AU667593B2 - Inhibitors of HIV protease useful for the treatment of AIDS - Google Patents
Inhibitors of HIV protease useful for the treatment of AIDSInfo
- Publication number
- AU667593B2 AU667593B2 AU52530/93A AU5253093A AU667593B2 AU 667593 B2 AU667593 B2 AU 667593B2 AU 52530/93 A AU52530/93 A AU 52530/93A AU 5253093 A AU5253093 A AU 5253093A AU 667593 B2 AU667593 B2 AU 667593B2
- Authority
- AU
- Australia
- Prior art keywords
- aids
- hiv protease
- inhibitors
- treatment
- protease useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 208000030507 AIDS Diseases 0.000 title abstract 2
- 108010010369 HIV Protease Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US994871 | 1992-12-22 | ||
| US07/994,871 US5434265A (en) | 1992-12-22 | 1992-12-22 | Inhibitors of HIV protease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5253093A AU5253093A (en) | 1994-07-07 |
| AU667593B2 true AU667593B2 (en) | 1996-03-28 |
Family
ID=25541167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU52530/93A Ceased AU667593B2 (en) | 1992-12-22 | 1993-12-20 | Inhibitors of HIV protease useful for the treatment of AIDS |
Country Status (24)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5679688A (en) | 1992-03-11 | 1997-10-21 | Narhex Limited | Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| DE4439193A1 (de) * | 1994-11-03 | 1996-05-09 | Bayer Ag | Mischung zur Korrosionshemmung von Metallen |
| US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
| US5932550A (en) * | 1995-06-30 | 1999-08-03 | Japan Energy Corporation | Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
| KR100490807B1 (ko) * | 1995-11-28 | 2005-10-14 | 세파론, 인코포레이티드 | 시스테인및세린프로테아제의d-아미노산함유억제제 |
| KR19980703369A (ko) * | 1996-01-29 | 1998-10-15 | 후루따 다께시 | 카르보닐 화합물의 환원 방법 |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| EP0900566A4 (en) | 1996-12-27 | 2001-04-25 | Japan Energy Corp | NEW TRIPEPTIDE COMPOUNDS AND MEDICINES AGAINST AIDS |
| US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US6096778A (en) * | 1997-10-07 | 2000-08-01 | Cephalon, Inc. | α-ketoamide multicatalytic protease inhibitors |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| US6150378A (en) * | 1997-10-07 | 2000-11-21 | Cephalon, Inc. | Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors |
| EP1095022A1 (en) * | 1998-07-08 | 2001-05-02 | G.D. Searle & Co. | Retroviral protease inhibitors |
| EP1954685A4 (en) * | 2005-11-16 | 2009-11-11 | Nitromed Inc | FUROXANE COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1954392A (en) * | 1991-07-10 | 1993-01-21 | Eli Lilly And Company | Inhibitors of hiv protease useful for the treatment of aids |
| AU2469092A (en) * | 1991-08-13 | 1993-03-16 | Schering Corporation | Anti-hiv (aids) agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| EP0558603B1 (en) * | 1990-11-19 | 1998-08-26 | Monsanto Company | Retroviral protease inhibitors |
| US5491166A (en) * | 1992-12-22 | 1996-02-13 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
-
1992
- 1992-12-22 US US07/994,871 patent/US5434265A/en not_active Expired - Fee Related
-
1993
- 1993-12-15 MX MX9308005A patent/MX9308005A/es not_active IP Right Cessation
- 1993-12-17 NZ NZ250492A patent/NZ250492A/en unknown
- 1993-12-17 ZA ZA939476A patent/ZA939476B/xx unknown
- 1993-12-17 CZ CZ932816A patent/CZ281693A3/cs unknown
- 1993-12-20 PL PL93301576A patent/PL301576A1/xx unknown
- 1993-12-20 ES ES93310357T patent/ES2101252T3/es not_active Expired - Lifetime
- 1993-12-20 DE DE69308514T patent/DE69308514T2/de not_active Expired - Fee Related
- 1993-12-20 NO NO934718A patent/NO301005B1/no unknown
- 1993-12-20 YU YU79693A patent/YU79693A/sh unknown
- 1993-12-20 DK DK93310357.4T patent/DK0604183T3/da active
- 1993-12-20 AT AT93310357T patent/ATE149488T1/de active
- 1993-12-20 EP EP93310357A patent/EP0604183B1/en not_active Expired - Lifetime
- 1993-12-20 IL IL108091A patent/IL108091A/en not_active IP Right Cessation
- 1993-12-20 HU HU9303680A patent/HUT70748A/hu unknown
- 1993-12-20 AU AU52530/93A patent/AU667593B2/en not_active Ceased
- 1993-12-21 CA CA002112041A patent/CA2112041A1/en not_active Abandoned
- 1993-12-21 CN CN93112961A patent/CN1098407A/zh active Pending
- 1993-12-21 BR BR9305164A patent/BR9305164A/pt not_active Application Discontinuation
- 1993-12-21 FI FI935777A patent/FI935777A/fi not_active Application Discontinuation
- 1993-12-21 JP JP5321988A patent/JPH07179417A/ja active Pending
- 1993-12-22 KR KR1019930029119A patent/KR940014335A/ko not_active Application Discontinuation
-
1994
- 1994-02-17 TW TW082110880A patent/TW280813B/zh active
-
1995
- 1995-04-04 US US08/416,568 patent/US5514802A/en not_active Expired - Fee Related
-
1997
- 1997-05-16 GR GR970401106T patent/GR3023457T3/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1954392A (en) * | 1991-07-10 | 1993-01-21 | Eli Lilly And Company | Inhibitors of hiv protease useful for the treatment of aids |
| AU2469092A (en) * | 1991-08-13 | 1993-03-16 | Schering Corporation | Anti-hiv (aids) agents |
Non-Patent Citations (1)
| Title |
|---|
| EP 533342 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2101252T3 (es) | 1997-07-01 |
| US5514802A (en) | 1996-05-07 |
| ZA939476B (en) | 1995-06-19 |
| US5434265A (en) | 1995-07-18 |
| NO301005B1 (no) | 1997-09-01 |
| HU9303680D0 (en) | 1994-04-28 |
| MX9308005A (es) | 1994-08-31 |
| DE69308514T2 (de) | 1997-07-10 |
| PL301576A1 (en) | 1994-06-27 |
| BR9305164A (pt) | 1994-11-01 |
| EP0604183A1 (en) | 1994-06-29 |
| CZ281693A3 (en) | 1994-07-13 |
| FI935777A (fi) | 1994-06-23 |
| CA2112041A1 (en) | 1994-06-23 |
| YU79693A (sh) | 1997-07-31 |
| AU5253093A (en) | 1994-07-07 |
| CN1098407A (zh) | 1995-02-08 |
| NO934718L (no) | 1994-06-23 |
| KR940014335A (ko) | 1994-07-18 |
| HUT70748A (en) | 1995-10-30 |
| NO934718D0 (no) | 1993-12-20 |
| EP0604183B1 (en) | 1997-03-05 |
| IL108091A (en) | 1998-04-05 |
| ATE149488T1 (de) | 1997-03-15 |
| DK0604183T3 (da) | 1997-05-26 |
| TW280813B (US06534493-20030318-C00329.png) | 1996-07-11 |
| JPH07179417A (ja) | 1995-07-18 |
| NZ250492A (en) | 1995-08-28 |
| DE69308514D1 (de) | 1997-04-10 |
| IL108091A0 (en) | 1994-04-12 |
| GR3023457T3 (en) | 1997-08-29 |
| FI935777A0 (fi) | 1993-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU667146B2 (en) | Inhibitors of HIV protease useful for the treatment of AIDS | |
| AU667593B2 (en) | Inhibitors of HIV protease useful for the treatment of AIDS | |
| DE69321845D1 (en) | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen | |
| AU6549394A (en) | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors | |
| GR3022604T3 (en) | Inhibitors of hiv protease useful for the treatment of aids. | |
| AU4706489A (en) | Oxadiazol-azabicycl compounds and their pharmaceutical use | |
| RU93055684A (ru) | Соединения, ингибирующие вич-протеазу, способ их получения, фармацевтическая композиция, промежуточный продукт | |
| AU6029090A (en) | Improvements in or relating to organic compounds | |
| RU93055680A (ru) | Ингибиторы вич-протеазы, способ получения, их использование, композиция | |
| RU93055683A (ru) | Ингибиторы вич-протеазы, способ их получения, их использование, композиция |