AU5555899A - N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders - Google Patents

Info

Publication number

AU5555899A

AU5555899A AU55558/99A AU5555899A AU5555899A AU 5555899 A AU5555899 A AU 5555899A AU 55558/99 A AU55558/99 A AU 55558/99A AU 5555899 A AU5555899 A AU 5555899A AU 5555899 A AU5555899 A AU 5555899A

Authority

AU

Australia

Prior art keywords

alkenyl

alkyl

straight

branched chain

thioester

Prior art date

1998-08-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• -1 heterocyclic thioesters Chemical class 0.000 title claims description 261
• 230000004438 eyesight Effects 0.000 title claims description 54
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title claims description 45
• 208000029257 vision disease Diseases 0.000 title claims description 37
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title claims description 30
• 239000004202 carbamide Substances 0.000 title claims description 30
• 208000026139 Memory disease Diseases 0.000 title description 2
• 125000000217 alkyl group Chemical group 0.000 claims description 316
• 125000003342 alkenyl group Chemical group 0.000 claims description 304
• 125000004432 carbon atom Chemical group C* 0.000 claims description 131
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 96
• 150000002148 esters Chemical class 0.000 claims description 95
• 125000000623 heterocyclic group Chemical group 0.000 claims description 81
• 150000007970 thio esters Chemical class 0.000 claims description 81
• 150000001875 compounds Chemical class 0.000 claims description 78
• 125000003545 alkoxy group Chemical group 0.000 claims description 73
• 125000003282 alkyl amino group Chemical group 0.000 claims description 73
• 125000004103 aminoalkyl group Chemical group 0.000 claims description 73
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 73
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 73
• 125000001188 haloalkyl group Chemical group 0.000 claims description 73
• 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims description 73
• 125000004001 thioalkyl group Chemical group 0.000 claims description 72
• 229910052799 carbon Inorganic materials 0.000 claims description 64
• 238000000034 method Methods 0.000 claims description 62
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 61
• 125000003396 thiol group Chemical group [H]S* 0.000 claims description 61
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 58
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• 229910052760 oxygen Inorganic materials 0.000 claims description 48
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 47
• 239000001301 oxygen Substances 0.000 claims description 47
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• 125000003118 aryl group Chemical group 0.000 claims description 42
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 42
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 38
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• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 14
• ZHUXMBYIONRQQX-UHFFFAOYSA-N hydroxidodioxidocarbon(.) Chemical compound [O]C(O)=O ZHUXMBYIONRQQX-UHFFFAOYSA-N 0.000 claims description 14
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• GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims description 7
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