AU6632094A - Enhanced triple-helix and double-helix formation with oligomers containing modified purines - Google Patents

Enhanced triple-helix and double-helix formation with oligomers containing modified purines

Info

Publication number
AU6632094A
AU6632094A AU66320/94A AU6632094A AU6632094A AU 6632094 A AU6632094 A AU 6632094A AU 66320/94 A AU66320/94 A AU 66320/94A AU 6632094 A AU6632094 A AU 6632094A AU 6632094 A AU6632094 A AU 6632094A
Authority
AU
Australia
Prior art keywords
helix
double
containing modified
oligomers containing
modified purines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU66320/94A
Other languages
English (en)
Inventor
Brian Froehler
Mark Matteucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AU6632094A publication Critical patent/AU6632094A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU66320/94A 1993-04-19 1994-04-12 Enhanced triple-helix and double-helix formation with oligomers containing modified purines Abandoned AU6632094A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5069893A 1993-04-19 1993-04-19
US050698 1993-04-19
PCT/US1994/004013 WO1994024144A2 (en) 1993-04-19 1994-04-12 Enhanced triple-helix and double-helix formation with oligomers containing modified purines

Publications (1)

Publication Number Publication Date
AU6632094A true AU6632094A (en) 1994-11-08

Family

ID=21966852

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66320/94A Abandoned AU6632094A (en) 1993-04-19 1994-04-12 Enhanced triple-helix and double-helix formation with oligomers containing modified purines

Country Status (3)

Country Link
EP (1) EP0695306A1 (de)
AU (1) AU6632094A (de)
WO (1) WO1994024144A2 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
DE4438918A1 (de) * 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US6150510A (en) * 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
US6274313B1 (en) 1996-03-21 2001-08-14 Pioneer-Hybrid International, Inc. Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US5734040A (en) * 1996-03-21 1998-03-31 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6331617B1 (en) 1996-03-21 2001-12-18 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6312897B1 (en) 1996-07-03 2001-11-06 President And Fellows Of Harvard College Template-directed interference footprinting of protein-adenine contacts
USRE44779E1 (en) 1997-03-07 2014-02-25 Santaris Pharma A/S Bicyclonucleoside and oligonucleotide analogues
DE19842527A1 (de) * 1998-09-18 2000-03-23 Friedrich Schiller Uni Jena Bu Verfahren zur Bildung tripelhelixbildender Oligomere und deren Verbindungen
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
AU2001247414A1 (en) 2000-03-14 2001-09-24 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US7070933B2 (en) 2001-09-28 2006-07-04 Gen-Probe Incorporated Inversion probes
US7144868B2 (en) 2003-10-27 2006-12-05 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2005044835A1 (en) 2003-10-27 2005-05-19 Genelabs Technologies, Inc. METHODS FOR PREPARING 7-(2'-SUBSTITUTED-ß-D-RIBOFURANOSYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
NZ546201A (en) 2003-10-27 2009-05-31 Genelabs Tech Inc Nucleoside compounds for treating viral infections
AU2004285923A1 (en) 2003-10-27 2005-05-12 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
US7202223B2 (en) 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
JP2010500011A (ja) 2006-08-08 2010-01-07 ガンサー ハートマン ５’リン酸オリゴヌクレオチドの構造および使用
EP2952587B1 (de) 2007-06-19 2023-07-05 Stratos Genomics Inc. Nukleinsäuresequenzierung mit hohem durchsatz durch expansion
WO2009035438A1 (en) * 2007-09-13 2009-03-19 Janos Borbely Polymeric nanoparticles by ion-ion interactions
EP2297323A1 (de) 2008-05-21 2011-03-23 Hartmann, Gunther 5 -triphosphat-oligonukleotid mit stumpfem ende und verwendugen davon
US20120088235A1 (en) 2009-01-29 2012-04-12 Stratos Genomics, Inc. High throughput nucleic acid sequencing by expansion and related methods
CA2756815A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Peri-fused pyrazolo-pyrimidine compounds
US8586301B2 (en) 2010-06-30 2013-11-19 Stratos Genomics, Inc. Multiplexed identification of nucleic acid sequences
EP2508530A1 (de) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
EP2712870A1 (de) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Neuartige RIG-I-Liganden und Herstellungsverfahren dafür
EP2971154A4 (de) 2013-03-14 2017-03-01 Ibis Biosciences, Inc. Nukleinsäurekontrollpanels
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
AU2015349730C1 (en) 2014-11-20 2020-04-30 F. Hoffmann-La Roche Ag Nulceoside phosphoroamidate esters and derivatives thereof, use and synthesis thereof
SG11201705069YA (en) 2014-12-26 2017-07-28 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
US10745685B2 (en) 2015-11-16 2020-08-18 Stratos Genomics, Inc. DP04 polymerase variants
EP3452616A4 (de) 2016-05-05 2020-01-22 Exact Sciences Development Company, LLC Nachweis von lungenneoplasie durch analyse von methylierter dna
CA3049459A1 (en) 2017-01-27 2018-08-02 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated dna
ES2987024T3 (es) 2017-05-04 2024-11-13 Hoffmann La Roche Variantes de polimerasa DP04
AU2018378832B9 (en) 2017-12-07 2021-05-27 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
EP3724323A4 (de) 2017-12-11 2021-08-18 Stratos Genomics Inc. Dpo4-polymerase-varianten mit verbesserter genauigkeit
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
GB2605952A (en) * 2021-04-12 2022-10-26 Stealth Labels Biotech Ab Fluorescent nucleoside triphosphates
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
AU2022303381A1 (en) 2021-07-01 2024-01-18 Illumina, Inc. Device having horizontal nanochannel for nanopore sequencing
CN117580961A (zh) 2021-09-01 2024-02-20 Illumina公司 用于加速碱基判读的幅度调制
US20230090867A1 (en) 2021-09-22 2023-03-23 Illumina, Inc. Sequencing polynucleotides using nanopores
US20230112203A1 (en) 2021-09-30 2023-04-13 Illumina, Inc. Isolation of cells in a nanopore sensor array
WO2023086391A1 (en) 2021-11-15 2023-05-19 Illumina, Inc. Nanopore systems and methods of fabrication
US20230183799A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
WO2023175026A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Methods of determining sequence information
US20230357307A1 (en) 2022-05-04 2023-11-09 Illumina, Inc. Cleavable cyclic loop nucleotides for nanopore sequencing
CN119301684A (zh) 2022-06-07 2025-01-10 因美纳有限公司 用于鉴定基因变体的方法和系统
WO2024010809A2 (en) 2022-07-07 2024-01-11 Illumina Software, Inc. Methods and systems for detecting recombination events
WO2024010812A2 (en) 2022-07-07 2024-01-11 Illumina Software, Inc. Methods and systems for determining copy number variant genotypes
WO2024073278A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Detecting and genotyping variable number tandem repeats
WO2024072685A1 (en) 2022-09-28 2024-04-04 Illumina, Inc. Fast pulsing for nanopore sensors
WO2024163233A1 (en) 2023-01-31 2024-08-08 Illumina, Inc. Copy number variant calling and recovery
WO2024191730A1 (en) 2023-03-10 2024-09-19 Illumina, Inc. K-mer-based methods for assembling polynucleotide sequences
WO2024228928A1 (en) 2023-05-03 2024-11-07 Illumina, Inc. Controlled polynucleotide translocation in nanopore sequencing
WO2025006460A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with modified bases
WO2025006464A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with alternative scatterplots
WO2025006466A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with four labeled nucleotides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337530A (en) * 1965-09-20 1967-08-22 Upjohn Co Dinucleoside 3', 5' -and 2', 5'-phosphates containing one 7-deazapurin riboside moiety
US3309358A (en) * 1965-09-20 1967-03-14 Upjohn Co 7-deazaadenine 2', 5'-and 3', 5'-dinucleoside phosphate and process therefor
US3962211A (en) * 1975-01-13 1976-06-08 The University Of Utah 7-substituted nucleoside compounds
PT71393B (en) * 1979-06-14 1981-10-22 Wellcome Found Antiprotozoal agents
US4352795A (en) * 1981-01-29 1982-10-05 Warner-Lambert Company 7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
DE68927055T2 (de) * 1988-06-09 1997-04-10 Temple University Of The Commonwealth System Of Higher Education, Philadelphia, Pa. 2',5'-oligoadenylat-derivate zur verwendung als heilmittel
WO1990003370A1 (en) * 1988-09-28 1990-04-05 Microprobe Corporation DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE
EP0450102A4 (en) * 1989-10-26 1992-05-06 Yamasa Shoyu Kabushiki Kaisha Nucleoside derivative
JPH06509945A (ja) * 1991-08-19 1994-11-10 マイクロプローブ・コーポレイション 酵素媒介三本鎖形成のための架橋性オリゴヌクレオチド
WO1993009127A1 (en) * 1991-11-07 1993-05-13 Gilead Sciences, Inc. Enhanced triple-helix formation directed by oligonucleotides composed of 2'-deoxy-7-deazaxanthosine and 2'-deoxy-7-deazaguanosine and related analogs
DE4140463A1 (de) * 1991-12-09 1993-06-17 Boehringer Mannheim Gmbh 2'-desoxy-isoguanosin, dessen isostere analoge sowie anwendung derselben

Also Published As

Publication number Publication date
WO1994024144A3 (en) 1995-03-16
WO1994024144A2 (en) 1994-10-27
EP0695306A1 (de) 1996-02-07

Similar Documents

Publication Publication Date Title
AU6632094A (en) Enhanced triple-helix and double-helix formation with oligomers containing modified purines
HK1018826A1 (en) Personal computer system with security features
AU5246096A (en) Polygonal information encoding article, process and system
AU3429789A (en) Antipilferage tags and their use
GB2279784B (en) Data acquisition and processing system
ZA893176B (en) Fluoroavermectin and fluoromilbemycin derivatives with antiparasitic and presticidal properties
AU4313993A (en) Card-shaped information carrier and its use
EP0551865A3 (en) Polycarbonate and use thereof
AU4747090A (en) Security and alarm system
AU1764292A (en) Re-catalyst and carrier
GB2251773B (en) Graphics accelerator system with line drawing and tracking operations
AU647625B2 (en) Transporter with function of maintaining and moving centre of gravity
AU4843293A (en) 3-azidomethyl-3-nitratomethyloxetane and polymers formed therefrom
GB9204984D0 (en) Bottle and mount therefor
EP0326341A3 (en) Optical detection and control system
AU1816488A (en) Keyless ignition and security system
AU1379788A (en) Polyethylene terephthalate and uses thereof
AU7078094A (en) Allatostatins and their use
AU7692394A (en) Phosphinic acid derivatives with anti-hyper glycemic and/or anti-obesity activity
IL118381A0 (en) Solutions containing erythromycylamine and their use
AU676770C (en) Cyclic peptide with higher stability and/or higher activity
GB9318120D0 (en) Welcome and security lighting
GB9324403D0 (en) Benzodioxanylimidazoline and benzodioxanylimidazole derivatives
GB9300568D0 (en) Benzodioxanylimidazoline and benzodioxanylimidazole derivatives
CA71358S (en) Notebook computer or similar article