AU651067B2 - Formation of triple helix complexes of double stranded DNA using nucleoside oligomers - Google Patents

Formation of triple helix complexes of double stranded DNA using nucleoside oligomers

Info

Publication number
AU651067B2
AU651067B2 AU58468/90A AU5846890A AU651067B2 AU 651067 B2 AU651067 B2 AU 651067B2 AU 58468/90 A AU58468/90 A AU 58468/90A AU 5846890 A AU5846890 A AU 5846890A AU 651067 B2 AU651067 B2 AU 651067B2
Authority
AU
Australia
Prior art keywords
oligomer
guanine
adenine
dna
nucleosidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU58468/90A
Other languages
English (en)
Other versions
AU5846890A (en
Inventor
Paul S. Miller
Paul Ts'o
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of AU5846890A publication Critical patent/AU5846890A/en
Application granted granted Critical
Publication of AU651067B2 publication Critical patent/AU651067B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU58468/90A 1989-06-19 1990-06-14 Formation of triple helix complexes of double stranded DNA using nucleoside oligomers Ceased AU651067B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36802789A 1989-06-19 1989-06-19
US368027 1989-06-19
PCT/US1990/003275 WO1990015884A1 (en) 1989-06-19 1990-06-14 Formation of triple helix complexes of double stranded dna using nucleoside oligomers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU75845/94A Division AU679111B2 (en) 1989-06-19 1994-10-14 Purine oligomers

Publications (2)

Publication Number Publication Date
AU5846890A AU5846890A (en) 1991-01-08
AU651067B2 true AU651067B2 (en) 1994-07-14

Family

ID=23449587

Family Applications (2)

Application Number Title Priority Date Filing Date
AU58468/90A Ceased AU651067B2 (en) 1989-06-19 1990-06-14 Formation of triple helix complexes of double stranded DNA using nucleoside oligomers
AU75845/94A Ceased AU679111B2 (en) 1989-06-19 1994-10-14 Purine oligomers

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU75845/94A Ceased AU679111B2 (en) 1989-06-19 1994-10-14 Purine oligomers

Country Status (9)

Country Link
EP (1) EP0478708A4 (enrdf_load_stackoverflow)
JP (1) JPH04506152A (enrdf_load_stackoverflow)
AU (2) AU651067B2 (enrdf_load_stackoverflow)
CA (1) CA2019156A1 (enrdf_load_stackoverflow)
IL (1) IL94752A (enrdf_load_stackoverflow)
NZ (1) NZ234082A (enrdf_load_stackoverflow)
TW (1) TW221829B (enrdf_load_stackoverflow)
WO (1) WO1990015884A1 (enrdf_load_stackoverflow)
ZA (1) ZA904689B (enrdf_load_stackoverflow)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
CA2083719A1 (en) * 1990-05-25 1991-11-26 Mark D. Matteucci "sequence-specific non-photoactivated crosslinking agents which bind to the major groove of duplex dna
WO1992011390A1 (en) * 1990-12-17 1992-07-09 Idexx Laboratories, Inc. Nucleic acid sequence detection by triple helix formation
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
CA2116343A1 (en) * 1991-08-30 1993-03-18 Paul S. Miller Formation of triple helix complexes of double stranded dna using nucleoside oligomers which comprise purine base analogs
IL103311A0 (en) * 1991-10-07 1993-03-15 Univ Johns Hopkins Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
CA2122365C (en) * 1991-11-26 2010-05-11 Brian Froehler Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5616461A (en) * 1992-05-14 1997-04-01 Dana-Farber Cancer Institute Assay for antiviral activity using complex of herpesvirus origin of replication and cellular protein
AU6296294A (en) * 1993-01-26 1994-08-15 Microprobe Corporation Bifunctional crosslinking oligonucleotides adapted for linking to a desired gene sequence of invading organism or cell

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4757055A (en) * 1980-11-12 1988-07-12 The Johns Hopkins University Method for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells

Also Published As

Publication number Publication date
JPH04506152A (ja) 1992-10-29
EP0478708A4 (en) 1993-06-09
ZA904689B (en) 1991-03-27
AU7584594A (en) 1994-12-15
AU679111B2 (en) 1997-06-19
CA2019156A1 (en) 1990-12-19
TW221829B (enrdf_load_stackoverflow) 1994-03-21
IL94752A (en) 1995-12-31
WO1990015884A1 (en) 1990-12-27
EP0478708A1 (en) 1992-04-08
AU5846890A (en) 1991-01-08
IL94752A0 (en) 1991-04-15
NZ234082A (en) 1997-06-24

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