AU654169B2 - Compositions and method for soft tissue tumors - Google Patents
Compositions and method for soft tissue tumors Download PDFInfo
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- AU654169B2 AU654169B2 AU10544/92A AU1054492A AU654169B2 AU 654169 B2 AU654169 B2 AU 654169B2 AU 10544/92 A AU10544/92 A AU 10544/92A AU 1054492 A AU1054492 A AU 1054492A AU 654169 B2 AU654169 B2 AU 654169B2
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- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- BHXBZLPMVFUQBQ-UHFFFAOYSA-K samarium(iii) chloride Chemical compound Cl[Sm](Cl)Cl BHXBZLPMVFUQBQ-UHFFFAOYSA-K 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052706 scandium Inorganic materials 0.000 description 1
- SIXSYDAISGFNSX-UHFFFAOYSA-N scandium atom Chemical compound [Sc] SIXSYDAISGFNSX-UHFFFAOYSA-N 0.000 description 1
- 210000001991 scapula Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Ceramic Products (AREA)
- Stringed Musical Instruments (AREA)
- Manufacture Of Alloys Or Alloy Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US648493 | 1991-01-30 | ||
| US07/648,493 US5342925A (en) | 1991-01-30 | 1991-01-30 | Radioactive compositions for soft tissue tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1054492A AU1054492A (en) | 1992-08-06 |
| AU654169B2 true AU654169B2 (en) | 1994-10-27 |
Family
ID=24601013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU10544/92A Ceased AU654169B2 (en) | 1991-01-30 | 1992-01-29 | Compositions and method for soft tissue tumors |
Country Status (18)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670456B2 (en) | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1242901A (fr) * | 1958-08-08 | 1960-10-07 | Ciba Geigy | Nouveaux sels complexes de fer, procédé pour leur préparation et leur utilisation |
| EP0367223A2 (en) * | 1988-10-31 | 1990-05-09 | The Dow Chemical Company | Chelants possessing ortho ligating functionality and complexes thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US421452A (en) * | 1890-02-18 | Island | ||
| GB718509A (en) * | 1950-06-16 | 1954-11-17 | Ciba Ltd | Manufacture of new imino-dicarboxylic acids and functional derivatives thereof |
| US3132934A (en) * | 1958-08-08 | 1964-05-12 | Ciba Ltd | Ferric chelates of 1-hyroxy-2:6-di-[(n, n1-bis-carboxy-ethyl or methyl)-amino-methyl] benzenes |
| US4091088A (en) * | 1975-02-19 | 1978-05-23 | Australian Atomic Energy Commission | Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals |
| USRE31463E (en) * | 1975-03-03 | 1983-12-13 | Research Corporation | Radiopharmaceutical chelates and method of external imaging |
| US4017596A (en) * | 1975-03-03 | 1977-04-12 | Research Corporation | Radiopharmaceutical chelates and method of external imaging |
| BE826846A (nl) | 1975-03-25 | 1975-09-19 | Ontwikkelaars voor fotografische zilverhalogenidematerialen | |
| CH607920A5 (enrdf_load_html_response) * | 1976-05-31 | 1978-12-15 | Solco Basel Ag | |
| DE2920174A1 (de) * | 1979-05-18 | 1980-11-20 | Hoechst Ag | Technetium-99m-markierte acetanilidoiminodiacetate zur leberfunktionsdiagnostik |
| US4308249A (en) * | 1979-12-13 | 1981-12-29 | G. D. Searle & Co. | Radiopharmaceutical complexes of N-(tri-substituted alkyl)-iminodiacetic acids |
| JPS5791927A (en) * | 1980-11-27 | 1982-06-08 | Nippon Mejifuijitsukusu Kk | Technetium-99m labelled diagnosticum |
| US4418208A (en) * | 1980-12-29 | 1983-11-29 | E. R. Squibb & Sons, Inc. | N-Substituted iminodiacetic acids |
| US4637988A (en) * | 1981-07-01 | 1987-01-20 | Eastman Kodak Company | Fluorescent labels for immunoassay |
| US4801722A (en) * | 1981-07-01 | 1989-01-31 | Eastman Kodak Company | Coumarin chelates |
| US4454107A (en) * | 1982-08-30 | 1984-06-12 | Merck & Co., Inc. | Tc99m-Phenida, radioscintigraphic agent for diagnosis of hepatoniliary disease |
| GB8413772D0 (en) * | 1984-05-30 | 1984-07-04 | Nyegaard & Co As | Chemical compounds |
| US4898724A (en) * | 1984-06-04 | 1990-02-06 | The Dow Chemical Company | Organis amine phosphonic acid complexes for the treatment of calcific tumors |
| US4897254A (en) * | 1984-09-21 | 1990-01-30 | The Dow Chemical Company | Radioactive compositions for the treatment of calcific tumors |
| US4909257A (en) * | 1986-05-01 | 1990-03-20 | The Regents Of The University Of California | Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging |
| WO1989006980A1 (en) * | 1988-01-29 | 1989-08-10 | University Of Queensland | Radiopharmaceuticals |
-
1991
- 1991-01-30 US US07/648,493 patent/US5342925A/en not_active Expired - Fee Related
-
1992
- 1992-01-29 IL IL10080192A patent/IL100801A/en not_active IP Right Cessation
- 1992-01-29 AU AU10544/92A patent/AU654169B2/en not_active Ceased
- 1992-01-30 AT AT92101568T patent/ATE169615T1/de not_active IP Right Cessation
- 1992-01-30 NZ NZ241464A patent/NZ241464A/en unknown
- 1992-01-30 ES ES92101568T patent/ES2118758T3/es not_active Expired - Lifetime
- 1992-01-30 JP JP50543892A patent/JP3300348B2/ja not_active Expired - Fee Related
- 1992-01-30 MX MX9200414A patent/MX9200414A/es not_active IP Right Cessation
- 1992-01-30 CA CA002060330A patent/CA2060330C/en not_active Expired - Fee Related
- 1992-01-30 WO PCT/US1992/000682 patent/WO1992013826A1/en active Application Filing
- 1992-01-30 DK DK92101568T patent/DK0497356T3/da active
- 1992-01-30 IE IE031092A patent/IE920310A1/en unknown
- 1992-01-30 KR KR1019920702363A patent/KR100256456B1/ko not_active Expired - Fee Related
- 1992-01-30 DE DE69226541T patent/DE69226541T2/de not_active Expired - Fee Related
- 1992-01-30 TW TW081100714A patent/TW215091B/zh active
- 1992-01-30 FI FI924362A patent/FI924362A0/fi not_active IP Right Cessation
- 1992-01-30 ZA ZA92664A patent/ZA92664B/xx unknown
- 1992-01-30 EP EP92101568A patent/EP0497356B1/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1242901A (fr) * | 1958-08-08 | 1960-10-07 | Ciba Geigy | Nouveaux sels complexes de fer, procédé pour leur préparation et leur utilisation |
| EP0367223A2 (en) * | 1988-10-31 | 1990-05-09 | The Dow Chemical Company | Chelants possessing ortho ligating functionality and complexes thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2060330C (en) | 2002-11-26 |
| AU1054492A (en) | 1992-08-06 |
| US5342925A (en) | 1994-08-30 |
| ATE169615T1 (de) | 1998-08-15 |
| JPH05505627A (ja) | 1993-08-19 |
| EP0497356B1 (en) | 1998-08-12 |
| MX9200414A (es) | 1992-07-01 |
| DK0497356T3 (da) | 1999-05-17 |
| JP3300348B2 (ja) | 2002-07-08 |
| DE69226541D1 (de) | 1998-09-17 |
| FI924362A7 (fi) | 1992-09-29 |
| EP0497356A1 (en) | 1992-08-05 |
| CA2060330A1 (en) | 1992-07-31 |
| NZ241464A (en) | 1994-11-25 |
| ZA92664B (en) | 1993-07-30 |
| IE920310A1 (en) | 1992-07-29 |
| TW215091B (enrdf_load_html_response) | 1993-10-21 |
| DE69226541T2 (de) | 1998-12-24 |
| ES2118758T3 (es) | 1998-10-01 |
| KR930700162A (ko) | 1993-03-13 |
| FI924362L (fi) | 1992-09-29 |
| WO1992013826A1 (en) | 1992-08-20 |
| IL100801A (en) | 1996-11-14 |
| IL100801A0 (en) | 1992-09-06 |
| FI924362A0 (fi) | 1992-09-29 |
| KR100256456B1 (ko) | 2000-08-01 |
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