EP1324763A4 - Stat3 agonists and antagonists and therapeutic uses thereof - Google Patents

Stat3 agonists and antagonists and therapeutic uses thereof

Info

Publication number
EP1324763A4
EP1324763A4 EP01970740A EP01970740A EP1324763A4 EP 1324763 A4 EP1324763 A4 EP 1324763A4 EP 01970740 A EP01970740 A EP 01970740A EP 01970740 A EP01970740 A EP 01970740A EP 1324763 A4 EP1324763 A4 EP 1324763A4
Authority
EP
European Patent Office
Prior art keywords
antagonists
therapeutic uses
stat3
agonists
stat3 agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01970740A
Other languages
German (de)
French (fr)
Other versions
EP1324763A1 (en
Inventor
Hua Yu
Drew Pardoll
Richard Jove
William Dalton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of South Florida
Johns Hopkins University
Original Assignee
University of South Florida
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of South Florida, Johns Hopkins University filed Critical University of South Florida
Publication of EP1324763A1 publication Critical patent/EP1324763A1/en
Publication of EP1324763A4 publication Critical patent/EP1324763A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP01970740A 2000-09-08 2001-09-10 Stat3 agonists and antagonists and therapeutic uses thereof Withdrawn EP1324763A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23121200P 2000-09-08 2000-09-08
US231212P 2000-09-08
PCT/US2001/028254 WO2002020032A1 (en) 2000-09-08 2001-09-10 Stat3 agonists and antagonists and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
EP1324763A1 EP1324763A1 (en) 2003-07-09
EP1324763A4 true EP1324763A4 (en) 2007-10-31

Family

ID=22868214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01970740A Withdrawn EP1324763A4 (en) 2000-09-08 2001-09-10 Stat3 agonists and antagonists and therapeutic uses thereof

Country Status (3)

Country Link
EP (1) EP1324763A4 (en)
CA (1) CA2421723A1 (en)
WO (1) WO2002020032A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044774A2 (en) 1999-01-27 2000-08-03 The University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US7638122B2 (en) * 2003-03-07 2009-12-29 University Of South Florida Stat3 antagonists and their use as vaccines against cancer
US7951374B2 (en) 2004-12-14 2011-05-31 University Of South Florida Methods for inhibiting STAT3 signaling in immune cells
WO2010118309A2 (en) 2009-04-10 2010-10-14 Board Of Regents, The University Of Texas System Inhibitors of stat3 and uses thereof
KR102619496B1 (en) * 2016-07-19 2023-12-29 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Oncolytic virus targeting STAT3

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044774A2 (en) * 1999-01-27 2000-08-03 The University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159694A (en) * 1999-04-08 2000-12-12 Isis Pharmaceuticals Inc. Antisense modulation of stat3 expression
US6235873B1 (en) * 1999-07-31 2001-05-22 The Rockefeller University Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044774A2 (en) * 1999-01-27 2000-08-03 The University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NEGORO, S. ET AL.: "Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction", CARDIOVASCULAR RESEARCH, vol. 47, 6 September 2000 (2000-09-06), pages 797 - 805, XP002448915 *
NEGORO, S. ET AL.: "Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxigenation-induced oxidative stress through the upregulation of manganese superoxide dismutase", CIRCULATION, vol. 104, 28 August 2001 (2001-08-28), pages 979 - 981, XP002448916 *
See also references of WO0220032A1 *
YAMAUCHI-TAKIHARA, K. & KISHIMOTO, T.: "A novel role for STAT3 in cardiac remodeling", TRENDS IN ARDIOVASCULAR MEDICINE, vol. 10, no. 7, October 2000 (2000-10-01), pages 298 - 303, XP002448914 *

Also Published As

Publication number Publication date
WO2002020032A1 (en) 2002-03-14
EP1324763A1 (en) 2003-07-09
CA2421723A1 (en) 2002-03-14
WO2002020032A9 (en) 2003-03-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030407

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: JOHN HOPKINS UNIVERSITY

Owner name: UNIVERSITY OF SOUTH FLORIDA

A4 Supplementary search report drawn up and despatched

Effective date: 20071001

17Q First examination report despatched

Effective date: 20081020

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110217

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