AU628653B2 - Novel cns-active hexapeptides with an antiamnesic effect - Google Patents
Novel cns-active hexapeptides with an antiamnesic effectInfo
- Publication number
- AU628653B2 AU628653B2 AU63064/90A AU6306490A AU628653B2 AU 628653 B2 AU628653 B2 AU 628653B2 AU 63064/90 A AU63064/90 A AU 63064/90A AU 6306490 A AU6306490 A AU 6306490A AU 628653 B2 AU628653 B2 AU 628653B2
- Authority
- AU
- Australia
- Prior art keywords
- denotes
- hexapeptides
- active
- lys
- met
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
Abstract
The present invention relates to hexapeptides of the general formula I R<1>-A<1>-A<2>-A<3>-A<4>-A<5>-A<6>-NH(CH2)n-NH2 (I> where R<1> denotes Z, formyl or (subst.) alkanoyl; A<1> denotes Met, Met(O) or Met(O2), all of which can be in the L or D form; A<2> denotes Glu, D-Glu, Ala or pyroglutamyl; A<3> denotes His, Ala, Phe or D-Lys; A<4> denotes the radical of a neutral aliphatic or aromatic alpha -amino acid; A<5> denotes Lys or D-Lys; A<6> denotes (subst.) Phe and n denotes an integer from 4 to 10. Processes for the preparation thereof, the use thereof as medicines, and pharmaceutical compositions containing these are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3931788A DE3931788A1 (en) | 1989-09-23 | 1989-09-23 | NEW CNS ACTIVE HEXAPEPTIDES WITH ANTIAMNESTIC EFFECT |
DE3931788 | 1989-09-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6306490A AU6306490A (en) | 1991-03-28 |
AU628653B2 true AU628653B2 (en) | 1992-09-17 |
Family
ID=6390039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU63064/90A Ceased AU628653B2 (en) | 1989-09-23 | 1990-09-21 | Novel cns-active hexapeptides with an antiamnesic effect |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0424670B1 (en) |
JP (1) | JPH03120295A (en) |
AT (1) | ATE118786T1 (en) |
AU (1) | AU628653B2 (en) |
CA (1) | CA2025941A1 (en) |
DE (2) | DE3931788A1 (en) |
DK (1) | DK0424670T3 (en) |
ES (1) | ES2070229T3 (en) |
GR (1) | GR3015492T3 (en) |
IE (1) | IE66529B1 (en) |
PT (1) | PT95381B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106608901B (en) * | 2015-10-22 | 2020-10-16 | 彭莉 | Dihydroxydimethyltetrahydroisoquinoline-3-formyl-Lys (Lys-Ala), and synthesis, activity and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0179332A2 (en) * | 1984-10-22 | 1986-04-30 | Hoechst Aktiengesellschaft | ZNS-active peptides acting on the cholinergetic system |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE758206A (en) * | 1969-10-31 | 1971-04-29 | Hoechst Ag | PEPTIDES WITH ADRENOCORTICOTROPIC ACTIVITY AND MEDICINAL PRODUCTS CONTAINING IT |
DE1965102A1 (en) * | 1969-12-27 | 1971-07-01 | Hoechst Ag | Tridecapeptides with adrenocorticotropic - activity |
-
1989
- 1989-09-23 DE DE3931788A patent/DE3931788A1/en not_active Withdrawn
-
1990
- 1990-09-20 DE DE59008515T patent/DE59008515D1/en not_active Expired - Fee Related
- 1990-09-20 DK DK90118102.4T patent/DK0424670T3/en active
- 1990-09-20 EP EP90118102A patent/EP0424670B1/en not_active Expired - Lifetime
- 1990-09-20 AT AT90118102T patent/ATE118786T1/en not_active IP Right Cessation
- 1990-09-20 ES ES90118102T patent/ES2070229T3/en not_active Expired - Lifetime
- 1990-09-21 AU AU63064/90A patent/AU628653B2/en not_active Ceased
- 1990-09-21 PT PT95381A patent/PT95381B/en not_active IP Right Cessation
- 1990-09-21 JP JP2250423A patent/JPH03120295A/en active Pending
- 1990-09-21 IE IE342090A patent/IE66529B1/en not_active IP Right Cessation
- 1990-09-21 CA CA002025941A patent/CA2025941A1/en not_active Abandoned
-
1995
- 1995-03-20 GR GR950400623T patent/GR3015492T3/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0179332A2 (en) * | 1984-10-22 | 1986-04-30 | Hoechst Aktiengesellschaft | ZNS-active peptides acting on the cholinergetic system |
Also Published As
Publication number | Publication date |
---|---|
EP0424670A1 (en) | 1991-05-02 |
CA2025941A1 (en) | 1991-03-24 |
DE3931788A1 (en) | 1991-04-04 |
DE59008515D1 (en) | 1995-03-30 |
IE903420A1 (en) | 1991-04-10 |
PT95381A (en) | 1991-05-22 |
IE66529B1 (en) | 1996-01-17 |
PT95381B (en) | 1997-07-31 |
GR3015492T3 (en) | 1995-06-30 |
AU6306490A (en) | 1991-03-28 |
ES2070229T3 (en) | 1995-06-01 |
ATE118786T1 (en) | 1995-03-15 |
JPH03120295A (en) | 1991-05-22 |
DK0424670T3 (en) | 1995-07-17 |
EP0424670B1 (en) | 1995-02-22 |
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