AU3448889A - Radiation/microbe bioassay - Google Patents
Radiation/microbe bioassayInfo
- Publication number
- AU3448889A AU3448889A AU34488/89A AU3448889A AU3448889A AU 3448889 A AU3448889 A AU 3448889A AU 34488/89 A AU34488/89 A AU 34488/89A AU 3448889 A AU3448889 A AU 3448889A AU 3448889 A AU3448889 A AU 3448889A
- Authority
- AU
- Australia
- Prior art keywords
- bacteria
- pattern
- sample
- response
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004166 bioassay Methods 0.000 title claims description 101
- 230000005855 radiation Effects 0.000 title claims description 64
- 241000894006 Bacteria Species 0.000 claims description 249
- 230000004044 response Effects 0.000 claims description 152
- 239000000126 substance Substances 0.000 claims description 145
- 238000003556 assay Methods 0.000 claims description 113
- 239000000523 sample Substances 0.000 claims description 107
- 244000063299 Bacillus subtilis Species 0.000 claims description 103
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 96
- 230000001580 bacterial effect Effects 0.000 claims description 95
- 238000012360 testing method Methods 0.000 claims description 82
- 238000000034 method Methods 0.000 claims description 76
- 230000008859 change Effects 0.000 claims description 58
- YHQDZJICGQWFHK-UHFFFAOYSA-N 4-nitroquinoline N-oxide Chemical compound C1=CC=C2C([N+](=O)[O-])=CC=[N+]([O-])C2=C1 YHQDZJICGQWFHK-UHFFFAOYSA-N 0.000 claims description 57
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 53
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical compound C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 claims description 46
- 230000007423 decrease Effects 0.000 claims description 35
- KWVPFECTOKLOBL-KTKRTIGZSA-N 2-[(z)-octadec-9-enoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCO KWVPFECTOKLOBL-KTKRTIGZSA-N 0.000 claims description 33
- 239000013642 negative control Substances 0.000 claims description 20
- 230000001665 lethal effect Effects 0.000 claims description 19
- 230000008569 process Effects 0.000 claims description 19
- 239000000725 suspension Substances 0.000 claims description 19
- 230000008791 toxic response Effects 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- 239000013068 control sample Substances 0.000 claims description 15
- 231100000252 nontoxic Toxicity 0.000 claims description 14
- 230000003000 nontoxic effect Effects 0.000 claims description 14
- 230000003228 microsomal effect Effects 0.000 claims description 13
- 230000004660 morphological change Effects 0.000 claims description 13
- 239000004094 surface-active agent Substances 0.000 claims description 12
- TXVHTIQJNYSSKO-UHFFFAOYSA-N BeP Natural products C1=CC=C2C3=CC=CC=C3C3=CC=CC4=CC=C1C2=C34 TXVHTIQJNYSSKO-UHFFFAOYSA-N 0.000 claims description 11
- 239000002270 dispersing agent Substances 0.000 claims description 11
- 239000013641 positive control Substances 0.000 claims description 11
- 231100000518 lethal Toxicity 0.000 claims description 10
- 230000003381 solubilizing effect Effects 0.000 claims description 10
- 101100301239 Myxococcus xanthus recA1 gene Proteins 0.000 claims description 7
- 239000012898 sample dilution Substances 0.000 claims description 7
- 239000003924 oil dispersant Substances 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- 239000008158 vegetable oil Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 238000013207 serial dilution Methods 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims 2
- 238000001370 static light scattering Methods 0.000 description 108
- 210000004027 cell Anatomy 0.000 description 75
- 108020004414 DNA Proteins 0.000 description 39
- 102000053602 DNA Human genes 0.000 description 39
- 230000001738 genotoxic effect Effects 0.000 description 39
- 230000008439 repair process Effects 0.000 description 36
- 230000001988 toxicity Effects 0.000 description 36
- 231100000419 toxicity Toxicity 0.000 description 36
- 150000001875 compounds Chemical class 0.000 description 33
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N gamma-hexachlorocyclohexane Natural products ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 30
- 231100000331 toxic Toxicity 0.000 description 30
- 230000002588 toxic effect Effects 0.000 description 30
- VZUNGTLZRAYYDE-UHFFFAOYSA-N N-methyl-N'-nitro-N-nitrosoguanidine Chemical compound O=NN(C)C(=N)N[N+]([O-])=O VZUNGTLZRAYYDE-UHFFFAOYSA-N 0.000 description 27
- 230000004913 activation Effects 0.000 description 27
- 238000004364 calculation method Methods 0.000 description 27
- JLYXXMFPNIAWKQ-GNIYUCBRSA-N gamma-hexachlorocyclohexane Chemical compound Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl JLYXXMFPNIAWKQ-GNIYUCBRSA-N 0.000 description 27
- 231100000024 genotoxic Toxicity 0.000 description 27
- 238000011534 incubation Methods 0.000 description 27
- 229960002809 lindane Drugs 0.000 description 27
- 230000002503 metabolic effect Effects 0.000 description 27
- 108090000623 proteins and genes Proteins 0.000 description 24
- 208000005623 Carcinogenesis Diseases 0.000 description 21
- 238000000149 argon plasma sintering Methods 0.000 description 21
- 230000036952 cancer formation Effects 0.000 description 21
- 231100000504 carcinogenesis Toxicity 0.000 description 21
- 230000006870 function Effects 0.000 description 21
- 230000012010 growth Effects 0.000 description 21
- 230000000813 microbial effect Effects 0.000 description 21
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 21
- 239000003440 toxic substance Substances 0.000 description 21
- 239000003183 carcinogenic agent Substances 0.000 description 18
- 230000002950 deficient Effects 0.000 description 18
- 239000008367 deionised water Substances 0.000 description 18
- 229910021641 deionized water Inorganic materials 0.000 description 18
- 230000000694 effects Effects 0.000 description 18
- 231100000481 chemical toxicant Toxicity 0.000 description 15
- 238000006073 displacement reaction Methods 0.000 description 15
- 239000000463 material Substances 0.000 description 15
- 239000003471 mutagenic agent Substances 0.000 description 15
- 231100000707 mutagenic chemical Toxicity 0.000 description 15
- 230000035945 sensitivity Effects 0.000 description 15
- 210000004215 spore Anatomy 0.000 description 15
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 12
- 231100000357 carcinogen Toxicity 0.000 description 12
- 230000007613 environmental effect Effects 0.000 description 12
- 230000002068 genetic effect Effects 0.000 description 12
- 230000008794 genotoxic response Effects 0.000 description 12
- 239000002609 medium Substances 0.000 description 12
- 230000003505 mutagenic effect Effects 0.000 description 12
- 230000035772 mutation Effects 0.000 description 12
- 239000002245 particle Substances 0.000 description 12
- 231100000167 toxic agent Toxicity 0.000 description 12
- 230000002411 adverse Effects 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 9
- 230000008901 benefit Effects 0.000 description 9
- 210000000349 chromosome Anatomy 0.000 description 9
- 230000001419 dependent effect Effects 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 235000013305 food Nutrition 0.000 description 9
- 238000005755 formation reaction Methods 0.000 description 9
- 239000001963 growth medium Substances 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 231100000219 mutagenic Toxicity 0.000 description 9
- 231100000150 mutagenicity / genotoxicity testing Toxicity 0.000 description 9
- 230000006798 recombination Effects 0.000 description 9
- 238000005215 recombination Methods 0.000 description 9
- 238000011084 recovery Methods 0.000 description 9
- 229940113082 thymine Drugs 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 231100000039 Ames test Toxicity 0.000 description 6
- -1 DNA Chemical class 0.000 description 6
- 231100000277 DNA damage Toxicity 0.000 description 6
- 230000005778 DNA damage Effects 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 6
- 239000003570 air Substances 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 210000004556 brain Anatomy 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 230000000711 cancerogenic effect Effects 0.000 description 6
- 239000002775 capsule Substances 0.000 description 6
- 238000012512 characterization method Methods 0.000 description 6
- 239000013043 chemical agent Substances 0.000 description 6
- 239000002962 chemical mutagen Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 231100000433 cytotoxic Toxicity 0.000 description 6
- 230000001472 cytotoxic effect Effects 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- 230000002255 enzymatic effect Effects 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 231100000722 genetic damage Toxicity 0.000 description 6
- 238000010353 genetic engineering Methods 0.000 description 6
- 230000005484 gravity Effects 0.000 description 6
- 230000009036 growth inhibition Effects 0.000 description 6
- 238000001802 infusion Methods 0.000 description 6
- 238000002955 isolation Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- 230000000717 retained effect Effects 0.000 description 6
- 239000002689 soil Substances 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 230000009466 transformation Effects 0.000 description 6
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 6
- 229960001082 trimethoprim Drugs 0.000 description 6
- 238000010953 Ames test Methods 0.000 description 3
- 241000304886 Bacilli Species 0.000 description 3
- 239000012623 DNA damaging agent Substances 0.000 description 3
- 238000007399 DNA isolation Methods 0.000 description 3
- 230000033616 DNA repair Effects 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 206010064571 Gene mutation Diseases 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 230000003698 anagen phase Effects 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 210000004666 bacterial spore Anatomy 0.000 description 3
- 230000000721 bacterilogical effect Effects 0.000 description 3
- 238000012455 bioassay technique Methods 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 230000008827 biological function Effects 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 231100000315 carcinogenic Toxicity 0.000 description 3
- 230000032823 cell division Effects 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000010668 complexation reaction Methods 0.000 description 3
- 230000002596 correlated effect Effects 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 230000009089 cytolysis Effects 0.000 description 3
- 230000003013 cytotoxicity Effects 0.000 description 3
- 231100000135 cytotoxicity Toxicity 0.000 description 3
- 238000013480 data collection Methods 0.000 description 3
- 238000013479 data entry Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 231100000673 dose–response relationship Toxicity 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- UGDGKPDPIXAUJL-UHFFFAOYSA-N ethyl n-[4-[benzyl(2-phenylethyl)amino]-2-(4-ethylphenyl)-1h-imidazo[4,5-c]pyridin-6-yl]carbamate Chemical compound N=1C(NC(=O)OCC)=CC=2NC(C=3C=CC(CC)=CC=3)=NC=2C=1N(CC=1C=CC=CC=1)CCC1=CC=CC=C1 UGDGKPDPIXAUJL-UHFFFAOYSA-N 0.000 description 3
- 239000013505 freshwater Substances 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- 238000012252 genetic analysis Methods 0.000 description 3
- 230000009395 genetic defect Effects 0.000 description 3
- 231100000025 genetic toxicology Toxicity 0.000 description 3
- 231100000734 genotoxic potential Toxicity 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 150000002605 large molecules Chemical class 0.000 description 3
- 238000002356 laser light scattering Methods 0.000 description 3
- 231100000225 lethality Toxicity 0.000 description 3
- 239000006194 liquid suspension Substances 0.000 description 3
- 210000001853 liver microsome Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 238000000386 microscopy Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000004001 molecular interaction Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000000877 morphologic effect Effects 0.000 description 3
- 231100000350 mutagenesis Toxicity 0.000 description 3
- 238000002703 mutagenesis Methods 0.000 description 3
- 230000000869 mutational effect Effects 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 239000006916 nutrient agar Substances 0.000 description 3
- 230000002186 photoactivation Effects 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 230000035790 physiological processes and functions Effects 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 238000011533 pre-incubation Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 231100000586 procarcinogen Toxicity 0.000 description 3
- 239000003891 promutagen Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000005180 public health Effects 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000013535 sea water Substances 0.000 description 3
- 238000012453 sprague-dawley rat model Methods 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 230000002459 sustained effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- 230000001131 transforming effect Effects 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
- G01N15/0227—Investigating particle size or size distribution by optical means using imaging; using holography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
- G01N15/0211—Investigating a scatter or diffraction pattern
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4711—Multiangle measurement
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18289888A | 1988-04-18 | 1988-04-18 | |
| US182898 | 1988-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU3448889A true AU3448889A (en) | 1989-11-24 |
Family
ID=22670530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU34488/89A Abandoned AU3448889A (en) | 1988-04-18 | 1989-04-18 | Radiation/microbe bioassay |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0449820A1 (fi) |
| JP (1) | JPH03505522A (fi) |
| AU (1) | AU3448889A (fi) |
| FI (1) | FI905113A0 (fi) |
| HU (1) | HUT56189A (fi) |
| WO (1) | WO1989010549A2 (fi) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9118981D0 (en) * | 1991-09-05 | 1991-10-23 | Pa Consulting Services | Toxicity sensing |
| CA2092373A1 (en) * | 1992-04-24 | 1993-10-25 | Klaus W. Berndt | Methods and apparatus for detecting biological activities in a specimen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3730842A (en) * | 1970-05-04 | 1973-05-01 | Science Spectrum | Process for determining bacterial drug sensitivity |
| US4541719A (en) * | 1982-07-20 | 1985-09-17 | Wyatt Philip J | Method and apparatus for characterizing microparticles and measuring their response to their environment |
-
1989
- 1989-04-18 EP EP19890904987 patent/EP0449820A1/en not_active Withdrawn
- 1989-04-18 WO PCT/US1989/001564 patent/WO1989010549A2/en not_active Application Discontinuation
- 1989-04-18 AU AU34488/89A patent/AU3448889A/en not_active Abandoned
- 1989-04-18 JP JP50479989A patent/JPH03505522A/ja active Pending
- 1989-04-18 HU HU263589A patent/HUT56189A/hu unknown
-
1990
- 1990-10-17 FI FI905113A patent/FI905113A0/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU892635D0 (en) | 1991-06-28 |
| EP0449820A1 (en) | 1991-10-09 |
| WO1989010549A3 (en) | 1990-02-22 |
| FI905113A0 (fi) | 1990-10-17 |
| HUT56189A (en) | 1991-07-29 |
| WO1989010549A2 (en) | 1989-11-02 |
| JPH03505522A (ja) | 1991-12-05 |
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