AU715512B2 - Spray-dried microparticles as therapeutic vehicles for use in gene therapy - Google Patents

Spray-dried microparticles as therapeutic vehicles for use in gene therapy Download PDF

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Publication number
AU715512B2
AU715512B2 AU23020/97A AU2302097A AU715512B2 AU 715512 B2 AU715512 B2 AU 715512B2 AU 23020/97 A AU23020/97 A AU 23020/97A AU 2302097 A AU2302097 A AU 2302097A AU 715512 B2 AU715512 B2 AU 715512B2
Authority
AU
Australia
Prior art keywords
microparticles
agent
microparticles according
spray
gene therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU23020/97A
Other languages
English (en)
Other versions
AU2302097A (en
Inventor
Richard Alan Johnson
Jill Elizabeth Ogden
Andrew Derek Sutton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Healthcare UK Ltd
Original Assignee
Quadrant Healthcare UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadrant Healthcare UK Ltd filed Critical Quadrant Healthcare UK Ltd
Publication of AU2302097A publication Critical patent/AU2302097A/en
Assigned to QUADRANT HEALTHCARE (UK) LIMITED reassignment QUADRANT HEALTHCARE (UK) LIMITED Change of Name of Applicant under S 104 Assignors: ANDARIS LIMITED
Application granted granted Critical
Publication of AU715512B2 publication Critical patent/AU715512B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU23020/97A 1996-04-03 1997-04-03 Spray-dried microparticles as therapeutic vehicles for use in gene therapy Ceased AU715512B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9607035.4A GB9607035D0 (en) 1996-04-03 1996-04-03 Spray-dried microparticles as therapeutic vehicles
GB9607035 1996-04-03
AU60103/96 1996-06-07
GB9601379 1996-06-07
PCT/GB1997/000953 WO1997036578A1 (en) 1996-04-03 1997-04-03 Spray-dried microparticles as therapeutic vehicles for use in gene therapy

Publications (2)

Publication Number Publication Date
AU2302097A AU2302097A (en) 1997-10-22
AU715512B2 true AU715512B2 (en) 2000-02-03

Family

ID=26308516

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23020/97A Ceased AU715512B2 (en) 1996-04-03 1997-04-03 Spray-dried microparticles as therapeutic vehicles for use in gene therapy

Country Status (14)

Country Link
EP (1) EP0936902B1 (enExample)
JP (1) JP2000507568A (enExample)
AR (1) AR007493A1 (enExample)
AT (1) ATE243027T1 (enExample)
AU (1) AU715512B2 (enExample)
CA (1) CA2250478A1 (enExample)
DE (1) DE69722952T2 (enExample)
DK (1) DK0936902T3 (enExample)
ES (1) ES2201283T3 (enExample)
GB (1) GB9607035D0 (enExample)
NO (1) NO984462D0 (enExample)
PT (1) PT936902E (enExample)
WO (1) WO1997036578A1 (enExample)
ZA (1) ZA972837B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
DE69608122T3 (de) 1995-11-09 2011-06-16 Microbiological Research Authority Camr, Salisbury Mikroverkapselte dna zur impfung und gentherapie
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
AU6124601A (en) 2000-05-10 2001-11-20 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
WO2002015880A2 (en) * 2000-08-25 2002-02-28 Merck Patent Gmbh Powdered mannitol and mannitol-containing compositions
KR100958235B1 (ko) 2001-12-19 2010-05-17 노바르티스 아게 아미노글리코시드의 폐 전달
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
EP1758558B1 (en) 2004-05-12 2013-10-16 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
US7815941B2 (en) 2004-05-12 2010-10-19 Baxter Healthcare S.A. Nucleic acid microspheres, production and delivery thereof
EP1834651A1 (en) * 2006-03-15 2007-09-19 Universiteit Gent Compositions and methods for veterinary vaccination
MX2009001226A (es) 2006-08-04 2009-03-20 Baxter Int Composicion basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nuevo inicio.
US8808747B2 (en) 2007-04-17 2014-08-19 Baxter International Inc. Nucleic acid microparticles for pulmonary delivery
DE102009033196A1 (de) * 2009-07-14 2011-01-20 Beiersdorf Ag Kosmetische Zubereitung mit einem Gehalt an dispergierten Mikrosphären
CN120514877A (zh) * 2018-07-23 2025-08-22 川斯勒佰尔公司 信使rna的干粉制剂
WO2020145872A1 (en) * 2019-01-09 2020-07-16 Ziccum Ab Stabilized non-enveloped virus compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
AU3530295A (en) * 1994-09-29 1996-04-19 Quadrant Drug Delivery Limited Spray-dried microparticles as therapeutic vehicles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5626871A (en) * 1992-06-12 1997-05-06 Teijin Limited Preparation for intratracheobronchial administration
NZ265555A (en) * 1993-04-19 1997-09-22 Medisorb Technologies Internat Biodegradable microparticle compositions of antisense oligodeoxyribonucleotides
EP0759939B1 (en) * 1994-05-18 2005-07-20 Nektar Therapeutics Methods and compositions for the dry powder formulation of interferons
WO1996027393A1 (en) * 1995-03-07 1996-09-12 University Of Pittsburgh A dry powder formulation for gene therapy
EP0840623B1 (en) * 1995-07-21 2007-07-18 Brown University Research Foundation Compositions for gene therapy comprising nucleic acid loaded polymeric microparticles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
AU3530295A (en) * 1994-09-29 1996-04-19 Quadrant Drug Delivery Limited Spray-dried microparticles as therapeutic vehicles

Also Published As

Publication number Publication date
AR007493A1 (es) 1999-11-10
DK0936902T3 (da) 2003-10-06
ES2201283T3 (es) 2004-03-16
DE69722952T2 (de) 2003-12-11
ATE243027T1 (de) 2003-07-15
DE69722952D1 (de) 2003-07-24
NO984462L (no) 1998-09-25
NO984462D0 (no) 1998-09-25
AU2302097A (en) 1997-10-22
CA2250478A1 (en) 1997-10-09
JP2000507568A (ja) 2000-06-20
EP0936902B1 (en) 2003-06-18
EP0936902A1 (en) 1999-08-25
GB9607035D0 (en) 1996-06-05
ZA972837B (en) 1998-04-03
PT936902E (pt) 2003-11-28
WO1997036578A1 (en) 1997-10-09

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