DK0424670T3 - Novel CNS-active hexapeptides with antiamnestic effect - Google Patents

Novel CNS-active hexapeptides with antiamnestic effect

Info

Publication number
DK0424670T3
DK0424670T3 DK90118102.4T DK90118102T DK0424670T3 DK 0424670 T3 DK0424670 T3 DK 0424670T3 DK 90118102 T DK90118102 T DK 90118102T DK 0424670 T3 DK0424670 T3 DK 0424670T3
Authority
DK
Denmark
Prior art keywords
denotes
hexapeptides
active
lys
met
Prior art date
Application number
DK90118102.4T
Other languages
Danish (da)
Inventor
Hermann Josef Dr Gerhards
Georg Dr Jaeger
Franz Dr Hock
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0424670T3 publication Critical patent/DK0424670T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to hexapeptides of the general formula I R<1>-A<1>-A<2>-A<3>-A<4>-A<5>-A<6>-NH(CH2)n-NH2 (I> where R<1> denotes Z, formyl or (subst.) alkanoyl; A<1> denotes Met, Met(O) or Met(O2), all of which can be in the L or D form; A<2> denotes Glu, D-Glu, Ala or pyroglutamyl; A<3> denotes His, Ala, Phe or D-Lys; A<4> denotes the radical of a neutral aliphatic or aromatic alpha -amino acid; A<5> denotes Lys or D-Lys; A<6> denotes (subst.) Phe and n denotes an integer from 4 to 10. Processes for the preparation thereof, the use thereof as medicines, and pharmaceutical compositions containing these are described.
DK90118102.4T 1989-09-23 1990-09-20 Novel CNS-active hexapeptides with antiamnestic effect DK0424670T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931788A DE3931788A1 (en) 1989-09-23 1989-09-23 NEW CNS ACTIVE HEXAPEPTIDES WITH ANTIAMNESTIC EFFECT

Publications (1)

Publication Number Publication Date
DK0424670T3 true DK0424670T3 (en) 1995-07-17

Family

ID=6390039

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90118102.4T DK0424670T3 (en) 1989-09-23 1990-09-20 Novel CNS-active hexapeptides with antiamnestic effect

Country Status (11)

Country Link
EP (1) EP0424670B1 (en)
JP (1) JPH03120295A (en)
AT (1) ATE118786T1 (en)
AU (1) AU628653B2 (en)
CA (1) CA2025941A1 (en)
DE (2) DE3931788A1 (en)
DK (1) DK0424670T3 (en)
ES (1) ES2070229T3 (en)
GR (1) GR3015492T3 (en)
IE (1) IE66529B1 (en)
PT (1) PT95381B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106608901B (en) * 2015-10-22 2020-10-16 彭莉 Dihydroxydimethyltetrahydroisoquinoline-3-formyl-Lys (Lys-Ala), and synthesis, activity and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758206A (en) * 1969-10-31 1971-04-29 Hoechst Ag PEPTIDES WITH ADRENOCORTICOTROPIC ACTIVITY AND MEDICINAL PRODUCTS CONTAINING IT
DE1965102A1 (en) * 1969-12-27 1971-07-01 Hoechst Ag Tridecapeptides with adrenocorticotropic - activity
US4623715A (en) * 1984-10-22 1986-11-18 Hoechst Aktiengeselleschaft Novel peptides which are active on the central nervous system and have an action on the cholinergic system

Also Published As

Publication number Publication date
GR3015492T3 (en) 1995-06-30
PT95381A (en) 1991-05-22
CA2025941A1 (en) 1991-03-24
AU628653B2 (en) 1992-09-17
DE59008515D1 (en) 1995-03-30
ES2070229T3 (en) 1995-06-01
AU6306490A (en) 1991-03-28
DE3931788A1 (en) 1991-04-04
IE903420A1 (en) 1991-04-10
EP0424670B1 (en) 1995-02-22
PT95381B (en) 1997-07-31
JPH03120295A (en) 1991-05-22
EP0424670A1 (en) 1991-05-02
ATE118786T1 (en) 1995-03-15
IE66529B1 (en) 1996-01-17

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