ATE307208T1 - Pseudomonas exotoxin-a-ähnliche chimerische immunogene - Google Patents

Pseudomonas exotoxin-a-ähnliche chimerische immunogene

Info

Publication number
ATE307208T1
ATE307208T1 AT98935604T AT98935604T ATE307208T1 AT E307208 T1 ATE307208 T1 AT E307208T1 AT 98935604 T AT98935604 T AT 98935604T AT 98935604 T AT98935604 T AT 98935604T AT E307208 T1 ATE307208 T1 AT E307208T1
Authority
AT
Austria
Prior art keywords
pseudomonas exotoxin
chimeric immunogens
immunogens
chimeric
exotoxin
Prior art date
Application number
AT98935604T
Other languages
German (de)
English (en)
Inventor
David J Fitzgerald
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE307208T1 publication Critical patent/ATE307208T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98935604T 1997-07-11 1998-07-10 Pseudomonas exotoxin-a-ähnliche chimerische immunogene ATE307208T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5237597P 1997-07-11 1997-07-11
PCT/US1998/014341 WO1999002713A1 (en) 1997-07-11 1998-07-10 Pseudomonas exotoxin a-like chimeric immunogens

Publications (1)

Publication Number Publication Date
ATE307208T1 true ATE307208T1 (de) 2005-11-15

Family

ID=21977213

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98935604T ATE307208T1 (de) 1997-07-11 1998-07-10 Pseudomonas exotoxin-a-ähnliche chimerische immunogene

Country Status (10)

Country Link
US (1) US8092809B2 (enExample)
EP (1) EP1000163B1 (enExample)
JP (2) JP2001510683A (enExample)
AT (1) ATE307208T1 (enExample)
AU (1) AU731703B2 (enExample)
CA (1) CA2295971C (enExample)
DE (1) DE69831951T2 (enExample)
DK (1) DK1000163T3 (enExample)
ES (1) ES2249838T3 (enExample)
WO (1) WO1999002713A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1078988A1 (en) * 1999-08-27 2001-02-28 Academia Sinica Pseudomonas fusion protein vaccines
US6838553B1 (en) * 1999-10-05 2005-01-04 Academia Sinica Peptide repeat immunogens
ATE444081T1 (de) * 1999-10-22 2009-10-15 Us Gov Health & Human Serv Proteine-abgabe durch polare epithelzellen schichte
TWI293957B (en) * 2004-07-21 2008-03-01 Healthbanks Biotech Co Ltd A superantigen fusion protein and the use thereof
AU2006247188A1 (en) 2005-05-18 2006-11-23 Children's Hospital & Research Center At Oakland Methods and compositions for immunizing against chlamydia infection
CN101969975B (zh) * 2008-01-31 2013-06-05 生控基因疫苗股份有限公司 作为疫苗的hiv嵌合融合蛋白
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
US8932586B2 (en) 2011-09-06 2015-01-13 Intrexon Corporation Modified forms of Pseudomonas exotoxin A
BR112015013183A2 (pt) * 2012-12-05 2017-09-26 Thevax Genetics Vaccine Co Ltd proteínas de fusão para uso como aperfeiçoadores imunogênicos para indução de respostas de células t específicas para antígenos
WO2014172309A2 (en) 2013-04-18 2014-10-23 The United States Of America As Represented By The Secretary Of The Army, On Behalf Of The United Therapeutic compositions for neutralizing type i interferons, and methods of use
DK3302543T3 (da) * 2015-06-01 2020-05-18 Reber Genetics Co Ltd Vaccinesammensætninger mod porcint reproduktions- og respirationssyndrom og porcint circovirus-associerede sygdomme
EP4316586A3 (en) 2018-03-08 2024-05-08 Applied Molecular Transport Inc. Toxin-derived delivery constructs for oral delivery
JP7487193B2 (ja) 2018-11-07 2024-05-20 アプライド モレキュラー トランスポート インコーポレイテッド 異種ペイロードの経口送達のためのコリックス由来担体

