AU712015B2 - Triterpene derivatives with immunosuppressant activity - Google Patents

Triterpene derivatives with immunosuppressant activity Download PDF

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Publication number
AU712015B2
AU712015B2 AU74781/96A AU7478196A AU712015B2 AU 712015 B2 AU712015 B2 AU 712015B2 AU 74781/96 A AU74781/96 A AU 74781/96A AU 7478196 A AU7478196 A AU 7478196A AU 712015 B2 AU712015 B2 AU 712015B2
Authority
AU
Australia
Prior art keywords
alkyl
defined above
aryl
heteroaryl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU74781/96A
Other languages
English (en)
Other versions
AU7478196A (en
Inventor
Robert K Baker
Jianming Bao
Frank Kayser
William H Parsons
Kathleen M. Rupprecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603833.6A external-priority patent/GB9603833D0/en
Priority claimed from GBGB9605156.0A external-priority patent/GB9605156D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU7478196A publication Critical patent/AU7478196A/en
Application granted granted Critical
Publication of AU712015B2 publication Critical patent/AU712015B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU74781/96A 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity Ceased AU712015B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US818995P 1995-10-31 1995-10-31
US816995P 1995-10-31 1995-10-31
US60/008189 1995-10-31
US60/008169 1995-10-31
GBGB9603833.6A GB9603833D0 (en) 1996-02-23 1996-02-23 Triterpene derivatives with immunosuppressive activity
GB9603833 1996-02-23
GB9605156 1996-03-12
GBGB9605156.0A GB9605156D0 (en) 1996-03-12 1996-03-12 Triterpene derivatives with immunosuppressant activity
PCT/US1996/017211 WO1997016068A1 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Publications (2)

Publication Number Publication Date
AU7478196A AU7478196A (en) 1997-05-22
AU712015B2 true AU712015B2 (en) 1999-10-28

Family

ID=27451409

Family Applications (1)

Application Number Title Priority Date Filing Date
AU74781/96A Ceased AU712015B2 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Country Status (4)

Country Link
EP (1) EP0877554A1 (ja)
JP (1) JPH11514648A (ja)
AU (1) AU712015B2 (ja)
WO (1) WO1997016068A1 (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998408A (en) * 1996-10-16 1999-12-07 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5952371A (en) * 1996-10-16 1999-09-14 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5874594A (en) * 1996-10-16 1999-02-23 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US6083980A (en) * 1997-10-17 2000-07-04 Merck & Co., Inc. Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity
US6100293A (en) * 1997-10-17 2000-08-08 Merck & Co., Inc. Tetracyclic triterpene derivatives with immunosuppressant activity
US6022890A (en) * 1997-11-14 2000-02-08 Merck & Co., Inc. Immunosuppressant tetracyclic triterpenes
US6051590A (en) * 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
PT1539157E (pt) 2002-09-18 2013-10-04 Univ Pennsylvania Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal
EP1639121A4 (en) * 2003-06-30 2008-04-16 Idenix Cayman Ltd SYNTHESIS OF BETA-L-2-DESOXYNUCLEOSIDES
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
BRPI0608152A2 (pt) 2005-02-09 2009-11-10 Macusight Inc formulações para tratamento ocular
WO2007092620A2 (en) 2006-02-09 2007-08-16 Macusight, Inc. Stable formulations, and methods of their preparation and use
CA2645488C (en) 2006-03-23 2014-09-02 Macusight, Inc. Formulations comprising rapamycin and methods using same for vascular permeability-related diseases or conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483191A (en) * 1963-09-13 1969-12-09 Squibb & Sons Inc Steroids
WO1997016182A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
CA2236171A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PHYTOCHEMISTRY, (1990), 29(7), 2257-2261 *

Also Published As

Publication number Publication date
EP0877554A1 (en) 1998-11-18
EP0877554A4 (ja) 1998-12-02
JPH11514648A (ja) 1999-12-14
WO1997016068A1 (en) 1997-05-09
AU7478196A (en) 1997-05-22

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired