AU6209896A - New cephalosporins containing in position 7 a substituted benzyloxyimino radical, their preparation process and intermediates, their use as medicaments - Google Patents

New cephalosporins containing in position 7 a substituted benzyloxyimino radical, their preparation process and intermediates, their use as medicaments

Info

Publication number
AU6209896A
AU6209896A AU62098/96A AU6209896A AU6209896A AU 6209896 A AU6209896 A AU 6209896A AU 62098/96 A AU62098/96 A AU 62098/96A AU 6209896 A AU6209896 A AU 6209896A AU 6209896 A AU6209896 A AU 6209896A
Authority
AU
Australia
Prior art keywords
medicaments
intermediates
preparation process
new cephalosporins
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU62098/96A
Other versions
AU708973B2 (en
Inventor
Jozsef Aszodi
Patrick Fauveau
Daniel Humbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU6209896A publication Critical patent/AU6209896A/en
Assigned to HOECHST MARION ROUSSEL reassignment HOECHST MARION ROUSSEL Alteration of Name(s) of Applicant(s) under S113 Assignors: ROUSSEL-UCLAF
Application granted granted Critical
Publication of AU708973B2 publication Critical patent/AU708973B2/en
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Alteration of Name(s) in Register under S187 Assignors: HOECHST MARION ROUSSEL
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Syn isomer of cpds. of formula (I), and their salts, are new. In (I), R1-R3, R5 = H, halo, OH, 1-4C alkyl (opt. substd. by halo, 1-4C alkyloxy, SH etc.); R4 = OH or 1-8C acyloxy; R7 = H or (1-3C alkyloxy)carbonyl; A = e.g. H, an equivalent of alkali(ne earth) metal, Mg, ammonium or aminated organic base etc.; or CO2A = CO2-; wavy line shows that CH2R6 can be in E- or Z-position; R6 = e.g. quat. ammonium or gp. of formula (i); X = CH2, NH, O or S; and Y, T, U, V, W and Z = CH or N; with the provisos.
AU62098/96A 1995-08-16 1996-08-15 New cephalosporins containing in position 7 a substituted benzyloxyimino radical, their preparation process and intermediates, their use as medicaments Ceased AU708973B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9509822 1995-08-16
FR9509822A FR2737893B1 (en) 1995-08-16 1995-08-16 NOVEL CEPHALOSPORINS COMPRISING IN POSITION 7, A SUBSTITUTED RADICAL BENZYLOXYIMINO, THEIR PREPARATION PROCESS AND INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS

Publications (2)

Publication Number Publication Date
AU6209896A true AU6209896A (en) 1997-02-20
AU708973B2 AU708973B2 (en) 1999-08-19

Family

ID=9481928

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62098/96A Ceased AU708973B2 (en) 1995-08-16 1996-08-15 New cephalosporins containing in position 7 a substituted benzyloxyimino radical, their preparation process and intermediates, their use as medicaments

Country Status (15)

Country Link
EP (1) EP0761672B1 (en)
JP (1) JPH0959281A (en)
KR (1) KR970010775A (en)
CN (2) CN1152575A (en)
AT (1) ATE208396T1 (en)
AU (1) AU708973B2 (en)
CA (1) CA2183469A1 (en)
DE (1) DE69616702T2 (en)
DK (1) DK0761672T3 (en)
EA (1) EA000165B1 (en)
ES (1) ES2164853T3 (en)
FR (1) FR2737893B1 (en)
HU (1) HUP9602254A3 (en)
PT (1) PT761672E (en)
ZA (1) ZA966465B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100388120B1 (en) * 1998-05-11 2003-06-18 다케다 야쿠힌 고교 가부시키가이샤 Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663332B1 (en) * 1990-06-15 1997-11-07 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A RADICAL PROPENYL SUBSTITUTED BY A QUATERNARY AMMONIUM, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED.
FR2684995A1 (en) * 1991-12-12 1993-06-18 Roussel Uclaf Cephalosporins containing a ( alpha -carboxy-3,4-dihydroxybenzyloxyimino) group, preparation process and intermediates, application as medicaments and pharmaceutical compositions
PT551034E (en) * 1991-12-12 2001-01-31 Hoechst Marion Roussel Inc CEFALOSPORIN ANTIBIOTICS WITH A BENZYLOXYMINE RADICAL REPLACED IN POSITION 7
KR100257130B1 (en) * 1993-09-11 2000-05-15 성재갑 Novel cephalosphorine antibiotics

Also Published As

Publication number Publication date
DE69616702D1 (en) 2001-12-13
EA000165B1 (en) 1998-10-29
CA2183469A1 (en) 1997-02-17
EA199600055A1 (en) 1997-03-31
KR970010775A (en) 1997-03-27
HUP9602254A3 (en) 2001-04-28
CN1388120A (en) 2003-01-01
AU708973B2 (en) 1999-08-19
PT761672E (en) 2002-04-29
JPH0959281A (en) 1997-03-04
FR2737893B1 (en) 1997-09-12
EP0761672B1 (en) 2001-11-07
CN1152575A (en) 1997-06-25
DK0761672T3 (en) 2002-03-11
DE69616702T2 (en) 2002-08-01
FR2737893A1 (en) 1997-02-21
EP0761672A1 (en) 1997-03-12
HU9602254D0 (en) 1996-10-28
HUP9602254A2 (en) 1997-05-28
ZA966465B (en) 1997-07-30
ES2164853T3 (en) 2002-03-01
ATE208396T1 (en) 2001-11-15

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: AVENTIS PHARMA S.A.

Free format text: FORMER OWNER WAS: HOECHST MARION ROUSSEL

MK14 Patent ceased section 143(a) (annual fees not paid) or expired