic circumstances prevailing in each case, and other factors determined by the type of application, timing of application and target crop. The application rates per hectare are generally 1 to 2000 g of WO 99/35913 PCT/EP99/00183 -62nitroimino- or nitroguanidino-compound per hectare, in particular 10 to 1000 g/ha, preferably to 500 g/ha, especially preferably 10 to 200 g/ha.
A preferred type of application in the field of crop protection within the scope of invention is S application to the foliage of the plants (foliar application), it being possible to adapt frequency and rate of application to the risk of infestation with the pest in question.
However, the active ingredient may also enter into the plants via the root system (systemic action), by drenching the site of the plants with a liquid composition or by incorporating the active ingredient in solid form into the site of the plants, for example into the soil, for example in the form of granules (soil application). In the case of paddy rice crops, such granules may be metered into the flooded paddy field.
The compositions according to invention are also suitable for protecting propagation material of transgenic plants, for example seed, such as fruits, tubers or kernels, or plant cuttings, from animal pests, in particular insects and representatives of the order Acarina.
The propagation material can be treated with the composition prior to application, for example, seed being dressed prior to sowing. The active ingredient may also be applied to seed kernels (coating), either by soaking the kernels in a liquid composition or by coating them with a solid composition. The composition may also be applied to the site of application when applying the propagation material, for example into the seed furrow during sowing. These treatment methods for plant propagation material and the plant propagation material treated thus are a further subject of the invention.
Examples of formulations of nitroimino- or nitroguanidino-compounds which can be used in the method according to the invention for instance solutions, granules, dusts, sprayable powders, emulsion concentrates, coated granules and suspension concentrates, are of the type as has been described in, for example, EP-A-580 553, Examples F1 to Biological examples Table B The following abreviations are used in the table: Active Principle of transgenic plant: AP Photorhabdus luminescens: PL Xenorhabdus nematophilus: XN Proteinase inhibitors: Plnh.
WO 99/35913 WO 9935913PCTIEP99/OO 183 -63- Plant lectins PLec.
Agglutinins: Aggi.
3-Hydroxysteroid oxidlase: HO Choilestero loxidase: CO Chitinase: OH Glucanase: GL Stilbensynthase SS Table B: 4AP Control of AP Control of B. I B.2 B.3 BA4 B.6 B.7 B.8 B.9 B.11I B. 12 B. 13 B. 14 B. 15 B. 16 B.17 CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CryIA(a) CrylA(a) CrylA(a) Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undialis Keiferia lycopersicella Leucoptera. scitella Lithocollethis spp.
Lobesia botrana B. 18 B. 19 B.20 B.21I B.22 B.23 B.24 B .25 B.26 B.27 B.28 B.29 B.30 B.31I B.32 B.33 B .34 B.35 B.36 B.37 CrylA(a) CrylA(a) CrylA(a) CryIA(a) CryIA(a) CryIA(a) CrylA(a) CrylA(a) CryIA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) Ostrinia nubilalis Pandemnis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodoptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curculio spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
WO 99/35913 WO 9935913PCT/EP99/OO 183 64- AP Control of IAP I Control of B.38 B.39 B.41 B.42 B.43 B .44 B .46 B.47 B.48 B.49 B.51I B.52 B.53 B.54 B.56 B.57 B.58 B.59 B.61 B.62 B.63 B.64 B.66 B.67 B.68 CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) C.ry!A(a) CryIA(a) CrylA(a) CryIA(a) CrylA(a) CryIA(a) CryIA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CryIA(a) CrylA(a) CryIA(a) CrylA(a) CrytA(a) CrylA(a) CrylA(a) CrylA(a) CrylA(a) CryIA(a) CrylA(b) CryIA(b) CryIA(b) Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemnisia tabaci Emnpoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.
Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantil Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama B.69 B.70 B.71 B.72 B.73 B.74 B.75 B.76 B.77 B.78 B.79 B.80 B.81 B.82 B.83 B .84 B.85 B.86 B.87 B.88 B.89 B .90 B.91 B.92 B.93 B .94 CrylA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(b) CryIA(b) CryIA(b) CrylA(b) CrylA(b) CrytA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(b) CrylA(b) CryIA(b) CrylA(b) CrylA(b) argillaceae Anticarsia gemmatalis Chilo spp.
Ciysia ambiguella Crocidolomia binotalis Cydlia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pienis spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodoptera spp.
Tortrix spp.
Thchoplusia ni WO 99/35913 WO 9935913PCT/EP99/OO1 83 I AP I Control of AP IControl of 4 4 B.96 B.97 B.98 B .9 B.100 B.101 B. 102 B. 103 B. 104 B. 105 B. 106 B. 107 B. 108 B. 109 10 BAI I1 B.1 12 B.1 13 B.A 14 B.1 15 B. 116 B.1 17 B.1 18 B. 119 B. 120 B. 121 B. 122 B. 123 B. 124 CrylA(b) CrylA(b) Cr'yIA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(b) CrylA(b) CrylA(b) CryIA(b) CryIA(b) CryIA(b) CrylA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) Agriotes spp.
Anthonomus grandis Curcuio spp.
Diabrotica balteata Leptisnotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidliella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.
Psylla spp.
Quadraspidliotus spp.
Schizaphis spp.
Tnialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantli Aceria spp.
Aculus spp.
B.125 B. 126 B. 127 B. 128 B. 129 B. 130 B. 131 B. 132 B.133 B. 134 B. 135 B. 136 B. 137 B. 138 B. 139 B. 140 B. 141 B. 142 B. 143 B. 144 B. 145 B. 146 B. 147 B. 148 B. 149 B. 150 CrylA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) Cry!'A(b) CryIA(c) CrylA(c) CrylA(c) Cry!A(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CryIA(c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemnmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keifenia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemis spp.
Pectinophora gossypiella.
WO 99/35913 WO 9935913PCTIEP99/OO 183 -66 IAP I Control of B.151 B. 152 B.153 B. 154 B. 155 B. 156 B. 157 B. 158 B. 159 B. 160 B. 161 B. 162 B. 163 B. 164 B. 165 B. 166 B. 167 B. 168 B. 169 B. 170 B. 171 B. 172 B.173 B. 174 B. 175 B. 176 B. 177 B. 178 B. 179 B.180 CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CrylA(c) CryIA(c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CrylA(c) Phyllocnistis citrella Pienis spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Spargancthis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcullo spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothnixus spp.
Aleyrodes spp.
Aonidliella spp.
Aphididae spp.
Aphis spp.
Bemnisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
B. 181 B. 182 B. 183 B. 184 B.185 B. 186 B. 187 B.188 B. 189 B. 190 B. 191 B. 192 B. 193 B. 194 B. 195 B. 196 B. 197 B. 198 B. 199 B.200 B.201I B.202 B .203 B.204 B.205 B.206 B.207 B.208 CrylA(c) CrylA(c) CryIA(c) CrylA(c) CryIA(c) CrylA(c) CrylA(c) CryIA(c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CryIA(c) CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA Control of Trialeurodes spp.
Lyniomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thnips spp.
Scirtothrips auranti Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemnmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydlia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis WO 99/35913 WO 9935913PCT/EP99/O1 83 67 IlAP Control of I I B.209 I CryllA B.21 0 B.211 B.212 B.2 13 B.214 B.215 B.216 B.2 17 B.218 B.219 B.220 B.221 B.222 B.223 B.224 B.22 5 B.226 B.227 B.228 B.229 B.230 B.231 B.232 B.233 B.234 B.235 B.236 B.237 CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA Keffenia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nub$-lalis Pandemnis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamnia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcullo spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidliella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci B.238 B.239 B.240 B.241 B.242 E.243 B.244 B.245 B.246 B.247 B.248 B.249 B.250 B.251I B.252 B.253 B.254 B.255 B.256 B.257 B.258 B.259 B.260 B.261 B.262 B.263
AP
CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CrylilA CrylilA CryillIA Control of Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata. spp.
Pseudlococcus spp.
Psyila spp.
Quadraspidliotus spp.
Schizaphis spp.
Tnialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thnips spp.
Scirtothnips aurantii Acenia spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella B.264 ICryiIIA B.265 B .266 CryliIA CrylIiA WO 99/35913 WO 9935913PCT/EP99/OOI 83 -68 IAP IControl of AP Control of B.267 B.268 B.269 B.270 B.271 B.272 B.273 B.274 B.275 B.276 B.277 B.278 B.279 B.280 B.281 B.282 B.283 B.284 B.285 B.286 B.287 B .288 B.289 B.290 B.291 B.292 B.293 CryillIA CrylliA CrylliA CrylliA CrylilA CryillIA CryillIA CrylilA CrylliA CrylilA CrylilA CrylliA CrylliA CrylliA CrylilA CrylliA CryillA CrylliA CrylilA CryilA CryillA CryillIA CrylilA CryllIA CryllIA CrylilA CryillIA Crocidolomnia bin otalis Cydlia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicelta Leucoptera scitelia Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemnis spp.
Pectinophora gossyp.
Phyllocnistis citretla Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodoptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcuio spp., Diabrotica balteata B.294 B.295 B.296 B.297 B.298 B.299 B.300 B.301 B.302 B.303 B.304 B.305 B.306 B.307 B.308 B.309 B.3 10 B.31 I B.312 B.313 B.314 B.315 B.316 B.3 17 B.318 B.319 B.320 B.321 B.322 B.323 B.324 CrylliA CryiIIA CryllIA CrytlA CrylilA CryillA CryllIA Cryill[A Cryill[A CrylilA CrylilA CrylliA CryillIA CrylilA CrylilA CrylilA CrylilA CrylilA CrylilA CryillIA CrylilA CryillIA CrylliA CrylilA CrylliA CryillIA CryillIA CrylilA CrylilA CrylilA CrylilA Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.
Psylla spp.
Quadraspidliotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
WO 99/35913 WO 9935913PCTIEP99/001 83 -69 IAP I Control of I AP IControl of B.325 B.326 B.327 B.328 B.329 B.330 B.331 B. 3321 B.333 B.334 B.335 B.3.36 B.337 B.338 B.339 B.340 B.341 B.342 B .343 B.344 B.345 B.346 B.347 B.348 B.350 CrylilA CryllIB2 CryllIB2 CryllIB2 CryllIB2 CrylllB2 CryllIB2 CrylIB2 CryllIB2 CryllB2 CryllIB2 CryllIB2 CrylllB2 CryIIIB2 CrylllB2 CrylIIB2 CrylllB2 CryllIB2 CrylIB2 CryllIB2 CryIllB2 CrylIlB2 CrylllB2 CryllIB2 CryllIB2 CryllB2 Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gem matalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydlia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostninia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyliocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
B.351 B.352 B.353 B.354 B.355 B.356 B.357 B.358 B.359 B .360 B.361 B.362 B.363 B.364 B.365 B.366 B.367 B.368 B.369 B.370 B.371 B.372 B.373 B .374 B.375 B.376 B.377 B.378 B.379 B.380 CryllIB2 CrylIB2 CrylIB2 CryIIIB2 CryllIB2 Cnry!11B2 CrylIIB2 CrylIIB2 CryllIB2 CrylIB2 CryllIB2 CrylllB2 CryllIB2 CrylllB2 CryIIIB2 CrylllB2 CrylllB2 CrylllB2 CryllIB2 CrylllB2 CrylIB2 CryflIB2 CryllB2 CryllIB2 CrylIIB2 CrylllB2 CrylIB2 CryllIB2 CryIIIB2 CryllIB2 Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Tnichoplusia ni Agriotes spp.
Anthonomus grand is Curcullo spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemnisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.
Psylla spp.
Quadraspidiotus sppD.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
WO 99/35913 WO 9935913PCTEP99/O1 83 AP Icontrol of I AP IControl of B.381 B.382 B.383 B .384 B.385 B.386 B.387 B.388 B.389 B.390 B.391 B.392 B.393 B.394 B.395 B.396 B.397 B.398 B.399 B.400 B.401 B.402 B.403 B.404 B.405 B.406 B.407 CryllIB2 CryIIIB2 CrylllB2 CryIlB2 CrylIiB2 CryIIIB2 CrylIIB2 CryllIB2 CryllIB2 CrylIlB2 CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argiflaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydlia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana B.408 B.409 B.4 10 B.411 B.412 B .413 B.414 B.415 B .416 B.417 B.418 B .419 B.420 B .421 B.422 B.423 B.424 B.425 B.426 B.427 B.428 B.429 B.430 B.431 B.432 B.433 B.434 B.435 B.436 B.437 CytA CytA CytA CytA Cyt-A CytA CMt CytA CytA CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt CMt Ostrinia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pienis spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agniotes spp.
Anthonomus grandis Curcuio spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.' WO 99/35913 WO 9935913PCTEP99/O1 83 -71- I AP IControl of IAP IControl of B.438 B.439 B.440 B.441 B.442 B .443 B .444 B.445 B.446 B.447 B.448 B.449 B.450 B.451 B.452 B.453 B.454 B.455 B.456 B.457 B.458 B.459 B.460 B.461 B.462 B.463 B.464 CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomuyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea B.465 B.466 B.467 B.468 B.469 B.470 B.471 B.472 B.473 B.474 B.475 B.476 B.477 B.478 B.479 B.480 B.481 B.482 B.483 B.484 B.485 B.486 B.487 B.488 B.489 B.490 B.491 B.492 B.493 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 Eanias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Cstrinia nubilalis Pandemnis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agniotes spp.
Anthonomus grandis Curcuio spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
WO 99/35913 WO 9935913PCTIEP99/O1 83 -72- I AP Control of
AP
Control of i i B.494 B.495 B.496 B.497 B.498 B.499 B.500 B.501 B.502 B.503 B .504 B.505 B.506 B.507 B.508 B.509 B.510 B.511I 12 B.513 B.514 B.515 B.516 B.517 B.518 B.519 B.520 B.521 B.522 B.523 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3
GL
GL
GL
Aonidliella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae B.524 B .525 B.526 B.527 B.528 B.529 B.530 B.531 B.532 B.533 B.534 B.535 B.536 B.537 B.538 B.539 B.540 B.541I B.542 B.543 B .544 B.545 B.546 B.547 B.548 B.549 B.550 Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Qstninia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga, spp.
Sesamia spp.
Sparganothis spp.
Spodoptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
WO 99/35913 WO 9935913PCT/EP99/OO1 83 -73 I AP I Control of IAP~ Control of B.551 B.552 B.553 B.554 B.556 B.557 B .558 B.559 B.560 B.561 B.562 B.563 B .564 B.565 B.566 B.567 B.568 B.569 B.570 B.571 B.572 B.573 B.574 B.575 B.576 B.577 B.578 B.579 B.580
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
Anthonomus grandis Curcuio spp.
Diabrotica balteata Leptinotarsa spp.
Lsssorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidliella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Emnpoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
Quadraspidliotus sppD.
Schizaphis spp.
Trialeurodes spp.
Lyniomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips auranti Aceria spp.
Aculus spp.
Brevipalpus spp.
B.581 B.582 B.583 B.584 B.585 B.586 B.587 B.588 B.589 B.590 B.591 B.592 B.593 B.594 B.595 B.596 B.597 B.598 B.599 B .600 B.601 B.602 B.603 B.604 B.605 B.606 Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemnmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemnis spp.
Pectinophora gossyp.
Phyllocnistis citrella WO 99/35913 WO 9935913PCT/EP99/O1 83 -74- AP Control of AP I Control of B.607 B.608 B.609 B.610 B.611 B.612 B.613 B.614 B.615 B.616 B.617 B.618 B.619 B.620 B.621 B.622 B.623 B.624 B.625 B.626 B.627 B.628 B.629 B.630 B.631 B.632 B.633 B.634 B.635 B.636 Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodoptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcullo spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidliella spp.
Aphididae spp.
Aphis spp.
Bemnisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
Quadraspidiotus sppD.
Schizaphis spp.
Trialeurodes spp.
B.637 PL B.638 PL B.639 PL B.640 PL B.641 Pl.
B.642 PL B.643 PL B.644 PL B.645 PL B.646 PL B.647 PL B.648 PL B.649 PL B.650 PL B.651 XN B.652 XN B.653 XN B.654 XN B.655 XN B.656 XN B.657 XN B.658 XN B.659 XN B.660 XN B.661 XN B.662 XN B.663 XN B.664 XN Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thnips spp.
Scirtothrips aurantil Aceria spp.
Aculus spp.
Brevipaipus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemnmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia WO 99/35913 WO 9935913PCT/EP99/O1 83 AP IControl of
AP
Control of B.665 B.666 B.667 B.668 B.669 B.670 B.671 B.672 B.673 B.674 B.675 B.676 B.677 B.678 B.679 B.680 B.681 B.682 B.683 B.684 B.685 B.686 B.687 B.688 B.689 B.690 B.691 B.692 B.693 lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandenmis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pienis spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus g randis Curcullo spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiefla spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
B.694 B.695 B.696 B.697 B.698 B.699 B.700 B.701 B.702 B.703 B.704 B.705 B.706 B.707 B.708 B.709 B.710 B.71 I B.712 B.713 B.714 B.715 B.716 B.717 B.718 B.719 B.720 B.721 B.722
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
XN
Plnh.
Pinh.
Plnh.
Plnh.
Plnh.
Plnh.
Pinh.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.
Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Acloxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomnia WO 99/35913 WO 9935913PCT/EP99/OO1 83 -76- AP I Control of AP I Control of B.723 B.724 B.725 B.72 6 B.727 B.728 B.729 B.730 B.731 B.732 B.733 B.734 B.735 B.736 B.737 B.738 B.739 B.740 B.741 B.742 B.743 B.744 B.745 B.746 B.747 B.748 B.749 Plnh.
Plnh.
Pinh.
Pinh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Pinh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Pinh.
Pinh.
Pinh.
Pinh.
binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodoptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curculio spp.
Diabrotica balteata Leptinotarsa spp.
B.750 B.751 h.752 B.753 B.754 B.755 B.756 B.757 B.758 B.759 B.760 B.761 B.762 B.763 B.764 B.765 B.766 B.767 B.768 B.769 B.770 B.771 B.772 B.773 B.774 B.775 B.776 B.777 B.778 B.779 B.780 Plnh.
Pinh.
Pinh.
Plnh.
Plnh.
Plnh.
Pinh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Pinh.
Pinh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Plnh.
Pinh.
Pinh.
Plnh.
Plnh.
Plnh.
Pinh.
Plnh.
Plnh.
Pinh.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemnisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.
Psyila spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyniomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Acenia spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
WO 99/35913 WO 9935913PCT/EP99/00183 -77- AP Control of AP Control of I* 4 1 B.781 B.782 B.783 B .784 B.785 B.786 B.787 B.788 B.789 B.790 B.791 B.792 B.793 B.794 B.795 B.796 B.797 B.798 B.799 B.800 B.801 B.802 B.803 B.804 B.805 B.806 PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemnmatalis Chilo spp.
Clysia amnbiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undialis Keiferia lycope rsicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
B.807 B.808 B.809 B.810 B.811 B .812 B.813 B.814 B.815 B.816 B.8 17 B.8 18 B.819 B.820 B.821 B.822 B .823 B.824 B.825 B.826 B.827 B-828 B.829 B.830 B.831 B.832 B.833 B.834 B.835 B.836 PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
Spodoptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcullo spp.
Diabrotica balteata Leptinotarsa spp.
Lassorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
Quadraspidiotus
SIDI.
Schizaphis spp.
Trialeurodes spp.
Lyniomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
WO 99/35913 WO 9935913PCT/EP99/OOI 83 -78 AP jControl of IAP IControl of B.837 B.838 B.839 B.840 B.841I B.842 B .843 B .844 B.845 B.846 B. 847 B.848 B.849 B.850 B.851 B.852 B.853 B.854 B.855 B.856 B.857 B.858 B.859 B.860 B.861 B.862 B.863 PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
PLec.
Aggi.
Aggi.
Aggl.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllccc-pt.ruta spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keifenia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis B.864 B.865 B.866 B.867 B.868 B.869 B.870 B.87 1 B.872 B.873 B.874 B.875 B.876 B.877 B.878 B.879 B.880 B.881 B.882 B.883 B.884 B.885 B.886 B.887 B.888 B.889 B.890 B.891 B.892 B.893 Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggl.
Aggi.
Aggl.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Pandemnis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pienis spp.
Plutelia xylostella Scirpophaga spp.
Sesamnia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agniotes spp.
Anthonomus grandis Curcuio spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemnisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
WO 99/35913 WO 9935913PCT/EP99/OOI 83 -79 IAP I Control of AP Control of B.894 B.895 B.896 B.897 B.898 B.899 B.900 B.901 B.902 B.903 B.904 B.905 B.906 B.907 B.908 B.909 B.910 B.91 I B.912 B.9 13 B.914 B.915 B.916 B.917 B.918 B.919 B.920 Aggi.
Aggi.
Aggi.
Aggl.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
Aggi.
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
Quadraspidiotus spp.
Schizaphis spp.
Tnialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantil Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydlia spp.
Diparopsis castanea Earias spp.
B.921 B.922 B.923 B.924 B.925 B.926 B.927 B.928 B.929 B.930 B.931 B.932 B.933 B.934 B.935 B.936 B.937 B.938 B.939 B.940 B .941 B.942 B.943 B.944 B .945 B .946 B .947 B.948 B .949
CO
CO
CO
CO
CO
CO
CO
Co Co
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
CO
Ephestia spp.
Heliothis spp.
Hellula undalis Keifenia lycopersicella Leucoptera. scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemis spp.
P ectin opho ra gossyp.
Phyllocnistis citrella Pienis spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcullo spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothrixus spp.
Aleyrodes spp.
Aonidiella spp.
WO 99/35913 WO 9935913PCTIEP99/OOI 83 AP Cnrlof AP Control of B.*950 B.951 B .952 B.953 B.954 B.93S B.956 B.957 B.958 B.959 B.960 B.961 B.962 B.963 B.964 B.965 B.966 B.967 B.968 B.969 B.970 B.971 B.972 B.973 B.974 B.975 B.976 B.977 B.978 B.979 Co
CO
Co Co
CO
Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co
CO
CH
CH
CH
CH
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudlococcus spp.
Psylla spp.
Quadraspidliotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia B-980 B.981 B.982 B-983 B.994 B.985 B.986 B.987 B.988 B.989 B.990 B.991 B.992 B.993 B.994 B.995 B.996 B.997 B.998 B.999 B. 1000 B. 1001 B. 1002 B. 1003 B. 1004 B. 1005 B. 1006 gemnmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Earias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agniotes spp.
Anthonomus WO 99/35913 WO 9935913PCT/EP99/OO1 83 -81 AP Control of AP IjControl of B. 1007 B. 1008 B. 1009 B.1010 B. 1011I B. 1012 B. 1013 B. 1014 B. 1015 B. 1016 B. 10 17 B. 10 18 B. 1019 B. 1020 B. 1021 B. 1022 B. 1023 B. 1024 B. 1025 B. 1026 B. 1027 B. 1028 B. 1029 B. 1030 B. 1031 B. 1032 B. 1033 B. 1034 B. 1035 B. 1036 grandis Curcuio spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynohus spp.
Aleurothnixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata. spp.
Pseudlococcus spp.
Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
B. 103 7 B. 1038 B. 1039 B. 1040 B. 1041 B. 1042 B. 1043 B. 1044 B. 1045 B. 1046 B. 1047 B. 1048 B. 1049 B. 1050 B. 105 1 B. 105 2 B. 1053 B. 1054 B. 105 5 B. 1056 B. 1057 B. 1058 B. 1059 B. 1060 B. 106 1 1062 Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidlogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia ambiguella Crocidolomia binotalis Cydia spp.
Diparopsis castanea Eanias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.
Lobesia botrana Ostrinia nubilalis Pandemis spp.
Pectinophora gossyp.
Phyllocnistis citrella Pieris spp.
WO 99/35913 WO 9935913PCT/EP99/00183 -82 AP Control of IAP I Control of B. 1063 B. 1064 B. 1065 B. 1066 B. 1067 B. 1068 B. 1069 B. 1070 B. 1071 B. 1072 B. 1073 B. 1074 1075 B. 1076 B. 1077 B. 1078 B. 1079 B. 1080 B. 1081 B. 1082 B. 1083 B. 1084 B. 1085 B. 1086 B. 1087 B. 1088 B. 1089 B. 1090 B. 109 1 B. 1092 Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodloptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcuio spp.
Diabrotica balteata.
Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothnixus spp.
Aleyrodes spp.
Aonidiella spp.
Aphididae spp.
