AU592474B2 - 5-nitrobenzo(DE)isoquinoline-1,3-diones, their preparation and their use - Google Patents

5-nitrobenzo(DE)isoquinoline-1,3-diones, their preparation and their use Download PDF

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Publication number
AU592474B2
AU592474B2 AU79990/87A AU7999087A AU592474B2 AU 592474 B2 AU592474 B2 AU 592474B2 AU 79990/87 A AU79990/87 A AU 79990/87A AU 7999087 A AU7999087 A AU 7999087A AU 592474 B2 AU592474 B2 AU 592474B2
Authority
AU
Australia
Prior art keywords
formula
dione
amino
acid
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79990/87A
Other languages
English (en)
Other versions
AU7999087A (en
Inventor
Jose Maria Castellano Berlanga
Miguel Brana Fernandez
Gerhard Keilhauer
Marina Moran Moset
Erich Schlick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Publication of AU7999087A publication Critical patent/AU7999087A/en
Application granted granted Critical
Publication of AU592474B2 publication Critical patent/AU592474B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
AU79990/87A 1986-10-21 1987-10-21 5-nitrobenzo(DE)isoquinoline-1,3-diones, their preparation and their use Ceased AU592474B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863635711 DE3635711A1 (de) 1986-10-21 1986-10-21 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
DE3635711 1986-10-21

Publications (2)

Publication Number Publication Date
AU7999087A AU7999087A (en) 1988-04-28
AU592474B2 true AU592474B2 (en) 1990-01-11

Family

ID=6312114

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79990/87A Ceased AU592474B2 (en) 1986-10-21 1987-10-21 5-nitrobenzo(DE)isoquinoline-1,3-diones, their preparation and their use

Country Status (9)

Country Link
US (1) US5552544A (enExample)
EP (1) EP0268093B1 (enExample)
JP (1) JPS63104963A (enExample)
AT (1) ATE76069T1 (enExample)
AU (1) AU592474B2 (enExample)
CA (1) CA1331382C (enExample)
DE (2) DE3635711A1 (enExample)
ES (1) ES2037055T3 (enExample)
ZA (1) ZA877859B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3939372A1 (de) * 1989-11-29 1991-06-06 Knoll Ag Mitonafide-infusionsloesung
DE3942280A1 (de) * 1989-12-21 1991-06-27 Knoll Ag N-substituierte naphthalimide, ihre herstellung und verwendung
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
AU728523C (en) 1996-10-21 2001-08-09 Nps Pharmaceuticals, Inc. Neurotrophin antagonist compositions
DE19714161A1 (de) * 1997-04-05 1998-10-08 Emtec Magnetics Gmbh Magnetischer Aufzeichnungsträger
AU760136B2 (en) * 1998-11-25 2003-05-08 Merck Patent Gmbh Substituted benzo(DE)isoquinoline-1,3-diones
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) * 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
WO2002036135A2 (en) * 2000-11-06 2002-05-10 Pharma Mar, S.A. Compositions for antitumour treatment containing ecteinascidin 743
DE10101319A1 (de) * 2001-01-09 2002-07-18 Schering Ag Morphometrisches Gewebe- oder Zellpräparat
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
US6693198B2 (en) * 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
US20040082788A1 (en) * 2002-07-08 2004-04-29 Chemgenex Therapeutics, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
JP2007511499A (ja) * 2003-11-13 2007-05-10 ファーマ・マール・エス・アー・ウー コンビネーション
JP2007511509A (ja) * 2003-11-14 2007-05-10 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
JP2007536283A (ja) * 2004-05-05 2007-12-13 ユニバイオスクリーン エス．アー． ナフタルイミド誘導体、それらの製造方法、およびそれらの医薬組成物
JP2008505862A (ja) * 2004-07-09 2008-02-28 ファルマ、マール、ソシエダード、アノニマ 予後分子マーカー
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
RS50822B (sr) * 2004-10-26 2010-08-31 Pharma Mar S.A., Sociedad Unipersonal Pegilovani lipozomalni doksorubicin u kombinaciji sa ekteinescidinom 743
KR101188691B1 (ko) * 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
US20070099900A1 (en) 2005-09-15 2007-05-03 Painceptor Pharma Corporation Methods of modulating neurotrophin-mediated activity
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
JP2009536169A (ja) * 2006-05-05 2009-10-08 ユニバイオスクリーン エス．アー． ５−尿素置換ナフタルイミド誘導体、製造方法、および癌治療用医薬組成物
WO2009050303A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for et-743 treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU534463B2 (en) * 1979-11-07 1984-02-02 Hoechst A.G. Napthalimides
AU7212587A (en) * 1986-04-29 1987-11-05 Knoll Aktiengesellschaft Benzo (de) isoquinoline-1,3-diones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES459497A1 (es) * 1977-06-04 1978-04-16 Made Labor Sa Un metodo para la preparacion industrial de naftalimidas y sus derivados.
US4614820A (en) * 1983-04-01 1986-09-30 Warner-Lambert Co. 3,6-disubstituted-1,8-naphthalimides
EP0125439B1 (en) * 1983-04-01 1990-01-24 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
US4782064A (en) * 1986-07-21 1988-11-01 American Cyanamid Co. 2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU534463B2 (en) * 1979-11-07 1984-02-02 Hoechst A.G. Napthalimides
AU7212587A (en) * 1986-04-29 1987-11-05 Knoll Aktiengesellschaft Benzo (de) isoquinoline-1,3-diones

Also Published As

Publication number Publication date
EP0268093B1 (de) 1992-05-13
ES2037055T3 (es) 1993-06-16
AU7999087A (en) 1988-04-28
ZA877859B (en) 1989-06-28
ATE76069T1 (de) 1992-05-15
JPS63104963A (ja) 1988-05-10
EP0268093A1 (de) 1988-05-25
US5552544A (en) 1996-09-03
DE3635711A1 (de) 1988-04-28
DE3779053D1 (enExample) 1992-06-17
CA1331382C (en) 1994-08-09

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