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545985A (en) 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
US6022950A (en) 1984-06-07 2000-02-08 Seragen, Inc. Hybrid molecules having translocation region and cell-binding region
US5668255A (en) 1984-06-07 1997-09-16 Seragen, Inc. Hybrid molecules having translocation region and cell-binding region
CA1289880C (en) 1985-12-06 1991-10-01 Jeffrey L. Winkelhake Anti-human ovarian cancer immunotoxins and methods of use thereof
US5082927A (en) 1986-09-24 1992-01-21 The United States Of America As Represented By The Department Of Health And Human Services Selectively cytotoxic IL-4-PE40 fusion protein
US6051405A (en) 1986-09-24 2000-04-18 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Constructs encoding recombinant antibody-toxin fusion proteins
US4892827A (en) 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US5206353A (en) 1988-07-23 1993-04-27 The United States Of America As Represented By The Department Of Health And Human Services CD-4/cytotoxic gene fusions
CA1340530C (en) 1989-04-28 1999-05-04 Kok Kheong Lee Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics
US5980896A (en) 1989-06-30 1999-11-09 Bristol-Myers Squibb Company Antibodies reactive with human carcinomas
US6020145A (en) 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
AU657087B2 (en) * 1989-12-22 1995-03-02 Seragen Incorporated Hybrid molecules having translocation region and cell-binding region
US5458878A (en) 1990-01-02 1995-10-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services P. exotoxin fusio proteins have COOHG220101al alterations which increase cytotoxicity
AU646673B2 (en) 1990-05-11 1994-03-03 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Improved pseudomonas exotoxins of low animal toxicity and high cytocidal activity
US5608039A (en) 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
US6099842A (en) 1990-12-03 2000-08-08 The United States Of America As Represented By The Department Of Health And Human Services Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin
US5328984A (en) * 1991-03-04 1994-07-12 The United States As Represented By The Department Of Health & Human Services Recombinant chimeric proteins deliverable across cellular membranes into cytosol of target cells
US5190873A (en) 1991-06-21 1993-03-02 California Institute Of Biological Research Hybrid tryptophan aporepressor containing ligand binding sites
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5935580A (en) 1992-04-21 1999-08-10 Institut Pasteur Recombinant mutants for inducing specific immune responses
ATE314475T1 (de) 1992-06-18 2006-01-15 Us Gov Health & Human Serv Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
US6303120B1 (en) 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5635599A (en) * 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands
ATE204300T1 (de) 1994-05-13 2001-09-15 Biovation Ltd Zielzellen-bindende chimäre peptide
US5573916A (en) 1994-05-19 1996-11-12 Coretech, Inc. Immunogenic constructs comprising b-cell and t-cell epitopes on common carrier
EP0789776B1 (en) 1994-11-01 2001-06-13 Winfried Wels Nucleic acid transfer system
US5843882A (en) 1995-04-27 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Antiviral proteins and peptides
US5980895A (en) 1995-10-13 1999-11-09 The United States Of America As Represented By The Department Of Health And Human Services Immunotoxin containing a disulfide-stabilized antibody fragment joined to a Pseudomonas exotoxin that does not require proteolytic activation
IL116559A (en) 1995-11-17 2005-11-20 Yissum Res Dev Co Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
CA2241604C (en) 1996-01-05 2010-03-30 Ira Pastan Mesothelium antigen and methods and kits for targeting it
AU716564B2 (en) * 1996-11-06 2000-03-02 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Protease-activatable pseudomonas exotoxin A-like proproteins
WO1998042876A1 (en) 1997-03-26 1998-10-01 Board Of Regents, The University Of Texas System Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
US20030054012A1 (en) 2000-05-12 2003-03-20 Fitzgerald David J. Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
US6140066A (en) 1998-03-24 2000-10-31 Lorberboum-Galski; Haya Methods of cancer diagnosis using a chimeric toxin
US6090388A (en) 1998-06-20 2000-07-18 United Biomedical Inc. Peptide composition for prevention and treatment of HIV infection and immune disorders
EP1224290B1 (en) 1999-10-22 2006-06-28 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Disulfide conjugated cell toxins and methods of making and using them
ATE444081T1 (de) * 1999-10-22 2009-10-15 Us Gov Health & Human Serv Proteine-abgabe durch polare epithelzellen schichte
US6783761B2 (en) 2000-05-05 2004-08-31 Aphton Corporation Chimeric peptide immunogens
WO2002060935A2 (en) * 2000-12-21 2002-08-08 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services A chimeric protein comprising non-toxic pseudomonas exotoxin a and type iv pilin sequences
CA2501235A1 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
JP2006516091A (ja) * 2002-10-07 2006-06-22 アンティジェニクス インコーポレーテッド 熱ショックタンパク質結合性のｃｄ９１断片およびその使用
US7335361B2 (en) 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
AU2005294436A1 (en) * 2004-10-04 2006-04-20 Trinity Biosystems, Inc. Methods and compositions for immunizing against Pseudomonas infection
US8877714B2 (en) * 2005-06-14 2014-11-04 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof
DK2308514T3 (da) * 2007-03-23 2013-09-02 To Bbb Holding B V Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren
WO2008124010A1 (en) * 2007-04-06 2008-10-16 The Trustees Of The University Of Pennsylvania Surfactant protein d is a biomarker for steroid responsiveness in asthma and chronic obstructive pulmonary disease

Also Published As

Publication number Publication date
DE69831951T2 (de) 2006-07-27
JP2009079068A (ja) 2009-04-16
AU8481398A (en) 1999-02-08
US20090269368A1 (en) 2009-10-29
DK1000163T3 (da) 2006-02-06
EP1000163B1 (en) 2005-10-19
CA2295971A1 (en) 1999-01-21
US8092809B2 (en) 2012-01-10
JP2001510683A (ja) 2001-08-07
DE69831951D1 (de) 2006-03-02
AU731703B2 (en) 2001-04-05
CA2295971C (en) 2011-02-08
WO1999002713A1 (en) 1999-01-21
ES2249838T3 (es) 2006-04-01
EP1000163A1 (en) 2000-05-17

Similar Documents

Publication Publication Date Title
ATE307208T1 (de) Pseudomonas exotoxin-a-ähnliche chimerische immunogene
EP1208085A4 (en) BENZANILIDE AS THE OPENER OF THE POTASSIUM CHANNEL
WO2002081646A3 (en) Epitope sequences
WO1999051275A3 (en) Mesenchymal stem cells as immunosuppressants
PL336306A1 (en) Proteinous fusions of tgf-beta ii type receptor with a constant immunoglobulin area
DK0854917T3 (da) Transgene ikke-humane dyr, som kan producere heterologe antistoffer
TR199700343A3 (tr) Titresimli blender.
GEPI20105119B (en) Chimeric anti-cd20 antibody
CY1109536T1 (el) Βελτιωμενες fc πρωτεϊνες συντηξης
DK137793D0 (da) Ekstrakter af cucurbita sp., fremgangsmaade til fremstilling og anvendelse af disse i laegemidler og kosmetiske praeparater
CY2016033I1 (el) Χιμαιρικα γονιδια που κωδικοποιουν τους αντιγονικους καθοριστες τεσσαρων πρωτεϊνων του l. infantum
DK0876398T3 (da) Induktion af immunrespons med ønskede determinanter
DE60042816D1 (de) T-helferzellen-epitope
BR9901328B1 (pt) membro fusor.
ATE340863T1 (de) Pseudomonas exotoxin a-ähnliche chimerische immunogene zum auslösen einer sekretorischen iga- vermittelten immunantwort
TR199500890A2 (tr) Bitki öldürücü maddeler olarak 4-fenoksikumarinler.
IT1267352B1 (it) Dispositivo di distribuzione di vapore.
DE69840326D1 (de) Steigerung der immunantwort unter verwendung von zielgerichteten molekülen
NO962125D0 (no) Anti-idiotypiske antistoffer som induserer en immunrespons mot epidermal vekstfaktorreseptor
DK0831881T3 (da) CETP til forøgelse af HDL-cholesterolniveau
WO1999016466A3 (en) Vaccine compositions and methods of enhancing vaccine efficacy
MX9804043A (es) Composiciones parasiticidas a base de polisiloxanos ciclicos.
DK1183044T3 (da) Adjuvanskombinationer til immunisering og vacciner
EP0606901A3 (en) An electrophotographic apparatus.
WO2003097663A3 (de) Immunogener, monoklonaler antikörper, der mindestens 2 verschiedene epitope ines tumor-assoziierten antigens aufweist

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1000163

Country of ref document: EP