Aphis spp.
Bemisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyriomyza spp.
B.1093 B .1094 B. 1095 B. 1096 B. 1097 B. 1098 B. 1099 B.1100 B.1101 B. 1102 B. 1103 B. 1104 B. 1105 B. 1106 B. 1107 B. 1108 B. 1109 B.1II10 B.1I11I1 B. 1112 B.1 113 B. 1114 B.]1115 B.1 116 B.]1117 B. 1118 B.1 119 Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thnips spp.
Scirtothnips aurantii Acenia spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta. spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Adoxophyes spp.
Agrotis spp.
Alabama argillaceae Anticarsia gemmatalis Chilo spp.
Clysia. ambiguella Crocidolomia binotalis Cydlia spp.
Diparopsis castanea Eanias spp.
Ephestia spp.
Heliothis spp.
Hellula undalis Keifenia lycopersicella WO 99135913 WO 9935913PCTEP99/O1 83 -83 IAP IControl of _AP IControl of B. 1120 B. 1121 B. 1122 B. 1123 B. 1124 B. 1125 B. 1126 B. 1127 B. 1128 B. 1129 B.1 130 B. 1131 B. 1132 B. 1133 B. 1134 B. 1135 B. 1136 B. 1137 B. 1138 B. 1139 B. 1140 B. 1141 B. 1142 B. 1143 B. 1144 Leucoptera scitella Lithocollethis spp.
Lobesia botrana.
Ostrinia nubilalis Pandemnis spp.
Pectinophora gossypiella Phyllocnistis citrella Pieris spp.
Plutella xylostella Scirpophaga spp.
Sesamia spp.
Sparganothis spp.
Spodo ptera spp.
Tortrix spp.
Trichoplusia ni Agriotes spp.
Anthonomus grandis Curcuio spp.
Diabrotica balteata Leptinotarsa spp.
Lissorhoptrus spp.
Otiorhynchus spp.
Aleurothnixus spp.
Aleyrodes spp.
Aonidiella spp.
B. 1145 B. 1146 B. 1147 B. 1148 B. 1149 B. 1150 B. 1151 B. 1152 B. 1153 B. 1154 B. 1155 B. 1156 B. 1157 B. 1158 B. 1159 B. 1160 B. 1161 B. 1162 B. 1163 B. 1164 B. 1165 B. 1166 B. 1167 B. 1168 B. 1169 B. 1170
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
Aphididae spp.
Aphis spp.
Bemnisia tabaci Empoasca spp.
Mycus spp.
Nephotettix spp.
Nilaparvata spp.
Pseudococcus spp.
Psylla spp.
Quadraspidiotus spp.
Schizaphis spp.
Trialeurodes spp.
Lyniomyza spp.
Oscinella spp.
Phorbia spp.
Frankliniella spp.
Thrips spp.
Scirtothrips aurantii Aceria spp.
Aculus spp.
Brevipalpus spp.
Panonychus spp.
Phyllocoptruta spp.
Tetranychus spp.
Heterodera spp.
Meloidogyne spp.
Biological Examples Table 1: A method of controlling pests comprising the application of thiamethoxam to transgenic cotton, wherein the combination of the active principle expressed by the WO 99/35913 PCTIEP99/00183 -84transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 2: A method of controlling pests comprising the application of thiamethoxam to S transgenic rice, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 3: A method of controlling pests comprising the application of thiamethoxam to transgenic potatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 4: A method of controlling pests comprising the application of thiamethoxam to transgenic brassica, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 5: A method of controlling pests comprising the application of thiamethoxam to transgenic tomatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 6: A method of controlling pests comprising the application of thiamethoxam to transgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 7: A method of controlling pests comprising the application of thiamethoxam to transgenic soybeans, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 8: A method of controlling pests comprising the application of thiamethoxam to transgenic maize, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
WO 99/35913 PCT/IEP99/001 83 Table 9: A method of controlling pests comprising the application of thiamethoxam to transgenic wheat, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 10: A method of controlling pests comprising the application of thiamethoxam to transgenic bananas, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individua!ised combinations B.1 to B.1170 of table B.
Table 11: A method of controlling pests comprising the application of thiamethoxam to transgenic citrus trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 12: A method of controlling pests comprising the application of thiamethoxam to transgenic pome fruit trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 13: A method of controlling pests comprising the application of thiamethoxam to transgenic peppers, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 14: A method of controlling pests comprising the application of imidacloprid to transgenic cotton, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 15: A method of controlling pests comprising the application of imidacloprid to transgenic rice, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 16: A method of controlling pests comprising the application of imidacloprid to transgenic potatoes, wherein the combination of the active principle expressed by the WO 99/35913 PCT/EP99/00183 -86transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 17: A method of controlling pests comprising the application of imidacloprid to 7, transgenic tomatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 18: A method of controlling pests comprising the application of imidacloprid to transgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 19: A method of controlling pests comprising the application of imidacloprid to transgenic soybeans, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 20: A method of controlling pests comprising the application of imidacloprid to transgenic maize, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 21: A method of controlling pests comprising the application of imidacloprid to transgenic wheat, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 22: A method of controlling pests comprising the application of imidacloprid to transgenic bananas, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 23: A method of controlling pests comprising the application of imidacloprid to transgenic orange trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
WO 99/35913 PCT/EP99/00183 -87- Table 24: A method of controlling pests comprising the application of imidacloprid to transgenic pome fruit, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 25: A method of controlling pests comprising the application of imidacloprid to transgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 26: A method of controlling pests comprising the application of imidacloprid to transgenic peppers, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 27: A method of controlling pests comprising the application of Ti-435 to transgenic cotton, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 28: A method of controlling pests comprising the application of Ti-435 to transgenic rice, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 29: A method of controlling pests comprising the application of Ti-435 to transgenic potatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 30: A method of controlling pests comprising the application of Ti-435 to transgenic brassica, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 r to B.1170 of table B.
Table 31: A method of controlling pests comprising the application of Ti-435 to transgenic tomatoes, wherein the combination of the active principle expressed by the transgenic plant WO 99/35913 PCT/EP99/001 83 -88and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 32: A method of controlling pests comprising the application of Ti-435 to transgenic S cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 33: A method of controlling pests comprising the application of Ti-435 to transgenic soybeans, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to 8.1170 of table B.
Table 34: A method of controlling pests comprising the application of Ti-435 to transgenic maize, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 35: A method of controlling pests comprising the application of Ti-435 to transgenic wheat, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 36: A method of controlling pests comprising the application of Ti-435 to transgenic bananas, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 37: A method of controlling pests comprising the application of Ti-435 to transgenic citrus trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 38: A method of controlling pests comprising the application of Ti-435 to transgenic pome fruit trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
WO 99/35913 PCT/EP99/00183 -89- Table 39: A method of controlling pests comprising the application of thiacloprid to transgenic cotton, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 40: A method of controlling pests comprising the application of thiacloprid to transgenic rice, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 41: A method of controlling pests comprising the application of thiacloprid to transgenic potatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 42: A method of controlling pests comprising the application of thiacloprid to transgenic brassica, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 43: A method of controlling pests comprising the application of thiacloprid to transgenic tomatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 44: A method of controlling pests comprising the application of thiacloprid to transgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 45: A method of controlling pests comprising the application of thiacioprid to transgenic soybeans, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 46: A method of controlling pests comprising the application of thiacloprid to transgenic maize, wherein the combination of the active principle expressed by the WO 99/35913 PCTIEP99/00183 transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 47: A method of controlling pests comprising the application of thiacloprid to transgenic wheat, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table 48: A method of controlling pests comprising the application of thiacloprid to transgenic bananas, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to anyone of the individualised combinations B.1 to B.1170 of table B.
