AU734950B2 - Ceramic fusion implants and compositions containing osteoinductive factors - Google Patents

Ceramic fusion implants and compositions containing osteoinductive factors Download PDF

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Publication number
AU734950B2
AU734950B2 AU49851/97A AU4985197A AU734950B2 AU 734950 B2 AU734950 B2 AU 734950B2 AU 49851/97 A AU49851/97 A AU 49851/97A AU 4985197 A AU4985197 A AU 4985197A AU 734950 B2 AU734950 B2 AU 734950B2
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Prior art keywords
ceramic
bmp
carrier
bone
implant
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Expired
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AU49851/97A
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English (en)
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AU4985197A (en
Inventor
William F. Mckay
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Warsaw Orthopedic Inc
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SDGI Holdings Inc
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Assigned to WARSAW ORTHOPEDIC, INC. reassignment WARSAW ORTHOPEDIC, INC. Alteration of Name(s) in Register under S187 Assignors: SDGI HOLDINGS, INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0082—Three-dimensional shapes parallelepipedal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
AU49851/97A 1996-10-24 1997-10-20 Ceramic fusion implants and compositions containing osteoinductive factors Expired AU734950B2 (en)

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US2901196P 1996-10-24 1996-10-24
US60/029011 1996-10-24
PCT/US1997/018692 WO1998017330A1 (en) 1996-10-24 1997-10-20 Ceramic fusion implants and compositions containing osteoinductive factors

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JP (2) JP2000508221A (de)
KR (1) KR20000052723A (de)
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AU (1) AU734950B2 (de)
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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033438A (en) 1997-06-03 2000-03-07 Sdgi Holdings, Inc. Open intervertebral spacer
KR100563476B1 (ko) * 1998-07-03 2006-03-27 이진용 골재생재료
JP4156197B2 (ja) * 1998-08-06 2008-09-24 ウォーソー・オーソペディック・インコーポレーテッド 複合型椎骨間スペーサ
US6174311B1 (en) 1998-10-28 2001-01-16 Sdgi Holdings, Inc. Interbody fusion grafts and instrumentation
JP3974276B2 (ja) 1998-11-30 2007-09-12 ペンタックス株式会社 セラミックス複合体の製造方法およびセラミックス複合体
DE60020526T2 (de) 1999-02-04 2006-05-11 SDGI Holdings, Inc., Wilmington Osteogene pastenzusammensetzungen und ihre verwendung
ATE253385T1 (de) 1999-02-04 2003-11-15 Sdgi Holdings Inc Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
US8226729B2 (en) 2000-10-24 2012-07-24 Warsaw Orthopedic, Inc. Spinal fusion methods and devices
SE514342C2 (sv) * 1999-05-31 2001-02-12 Nobel Biocare Ab Metod, anordning och användning vid implantat för att tillförsäkra tillförsel av bioaktiv substans till implantatets omgivande ben och/eller vävnad
DE19944681A1 (de) * 1999-08-20 2001-03-01 Metz Stavenhagen Peter Knochenersatzstoff zur Implantation im menschlichen oder tierischen Körper
JP4172883B2 (ja) 1999-09-08 2008-10-29 Ｈｏｙａ株式会社 薬物徐放用担体および薬物徐放用担体の製造方法
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
JP4790917B2 (ja) * 2001-02-23 2011-10-12 独立行政法人科学技術振興機構 人工椎体
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US7722895B1 (en) 2004-09-20 2010-05-25 Warsaw Orthopedic, Inc. Osteogenic implants with combined implant materials, and materials and methods for same
US7780709B2 (en) * 2005-04-12 2010-08-24 Warsaw Orthopedic, Inc. Implants and methods for inter-transverse process dynamic stabilization of a spinal motion segment
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
WO2008101300A1 (en) * 2007-02-23 2008-08-28 Cellixe Pty Ltd Composition and method for the treatment or prevention of spinal disorders
EP2162283B1 (de) 2007-06-14 2015-08-12 Massachusetts Institute of Technology Selbstaufbauende filme für protein- und arzneimittelabgabeanwendungen
EP2143451A1 (de) 2008-07-11 2010-01-13 Nobel Biocare Services AG Knochenimplantat-Anwendung
KR101109431B1 (ko) * 2008-10-13 2012-02-15 (주) 코웰메디 다공성 인산삼칼슘계 과립의 제조 방법 및 이를 이용한 기능성 골이식재의 제조방법
AU2009307024B2 (en) * 2008-10-21 2015-09-03 Ww Technology Ag Fusion device and tool set for fusing a human or animal joint
ES2342707B1 (es) * 2008-12-31 2011-06-10 Universidad De Malaga Proteina morfogenetica de hueso-2 (bmp-2) con un dominio de union especifico a colageno tipo i, procedimiento de obtencion y aplicaciones.
EP2529764A1 (de) * 2011-05-31 2012-12-05 Curasan AG Biologisch degradierbares kompositmaterial
RU2496452C2 (ru) * 2011-12-01 2013-10-27 Общество с ограниченной ответственностью "НЭВЗ-Н" Устройство для стабилизации сегментов позвоночника
KR101479812B1 (ko) 2011-12-30 2015-01-08 고려대학교 산학협력단 척추골 유합 와셔 및 이를 이용한 척추경 나사못
WO2013110047A1 (en) * 2012-01-20 2013-07-25 Massachusetts Institute Of Technology Compositions and methods for coating
EP2841056A4 (de) 2012-04-23 2015-09-16 Massachusetts Inst Technology Stabile schichtweise beschichtete teilchen
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306303A (en) * 1991-11-19 1994-04-26 The Medical College Of Wisconsin, Inc. Bone induction method
WO1996040014A1 (en) * 1995-06-07 1996-12-19 Sdgi Holdings, Inc. Reinforced porous spinal implants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
SE469653B (sv) * 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
CA2119090A1 (en) * 1993-03-26 1994-09-27 Wayne R. Gombotz Compositions for controlled release of biologically active tgf-.beta.
JP3424049B2 (ja) * 1994-03-09 2003-07-07 山之内製薬株式会社 骨形成用移植体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306303A (en) * 1991-11-19 1994-04-26 The Medical College Of Wisconsin, Inc. Bone induction method
WO1996040014A1 (en) * 1995-06-07 1996-12-19 Sdgi Holdings, Inc. Reinforced porous spinal implants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TOTH JM ET AL:VOL.20,SPINE,NO.20,15/10/95,2203-2210 *

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AU4985197A (en) 1998-05-15
CA2269254A1 (en) 1998-04-30
EP0934087A1 (de) 1999-08-11
WO1998017330A1 (en) 1998-04-30
JP4607841B2 (ja) 2011-01-05
EP0934087B1 (de) 2007-03-21
ATE357264T1 (de) 2007-04-15
JP2000508221A (ja) 2000-07-04
KR20000052723A (ko) 2000-08-25
CA2269254C (en) 2008-12-02
DE69737504T2 (de) 2007-11-29
DE69737504D1 (de) 2007-05-03
JP2007061639A (ja) 2007-03-15

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