AU731703B2 - Pseudomonas exotoxin A-like chimeric immunogens - Google Patents
Pseudomonas exotoxin A-like chimeric immunogensInfo
- Publication number
- AU731703B2 AU731703B2 AU84813/98A AU8481398A AU731703B2 AU 731703 B2 AU731703 B2 AU 731703B2 AU 84813/98 A AU84813/98 A AU 84813/98A AU 8481398 A AU8481398 A AU 8481398A AU 731703 B2 AU731703 B2 AU 731703B2
- Authority
- AU
- Australia
- Prior art keywords
- domain
- amino acid
- immunogen
- native epitope
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
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- Veterinary Medicine (AREA)
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- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5237597P | 1997-07-11 | 1997-07-11 | |
| US60/052375 | 1997-07-11 | ||
| PCT/US1998/014341 WO1999002713A1 (en) | 1997-07-11 | 1998-07-10 | Pseudomonas exotoxin a-like chimeric immunogens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8481398A AU8481398A (en) | 1999-02-08 |
| AU731703B2 true AU731703B2 (en) | 2001-04-05 |
Family
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|---|---|---|---|
| AU84813/98A Ceased AU731703B2 (en) | 1997-07-11 | 1998-07-10 | Pseudomonas exotoxin A-like chimeric immunogens |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8092809B2 (enExample) |
| EP (1) | EP1000163B1 (enExample) |
| JP (2) | JP2001510683A (enExample) |
| AT (1) | ATE307208T1 (enExample) |
| AU (1) | AU731703B2 (enExample) |
| CA (1) | CA2295971C (enExample) |
| DE (1) | DE69831951T2 (enExample) |
| DK (1) | DK1000163T3 (enExample) |
| ES (1) | ES2249838T3 (enExample) |
| WO (1) | WO1999002713A1 (enExample) |
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| EP1078988A1 (en) * | 1999-08-27 | 2001-02-28 | Academia Sinica | Pseudomonas fusion protein vaccines |
| US6838553B1 (en) * | 1999-10-05 | 2005-01-04 | Academia Sinica | Peptide repeat immunogens |
| ATE444081T1 (de) * | 1999-10-22 | 2009-10-15 | Us Gov Health & Human Serv | Proteine-abgabe durch polare epithelzellen schichte |
| TWI293957B (en) * | 2004-07-21 | 2008-03-01 | Healthbanks Biotech Co Ltd | A superantigen fusion protein and the use thereof |
| AU2006247188A1 (en) | 2005-05-18 | 2006-11-23 | Children's Hospital & Research Center At Oakland | Methods and compositions for immunizing against chlamydia infection |
| CN101969975B (zh) * | 2008-01-31 | 2013-06-05 | 生控基因疫苗股份有限公司 | 作为疫苗的hiv嵌合融合蛋白 |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| US8932586B2 (en) | 2011-09-06 | 2015-01-13 | Intrexon Corporation | Modified forms of Pseudomonas exotoxin A |
| BR112015013183A2 (pt) * | 2012-12-05 | 2017-09-26 | Thevax Genetics Vaccine Co Ltd | proteínas de fusão para uso como aperfeiçoadores imunogênicos para indução de respostas de células t específicas para antígenos |
| WO2014172309A2 (en) | 2013-04-18 | 2014-10-23 | The United States Of America As Represented By The Secretary Of The Army, On Behalf Of The United | Therapeutic compositions for neutralizing type i interferons, and methods of use |
| DK3302543T3 (da) * | 2015-06-01 | 2020-05-18 | Reber Genetics Co Ltd | Vaccinesammensætninger mod porcint reproduktions- og respirationssyndrom og porcint circovirus-associerede sygdomme |
| EP4316586A3 (en) | 2018-03-08 | 2024-05-08 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| JP7487193B2 (ja) | 2018-11-07 | 2024-05-20 | アプライド モレキュラー トランスポート インコーポレイテッド | 異種ペイロードの経口送達のためのコリックス由来担体 |
Citations (1)
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| EP0439954A2 (en) * | 1989-12-22 | 1991-08-07 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
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| US4545985A (en) | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
| US6022950A (en) | 1984-06-07 | 2000-02-08 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
| US5668255A (en) | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
| CA1289880C (en) | 1985-12-06 | 1991-10-01 | Jeffrey L. Winkelhake | Anti-human ovarian cancer immunotoxins and methods of use thereof |
| US5082927A (en) | 1986-09-24 | 1992-01-21 | The United States Of America As Represented By The Department Of Health And Human Services | Selectively cytotoxic IL-4-PE40 fusion protein |
| US6051405A (en) | 1986-09-24 | 2000-04-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Constructs encoding recombinant antibody-toxin fusion proteins |
| US4892827A (en) | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| US5206353A (en) | 1988-07-23 | 1993-04-27 | The United States Of America As Represented By The Department Of Health And Human Services | CD-4/cytotoxic gene fusions |
| CA1340530C (en) | 1989-04-28 | 1999-05-04 | Kok Kheong Lee | Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics |
| US5980896A (en) | 1989-06-30 | 1999-11-09 | Bristol-Myers Squibb Company | Antibodies reactive with human carcinomas |
| US6020145A (en) | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
| US5458878A (en) | 1990-01-02 | 1995-10-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | P. exotoxin fusio proteins have COOHG220101al alterations which increase cytotoxicity |
| AU646673B2 (en) | 1990-05-11 | 1994-03-03 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Improved pseudomonas exotoxins of low animal toxicity and high cytocidal activity |
| US5608039A (en) | 1990-10-12 | 1997-03-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Single chain B3 antibody fusion proteins and their uses |
| US6099842A (en) | 1990-12-03 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin |
| US5328984A (en) * | 1991-03-04 | 1994-07-12 | The United States As Represented By The Department Of Health & Human Services | Recombinant chimeric proteins deliverable across cellular membranes into cytosol of target cells |
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| ATE314475T1 (de) | 1992-06-18 | 2006-01-15 | Us Gov Health & Human Serv | Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität |
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| US8877714B2 (en) * | 2005-06-14 | 2014-11-04 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof |
| DK2308514T3 (da) * | 2007-03-23 | 2013-09-02 | To Bbb Holding B V | Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren |
| WO2008124010A1 (en) * | 2007-04-06 | 2008-10-16 | The Trustees Of The University Of Pennsylvania | Surfactant protein d is a biomarker for steroid responsiveness in asthma and chronic obstructive pulmonary disease |
-
1998
- 1998-07-10 AT AT98935604T patent/ATE307208T1/de active
- 1998-07-10 WO PCT/US1998/014341 patent/WO1999002713A1/en not_active Ceased
- 1998-07-10 ES ES98935604T patent/ES2249838T3/es not_active Expired - Lifetime
- 1998-07-10 DE DE69831951T patent/DE69831951T2/de not_active Expired - Lifetime
- 1998-07-10 AU AU84813/98A patent/AU731703B2/en not_active Ceased
- 1998-07-10 DK DK98935604T patent/DK1000163T3/da active
- 1998-07-10 CA CA2295971A patent/CA2295971C/en not_active Expired - Fee Related
- 1998-07-10 JP JP2000502207A patent/JP2001510683A/ja active Pending
- 1998-07-10 EP EP98935604A patent/EP1000163B1/en not_active Expired - Lifetime
-
2007
- 2007-12-20 US US11/962,007 patent/US8092809B2/en not_active Expired - Fee Related
-
2008
- 2008-12-11 JP JP2008316284A patent/JP2009079068A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0439954A2 (en) * | 1989-12-22 | 1991-08-07 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69831951T2 (de) | 2006-07-27 |
| JP2009079068A (ja) | 2009-04-16 |
| ATE307208T1 (de) | 2005-11-15 |
| AU8481398A (en) | 1999-02-08 |
| US20090269368A1 (en) | 2009-10-29 |
| DK1000163T3 (da) | 2006-02-06 |
| EP1000163B1 (en) | 2005-10-19 |
| CA2295971A1 (en) | 1999-01-21 |
| US8092809B2 (en) | 2012-01-10 |
| JP2001510683A (ja) | 2001-08-07 |
| DE69831951D1 (de) | 2006-03-02 |
| CA2295971C (en) | 2011-02-08 |
| WO1999002713A1 (en) | 1999-01-21 |
| ES2249838T3 (es) | 2006-04-01 |
| EP1000163A1 (en) | 2000-05-17 |
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| FGA | Letters patent sealed or granted (standard patent) |