AU741041B2 - DNA encoding galanin GALR3 receptors and uses thereof - Google Patents

DNA encoding galanin GALR3 receptors and uses thereof Download PDF

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Publication number
AU741041B2
AU741041B2 AU48125/97A AU4812597A AU741041B2 AU 741041 B2 AU741041 B2 AU 741041B2 AU 48125/97 A AU48125/97 A AU 48125/97A AU 4812597 A AU4812597 A AU 4812597A AU 741041 B2 AU741041 B2 AU 741041B2
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AU
Australia
Prior art keywords
receptor
galr3 receptor
galr3
cell
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU48125/97A
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English (en)
Other versions
AU4812597A (en
Inventor
Jonathan A Bard
Beth Borowsky
Theresa A Branchek
Christophe P.G. Gerald
Kenneth A. Jones
Kelli E Smith
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H Lundbeck AS
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Synaptic Pharmaceutical Corp
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Publication date
Application filed by Synaptic Pharmaceutical Corp filed Critical Synaptic Pharmaceutical Corp
Publication of AU4812597A publication Critical patent/AU4812597A/en
Application granted granted Critical
Publication of AU741041B2 publication Critical patent/AU741041B2/en
Assigned to H. LUNDBECK A/S reassignment H. LUNDBECK A/S Alteration of Name(s) in Register under S187 Assignors: SYNAPTIC PHARMACEUTICAL CORPORATION
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU48125/97A 1996-10-09 1997-10-09 DNA encoding galanin GALR3 receptors and uses thereof Ceased AU741041B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US72813996A 1996-10-09 1996-10-09
US08/728139 1996-10-09
US76796496A 1996-12-17 1996-12-17
US08/767964 1996-12-17
US78726197A 1997-01-24 1997-01-24
US08/787261 1997-01-24
US08/900,230 US6329197B2 (en) 1996-10-09 1997-07-23 DNA encoding galanin GALR3 receptors and uses thereof
US08/900230 1997-07-23
PCT/US1997/018222 WO1998015570A1 (en) 1996-10-09 1997-10-09 Dna encoding galanin galr3 receptors and uses thereof

Publications (2)

Publication Number Publication Date
AU4812597A AU4812597A (en) 1998-05-05
AU741041B2 true AU741041B2 (en) 2001-11-22

Family

ID=27505578

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48125/97A Ceased AU741041B2 (en) 1996-10-09 1997-10-09 DNA encoding galanin GALR3 receptors and uses thereof

Country Status (8)

Country Link
US (5) US6329197B2 (https=)
EP (1) EP0956291A4 (https=)
JP (1) JP2002514055A (https=)
AU (1) AU741041B2 (https=)
CA (1) CA2248222A1 (https=)
DE (1) DE956291T1 (https=)
ES (1) ES2151465T1 (https=)
WO (1) WO1998015570A1 (https=)

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US6329197B2 (en) * 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
US20030119096A1 (en) * 1997-01-24 2003-06-26 Bard Jonathan A. Method of treating an abnormality using a GALR3 receptor antagonist
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6693182B1 (en) * 1997-08-22 2004-02-17 Schering Corporation Mammalian galanin receptors
US6733990B1 (en) 1999-08-03 2004-05-11 Millennium Pharmaceuticals, Inc. Nucleic acid encoding 15571, a GPCR-like molecule of the secretin-like family
EP1037913A4 (en) * 1997-12-17 2002-11-20 Merck & Co Inc GALANINE RECEPTOR GALR3 AND NUCLEOTIDES CODING THEM
AU4728599A (en) 1998-06-30 2000-01-17 Millennium Pharmaceuticals, Inc. 14273 receptor, a g-protein coupled receptor
US7534579B2 (en) 1998-06-30 2009-05-19 Millennium Pharmaceuticals, Inc. 14273 receptor, a novel G-protein coupled receptor
US6395877B1 (en) 1998-06-30 2002-05-28 Millennium Pharmaceuticals, Inc. 14273 receptor, a novel G-protein coupled receptor
US6448005B1 (en) 1998-06-30 2002-09-10 Millennium Pharmaceuticals, Inc. 14723 Receptor, a novel G-protein coupled receptor
US6221613B1 (en) 1998-12-31 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
WO2001087930A2 (en) * 2000-05-18 2001-11-22 Bayer Aktiengesellschaft Human galanin receptor-like g protein coupled receptor
BR0206844A (pt) 2001-01-31 2005-07-12 Synaptic Pharma Corp Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos
US7081470B2 (en) * 2001-01-31 2006-07-25 H. Lundbeck A/S Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
US20040127502A1 (en) * 2001-01-31 2004-07-01 Synaptic Pharmaceutical Corporation Use of GAL3 antagonist for treatment of depression
CA2459183A1 (en) * 2001-08-27 2003-03-06 Tularik Inc. Amplified oncogenes and their involvement in cancer
US7220775B2 (en) 2002-08-07 2007-05-22 H. Lundbeck A/S Compound useful for the treatment of neuropathic pain
US7642281B2 (en) * 2002-08-07 2010-01-05 Helicon Therapeutics, Inc. Indolone compounds useful to treat cognitive impairment
AU2003259759A1 (en) * 2002-08-07 2004-02-25 Synaptic Pharmaceutical Corporation Gal3 receptor antagonists for the treatment of affective disorders
WO2006047302A1 (en) * 2004-10-21 2006-05-04 Transtech Pharma, Inc. Bissulfonamide compounds as agonists of galr1, compositions, and methods of use
EP2636756B2 (en) 2008-05-27 2019-11-20 Dako Denmark A/S Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers
EP2401396B1 (en) 2009-02-26 2016-11-23 Dako Denmark A/S Methods for performing a stringent wash step in hybridization applications
US20100284977A1 (en) * 2009-04-28 2010-11-11 University Of South Carolina Expression of Anti-Nociceptive Compounds from Endogenously Regulated Promoters
KR101652737B1 (ko) * 2010-12-03 2016-09-01 가부시키가이샤 쓰무라 대건중탕의 생물학적 검정 방법 및 이것을 사용하는 품질관리 방법
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
EP2768974B1 (en) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridization compositions and methods
WO2013109713A1 (en) * 2012-01-18 2013-07-25 The General Hospital Corporation Targeting rnas to microvesicles
KR101514440B1 (ko) * 2013-12-13 2015-04-22 고려대학교 산학협력단 갈라닌 수용체 3형의 리간드로서 스펙신의 용도
CN113512592A (zh) * 2021-04-23 2021-10-19 中国科学院深圳先进技术研究院 用于检测甘丙肽分泌细胞的引物、探针以及试剂盒
CN120583955A (zh) * 2022-11-29 2025-09-02 纽洛可科学有限公司 Galr2激动剂治疗消化道病症和/或内分泌病症的用途