Table C: Abbreviations: Acetyl-COA Carboxylase: ACCase Acetolactate Synthase: ALS Hydroxyphenylpyruvat dioxygenase: HPPD Inhibition of protein synthesis: IPS Hormone mimic: HO Glutamine Synthetase: GS Protoporphyrinogen oxidase: PROTOX 5-Enolpyruvyl-3-Phosphoshikimate Synthase: EPSPS Principle Tolerant to Crop C.I ALS Sulfonylureas etc.*" Cotton C.2 ALS Sulfonylureas etc. Rice C.3 ALS Sulfonylureas etc. Brassica C.4 ALS Sulfonylureas etc. Potatoes ALS Sulfonylureas etc. Tomatoes C.6 ALS Sulfonylureas etc. Cucurbits C.7 ALS Sulfonylureas etc. Soybeans C.8 ALS Sulfonylureas etc. Maize C.9 ALS Sulfonylureas etc. Wheat ALS Sulfonylureas etc. pome fruit WO 99/35913 WO 9935913PCTEP99/OO1 83 -91 Principle T-olerant to Crop c.11 C.12 C. 13 C. 14 C. 16 C. 17 C.18 C. 19 C.21 C.22 C.23 C.24 C.26 C.27 C.28 C.29 C.31 C.32 C.33 C.34 C.36 C.37 C.38 C.39 CAI1 C.42
ALS
ALS
ACCase ACCase ACCase ACCase ACCase ACCase ACCase ACCase ACCase ACCase ACCase ACCase
HPPD
HPPD
HPPD
HPPD
HPPD
HPPD
HPPD
HPPD
HPPD
HPPD
HPPD
HPPD
Nitrilase Nitrilase Nitrilase Nitrilase Nitrilase Nitrilase Suit onylureas etc.
Sulf onylureas etc.
!sxfltl isxahote Isoxaflutol, Isoxachlotol, Isoxaflutol, Isoxachlotol, Isoxafiutol, Isoxachlotol, Isoxaflutol, Isoxachlotol, Isoxaflutol, Isoxachlotol, Isoxaflutol, Isoxachiotol, Isoxaflutol, Isoxachiotol, Isoxaflutol, Isoxachlotol, Isoxaflutol, Isoxachlotol, isoxaflutol, isoxachlotol, Isoxaflutol, Isoxachlotol, Bromoxyniol, lsoxynilotl Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxyni!, loxynil Bromoxynil, loxynil Sulcotrion, Mesotrion Sulcotnion, Mesotnion Sulcotrion, Mesotnion Sulcotnion, Mesotnion Sulcotrion, Mesotrion Sulcotrion, Mesotnion Sulcotrion, Mesotnion Sulcotrion, Mesotrion Sulcotrion, Mesotrion Sulcotrion, Mesotrion Sulcotnion, Mesotrion Sulcotrion, Mesotrion stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome f ruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits WO 99/35913 WO 9935913PCTIEP99/001 83 92- Principle__I Tolerant to I Crop 9 C.43 C.44 C.46 C.47 C.48 C.49 C.52 C.53 C.54 C.56 C.57 C.58 C.59 C.61 C.62 C.63 C.64 C.66 C.67 C.68 C.69 C.71 C.72 C.73 C.74 Nitrilase Nitrilase Nitrilase Nitrilase Nitrilase Nitrilase
'PS
'PS
'PS
'PS
IPS
'PS
'PS
'PS
'PS
'PS
'PS
'PS
HOM
HOM
HOM
HOM
HOM
HOM
HOM
HOM
HOM
HOM
HOM
HOM
PROTOX
PROTOX
Bromoxynil, loxynil Bromoxynil, loxyni! Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Chioroactanilides Chioroactanil ides Chioroactanilide Chioroactanilidies Chioroactanilides Chioroactanilides Chioroactanilides Chioroactanilides Chloroactanilides Chioroactanilides Chioroactanilides Chioroactanilidles 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-Dl, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-Dl, Mecoprop-P 2,4-D, Mecoprop-P 2,4-Dl, Mecoprop-P 2,4-Dl, Mecoprop-P 2,4-D, Mecoprop-P Protox inhibitors N/ Protox inhibitors N/ Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice WO 99/35913 WO 9935913PCT/EP99/OO1 83 93.
Principle JTolerant to JCrop C.76 C.77 C.78 C.79 C.81I C.82 C.83 C. 84 C.86 C.87 C.88 C.89 C.91 C.92 C.93 C.94 C.96 C.97 C.98 C.99 C. 100 C.101 C. 102 C. 103 C. 104 C. 105 C. 106
PROTOX
PROTOX
PROTOX
PROTOX
PROTOX
PROTOX
PROTOX
PROTOX
PROTOX
PROTOX
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
EPSPS
GS
GS
GS
GS
GS
GS
GS
GS
GS
GS
Protox inhibitors N/ Protox inhibitors X1 Protox inhibitors 1/ Protox inhibitors N1 Protox inhibitors/1 Protox inhibitors1/ Protox inhibitors1/ Protox inhibitors I Protox inhibitors Nl Protox inhibitors 1/ Glyphosate and for Sulphosate Glyphosate and for Suiphosate Glyphosate and /or Suiphosate Glyphosate and for Suiphosate Glyphosate and /or Suiphosate Glyphosate and /or Sulphosate Glyphosate and for Suiphosate Glyphosate and. /or Suiphosate Glyphosate and /or Suiphosate Glyphosate and for Suiphosate Glyphosate and for Suiphosate Glyphosate and for Sulphosate Gluphosinate and for Bialaphos Gluphosinate and for Bialaphos Gluphosinate and for Bialaphos Gluphosinate and for Bialaphos Gluphosinate and for Bialaphos Gluphosinate and for Biataphos Gluphosinate and for Bialaphos Gluphosinate and for Bialaphos Gluphosinate and for Bialaphos Gluphosinate and for Bialaphos Brassica Potatoes Tomatoes Cucurb its Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits, Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome fruit WO 99/35913 WO 9935913PCT/EP99/O1 83 94- Principle Tolerant to Crop C. 107 GS Gluphosinate and /or Bialaphos stone fruit C. 108 GS Gluphosinate and /or Bialaphos citrus Included are Sulfonylureas, Imidazolinones, Thiazolopynimidines, Dimethoxypyrimidines and N-Acylsulfonamnides: Sulfonylureas such as Chlorsulfuron, Chlorimuron, Ethamethsulfuron, Metsulfuron, Primisulfuron, Prosulfuron, Triasulfuron, Cinosulfuron, Trifusulfuron, Oxasulfuron, Bensulfuron, Tribenuron, ACC 322140, Fluzasulfuron, Ethoxysulfuron, Fluzasdulfuron, Nicosulfuron, Rimsulfuron, Thifensulfuron, Pyrazosulfuron, Clopyrasulfuron, NC 330, Azimsulfuron, Imazosulfuron, Sulfosulfuron, Amidosulfuron, Flupyrsulfuron, CGA 362622 Imidazolinones such as lmazamnethabenz, Imazaquin, Imazamethypyr, Imazethapyr, Imazapyr and Imazamox; Triazolopyrimidines such as DE 511, Flumelsulamn and Chioransulamn; Dimethoxypyrimidines such as Pyrithiobac, Pyriminobac, Bispyribac and Pyribenzoxim.
Tolerant to Diclof op-methyl, Fluazifop-P-butyl, Haloxyfop-P-methyl, Haloxyfop-P-ethyl, Quizalaf op-P-ethyl clodlinafop propargyl, fenoxaprop -ethyl, Tepraloxydim, Alloxydim, Sethoxydim, Cycloxydim, Cloproxydim, Tralkoxydim, Butoxydimn, Caloxydim, Clef oxydim, Clethodim.
Chioroacetanilides such as Alachlor Acetochlor, Dimethenamid Protox inhibitors: For instance diphenyethers such as Acif luorf en, Aclonifen, Bifenox, Chlornitrof en, Ethoxyf en, Fluoroglycof en, Fomesafen, Lactof en, Oxyfluorfen; Imides such as Azafenidin, Cartfentrazone-ethyl, Cinidon-ethyl, Flumiclorac-pentyl, Flumioxazin, Fluthiacet-methyl, Oxadiargyl, Oxadiazon, Pentoxazone, Sulfentrazone, Imides and others,such as Flumipropyn, Flupropacil, Nipyraclofen and Thidiazimin; and further Fluazolate and Pyraf luf en-ethyl Biolociical Examples Table 49: A method of controlling representatives of the genus Adoxophyes comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the WO 99/35913 PCT/EP99/00183 combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 50: A method of controlling representatives of the genus Agrotis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 51: A method of controlling Alabama argillaceae comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 52: A method of controlling Anticarsia gemmatalis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 53: A method of controlling representatives of the genus Chilo comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 54: A method of controlling Clysia ambiguella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 55: A method of controlling representatives of the genus Cnephalocrocis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 56: A method of controlling Crocidolomia binotalis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCTIEP99/00183 -96- Table 57: A method of controlling representatives of the genus Cydia comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 58: A method of controlling Diparopsis castanea comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 59: A method of controlling representatives of the genus Earias comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 60: A method of controlling representatives of the genus Ephestia comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 61: A method of controlling representatives of the genus Heliothis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 62: A method of controlling Hellula undalis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 63: A method of controlling Keiferia iycopersicella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 64: A method of controlling Leucoptera scitella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the WO 99/35913 PCTIEP99/00183 -97active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 65: A method of controlling representatives of the genus Lithocollethis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 66: A method of controlling Lobesia botrana comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 67: A method of controlling Ostrinia nubilalis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 68: A method of controlling representatives of the genus Pandemis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 69: A method of controlling Pectinophora gossypiella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 70: A method of controlling Phyllocnistis citrella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 71: A method of controlling representatives of the genus Pieris comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -98- Table 72: A method of controlling Plutella xylostella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 73: A method of controlling representatives of the genus Scirpophaga comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 74: A method of controlling representatives of the genus Sesamia comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 75: A method of controlling representatives of the genus Sparganothis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 76: A method of controlling representatives of the genus Spodoptera comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 77: A method of controlling representatives of the genus Tortrix comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 78: A method of controlling Trichoplusia ni comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 79: A method of controlling representatives of the genus Agriotes comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the WO 99/35913 PCT/EP99/00183 -99combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 80: A method of controlling Anthonomus grandis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 81: A method of controlling representatives of the genus Curculio comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 82: A method of controlling Diabrotica balteata comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 83: A method of controlling representatives of the genus Leptinotarsa comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 84: A method of controlling representatives of the genus Lissorhoptrus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 85: A method of controlling representatives of the genus Otiorhynchus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 86: A method of controlling representatives of the genus Aleurothrixus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -100- Table 87: A method of controlling representatives of the genus Aleyrodes comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 88: A method of controlling representatives of the genus Aonidiella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 89: A method of controlling representatives of the family Aphididae comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 90: A method of controlling representatives of the genus Aphis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 91: A method of controlling Bemisia tabaci comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 92: A method of controlling representatives of the genus Empoasca comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 93: A method of controlling representatives of the genus Mycus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 94: A method of controlling representatives of the genus Nephotettix comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the WO 99/35913 PCT/EP99/00183 -101 combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 95: A method of controlling representatives of the genus Nilaparvata comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 96: A method of controlling representatives of the genus Pseudococcus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 97: A method of controlling representatives of the genus Psylla comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 98: A method of controlling representatives of the genus Quadraspidiotus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 99: A method of controlling representatives of the genus Schizaphis comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 100: A method of controlling representatives of the genus Trialeurodes comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 101: A method of controlling representatives of the genus Lyriomyza comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -102- Table 102: A method of controlling representatives of the genus Oscinella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 103: A method of controlling representatives of the genus Phorbia comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 104: A method of controlling representatives of the genus Frankliniella comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 105: A method of controlling representatives of the genus Thrips comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 106: A method of controlling Scirtothrips aurantii comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 107: A method of controlling representatives of the genus Aceria comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 108: A method of controlling representatives of the genus Aculus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 109: A method of controlling representatives of the genus Brevipalpus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the WO 99/35913 PCT/EP99/00183 -103combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 110: A method of controlling representatives of the genus Panonychus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 111: A method of controlling representatives of the genus Phyllocoptruta comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 112: A method of controlling representatives of the genus Tetranychus comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 113: A method of controlling representatives of the genus Heterodera comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 114: A method of controlling representatives of the genus Meloidogyne comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 115: A method of controlling Mamestra brassica comprising the application of thiamethoxam to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 116: A method of controlling representatives of the genus Adoxophyes comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCTIEP99/00183 -104- Table 117: A method of controlling representatives of the genus Agrotis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 118: A method of controlling Alabama argillaceae comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 119: A method of controlling Anticarsia gemmatalis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 120: A method of controlling representatives of the genus Chilo comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 121: A method of controlling Clysia ambiguella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 122: A method of controlling representatives of the genus Cnephalocrocis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 123: A method of controlling Crocidolomia binotalis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 124: A method of controlling representatives of the genus Cydia comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the WO 99/35913 PCTIEP99/00183 -105combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 125: A method of controlling Diparopsis castanea comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 126: A method of controlling representatives of the genus Earias comprising the application of imidacioprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 127: A method of controlling representatives of the genus Ephestia comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 128: A method of controlling representatives of the genus Heliothis of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 129: A method of controlling Hellula undalis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 130: A method of controlling Keiferia lycopersicella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 131: A method of controlling Leucoptera scitella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -106- Table 132: A method of controlling representatives of the genus Lithocollethis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 133: A method of controlling Lobesia botrana comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 134: A method of controlling Ostrinia nubilalis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 135: A method of controlling representatives of the genus Pandemis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 136: A method of controlling Pectinophora gossypiella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 137: A method of controlling Phyllocnistis citrella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 138: A method of controlling representatives of the genus Pieris comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 139: A method of controlling Plutella xylostella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the WO 99/35913 PCT/EP99/00183 -107.
active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 140: A method of controlling representatives of the genus Scirpophaga comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 141: A method of controlling representatives of the genus Sesamia comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 142: A method of controlling representatives of the genus Sparganothis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 143: A method of controlling representatives of the genus Spodoptera comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 144: A method of controlling representatives of the genus Tortrix comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 145: A method of controlling Trichoplusia ni comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 146: A method of controlling representatives of the genus Agriotes comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -108- Table 147: A method of controlling Anthonomus grandis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 148: A method of controlling representatives of the genus Curculio comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 149: A method of controlling Diabrotica balteata comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 150: A method of controlling representatives of the genus Leptinotarsa comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 151: A method of controlling representatives of the genus Lissorhoptrus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 152: A method of controlling representatives of the genus Otiorhynchus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 153: A method of controlling representatives of the genus Aleurothrixus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 154: A method of controlling representatives of the genus Aleyrodes comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the WO 99/35913 PCT/EP99/00183 -109combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 155: A method of controlling representatives of the genus Aonidiella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 156: A method of controlling representatives of the family Aphididae comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 157: A method of controlling representatives of the genus Aphis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 158: A method of controlling Bemisia tabaci comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 159: A method of controlling representatives of the genus Empoasca comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 160: A method of controlling representatives of the genus Mycus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 161: A method of controlling representatives of the genus Nephotettix comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -110- Table 162: A method of controlling representatives of the genus Nilaparvata comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 163: A method of controlling representatives of the genus Pseudococcus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgcnic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 164: A method of controlling representatives of the genus Psylla comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 165: A method of controlling representatives of the genus Quadraspidiotus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 166: A method of controlling representatives of the genus Schizaphis comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 167: A method of controlling representatives of the genus Trialeurodes comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 168: A method of controlling representatives of the genus Lyriomyza comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 169: A method of controlling representatives of the genus Oscinella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the WO 99/35913 PCT/EP99/00183 -111 combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 170: A method of controlling representatives of the genus Phorbia comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 171: A method of controlling representatives of the genus Frankliniella comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 172: A method of controlling representatives of the genus Thrips comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 173: A method of controlling Scirtothrips aurantii comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 174: A method of controlling representatives of the genus Aceria comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 175: A method of controlling representatives of the genus Aculus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 176: A method of controlling representatives of the genus Brevipalpus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -112- Table 177: A method of controlling representatives of the genus Panonychus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 178: A method of controlling representatives of the genus Phyllocoptruta comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 179: A method of controlling representatives of the genus Tetranychus comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 180: A method of controlling representatives of the genus Heterodera comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 181: A method of controlling representatives of the genus Meloidogyne comprising the application of imidacloprid to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 182: A method of controlling representatives of the genus Adoxophyes comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 183: A method of controlling representatives of the genus Agrotis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 184: A method of controlling Alabama argillaceae comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle WO 99/35913 PCTIEP99/00183 -113expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 185: A method of controlling Anticarsia gemmatalis comprising the application of Ti- 435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 186: A method of controlling representatives of the genus Chilo comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 187: A method of controlling Clysia ambiguella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 188: A method of controlling Crocidolomia binotalis comprising the application of Ti- 435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
v Table 189: A method of controlling representatives of the genus Cydia comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 190: A method of controlling Diparopsis castanea comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 191: A method of controlling representatives of the genus Earias comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT[EP99/00183 -114- Table 192: A method of controlling representatives of the genus Ephestia comprising the application of Ti-435 to a herbicidally resistant transgenic crop,. wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 193: A method of controlling representatives of the genus Heliothis of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 194: A method of controlling Hellula undalis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 195: A method of controlling Keiferia lycopersicella comprising the application of Ti- 435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 196: A method of controlling Leucoptera scitella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 197: A method of controlling representatives of the genus Lithocollethis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 198: A method of controlling Lobesia botrana comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 199: A method of controlling Ostrinia nubilalis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle WO 99/35913 PCT/EP99/00183 -115expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 200: A method of controlling representatives of the genus Pandemis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 201: A method of controlling Pectinophora gossypiella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 202: A method of controlling Phyllocnistis citrella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 203: A method of controlling representatives of the genus Pieris comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 204: A method of controlling Plutella xylostella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 205: A method of controlling representatives of the genus Scirpophaga comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 206: A method of controlling representatives of the genus Sesamia comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -116- Table 207: A method of controlling representatives of the genus Sparganothis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 208: A method of controlling representatives of the genus Spodoptera comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 209: A method of controlling representatives of the genus Tortrix comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 210: A method of controlling Trichoplusia ni comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 211: A method of controlling representatives of the genus Agriotes comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 212: A method of controlling Anthonomus grandis comprising the application of Ti- 435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 213: A method of controlling representatives of the genus Curculio comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 214: A method of controlling Diabrotica balteata comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle WO 99/35913 PCT/EP99/00183 -117.
expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 215: A method of controlling representatives of the genus Leptinotarsa comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 216: A method of controlling representatives of the genus Lissorhoptrus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 217: A method of controlling representatives of the genus Otiorhynchus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 218: A method of controlling representatives of the genus Aleurothrixus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 219: A method of controlling representatives of the genus Aleyrodes comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 220: A method of controlling representatives of the genus Aonidiella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 221: A method of controlling representatives of the family Aphididae comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -118- Table 222: A method of controlling representatives of the genus Aphis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 223: A method of controlling Bemisia tabaci comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 224: A method of controlling representatives of the genus Empoasca comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 225: A method of controlling representatives of the genus Mycus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 226: A method of controlling representatives of the genus Nephotettix comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 227: A method of controlling representatives of the genus Nilaparvata comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 228: A method of controlling representatives of the genus Pseudococcus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 229: A method of controlling representatives of the genus Psylla comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of WO 99/35913 PCT/EP99/00183 -119the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 230: A method of controlling representatives of the genus Quadraspidiotus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 231: A method of controlling representatives of the genus Schizaphis comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 232: A method of controlling representatives of the genus Trialeurodes comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 233: A method of controlling representatives of the genus Lyriomyza comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 234: A method of controlling representatives of the genus Oscinella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 235: A method of controlling representatives of the genus Phorbia comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 236: A method of controlling representatives of the genus Frankliniella comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
WO 99/35913 PCT/EP99/00183 -120- Table 237: A method of controlling representatives of the genus Thrips comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 238: A method of controlling Scirtothrips aurantii comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 239: A method of controlling representatives of the genus Aceria comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 240: A method of controlling representatives of the genus Aculus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 241: A method of controlling representatives of the genus Brevipalpus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 242: A method of controlling representatives of the genus Panonychus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 243: A method of controlling representatives of the genus Phyllocoptruta comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 244: A method of controlling representatives of the genus Tetranychus comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination WO 99/35913 PCT/EP99/00183 -121of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 245: A method of controlling representatives of the genus Heterodera comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 246: A method of controlling representatives of the genus Meloidogyne comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Table 247: A method of controlling Mamestra brassica comprising the application of Ti-435 to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to anyone of the lines C.1 to C.108 of table C.
Example B1: Action against Anthonomus grandis adults. Spodoptera littoralis or Heliothis virescens Young transgenic cotton plants which express the S-endotoxin CrylllA are sprayed with an aqueous emulsion spray mixture comprising 100, 50,10, 5, 1 ppm of imidacloprid respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising imidacloprid and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.
In this test, the control of the tested insects in the transgenic plant is superior to the control on the non-transgenic plant.
Example B2: Action against Anthonomus grandis adults. SDodoDtera littoralis or Heliothis virescens WO 99/35913 PCT/EP99/001 83 -122- Young transgenic cotton plants which express the 8-endotoxin CrylllA are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of thiamethoxam respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising thiamethoxam and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.
In this test, the control of the tested insects in the transgenic plant is superior, while it is insufficient in the non-transgenic plant.
Example B3: Action against Anthonomus grandis adults. Spodoptera littoralis or Heliothis virescens Young transgenic cotton plants which express the 8-endotoxin CrylllA are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of Ti-435 respectively.
After the spray coating has dried on, the cotton plants are populated with 10 adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising Ti-435 and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.
In this test, the control of the tested insects in the transgenic plant is superior, while it is insufficient in the non-transgenic plant.
Example B4: Action against Anthonomus grandis adults. Spodoptera littoralis or Heliothis virescens Young transgenic cotton plants which express the 8-endotoxin Cryla(c) are sprayed with an aqueous emulsion spray mixture comprising 100, 50,10, 5, 1 ppm of Ti-435 respectively.
After the spray coating has dried on, the cotton plants are populated with 10 adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae WO 99/35913 PCT/EP99/00183 -123respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising Ti-435 and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.
In this test, the controi of the tested insects in the transgenic plant is superior, while it is insufficient in the non-transgenic plant.
Example B5: Action against Anthonomus grandis adults. Spodoptera littoralis or Heliothis virescens Young transgenic cotton plants which express the 8-endotoxin Cryla(c) are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of thiamethoxam respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising thiamethoxam and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.
In this test, the control of the tested insects in the transgenic plant is superior, while it is insufficient in the non-transgenic plant.
Example B6: Action against Anthonomus grandis adults. Spodootera littoralis or Heliothis virescens Young transgenic cotton plants which express the -endotoxin Cryla(c) are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of imidacloprid respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants WO 99/35913 PCT/EP99/00183 -124which have been treated with an emulsion spray mixture comprising imidacloprid conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.
In this test, the control of the tested insects in the transgenic plant is superior, while it is insufficient in the non-transgenic plant.
Example B7: Action against Ostrinia nubilalis. Spodoptera spp. or Heliothis spp.
A plot planted with maize cv. KnockOut® and an adjacent plot of the same size which is planted with conventional maize, both showing natural infestation with Ostrinia nubilalis. Spodoptera spp. or Heliothis, are sprayed with an aqueous emulsion spray mixture comprising 200, 100, 50, 10, 5, 1ppm of Ti-435. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 200, 100, 50, 10, 5, 1 ppm of the endotoxin expressed by KnockOut®. Evaluation takes place 6 days later. The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Ostrinia nubilalis. Spodoptera spp. or Heliothis is observed on the plants of plot while plot shows a control level of not over Example B8: Action against Ostrinia nubilalis. Spodoptera spp. or Heliothis spD.
A plot planted with maize cv. KnockOut® and an adjacent plot of the same size which is planted with conventional maize, both showing natural infestation with Ostrinia nubilalis, Spodoptera spp. or Heliothis, are sprayed with an aqueous emulsion spray mixture comprising 200, 100, 50, 10, 5, 1ppm of thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 200, 100, 50, 10, 5, 1 ppm of the endotoxin expressed by KnockOut®. Evaluation takes place 6 days later. The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Ostrinia nubilalis, Spodoptera spp. or Heliothis is observed on the plants of plot while plot shows a control level of not over Example B9: Action against Ostrinia nubilalis, Soodoptera spp. or Heliothis spp.
A plot planted with maize cv. KnockOut® and an adjacent plot of the same size which is planted with conventional maize, both showing natural infestation with Ostrinia nubilalis. Spodoptera spp. or Heliothis, are sprayed with an aqueous emulsion spray mixture WO 99/35913 PCT/EP99/00183 -125comprising 200, 100, 50, 10, 5, 1ppm of imidacloprid. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 200, 100, 50, 10, 5, 1 ppm of the endotoxin expressed by KnockOut®. Evaluation takes place 6 days later. The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Ostrinia nubilalis. Spodoptera spD. or Heliothis spp. is observed on the plants of plot while plot snows a control level of not over Example B10: Action against Diabrotica balteata A plot planted with maize seedlings cv. KnockOut® and an adjacent plot of the same size which is planted with conventional maize are sprayed with an aqueous emulsion of a spray mixture comprising 400 ppm thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the endotoxin expressed by KnockOut@. After the spray coating has dried on, the seedlings are populated with Diabrotica balteata larvae in the second stage and transferred to a plastic container. The test is evaluated 6 days later. The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Diabrotica balteata is observed on the plants of plot while plot (b) shows a control level of not over Example B11: Action against Aphis oossypii Cotton seedlings on a plot expressing the 6-endotoxin Cryllla on a plot and conventional cotton seedlings on a plot are infected with Aphis gossypi and subsequently sprayed with a spray mixture comprising 400 ppm thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the Cryllla. The seedlings of plot and are then incubated at 20"C. The test is evaluated after 3 and 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Aphis gossypi is observed on the plants of plot while plot shows a control level of not over WO 99/35913 PCT/EP99/00183 -126- Example 812: Action against Frankliniella occidentalis Cotton seedlings expressing the 6-endotoxin Cryllta on a plot and conventional cotton seedlings on a plot are infected with Frankliniella occidentalis and subsequently sprayed with a spray mixture comprising 400 ppm thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the 6-endotoxin Cryllla. The seedlings of plot and are then incubated at 20 0 C. The test is evaluated after 3 and 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Frankliniella occidentalis is observed on the plants of plot while plot shows a control level of not over Example B13: Action against Aphis gossypii Cotton seedlings expressing the 6-endotoxin CrylA(c) on a plot and conventional cotton seedlings on a plot are infected with Aphis gossypii and subsequently sprayed with a spray mixture comprising 400 ppm thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the 6-endotoxin Cryllla. The seedlings of plot and are then incubated at 20"C. The test is evaluated after 3 and 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Aphis aossypii is observed on the plants of plot while plot shows a control level of not over Example B14: Action against Frankliniella occidentalis Cotton seedlings expressing the 8-endotoxin Cryla(c) on a plot and conventional cotton seedlings on a plot are infected with Frankliniella occidentalis and subsequently sprayed with a spray mixture comprising 400 ppm thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the 6-endotoxin Cryla(c). The seedlings of plot and are then incubated at 20 0 C. The test is evaluated after 3 and 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of WO 99/35913 PCT/EP99/00183 -127- Frankliniella occidentalis is observed on the plants of plot while plot shows a control level of not over Example B15: Action against Neohotettix cincticeps Rice plants on a plot expressing the -endotoxin CrylA(b) and conventional rice plants on a plot are sprayed with a spray mixture comprising 400 ppm thiamethoxam.
Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the 8-endotoxin CrylA(b). After the spray coating has dried on, the plants are infected with Nephotettix cincticeps of the 2nd and 3rd stages. The seedlings of plot and are then incubated at 20 0 C. The test is evaluated after 21 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Nephotettix cincticeps is observed on the plants of plot while plot shows a control level of not over Example B16: Action against Nephotettix cincticeps (systemic) Rice plants expressing the 8-endotoxin Cryla(b) are planted in a in pot and conventional ice plants are planted in a pot Pot is placed in an aqueous emulsion containing 400 ppm thiamethoxam, whereas plot is placed in a pot containing 400 ppm thiamethoxam and 400 ppm of the S-endotoxin Cryl(b). The plants are subsequently infected with Nephotettix cincticeps larvae of the second and third stage. The test is evaluated after 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of pot with that on the plants of pot Improved control of Nephotettix cincticeps is observed on the plants of pot while pot shows a control level of not over Example B17: Action against Nilaparvata luqens Rice plants on a plot expressing the S-endotoxin CrylA(b) and conventional rice plants on a plot are infected with Nilaparvata lugens, subsequently sprayed with a spray mixture comprising 400 ppm thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the S-endotoxin CrylA(b). The seedlings of plot and are then incubated at 20*C. The test is evaluated after 21 days.
WO 99/35913 PCT/EP99/001 83 -128- The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Nilaparvata luaens is observed on the plants of plot while plot shows a control level of not over Example B18: Action against Nilaparvata luaens (systemic) Rice plants expressing the &endotoxin CrylA(b) are planted in a in pot and conventional rice plants are planted in a pot Pot is placed in an aqueous emulsion containing 400 ppm thiamethoxam, whereas plot is place in a pot copntaining 400 ppm thiamethoxam and 400 ppm of the 5-endotoxin CrylA(b). The plants are subsequently infected with Nilaparvata lugens larvae of the second and third stage. The test is evaluated after 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of pot with that on the plants of pot Improved control of Nephotettix cincticeps is observed on the plants of pot while pot shows a control level of not over Example B19: Action against Nephotettix cincticeps Rice plants on a plot expressing the 5-endotoxin CrylA(c) and conventional rice plants on a plot are sprayed with a spray mixture comprising 400 ppm thiamethoxam.
Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the S-endotoxin CrylA(c). After the spray coating has dried on, the plants are infected with Nephotettix cincticeps of the 2nd and 3rd stages. The seedlings of plot and are then incubated at 20 0 C. The test is evaluated after 21 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Nephotettix cincticeps is observed on the plants of plot while plot shows a control level of not over Example B20: Action against Nephotettix cincticeps (systemic) Rice plants expressing the 8-endotoxin Cryla(c) are planted in a in pot and conventional ice plants are planted in a pot Pot is placed in an aqueous emulsion containing 400 ppm thiamethoxam, whereas plot is placed in a pot containing 400 ppm thiamethoxam and 400 ppm of the 8-endotoxin Cryl(c). The plants are subsequently infected with WO 99/35913 PCT/EP99/00183 -129- Nephotettix cincticeps larvae of the second and third stage. The test is evaluated after 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of pot with that on the plants of pot Improved control of Nephotettix cincticeps is observed on the plants of pot while pot shows a control level of not over Example B21: Action against Nilaparvata luoens Rice plants on a plot expressing the 5-endotoxin CrylA(c) and conventional rice plants on a plot are infected with Nilaparvata luqens, subsequently sprayed with a spray mixture comprising 400 ppm thiamethoxam. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 400 ppm of the 8-endotoxin CrylA(c). The seedlings of plot and are then incubated at 20 0 C. The test is evaluated after 21 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Nilaparvata luqens is observed on the plants of plot while plot shows a control level of not over 0%.
Example B22: Action against Nilaoarvata lugens (systemic) Rice plants expressing the -endotoxin CrylA(c) are planted in a in pot and conventional rice plants are planted in a pot Pot is placed in an aqueous emulsion containing 400 ppm thiamethoxam, whereas plot is place in a pot copntaining 400 ppm thiamethoxam and 400 ppm of the -endotoxin CrylA(c). The plants are subsequently infected with Nilaparvata luaens larvae of the second and third stage. The test is evaluated after 6 days.
The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of pot with that on the plants of pot Improved control of Nephotettix cincticeps is observed on the plants of pot while pot shows a control level of not over 60 17b99 spe doc-13/12/01 129A- The reference to any prior art in this specification is not, and should not be taken as, an acknowledgment or any form of suggestion that that prior art forms part of the common general knowledge in Australia.
Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.
e go o*o o•*

Claims (1)

176-99 sp doc-.3/12,01 130- THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS: 1. Method of controlling pests in crops of transgenic useful plants, wherein a pesticidal composition comprising 0.1 to 99% per weight of a compound selected from the group consisting of Thiamethoxam, Thiacloprid and Clothiamidin in free form or in agrochemically useful salt form as active ingredient and 1 to 99.9% per weight of at least one auxiliary is applied to the pests or their environment. 2. Method according to claim 1, wherein thiamethoxam is employed. V 3. Method according to claim 1, wherein the transgenic plant is treated. 4. Method according to any one of claims 1 to 3, wherein the transgenic crop of useful plants is maize. 5. Method according to any one of claims 1 to 3, wherein the transgenic crop of useful plants is soya beans. 6. Method according to claim 3, wherein the propagation material of the transgenic 20 useful plant is treated. 7. A method according to claim 1 substantially herein before described with reference to the examples. Dated this 12 th day of December 2001 Novartis AG DAVIES COLLISON CAVE Patent attorneys for the applicant(s)
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