AU729886B2 - Method of inhibiting cancer growth - Google Patents

Method of inhibiting cancer growth Download PDF

Info

Publication number
AU729886B2
AU729886B2 AU59104/98A AU5910498A AU729886B2 AU 729886 B2 AU729886 B2 AU 729886B2 AU 59104/98 A AU59104/98 A AU 59104/98A AU 5910498 A AU5910498 A AU 5910498A AU 729886 B2 AU729886 B2 AU 729886B2
Authority
AU
Australia
Prior art keywords
cmt
dimethylamino
tetracycline
cancer
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU59104/98A
Other languages
English (en)
Other versions
AU5910498A (en
Inventor
Norman L. Block
Lorne M. Golub
Hsi-Ming Lee
Balakrishna L. Lokeshwar
Thomas F. Mcnamara
Nungavaram S. Ramamurthy
Marie G. Selzer
Sanford Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Research Foundation of the State University of New York
Original Assignee
University of Miami
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami, Research Foundation of the State University of New York filed Critical University of Miami
Publication of AU5910498A publication Critical patent/AU5910498A/en
Application granted granted Critical
Publication of AU729886B2 publication Critical patent/AU729886B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU59104/98A 1997-01-15 1998-01-15 Method of inhibiting cancer growth Ceased AU729886B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/783655 1997-01-15
US08/783,655 US5837696A (en) 1997-01-15 1997-01-15 Method of inhibiting cancer growth
PCT/US1998/000332 WO1998031224A1 (en) 1997-01-15 1998-01-15 Method of inhibiting cancer growth

Publications (2)

Publication Number Publication Date
AU5910498A AU5910498A (en) 1998-08-07
AU729886B2 true AU729886B2 (en) 2001-02-15

Family

ID=25130005

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59104/98A Ceased AU729886B2 (en) 1997-01-15 1998-01-15 Method of inhibiting cancer growth

Country Status (11)

Country Link
US (2) US5837696A (enExample)
EP (1) EP0971585B1 (enExample)
JP (1) JP4428727B2 (enExample)
KR (1) KR20000070212A (enExample)
AT (1) ATE321452T1 (enExample)
AU (1) AU729886B2 (enExample)
CA (1) CA2277865C (enExample)
DE (1) DE69834024T2 (enExample)
ES (1) ES2262221T3 (enExample)
PT (1) PT971585E (enExample)
WO (1) WO1998031224A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth
US6429204B1 (en) 1997-01-15 2002-08-06 University Of Miami Method of inhibiting cancer growth
DK1041991T3 (da) * 1997-12-19 2008-07-28 Univ New York Ikke-antibakterielle tetracycliner til behandling af multipel sklerose
US6277061B1 (en) * 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
WO2000038715A2 (en) * 1998-12-23 2000-07-06 G.D. Searle & Co. Use of an integrin antagonist and radiation in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6984619B1 (en) * 1999-03-19 2006-01-10 Arch Development Corporation Method for protection against tumor metastasis formation
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
CA2447008A1 (en) * 2001-04-05 2002-10-24 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
EP1408987B1 (en) 2001-07-13 2013-04-10 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003030819A2 (en) * 2001-10-05 2003-04-17 Tetragenex Pharmaceuticals, Inc. Tetracycline derivatives and methods of use thereof
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP2005526754A (ja) 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
WO2003092629A2 (en) * 2002-05-06 2003-11-13 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating mucositis and fungal infection
EP1505961A4 (en) * 2002-05-20 2009-09-02 Collagenex Pharm Inc METHOD FOR TREATING ALLERGIC REACTIONS
WO2004006850A2 (en) 2002-07-12 2004-01-22 Paratek Pharmaceuticals, Inc 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
JP4686189B2 (ja) * 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法
CA2521885C (en) * 2003-04-07 2013-06-25 Shire Laboratories, Inc. Once daily formulations of tetracyclines
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
WO2005009943A2 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2332904A3 (en) * 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
WO2006047756A2 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP2008518025A (ja) 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド ４−アミノテトラサイクリンおよびその使用の方法
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
PL2120963T3 (pl) 2006-12-21 2019-05-31 Paratek Pharm Innc Podstawione związki tetracyklinowe do leczenia zaburzeń zapalnych skóry
IL270446B2 (en) * 2006-12-21 2023-10-01 Paratek Pharm Innc A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition
EP2144870A2 (en) * 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
WO2009009042A1 (en) * 2007-07-06 2009-01-15 Paratek Pharmaceuticals, Inc. Methods for synthesizing substituted tetracycline compounds
TWI585071B (zh) 2008-05-19 2017-06-01 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
HUE026562T2 (hu) 2008-08-08 2016-06-28 Tetraphase Pharmaceuticals Inc C7-fluor-helyettesített tetraciklin vegyületek
CN102459153A (zh) 2009-05-08 2012-05-16 四相制药公司 四环素类化合物
EP2470500B1 (en) 2009-08-28 2017-10-04 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US20120329761A1 (en) * 2010-03-10 2012-12-27 University Health Network Use of tigecycline for treatment of cancer
WO2011123536A1 (en) 2010-03-31 2011-10-06 Tetraphase Pharmaceuticals, Inc. Polycyclic tetracycline compounds
TR201902057T4 (tr) 2012-08-31 2019-03-21 Tetraphase Pharmaceuticals Inc Tetrasiklin bileşikleri.
CA2898113C (en) * 2013-01-14 2022-05-31 Health Clinics Limited Combination cancer therapeutics and uses thereof
MA46567A (fr) 2016-10-19 2019-08-28 Tetraphase Pharmaceuticals Inc Formes cristallines de l'éravacycline
EP3612177A4 (en) 2017-04-21 2021-01-13 Lunella Biotech, Inc. TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
CA3060510A1 (en) 2017-04-21 2018-10-25 Lunella Biotech, Inc. Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
US12006553B2 (en) 2017-05-19 2024-06-11 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
JP6938682B2 (ja) 2017-05-19 2021-09-22 ルネラ・バイオテック・インコーポレーテッド アンチミトシン：癌幹細胞を根絶するためのミトコンドリア生合成の標的阻害薬
WO2020097450A1 (en) 2018-11-09 2020-05-14 Tetraphase Pharmaceuticals, Inc. Polymorphic forms of a compound and uses thereof
CN115006411A (zh) * 2022-07-26 2022-09-06 中南大学湘雅医院 依拉环素类化合物的应用、药物及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012717A2 (en) * 1991-01-15 1992-08-06 A composition containing a tetracycline and use for inhibiting angiogenesis
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5321017A (en) * 1989-12-04 1994-06-14 The Research Foundation Of State University Of New York Composition comprising fluriprofen and effectively non-antibacterial tetracycline to reduce bone loss

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668122A (en) * 1993-07-28 1997-09-16 Fife; Rose S. Method to treat cancer with tetracyclines
US5563130A (en) * 1994-12-13 1996-10-08 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5567693A (en) * 1994-12-13 1996-10-22 American Cyanamid Company Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5574026A (en) * 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5321017A (en) * 1989-12-04 1994-06-14 The Research Foundation Of State University Of New York Composition comprising fluriprofen and effectively non-antibacterial tetracycline to reduce bone loss
WO1992012717A2 (en) * 1991-01-15 1992-08-06 A composition containing a tetracycline and use for inhibiting angiogenesis

Also Published As

Publication number Publication date
ES2262221T3 (es) 2006-11-16
ATE321452T1 (de) 2006-04-15
WO1998031224A1 (en) 1998-07-23
DE69834024T2 (de) 2006-12-07
JP4428727B2 (ja) 2010-03-10
AU5910498A (en) 1998-08-07
EP0971585B1 (en) 2006-03-29
KR20000070212A (ko) 2000-11-25
DE69834024D1 (de) 2006-05-18
CA2277865A1 (en) 1998-07-23
JP2001508794A (ja) 2001-07-03
EP0971585A4 (en) 2001-01-24
PT971585E (pt) 2006-08-31
US5837696A (en) 1998-11-17
US6100248A (en) 2000-08-08
CA2277865C (en) 2009-06-02
EP0971585A1 (en) 2000-01-19

Similar Documents

Publication Publication Date Title
EP0971585B1 (en) Tetracycline compounds in the treatment of certain types of cancers
AU748870B2 (en) Method of inhibiting membrane-type matrix metalloproteinase
US6429204B1 (en) Method of inhibiting cancer growth
AU755871B2 (en) Combination of bisphosphonate and tetracycline
Davies et al. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
Fan et al. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy
US5308839A (en) Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
EP1119362B1 (en) Use of tetracycline derivatives to enhance interleukin-10 production
Perez-Giraldo et al. Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis.
US20190091244A1 (en) Methods of treating acne
CA2031368C (en) Composition comprising non-steroidal non-inflammatory agent and effectively non-antibacterial tetracycline
AU733308B2 (en) Serine proteinase inhibitory activity by hydrophobic tetracycline
Zervos et al. Matrix Metalloproteinase Inhibition Attenuates Human Pancreatic Cancer Growthin Vitroand Decreases Mortality and Tumorigenesisin Vivo
CA2440472C (en) Methods of treating acne
MXPA99006554A (en) Method of inhibiting cancer growth
Seftor et al. Application of chemically modified tetracyclines (CMTs) in experimental models of cancer and arthritis
Schneider et al. Tetracyclines inhibit intracellular muscle proteolysis in vitro
CN101420960A (zh) 使用非抗菌四环素制剂治疗主动脉狭窄的方法
NZ522733A (en) Non-antibacterial tetracycline as anti-fungal agents

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)