AU474443B2 - 7-hydroxy fluorophenylacetamido-3-heterocyclic-thiomethyl cephalosporins and their intermediates - Google Patents

7-hydroxy fluorophenylacetamido-3-heterocyclic-thiomethyl cephalosporins and their intermediates

Info

Publication number
AU474443B2
AU474443B2 AU56952/73A AU5695273A AU474443B2 AU 474443 B2 AU474443 B2 AU 474443B2 AU 56952/73 A AU56952/73 A AU 56952/73A AU 5695273 A AU5695273 A AU 5695273A AU 474443 B2 AU474443 B2 AU 474443B2
Authority
AU
Australia
Prior art keywords
fluorophenylacetamido
intermediates
heterocyclic
hydroxy
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU56952/73A
Other languages
English (en)
Other versions
AU5695273A (en
Inventor
LAWRENCE DUNN and JOHN RUSSEL EUGENE HOOVER GEORGE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US262903A external-priority patent/US3867380A/en
Priority claimed from US00289499A external-priority patent/US3855213A/en
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of AU5695273A publication Critical patent/AU5695273A/en
Application granted granted Critical
Publication of AU474443B2 publication Critical patent/AU474443B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
AU56952/73A 1972-06-14 1973-06-14 7-hydroxy fluorophenylacetamido-3-heterocyclic-thiomethyl cephalosporins and their intermediates Expired AU474443B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US262903A US3867380A (en) 1971-02-18 1972-06-14 3-Heterocyclic thiomethylcephalosporins
USUS262,903 1972-06-14
US00289499A US3855213A (en) 1971-02-18 1972-09-15 3-heterocyclic thiomethyl-cephalosporins
US35956773A 1973-05-11 1973-05-11

Publications (2)

Publication Number Publication Date
AU5695273A AU5695273A (en) 1974-12-19
AU474443B2 true AU474443B2 (en) 1976-07-22

Family

ID=27401552

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56952/73A Expired AU474443B2 (en) 1972-06-14 1973-06-14 7-hydroxy fluorophenylacetamido-3-heterocyclic-thiomethyl cephalosporins and their intermediates

Country Status (10)

Country Link
JP (1) JPS4949984A (es)
AU (1) AU474443B2 (es)
CA (1) CA999574A (es)
CH (1) CH585228A5 (es)
DE (1) DE2330307C2 (es)
ES (1) ES415874A1 (es)
FR (1) FR2187305B1 (es)
GB (1) GB1416503A (es)
IE (1) IE37793B1 (es)
NL (1) NL7308199A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2404592C2 (de) * 1973-01-31 1984-01-19 Bristol-Myers Co., 10154 New York, N.Y. In 3-Stellung thiolierte 7-Acyl-amidocephalosporansäurederivate, Verfahren zu deren Herstellung und sie enthaltende Mittel
AR207752A1 (es) 1973-03-30 1976-10-29 Fujisawa Pharmaceutical Co Procedimiento para obtener acidos 7-amino-sustituido-3-tiometilsustituido-3-cefem-4-carboxilicos
CA1074784A (en) * 1974-09-06 1980-04-01 Sumitomo Chemical Company N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS
IL49183A0 (en) * 1975-03-27 1976-05-31 Pfizer Novel cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
JPS5346995A (en) * 1976-10-12 1978-04-27 Sangyo Kagaku Kenkyu Kyokai Antibacterial agents
JPWO2010087425A1 (ja) 2009-01-30 2012-08-02 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
DE2330307C2 (de) 1983-03-10
IE37793B1 (en) 1977-10-12
CA999574A (en) 1976-11-09
AU5695273A (en) 1974-12-19
FR2187305B1 (es) 1976-12-03
IE37793L (en) 1973-12-14
ES415874A1 (es) 1976-02-01
FR2187305A1 (es) 1974-01-18
GB1416503A (en) 1975-12-03
NL7308199A (es) 1973-12-18
JPS4949984A (es) 1974-05-15
CH585228A5 (es) 1977-02-28
DE2330307A1 (de) 1974-01-03

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