AU506262B2 - Glycosyl derivatives of neamine - Google Patents

Glycosyl derivatives of neamine

Info

Publication number
AU506262B2
AU506262B2 AU16626/76A AU1662676A AU506262B2 AU 506262 B2 AU506262 B2 AU 506262B2 AU 16626/76 A AU16626/76 A AU 16626/76A AU 1662676 A AU1662676 A AU 1662676A AU 506262 B2 AU506262 B2 AU 506262B2
Authority
AU
Australia
Prior art keywords
compound
nht
acetyl
group
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU16626/76A
Other languages
English (en)
Other versions
AU1662676A (en
Inventor
B. J Magerlein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU1662676A publication Critical patent/AU1662676A/en
Application granted granted Critical
Publication of AU506262B2 publication Critical patent/AU506262B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU16626/76A 1975-09-08 1976-08-06 Glycosyl derivatives of neamine Expired AU506262B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USUS611349 1975-09-08
US05/611,349 US3996205A (en) 1975-09-08 1975-09-08 Aminoglycoside antibiotics and intermediates

Publications (2)

Publication Number Publication Date
AU1662676A AU1662676A (en) 1978-02-09
AU506262B2 true AU506262B2 (en) 1979-12-20

Family

ID=24448676

Family Applications (1)

Application Number Title Priority Date Filing Date
AU16626/76A Expired AU506262B2 (en) 1975-09-08 1976-08-06 Glycosyl derivatives of neamine

Country Status (14)

Country Link
US (1) US3996205A (enExample)
JP (1) JPS5233649A (enExample)
AU (1) AU506262B2 (enExample)
BE (1) BE845942A (enExample)
CA (1) CA1067899A (enExample)
CH (1) CH626896A5 (enExample)
DE (1) DE2638794A1 (enExample)
FR (2) FR2322608A1 (enExample)
GB (1) GB1530643A (enExample)
HU (1) HU177271B (enExample)
NL (1) NL7609874A (enExample)
PL (1) PL111474B1 (enExample)
SU (1) SU700066A3 (enExample)
ZA (1) ZA764726B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182855A (en) * 1977-05-05 1980-01-08 The Upjohn Company Nitrosugar
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
HUE031643T2 (en) * 2006-04-03 2017-07-28 Technion Res & Dev Foundation New aminoglycosides and their applications in the treatment of genetic disorders
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
CN114957357A (zh) 2015-09-02 2022-08-30 Eloxx制药有限公司 氨基糖苷衍生物及其在治疗遗传性病症中的应用
US10786520B2 (en) 2015-09-02 2020-09-29 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
EP3344640A4 (en) 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
BR112019018834A2 (pt) 2017-03-15 2020-04-14 Eloxx Pharmaceuticals Ltd preparação em grande escala de aminoglicosídeos de pseudotrissacarídeos e de seus intermediários
WO2020105054A1 (en) 2018-11-22 2020-05-28 Technion Research & Development Foundation Limited Modified aminoglycoside compounds and uses thereof in disabling bacterial ribosome

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH84A (fr) * 1889-01-10 Fontainemelon Horlogerie Perfectionnement apporté dans la construction des mécanismes de remontoir des montres de tous calibres
JPS507595B1 (enExample) * 1970-07-29 1975-03-27
US3792037A (en) * 1971-11-04 1974-02-12 Bristol Myers Co Process for preparing ambutyrosin
CA992535A (en) * 1972-03-08 1976-07-06 Bristol-Myers Squibb Company Antibiotic derivatives
US3897412A (en) * 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
US3860574A (en) * 1972-12-06 1975-01-14 Bristol Myers Co Derivatives of neomycin b and neomycin c
US3886139A (en) * 1973-02-23 1975-05-27 Bristol Myers Co Derivatives of kanamycin
US3893997A (en) * 1974-07-01 1975-07-08 Smithkline Corp Pseudodisaccharide intermediates

Also Published As

Publication number Publication date
FR2355852A1 (fr) 1978-01-20
PL111474B1 (en) 1980-08-30
PL192253A1 (pl) 1979-02-26
JPS5233649A (en) 1977-03-14
US3996205A (en) 1976-12-07
AU1662676A (en) 1978-02-09
CA1067899A (en) 1979-12-11
SU700066A3 (ru) 1979-11-25
NL7609874A (nl) 1977-03-10
GB1530643A (en) 1978-11-01
DE2638794A1 (de) 1977-03-10
FR2355852B1 (enExample) 1980-04-04
CH626896A5 (enExample) 1981-12-15
FR2322608A1 (fr) 1977-04-01
ZA764726B (en) 1977-07-27
BE845942A (fr) 1977-03-08
FR2322608B1 (enExample) 1979-09-07
HU177271B (en) 1981-08-28

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