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WO1995022608A1 (fr) * 1994-02-17 1995-08-24 Rhone-Poulenc Rorer S.A. Recepteur galanine, acides nucleiques, cellules transformees et utilisations

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US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
JPH06510363A (ja) 1990-10-29 1994-11-17 ディカルブ　プラント　ジェネティクス 磁気性粒子を使用する生物学的材料の単離
WO1992012997A1 (en) 1991-01-16 1992-08-06 The General Hospital Corporation Human galanin
WO1992015015A1 (en) 1991-02-25 1992-09-03 Zymogenetic, Inc. Methods for detecting galanin antagonists
DE69225706T2 (de) 1991-03-06 1998-11-26 Garvan Institute Of Medical Research, Darlinghurst, Neu Sued Wales/New South Wales Humanes galanin, cdna-klone die für humanes galanin kodieren und eine methode humanes galamin herzustellen
US5576296A (en) 1991-05-15 1996-11-19 Aktiebolaget Astra Galanin antagonist
SE9101472D0 (sv) 1991-05-15 1991-05-15 Trion Forskning & Utveckling Galanin antagonist
US5436155A (en) 1991-12-31 1995-07-25 Arch Development Corporation Isolated DNA encoding a somatostatin receptor
US5290808A (en) 1992-11-06 1994-03-01 Carter-Wallace, Inc. Method to control the intake of food
EP0711830A3 (en) 1994-10-13 1997-06-11 Takeda Chemical Industries Ltd Murine and human galanin receptor
US6562862B1 (en) 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
US6410686B1 (en) 1996-06-05 2002-06-25 Bayer Corporation Galanin receptor 2 protein
SE9602822D0 (sv) 1996-07-19 1996-07-19 Astra Pharma Inc New receptor
DE69739760D1 (de) 1996-07-24 2010-03-25 Neurotargets Ltd Verwendung eines Galanin-agonisten in der Herstellung eines Medikaments zur Verbesserung des Gedächtnisses und anderer cognitiver Funktionen
US6329197B2 (en) * 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
EP1037913A4 (en) 1997-12-17 2002-11-20 Merck & Co Inc GALANINE RECEPTOR GALR3 AND NUCLEOTIDES CODING THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022608A1 (fr) * 1994-02-17 1995-08-24 Rhone-Poulenc Rorer S.A. Recepteur galanine, acides nucleiques, cellules transformees et utilisations

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
US6287788B1 (en) 2001-09-11
JP2002514055A (ja) 2002-05-14
US20010009766A1 (en) 2001-07-26
DE956291T1 (de) 2001-05-23
CA2248222A1 (en) 1998-04-16
EP0956291A4 (en) 2002-10-24
US7022489B2 (en) 2006-04-04
US20030027254A1 (en) 2003-02-06
EP0956291A1 (en) 1999-11-17
WO1998015570A1 (en) 1998-04-16
US6368812B1 (en) 2002-04-09
US20030082641A1 (en) 2003-05-01
AU4812597A (en) 1998-05-05
US6329197B2 (en) 2001-12-11
ES2151465T1 (es) 2001-01-01

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: H. LUNDBECK A/S

Free format text: FORMER OWNER WAS: SYNAPTIC PHARMACEUTICAL CORPORATION