AU547923B2 - Endo-8-methyl-8-syn-aikly-8-azonia bicyclo- (3.2.1)-octane-derivatives - Google Patents

Endo-8-methyl-8-syn-aikly-8-azonia bicyclo- (3.2.1)-octane-derivatives

Info

Publication number
AU547923B2
AU547923B2 AU71953/81A AU7195381A AU547923B2 AU 547923 B2 AU547923 B2 AU 547923B2 AU 71953/81 A AU71953/81 A AU 71953/81A AU 7195381 A AU7195381 A AU 7195381A AU 547923 B2 AU547923 B2 AU 547923B2
Authority
AU
Australia
Prior art keywords
syn
endo
octane
methyl
aikly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU71953/81A
Other languages
English (en)
Other versions
AU7195381A (en
Inventor
Virgilio Bernareggi
Fausto Bonifacio
Maurizio Fano
Roberto Margutti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeas SpA Industria Chimica e Farmaceutica
Original Assignee
Valeas SpA Industria Chimica e Farmaceutica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeas SpA Industria Chimica e Farmaceutica filed Critical Valeas SpA Industria Chimica e Farmaceutica
Publication of AU7195381A publication Critical patent/AU7195381A/en
Application granted granted Critical
Publication of AU547923B2 publication Critical patent/AU547923B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU71953/81A 1980-06-18 1981-06-18 Endo-8-methyl-8-syn-aikly-8-azonia bicyclo- (3.2.1)-octane-derivatives Ceased AU547923B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22843/80A IT1140998B (it) 1980-06-18 1980-06-18 Sali di endo-8-metil-8-sin-alchil-8-azoniabiciclo aperta par. quadrata 3.2.1. chiusa par. quadrata-ottan-3-alchilcarbossilati, processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
IT22843/80 1980-06-18

Publications (2)

Publication Number Publication Date
AU7195381A AU7195381A (en) 1981-12-24
AU547923B2 true AU547923B2 (en) 1985-11-14

Family

ID=11201066

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71953/81A Ceased AU547923B2 (en) 1980-06-18 1981-06-18 Endo-8-methyl-8-syn-aikly-8-azonia bicyclo- (3.2.1)-octane-derivatives

Country Status (9)

Country Link
US (1) US4411902A (enExample)
EP (1) EP0042365B1 (enExample)
JP (1) JPS5728086A (enExample)
AT (1) ATE9347T1 (enExample)
AU (1) AU547923B2 (enExample)
CA (1) CA1161040A (enExample)
DE (1) DE3165993D1 (enExample)
IT (1) IT1140998B (enExample)
ZA (1) ZA813786B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1194343B (it) * 1983-07-26 1988-09-14 Valeas Spa Sali di endo-8,8-dialchil-8-azoniabiciclo (3.2.1) ottan-6,7-esso-epossi-3-alchilcarbossilati,processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
US4698217A (en) * 1985-02-26 1987-10-06 Mobil Oil Corporation Crystalline silicate ZSM-58 and process for its preparation using a methyltropinium cation
AT397962B (de) * 1985-12-27 1994-08-25 Madaus & Co Dr Verfahren zur herstellung von azoniaspironortropanolestern
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
AU2916301A (en) * 1999-10-28 2001-05-08 Isotech Of Illinois, Inc. Improved bearing isolator
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
TW200534855A (en) * 2004-01-13 2005-11-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
PE20060826A1 (es) * 2004-12-06 2006-10-08 Smithkline Beecham Corp Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende
RU2714135C1 (ru) * 2019-11-22 2020-02-12 Федеральное государственное бюджетное учреждение науки "Институт токсикологии Федерального медико-биологического агентства" Гидрохлорид (1-метилпиперидин-4-ил)-2-пропилпентаноата, обладающий холинолитической и противосудорожной активностью

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3170927A (en) * 1965-02-23 O chzoh
US2962499A (en) * 1957-07-03 1960-11-29 Endo Lab Certain esters of tropine and tropinium salts
US3145211A (en) * 1962-01-04 1964-08-18 Sterling Drug Inc Tropyl esters of alpha-cycloalkylalkanoic acids

Also Published As

Publication number Publication date
CA1161040A (en) 1984-01-24
JPH0335319B2 (enExample) 1991-05-27
DE3165993D1 (en) 1984-10-18
US4411902A (en) 1983-10-25
EP0042365A1 (en) 1981-12-23
AU7195381A (en) 1981-12-24
EP0042365B1 (en) 1984-09-12
IT8022843A0 (it) 1980-06-18
ZA813786B (en) 1982-07-28
JPS5728086A (en) 1982-02-15
IT1140998B (it) 1986-10-10
ATE9347T1 (de) 1984-09-15

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired