AU578314B2 - Octahydroindolo (2,3-a) quinolizin-1-yl-alkane- carboxylic acid amides - Google Patents

Octahydroindolo (2,3-a) quinolizin-1-yl-alkane- carboxylic acid amides

Info

Publication number
AU578314B2
AU578314B2 AU48329/85A AU4832985A AU578314B2 AU 578314 B2 AU578314 B2 AU 578314B2 AU 48329/85 A AU48329/85 A AU 48329/85A AU 4832985 A AU4832985 A AU 4832985A AU 578314 B2 AU578314 B2 AU 578314B2
Authority
AU
Australia
Prior art keywords
group
alkyl group
acid
general formula
broad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU48329/85A
Other languages
English (en)
Other versions
AU4832985A (en
Inventor
Zsuzsanna Bologh
Elemer Ezer
Gyorgy Hajos
Maria Incze
Csaba Kuthi
Judit Matuz
Ferenc Soti
Csaba Szantay
Laszlo Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of AU4832985A publication Critical patent/AU4832985A/en
Application granted granted Critical
Publication of AU578314B2 publication Critical patent/AU578314B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU48329/85A 1984-10-05 1985-10-04 Octahydroindolo (2,3-a) quinolizin-1-yl-alkane- carboxylic acid amides Ceased AU578314B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU843776A HU191454B (en) 1984-10-05 1984-10-05 Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU3776/84 1984-10-05

Publications (2)

Publication Number Publication Date
AU4832985A AU4832985A (en) 1986-04-10
AU578314B2 true AU578314B2 (en) 1988-10-20

Family

ID=10965440

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48329/85A Ceased AU578314B2 (en) 1984-10-05 1985-10-04 Octahydroindolo (2,3-a) quinolizin-1-yl-alkane- carboxylic acid amides

Country Status (23)

Country Link
US (1) US4782052A (enExample)
EP (1) EP0177361A3 (enExample)
JP (1) JPS61126086A (enExample)
KR (1) KR860003254A (enExample)
CN (1) CN85109716A (enExample)
AU (1) AU578314B2 (enExample)
CA (1) CA1267145A (enExample)
DD (1) DD237659A5 (enExample)
DK (1) DK453485A (enExample)
ES (1) ES8701176A1 (enExample)
FI (1) FI853867L (enExample)
GR (1) GR852410B (enExample)
HU (1) HU191454B (enExample)
IL (1) IL76579A0 (enExample)
IN (1) IN162609B (enExample)
NO (1) NO161857B (enExample)
NZ (1) NZ213710A (enExample)
PH (1) PH23265A (enExample)
PL (1) PL145678B1 (enExample)
PT (1) PT81256B (enExample)
SU (1) SU1470193A3 (enExample)
YU (1) YU159085A (enExample)
ZA (1) ZA857687B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582663B2 (en) * 1985-08-10 1989-04-06 John Wyeth & Brother Limited Sulphonamides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8479882A (en) * 1981-06-12 1982-12-16 Richter Gedeon Vegyeszeti Gyar Rt. Process for preparation of apovincaminic acid esters
AU5638386A (en) * 1985-04-19 1986-10-23 Richter Gedeon Vegyeszeti Gyar Rt. (-)-1 Beta-Ethyl-1 alpha- hydroxymethyl-1,2,3,4,6,7,12, 12balpha octahydroindolo (2,3-a) quinolizine, process for its preparation and pharmaceutical compositions containing same
AU5638286A (en) * 1985-04-19 1986-10-23 Richter Gedeon Vegyeszeti Gyar Rt. 12b-substituted 1-hydroxymethyl-octahydroindolo-``2,3-a`` quinolizine derivatives, process for their preparation and pharmaceutical compositions containing them

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565804A (en) * 1975-10-28 1980-04-23 Inverni Della Beffa Spa Alkaloid derivatives
ZA786426B (en) * 1977-11-25 1979-10-31 Scras New indulo(2,3-a)quinolizidines,preparation and therapeutic use
HU178700B (en) * 1978-02-10 1982-06-28 Richter Gedeon Vegyeszet Process for preparing 1,1-disubstituted octahydro-indolo/2,3-a/-quinolizines
US4353911A (en) * 1979-07-20 1982-10-12 Andre Buzas Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
EP0079411B1 (fr) * 1981-11-18 1987-02-04 Thal, Claude Dérivés d'indoloquinolizine, leur procédé de préparation et leur application en thérapeutique
DE3204960A1 (de) * 1982-02-12 1983-08-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Corynanthein-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8479882A (en) * 1981-06-12 1982-12-16 Richter Gedeon Vegyeszeti Gyar Rt. Process for preparation of apovincaminic acid esters
AU5638386A (en) * 1985-04-19 1986-10-23 Richter Gedeon Vegyeszeti Gyar Rt. (-)-1 Beta-Ethyl-1 alpha- hydroxymethyl-1,2,3,4,6,7,12, 12balpha octahydroindolo (2,3-a) quinolizine, process for its preparation and pharmaceutical compositions containing same
AU5638286A (en) * 1985-04-19 1986-10-23 Richter Gedeon Vegyeszeti Gyar Rt. 12b-substituted 1-hydroxymethyl-octahydroindolo-``2,3-a`` quinolizine derivatives, process for their preparation and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582663B2 (en) * 1985-08-10 1989-04-06 John Wyeth & Brother Limited Sulphonamides

Also Published As

Publication number Publication date
EP0177361A2 (en) 1986-04-09
PT81256B (pt) 1987-10-20
ES8701176A1 (es) 1986-11-16
CA1267145A (en) 1990-03-27
FI853867A0 (fi) 1985-10-04
PT81256A (en) 1985-11-01
SU1470193A3 (ru) 1989-03-30
NZ213710A (en) 1988-08-30
FI853867A7 (fi) 1986-04-06
PL255646A1 (en) 1986-10-21
PL145678B1 (en) 1988-10-31
HU191454B (en) 1987-02-27
PH23265A (en) 1989-06-23
YU159085A (en) 1988-04-30
FI853867L (fi) 1986-04-06
ES547605A0 (es) 1986-11-16
AU4832985A (en) 1986-04-10
NO853936L (no) 1986-04-07
IN162609B (enExample) 1988-06-18
NO161857B (no) 1989-06-26
KR860003254A (ko) 1986-05-21
IL76579A0 (en) 1986-02-28
DK453485D0 (da) 1985-10-04
GR852410B (enExample) 1986-02-04
EP0177361A3 (en) 1987-09-02
ZA857687B (en) 1986-05-28
US4782052A (en) 1988-11-01
JPS61126086A (ja) 1986-06-13
DD237659A5 (de) 1986-07-23
DK453485A (da) 1986-04-06
CN85109716A (zh) 1986-10-08

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