AU698885B2 - Alpha 1a adrenergic receptors antagonists - Google Patents

Alpha 1a adrenergic receptors antagonists

Info

Publication number
AU698885B2
AU698885B2 AU60973/96A AU6097396A AU698885B2 AU 698885 B2 AU698885 B2 AU 698885B2 AU 60973/96 A AU60973/96 A AU 60973/96A AU 6097396 A AU6097396 A AU 6097396A AU 698885 B2 AU698885 B2 AU 698885B2
Authority
AU
Australia
Prior art keywords
compound
pharmaceutically acceptable
testosterone
compounds
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU60973/96A
Other languages
English (en)
Other versions
AU6097396A (en
Inventor
Mark G. Bock
Roger M. Freidinger
Michael A. Patane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU6097396A publication Critical patent/AU6097396A/en
Application granted granted Critical
Publication of AU698885B2 publication Critical patent/AU698885B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU60973/96A 1995-06-07 1996-06-04 Alpha 1a adrenergic receptors antagonists Ceased AU698885B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/488,267 US5620993A (en) 1995-06-07 1995-06-07 Alpha-1a adrenergic receptor antagonists
US08/488267 1995-06-07
PCT/US1996/009363 WO1996040135A1 (fr) 1995-06-07 1996-06-04 ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a

Publications (2)

Publication Number Publication Date
AU6097396A AU6097396A (en) 1996-12-30
AU698885B2 true AU698885B2 (en) 1998-11-12

Family

ID=23939029

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60973/96A Ceased AU698885B2 (en) 1995-06-07 1996-06-04 Alpha 1a adrenergic receptors antagonists

Country Status (6)

Country Link
US (2) US5620993A (fr)
EP (1) EP0831823A4 (fr)
JP (1) JPH11507339A (fr)
AU (1) AU698885B2 (fr)
CA (1) CA2221746A1 (fr)
WO (1) WO1996040135A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
US6177430B1 (en) 1997-03-27 2001-01-23 Pfizer Inc Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia
JP2002511086A (ja) * 1997-06-18 2002-04-09 メルク エンド カンパニー インコーポレーテッド α１ａアドレナリン受容体拮抗薬
US6485922B1 (en) * 1997-10-10 2002-11-26 Atairgin Technologies, Inc. Methods for detecting compounds which modulate the activity of an LPA receptor
AU1808400A (en) 1998-10-29 2000-05-22 Merck & Co., Inc. Dihydropyridinones and pyrrolinones useful as alpha 1a adrenoceptor antagonists
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
WO2000029386A1 (fr) 1998-11-12 2000-05-25 Merck & Co., Inc. Derives de la pyrimidinedione, antagonistes de l'adrenocepteur alpha 1a
US6358959B1 (en) 1999-01-26 2002-03-19 Merck & Co., Inc. Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
AU2512800A (en) 1999-02-03 2000-08-25 Eli Lilly And Company Alpha1-adrenergic receptor antagonists
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
GB2355263A (en) 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
GB2355456A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CA2395075A1 (fr) * 1999-12-16 2001-06-21 Miles P. Smith Analogues de piperidine 1,3,4-substituee et leurs utilisations dans le traitement de la toxicomanie
US8324178B2 (en) 2008-10-31 2012-12-04 The Regents Of The University Of California Method of treatment using alpha-1-adrenergic agonist compounds
US9364462B2 (en) 2012-10-30 2016-06-14 The Regents Of The University Of California Alpha-1-adrenergic receptor agonist therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3267096A (en) * 1965-02-24 1966-08-16 Miles Lab Derivatives of 2h, 4h-benzothiadiazine 1, 1-dioxide
WO1992019606A1 (fr) * 1991-04-26 1992-11-12 Rhone-Poulenc Rorer S.A. Derives heterocycliques antiserotonines, leur preparation et les medicaments les contenant
US5488062A (en) * 1991-12-30 1996-01-30 Sterling Winthrop Inc. 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97053A (en) * 1990-02-12 1995-10-31 Bristol Meyers Squibb Co Pharmaceutical preparations containing azapyrone for the treatment of coma
WO1994008040A1 (fr) * 1992-09-25 1994-04-14 Synaptic Pharmaceutical Corporation Adn codant des recepteurs adrenergiques alpha 1 humains et leurs utilisations
US5403847A (en) * 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
US5508306A (en) * 1992-11-13 1996-04-16 Synaptic Pharmaceutical Corporation Aromatic amine derivatives
JPH08508163A (ja) * 1993-03-15 1996-09-03 メルク エンド カンパニー インコーポレーテッド クローン化ヒトアドレナリンα１Ｃ受容体
IL109220A0 (en) * 1993-04-05 1994-07-31 Synaptic Pharma Corp Dihydropyridines and new uses thereof
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
CZ134296A3 (en) * 1993-11-09 1996-12-11 Merck & Co Inc Piperidine, pyrrolidine and hexahydro-1h-azepine derivatives, process of their preparation and pharmaceutical compositions containing thereof
CN1148853A (zh) * 1994-03-31 1997-04-30 日本化学医药株式会社 亚烷基二胺衍生物
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
WO1997036873A1 (fr) * 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines et hexahydro-1h-azepines declenchant la liberation de l'hormone de croissance

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3267096A (en) * 1965-02-24 1966-08-16 Miles Lab Derivatives of 2h, 4h-benzothiadiazine 1, 1-dioxide
WO1992019606A1 (fr) * 1991-04-26 1992-11-12 Rhone-Poulenc Rorer S.A. Derives heterocycliques antiserotonines, leur preparation et les medicaments les contenant
US5488062A (en) * 1991-12-30 1996-01-30 Sterling Winthrop Inc. 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Also Published As

Publication number Publication date
US5620993A (en) 1997-04-15
AU6097396A (en) 1996-12-30
JPH11507339A (ja) 1999-06-29
EP0831823A1 (fr) 1998-04-01
CA2221746A1 (fr) 1996-12-19
WO1996040135A1 (fr) 1996-12-19
US6075038A (en) 2000-06-13
EP0831823A4 (fr) 1998-10-21

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired