AU654349B2 - Benzofuran derivatives - Google Patents

Benzofuran derivatives Download PDF

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Publication number
AU654349B2
AU654349B2 AU16320/92A AU1632092A AU654349B2 AU 654349 B2 AU654349 B2 AU 654349B2 AU 16320/92 A AU16320/92 A AU 16320/92A AU 1632092 A AU1632092 A AU 1632092A AU 654349 B2 AU654349 B2 AU 654349B2
Authority
AU
Australia
Prior art keywords
group
compound
bromo
methyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU16320/92A
Other languages
English (en)
Other versions
AU1632092A (en
Inventor
Kevin Stuart Cardwell
Michael Dennis Dowle
Torquil Iain Maclean Jack
Duncan Bruce Judd
David Middlemiss
John Gary Montana
Martin Pass
Barry Clive Ross
David Ian Carter Scopes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110633A external-priority patent/GB9110633D0/en
Priority claimed from GB929201358A external-priority patent/GB9201358D0/en
Priority claimed from GB929205174A external-priority patent/GB9205174D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU1632092A publication Critical patent/AU1632092A/en
Application granted granted Critical
Publication of AU654349B2 publication Critical patent/AU654349B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU16320/92A 1991-05-16 1992-05-15 Benzofuran derivatives Ceased AU654349B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9110633 1991-05-16
GB919110633A GB9110633D0 (en) 1991-05-16 1991-05-16 Chemical compounds
GB929201358A GB9201358D0 (en) 1992-01-22 1992-01-22 Chemical compounds
GB9201358 1992-01-22
GB9205174 1992-03-10
GB929205174A GB9205174D0 (en) 1992-03-10 1992-03-10 Chemical compounds

Publications (2)

Publication Number Publication Date
AU1632092A AU1632092A (en) 1993-03-11
AU654349B2 true AU654349B2 (en) 1994-11-03

Family

ID=27265657

Family Applications (2)

Application Number Title Priority Date Filing Date
AU16320/92A Ceased AU654349B2 (en) 1991-05-16 1992-05-15 Benzofuran derivatives
AU17511/92A Abandoned AU1751192A (en) 1991-05-16 1992-05-15 Benzofuran derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU17511/92A Abandoned AU1751192A (en) 1991-05-16 1992-05-15 Benzofuran derivatives

Country Status (15)

Country Link
US (1) US5317023A (Direct)
EP (1) EP0514197A1 (Direct)
JP (1) JPH06507608A (Direct)
KR (1) KR920021542A (Direct)
AU (2) AU654349B2 (Direct)
CA (1) CA2068756A1 (Direct)
CZ (1) CZ242993A3 (Direct)
FI (1) FI935043A0 (Direct)
HU (1) HUT67014A (Direct)
IE (1) IE921569A1 (Direct)
IL (1) IL101888A0 (Direct)
MX (1) MX9202300A (Direct)
NO (1) NO921951L (Direct)
TW (1) TW221997B (Direct)
WO (1) WO1992020679A1 (Direct)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9110636D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
DE4140519A1 (de) * 1991-12-09 1993-06-17 Merck Patent Gmbh Benzofurane
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
GB9223860D0 (en) * 1992-11-13 1993-01-06 Glaxo Group Ltd Chemical compounds
GB2279346A (en) * 1993-07-01 1995-01-04 Glaxo Group Ltd Benzofuran intermediates
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
WO2005082904A1 (ja) * 2004-02-26 2005-09-09 Kyowa Hakko Kogyo Co., Ltd. 好中球性炎症疾患の予防及び／または治療剤
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
UY38912A (es) * 2019-10-09 2021-05-31 Biocryst Pharm Inc Inhibidores del factor d del complemento para administración oral

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6763290A (en) * 1989-12-01 1991-06-06 Glaxo Group Limited Benzofuran derivatives
AU7820191A (en) * 1990-06-08 1991-12-12 Roussel-Uclaf New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
AU2993792A (en) * 1991-12-09 1993-06-10 Merck Patent Gesellschaft Mit Beschrankter Haftung Benzofurans

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
IL95975A (en) * 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
IL96019A0 (en) * 1989-10-31 1991-07-18 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0430300A3 (en) * 1989-12-01 1992-03-25 Takeda Chemical Industries, Ltd. Xanthine derivatives, their production and use
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
DE4006693A1 (de) * 1990-03-01 1991-09-05 Schering Ag Neue benzimidazolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6763290A (en) * 1989-12-01 1991-06-06 Glaxo Group Limited Benzofuran derivatives
AU7820191A (en) * 1990-06-08 1991-12-12 Roussel-Uclaf New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
AU2993792A (en) * 1991-12-09 1993-06-10 Merck Patent Gesellschaft Mit Beschrankter Haftung Benzofurans

Also Published As

Publication number Publication date
MX9202300A (es) 1992-11-01
IL101888A0 (en) 1992-12-30
CZ242993A3 (en) 1994-03-16
WO1992020679A1 (en) 1992-11-26
FI935043A7 (fi) 1993-11-15
JPH06507608A (ja) 1994-09-01
TW221997B (Direct) 1994-04-01
US5317023A (en) 1994-05-31
CA2068756A1 (en) 1992-11-17
IE921569A1 (en) 1992-11-18
KR920021542A (ko) 1992-12-18
AU1632092A (en) 1993-03-11
EP0514197A1 (en) 1992-11-19
NO921951L (no) 1992-11-17
NO921951D0 (no) 1992-05-15
AU1751192A (en) 1992-12-30
FI935043A0 (fi) 1993-11-15
HUT67014A (en) 1995-01-30
HU9303225D0 (en) 1994-03-28

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