AU658255B2 - New peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade, process for preparing them and pharmaceutical compositions containing them - Google Patents

New peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade, process for preparing them and pharmaceutical compositions containing them Download PDF

Info

Publication number
AU658255B2
AU658255B2 AU31170/93A AU3117093A AU658255B2 AU 658255 B2 AU658255 B2 AU 658255B2 AU 31170/93 A AU31170/93 A AU 31170/93A AU 3117093 A AU3117093 A AU 3117093A AU 658255 B2 AU658255 B2 AU 658255B2
Authority
AU
Australia
Prior art keywords
glu
residue
group
acid
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU31170/93A
Other languages
English (en)
Other versions
AU3117093A (en
Inventor
Jean-Luc Fauchere
Joseph Paladino
Christophe Thurieau
Tony Verbeuren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of AU3117093A publication Critical patent/AU3117093A/en
Application granted granted Critical
Publication of AU658255B2 publication Critical patent/AU658255B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU31170/93A 1992-01-15 1993-01-14 New peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade, process for preparing them and pharmaceutical compositions containing them Ceased AU658255B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9200340A FR2686086A1 (fr) 1992-01-15 1992-01-15 Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR9200340 1992-01-15

Publications (2)

Publication Number Publication Date
AU3117093A AU3117093A (en) 1993-07-22
AU658255B2 true AU658255B2 (en) 1995-04-06

Family

ID=9425635

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31170/93A Ceased AU658255B2 (en) 1992-01-15 1993-01-14 New peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade, process for preparing them and pharmaceutical compositions containing them

Country Status (8)

Country Link
US (1) US5371071A (enExample)
EP (1) EP0552999A1 (enExample)
JP (1) JPH0784476B2 (enExample)
AU (1) AU658255B2 (enExample)
CA (1) CA2087328A1 (enExample)
FR (1) FR2686086A1 (enExample)
NZ (1) NZ245679A (enExample)
ZA (1) ZA93274B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2710917B1 (fr) * 1993-10-07 1995-11-24 Adir Nouveaux dérivés de peptides thérapeutiquement actifs dans la cascade de coagulation sanguine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
MXPA03000627A (es) * 2000-07-21 2004-07-30 Schering Corp Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0408448A1 (fr) * 1989-07-11 1991-01-16 L'oreal Nouveaux dérivés d'uréthanne, leur préparation et leur application notamment comme agents hydratants dans des compositions cosmétiques ou pharmaceutiques destinées au traitement des peaux sèches

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU640502B2 (en) * 1990-07-24 1993-08-26 Merrell Dow Pharmaceuticals Inc. Analogs of hirudin having antiplatelet activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0408448A1 (fr) * 1989-07-11 1991-01-16 L'oreal Nouveaux dérivés d'uréthanne, leur préparation et leur application notamment comme agents hydratants dans des compositions cosmétiques ou pharmaceutiques destinées au traitement des peaux sèches

Also Published As

Publication number Publication date
JPH0784476B2 (ja) 1995-09-13
US5371071A (en) 1994-12-06
CA2087328A1 (fr) 1993-07-16
EP0552999A1 (fr) 1993-07-28
ZA93274B (en) 1993-08-23
NZ245679A (en) 1995-06-27
AU3117093A (en) 1993-07-22
FR2686086B1 (enExample) 1995-06-02
JPH05286996A (ja) 1993-11-02
FR2686086A1 (fr) 1993-07-16

Similar Documents

Publication Publication Date Title
CA1311583C (en) Peptide derivatives and their application, in particular in therapy
US6060451A (en) Thrombin inhibitors based on the amino acid sequence of hirudin
JPH04507253A (ja) トロンビンの新規インヒビター
CA2052022A1 (en) Peptides having thrombospondin-like activity and their therapeutic use
WO1997009346A1 (en) Des-arg9-bk antagonists
US5516889A (en) Synthetic thrombin receptor peptides
JPH03120297A (ja) 抗凝固ペプチド
AU641215B2 (en) Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US5371071A (en) Peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade
JP3532920B2 (ja) 三機能性の抗血栓及び抗血小板ペプチド類
US5393873A (en) Peptides with anticoagulant activity
JP2899415B2 (ja) 血液凝固のカスケードにおいて治療上活性である新規ペプチド誘導体、その製造方法、及びそれらを含有する医薬組成物
US5858972A (en) Antithrombotic agents and methods of use
IE913361A1 (en) New peptide and pseudopeptide compounds that are¹therapeutically active in the blood coagulation cascade,¹process for the preparation thereof, and pharmaceutical¹compositions containing them
CA2009613A1 (en) Polypeptide synthesis
WO1996030407A1 (en) Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
BG60759B2 (bg) Инхибитори на тромбин