AU4200400A - Antisense oligonucleotide modulation of stat3 expression - Google Patents
Antisense oligonucleotide modulation of stat3 expressionInfo
- Publication number
- AU4200400A AU4200400A AU42004/00A AU4200400A AU4200400A AU 4200400 A AU4200400 A AU 4200400A AU 42004/00 A AU42004/00 A AU 42004/00A AU 4200400 A AU4200400 A AU 4200400A AU 4200400 A AU4200400 A AU 4200400A
- Authority
- AU
- Australia
- Prior art keywords
- antisense oligonucleotide
- stat3 expression
- oligonucleotide modulation
- modulation
- stat3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- 101100311214 Xenopus laevis stat3.1 gene Proteins 0.000 title 1
- 239000000074 antisense oligonucleotide Substances 0.000 title 1
- 238000012230 antisense oligonucleotides Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/288,461 US6159694A (en) | 1999-04-08 | 1999-04-08 | Antisense modulation of stat3 expression |
US09288461 | 1999-04-08 | ||
PCT/US2000/009054 WO2000061602A1 (en) | 1999-04-08 | 2000-04-06 | Antisense oligonucleotide modulation of stat3 expression |
Publications (1)
Publication Number | Publication Date |
---|---|
AU4200400A true AU4200400A (en) | 2000-11-14 |
Family
ID=23107203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU42004/00A Abandoned AU4200400A (en) | 1999-04-08 | 2000-04-06 | Antisense oligonucleotide modulation of stat3 expression |
Country Status (5)
Country | Link |
---|---|
US (2) | US6159694A (en) |
EP (1) | EP1165594A4 (en) |
JP (1) | JP2002541784A (en) |
AU (1) | AU4200400A (en) |
WO (1) | WO2000061602A1 (en) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5333298A (en) | 1996-12-27 | 1998-07-31 | Instituto De Investigaciones Bioquimicas Fundacion Campomar | Compositions and methods for tumour therapy |
AU731909B2 (en) | 1997-07-01 | 2001-04-05 | Isis Pharmaceuticals, Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
US6518017B1 (en) * | 1997-10-02 | 2003-02-11 | Oasis Biosciences Incorporated | Combinatorial antisense library |
US20030165888A1 (en) * | 2001-07-18 | 2003-09-04 | Brown Bob D. | Oligonucleotide probes and primers comprising universal bases for diagnostic purposes |
EP1469009A2 (en) * | 1998-05-21 | 2004-10-20 | Isis Parmaceuticals, Inc. | Compositions and methods for non-parenteral delivery of oligonucleotides |
JP2003525862A (en) * | 1999-01-27 | 2003-09-02 | ザ ユニヴァーシティー オブ サウス フロリダ | Inhibition of STAT3 signaling for treatment of human cancer |
AU777499B2 (en) * | 1999-04-08 | 2004-10-21 | Gen-Probe Incorporated | Antisense oligonucleotides comprising universal and/or degenerate bases |
US7098192B2 (en) * | 1999-04-08 | 2006-08-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of STAT3 expression |
US6159694A (en) * | 1999-04-08 | 2000-12-12 | Isis Pharmaceuticals Inc. | Antisense modulation of stat3 expression |
US20030166592A1 (en) * | 1999-07-19 | 2003-09-04 | Monia Brett P. | Antisense modulation of liver glycogen phosphorylase expression |
DE60129926T2 (en) * | 2000-01-24 | 2008-06-19 | Genzyme Corp., Cambridge | INHIBITORS OF THE JAK / STAT PATH AND ITS USE IN TREATING GENERAL PRIMARY OSTEOARTHRITIS |
US20030012788A1 (en) * | 2000-07-27 | 2003-01-16 | Jean-Christophe Renauld | Method for influencing kinase pathways with IL-22 |
US20040052762A1 (en) * | 2001-09-10 | 2004-03-18 | Hua Yu | Stat3 agonists and antagonists and therapeutic uses thereof |
EP1324763A4 (en) * | 2000-09-08 | 2007-10-31 | Univ Johns Hopkins | Stat3 agonists and antagonists and therapeutic uses thereof |
US20050196781A1 (en) * | 2001-05-18 | 2005-09-08 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of STAT3 gene expression using short interfering nucleic acid (siNA) |
NZ534107A (en) * | 2001-12-18 | 2007-02-23 | Cancer Rec Tech Ltd | Creating and maintaining a cell line that produces a constitutively active signal transducer of activation and transcription (CA-STAT) protein |
US20040028661A1 (en) * | 2002-08-07 | 2004-02-12 | Bartelmez Stephen H. | Expansion of cells using thrombopoietin and anti-transforming growth factor-beta |
US7638122B2 (en) * | 2003-03-07 | 2009-12-29 | University Of South Florida | Stat3 antagonists and their use as vaccines against cancer |
JP4817599B2 (en) * | 2003-12-25 | 2011-11-16 | 独立行政法人科学技術振興機構 | Immune activity enhancer and method for enhancing immune activity using the same |
WO2006012625A2 (en) * | 2004-07-22 | 2006-02-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Stat3 decoy oligonucleotides and uses therefor |
MX2007001215A (en) * | 2004-08-06 | 2007-04-17 | Otsuka Pharma Co Ltd | Aromatic compounds. |
US20070010428A1 (en) * | 2004-09-03 | 2007-01-11 | Mcmurray John S | Inhibitors of signal transduction and activator of transcription 3 |
US7244829B2 (en) * | 2004-11-08 | 2007-07-17 | Gem Pharmaceuticals, Llc | Compositions and processes for preparing 13-deoxy-anthracyclines |
WO2007021896A2 (en) * | 2005-08-10 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
US20070213292A1 (en) * | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
JP2007131548A (en) * | 2005-11-08 | 2007-05-31 | Hirosaki Univ | New medicinal use of proteoglycan |
ZA200804445B (en) * | 2005-12-05 | 2009-11-25 | Otsuka Pharma Co Ltd | Diarylether derivatives as antitumor agents |
UA95978C2 (en) * | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Stat3/5 activation inhibitor |
US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
AU2007345648A1 (en) * | 2007-01-26 | 2008-08-07 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
TW200932260A (en) * | 2007-11-28 | 2009-08-01 | Oncotherapy Science Inc | STAT3 epitope peptides |
US8841257B2 (en) | 2009-04-10 | 2014-09-23 | Board Of Regents, The University Of Texas System | Inhibitors of STAT3 and uses thereof |
CN107012144A (en) | 2011-04-01 | 2017-08-04 | Ionis制药公司 | Signal transduction and the regulation of transcription activating protein 3 (STAT3) expression |
EP2920308B1 (en) | 2012-10-31 | 2018-12-12 | Ionis Pharmaceuticals, Inc. | Cancer treatment |
EP2992098B1 (en) | 2013-05-01 | 2019-03-27 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating hbv and ttr expression |
WO2015106255A1 (en) | 2014-01-13 | 2015-07-16 | City Of Hope | Multivalent oligonucleotide assemblies |
WO2015179693A1 (en) | 2014-05-22 | 2015-11-26 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
EP3209778B1 (en) | 2014-10-24 | 2019-04-03 | Astrazeneca AB | Combination |
WO2016204515A1 (en) * | 2015-06-15 | 2016-12-22 | (주)바이오니아 | Stat3 gene specific sirna, double-helical oligo rna structure including sirna, composition containing same, and use thereof |
EP3316894A4 (en) * | 2015-07-02 | 2019-06-19 | City of Hope | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof |
WO2018067900A1 (en) | 2016-10-06 | 2018-04-12 | Ionis Pharmaceuticals, Inc. | Method of conjugating oligomeric compounds |
WO2019191493A1 (en) | 2018-03-30 | 2019-10-03 | Regents Of The University Of Minnesota | Cancer chemoprevention with stat3 blockers |
WO2020191177A1 (en) * | 2019-03-21 | 2020-09-24 | Sudhir Agrawal | Antisense oligonucleotides for allele specificity |
JP2022550783A (en) | 2019-09-30 | 2022-12-05 | アストラゼネカ・アクチエボラーグ | Combined treatment |
CN114908094B (en) * | 2022-05-31 | 2024-03-12 | 中山大学 | Antisense oligonucleotide molecule and application thereof in preparing medicament for treating malignant tumor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
EP0676469A3 (en) * | 1994-04-04 | 1998-03-25 | Tadamitsu Kishimoto | Transcription Factor APRF |
JP4065030B2 (en) * | 1997-01-10 | 2008-03-19 | 忠三 岸本 | Novel STAT function inhibitory protein |
US6159694A (en) * | 1999-04-08 | 2000-12-12 | Isis Pharmaceuticals Inc. | Antisense modulation of stat3 expression |
-
1999
- 1999-04-08 US US09/288,461 patent/US6159694A/en not_active Expired - Lifetime
-
2000
- 2000-04-06 JP JP2000611544A patent/JP2002541784A/en active Pending
- 2000-04-06 WO PCT/US2000/009054 patent/WO2000061602A1/en not_active Application Discontinuation
- 2000-04-06 AU AU42004/00A patent/AU4200400A/en not_active Abandoned
- 2000-04-06 EP EP00921727A patent/EP1165594A4/en not_active Withdrawn
-
2001
- 2001-01-11 US US09/758,881 patent/US6727064B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6159694A (en) | 2000-12-12 |
JP2002541784A (en) | 2002-12-10 |
EP1165594A1 (en) | 2002-01-02 |
WO2000061602A1 (en) | 2000-10-19 |
US20010029250A1 (en) | 2001-10-11 |
EP1165594A4 (en) | 2002-07-03 |
US6727064B2 (en) | 2004-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |