AU526160B2 - Milbemycin compounds as anthelmintic agents - Google Patents

Milbemycin compounds as anthelmintic agents

Info

Publication number
AU526160B2
AU526160B2 AU42309/78A AU4230978A AU526160B2 AU 526160 B2 AU526160 B2 AU 526160B2 AU 42309/78 A AU42309/78 A AU 42309/78A AU 4230978 A AU4230978 A AU 4230978A AU 526160 B2 AU526160 B2 AU 526160B2
Authority
AU
Australia
Prior art keywords
anthelmintic agents
milbemycin compounds
milbemycin
compounds
anthelmintic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU42309/78A
Other languages
English (en)
Other versions
AU4230978A (en
Inventor
Potter Irving
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU4230978A publication Critical patent/AU4230978A/en
Application granted granted Critical
Publication of AU526160B2 publication Critical patent/AU526160B2/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
AU42309/78A 1977-12-19 1978-12-07 Milbemycin compounds as anthelmintic agents Expired AU526160B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/861,808 US4144352A (en) 1977-12-19 1977-12-19 Milbemycin compounds as anthelmintic agents
USUS861808 1977-12-19

Publications (2)

Publication Number Publication Date
AU4230978A AU4230978A (en) 1979-06-28
AU526160B2 true AU526160B2 (en) 1982-12-23

Family

ID=25336823

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42309/78A Expired AU526160B2 (en) 1977-12-19 1978-12-07 Milbemycin compounds as anthelmintic agents

Country Status (7)

Country Link
US (1) US4144352A (enExample)
EP (1) EP0002916B1 (enExample)
JP (1) JPS5489041A (enExample)
AU (1) AU526160B2 (enExample)
DE (1) DE2861426D1 (enExample)
NZ (1) NZ189103A (enExample)
ZA (1) ZA787082B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599383B2 (en) * 1986-06-07 1990-07-19 Coopers Animal Health Limited Ectoparasiticidal pour-on formulations

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US4597969A (en) * 1982-04-05 1986-07-01 Merck Sharp & Dohme Stabilization of unstable drugs or food supplements
NZ210505A (en) * 1983-12-22 1988-06-30 Merck & Co Inc Parasiticidal compositions containing avermectin or milbemycin derivatives
GB8502925D0 (en) * 1985-02-05 1985-03-06 Ici Plc Macrocyclic lactones
US4680419A (en) * 1985-07-22 1987-07-14 The Upjohn Company Spiroketals and process for preparing same
US4820758A (en) * 1985-07-22 1989-04-11 The Upjohn Company Novel [5.5]-spiroketals
US4814347A (en) * 1985-07-22 1989-03-21 The Upjohn Company Anthelmintic spiroketals and method of use
US4812582A (en) * 1985-07-22 1989-03-14 The Upjohn Company Process for preparing aldol intermediates
US4686297A (en) * 1985-07-22 1987-08-11 The Upjohn Company Anthelmintic spiroketals useful for killing parasitic worms
EP0254583B1 (en) * 1986-07-24 1994-09-07 Beecham Group Plc Parasiticidal milbemycin derivatives, a process for their production, and compositions containing the same
EP0325462A3 (en) * 1988-01-22 1989-11-02 Beecham Group Plc Anthelmintic milbemycin derivatives
ATE134873T1 (de) * 1991-07-23 1996-03-15 American Cyanamid Co Stabile zusammensetzungen für parenterale verabrechung und ihre verwendung
NZ335166A (en) * 1999-04-14 2001-11-30 Ashmont Holdings Ltd Anthelmintic composition containing triclabendazole in at least one solvent
US6495591B1 (en) 1997-10-02 2002-12-17 Essential Therapeutics, Inc. Fungal efflux pump inhibitors
ES2359973T3 (es) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
US7671034B2 (en) 2003-12-19 2010-03-02 Merial Limited Stabilized formulation of ivermectin feed premix with an extended shelf life
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
KR101437704B1 (ko) 2006-07-05 2014-09-04 아벤티스 애그리컬쳐 1-아릴-5-알킬 피라졸 유도체 화합물, 이의 제조 방법 및 이의 사용 방법
FR2906466B1 (fr) * 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des milbemycines pour le traitement de desordres dermatologiques chez l'homme
CN100467473C (zh) * 2007-01-17 2009-03-11 东北农业大学 用冰城链霉菌制备化合物的方法
LT2639228T (lt) 2007-05-15 2016-11-10 Merial, Inc. Arilazol-2-ilo cianetilamino junginiai, jų gamybos būdas ir panaudojimo būdas
MX2010005685A (es) 2007-11-26 2010-09-28 Merial Ltd Sistemas de solventes para formulaciones de vaciado determinado para combatir parasitos.
SI3050874T1 (sl) 2008-11-14 2019-04-30 Merial Inc. Enantiomerno obogatene ariloazol-2-il cianoetilamino paraziticidne spojine
CN102271672B (zh) 2008-11-19 2015-02-04 梅里亚有限公司 用于治疗寄生物感染的包含单独的或与甲脒组合的1-芳基吡唑的组合物
CA2745434C (en) 2008-12-04 2017-06-20 Merial Limited Dimeric avermectin and milbemycin derivatives
NZ600252A (en) 2009-12-04 2014-03-28 Merial Ltd Pesticidal bis-organosulfur compounds
CA2784141C (en) 2009-12-17 2017-10-24 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
NZ600922A (en) 2009-12-17 2013-10-25 Merial Ltd Anti parasitic dihydroazole compounds and compositions comprising same
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
CA2811924C (en) 2010-10-20 2015-06-16 Galderma S.A. Method of treating hemorrhoids using macrocyclic lactone compound
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US8822528B2 (en) 2010-11-16 2014-09-02 Merial Limited Monensin derivatives for the treatment and prevention of protozoal infections
WO2012150543A1 (en) 2011-05-02 2012-11-08 Universite De Geneve Macrocyclic lactones and use thereof
CA2840396C (en) 2011-06-27 2020-07-14 Merial Limited Amido-pyridyl ether compounds and compositions and their use against parasites
US20120329832A1 (en) 2011-06-27 2012-12-27 Jean Delaveau Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
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WO2013044118A2 (en) 2011-09-23 2013-03-28 Merial Limited Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
CA2855954C (en) 2011-11-17 2020-09-01 Merial Limited Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof.
DK3351546T5 (da) 2011-12-02 2024-08-12 Boehringer Ingelheim Vetmedica Gmbh Langtidsvirkende injicerbare moxidectinformuleringer
PL232463B1 (pl) 2012-02-06 2019-06-28 Merial Inc Miękka, nadająca się do żucia kompozycja weterynaryjna do leczenia i/lub zapobiegania infekcji lub inwazji pasożytniczej u zwierzęcia oraz jej zastosowanie
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
MX351636B (es) 2012-04-20 2017-10-23 Merial Ltd Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos.
NZ708350A (en) 2012-11-20 2016-08-26 Merial Inc Anthelmintic compounds and compositions and method of using thereof
PT2950795T (pt) 2013-01-31 2018-07-30 Merial Inc Método de tratamento e cura de leishmaniose utilizando fexinidazole
NZ712345A (en) 2013-04-12 2016-04-29 Zoetis Services Llc Composition of macrocyclic lactones, levamisole, an amino sugar and an additional antiparasitic agent
EP3063144B1 (en) 2013-11-01 2021-09-08 Boehringer Ingelheim Animal Health USA Inc. Antiparasitic and pesticidal isoxazoline compounds
EP2886640A1 (en) 2013-12-18 2015-06-24 Riga Technical University Process for isolation of milbemycins A3 and A4
CA2945766C (en) 2014-04-17 2023-09-26 Merial, Inc. Use of malononitrile compounds for protecting animals from parasites
AR100530A1 (es) 2014-05-19 2016-10-12 Merial Inc Compuestos antihelmínticos
BR122020023385B1 (pt) 2014-06-19 2021-05-25 Merial, Inc composições parasiticidas compreendendo derivados de indol, métodos e usos dos mesmos
ES2887302T3 (es) 2014-10-31 2021-12-22 Boehringer Ingelheim Animal Health Usa Inc Composiciones parasiticidas que comprenden fipronil
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US11058700B2 (en) 2015-10-28 2021-07-13 City Of Hope Macrocyclic lactones and uses thereof as modulators of purinergic receptors
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CN110381738B (zh) 2016-10-14 2021-07-16 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的乙烯基异噁唑啉化合物
WO2018093920A1 (en) 2016-11-16 2018-05-24 Merial, Inc. Anthelmintic depsipeptide compounds
WO2019005700A1 (en) 2017-06-26 2019-01-03 Merial, Inc. DOUBLE-ACTING PARASITICIDE GRANULATE COMPOSITIONS, METHODS AND USES THEREOF
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JP2022522200A (ja) 2019-03-01 2022-04-14 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 注射用クロルスロン組成物、その方法および使用
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
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JP2024504208A (ja) 2020-12-21 2024-01-30 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー イソオキサゾリン化合物を含む殺寄生虫首輪
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599383B2 (en) * 1986-06-07 1990-07-19 Coopers Animal Health Limited Ectoparasiticidal pour-on formulations

Also Published As

Publication number Publication date
ZA787082B (en) 1980-08-27
AU4230978A (en) 1979-06-28
EP0002916B1 (en) 1981-12-02
NZ189103A (en) 1984-10-19
JPS5489041A (en) 1979-07-14
JPS6121453B2 (enExample) 1986-05-27
EP0002916A3 (en) 1979-07-25
US4144352A (en) 1979-03-13
DE2861426D1 (en) 1982-01-28
EP0002916A2 (en) 1979-07-11

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