AU5066900A - Benzimidazole derivatives and their use as methionyl t-rna synthetase inhibitors - Google Patents

Benzimidazole derivatives and their use as methionyl t-rna synthetase inhibitors

Info

Publication number
AU5066900A
AU5066900A AU50669/00A AU5066900A AU5066900A AU 5066900 A AU5066900 A AU 5066900A AU 50669/00 A AU50669/00 A AU 50669/00A AU 5066900 A AU5066900 A AU 5066900A AU 5066900 A AU5066900 A AU 5066900A
Authority
AU
Australia
Prior art keywords
methionyl
benzimidazole derivatives
synthetase inhibitors
rna synthetase
rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU50669/00A
Inventor
John Stephen Elder
Andrew Keith Forrest
Catherine Simone Victoire Frydrych
Richard Lewis Jarvest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU5066900A publication Critical patent/AU5066900A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU50669/00A 1999-05-19 2000-05-16 Benzimidazole derivatives and their use as methionyl t-rna synthetase inhibitors Abandoned AU5066900A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9911594 1999-05-19
GBGB9911594.1A GB9911594D0 (en) 1999-05-19 1999-05-19 Novel compounds
PCT/EP2000/004435 WO2000071522A1 (en) 1999-05-19 2000-05-16 Benzimidazole derivatives and their use as methionyl t-rna synthetase inhibitors

Publications (1)

Publication Number Publication Date
AU5066900A true AU5066900A (en) 2000-12-12

Family

ID=10853710

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50669/00A Abandoned AU5066900A (en) 1999-05-19 2000-05-16 Benzimidazole derivatives and their use as methionyl t-rna synthetase inhibitors

Country Status (4)

Country Link
JP (1) JP2003500395A (en)
AU (1) AU5066900A (en)
GB (1) GB9911594D0 (en)
WO (1) WO2000071522A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2433197C (en) * 2000-12-15 2009-11-24 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
RU2333208C2 (en) 2002-06-13 2008-09-10 Вертекс Фармасьютикалз Инкорпорейтед 2-ureido-6-heteroaryl-3n-benzimidazole-6-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase inhibitors for bacterial infection treatment
GB0228545D0 (en) * 2002-12-06 2003-01-15 Glaxo Group Ltd Novel compounds
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (en) 2003-01-31 2005-07-13 Vertex Pharma GIRASA INHIBITORS AND USES OF THE SAME
GB0302546D0 (en) * 2003-02-04 2003-03-12 Glaxo Group Ltd Novel compounds
GB0304809D0 (en) 2003-03-03 2003-04-09 Glaxo Group Ltd Novel compounds
WO2004078119A2 (en) 2003-03-03 2004-09-16 Replidyne Inc. Substituted thiophenes with antibacterial activity
EP1619947A4 (en) * 2003-05-01 2006-05-31 Replidyne Inc Antibacterial methods and compositions
KR101900249B1 (en) 2011-01-14 2018-11-02 스페로 트리넴, 인코포레이티드 Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
WO2012097274A1 (en) 2011-01-14 2012-07-19 Vertex Pharmaceuticals Incorporation Process of making gyrase and topoisomerase iv inhibitors
AU2012205416B2 (en) 2011-01-14 2017-02-02 Spero Therapeutics, Inc. Solid forms of gyrase inhibitor (R)-1-ethyl-3-(5-(2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl}-1H-benzimidazol-2-yl)urea
ES2545516T3 (en) 2011-01-14 2015-09-11 Vertex Pharmaceuticals Incorporated Inhibitors of pyrimidine gyrase and topoisomerase IV
JP5977344B2 (en) 2011-06-20 2016-08-24 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Phosphate esters of gyrase and topoisomerase inhibitors
AR093226A1 (en) 2012-07-18 2015-05-27 Vertex Pharma SOLID FORMS OF DIHYDROGEN PHOSPHATE OF (R) -2- (5- (2- (3-ETILUREIDO) -6-FLUORO-7- (TETRAHIDROFURAN-2-IL) -1H-BENZO [D] IMIDAZOL-5-IL) PIRIMIDIN-2-IL) PROPAN-2-ILO AND ITS SALTS
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases
WO2016029146A1 (en) * 2014-08-22 2016-02-25 University Of Washington Specific inhibitors of methionyl-trna synthetase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1307565A (en) * 1998-04-29 2001-08-08 史密丝克莱恩比彻姆有限公司 Quinolones used as MRS inhibitor and bactericides
GB9822241D0 (en) * 1998-10-12 1998-12-09 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
WO2000071522A1 (en) 2000-11-30
JP2003500395A (en) 2003-01-07
GB9911594D0 (en) 1999-07-21

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase