AU3109095A - Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production - Google Patents

Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production

Info

Publication number
AU3109095A
AU3109095A AU31090/95A AU3109095A AU3109095A AU 3109095 A AU3109095 A AU 3109095A AU 31090/95 A AU31090/95 A AU 31090/95A AU 3109095 A AU3109095 A AU 3109095A AU 3109095 A AU3109095 A AU 3109095A
Authority
AU
Australia
Prior art keywords
conjugates
oligonucleotides
production
well
metal complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU31090/95A
Other languages
English (en)
Inventor
Dietmar Berndorff
Larry Gold
Andreas Muhler
Ulrich Niedballa
Wolfgang Pieken
Johannes Dr. Platzek
Bernd Dr. Raduchel
Ulrich Speck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Nexstar Pharmaceuticals Inc
Original Assignee
Schering AG
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4424923A external-priority patent/DE4424923A1/de
Priority claimed from DE19944445076 external-priority patent/DE4445076A1/de
Application filed by Schering AG, Nexstar Pharmaceuticals Inc filed Critical Schering AG
Publication of AU3109095A publication Critical patent/AU3109095A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU31090/95A 1994-07-14 1995-07-12 Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production Abandoned AU3109095A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4424923A DE4424923A1 (de) 1994-07-14 1994-07-14 Konjugate aus Metallkomplexen und Oligonucleotiden, die spezifisch an bestimmte Zielstrukturen binden für MRI
DE4424923 1994-07-14
DE19944445076 DE4445076A1 (de) 1994-12-05 1994-12-05 Konjugate aus Metallkomplexen und Oligonucleotiden, die spezifisch an bestimmte Zielstrukturen binden, diese Konjugate enthaltende Mittel, deren Verwendung in der NMR-Diagnostik sowie Verfahren zu deren Herstellung
DE4445076 1994-12-05
PCT/EP1995/002686 WO1996002669A1 (fr) 1994-07-14 1995-07-12 Conjugues de complexes metalliques et d'oligonucleotides, se fixant de façon specifique a des structures cibles specifiques, agents contenant ces conjugues, leur utilisation dans le diagnostic par rmn ainsi que leur procede de production

Publications (1)

Publication Number Publication Date
AU3109095A true AU3109095A (en) 1996-02-16

Family

ID=25938360

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31090/95A Abandoned AU3109095A (en) 1994-07-14 1995-07-12 Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production

Country Status (5)

Country Link
EP (1) EP0770146A1 (fr)
JP (1) JPH10511842A (fr)
AU (1) AU3109095A (fr)
IL (1) IL114235A0 (fr)
WO (1) WO1996002669A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11507027A (ja) * 1995-06-07 1999-06-22 シェリング アクチェンゲゼルシャフト 特定の標的構造に特異的に結合するフェライト及びオリゴヌクレオチドのコンジュゲート
DE19741084A1 (de) * 1997-09-18 1999-03-25 Knoell Hans Forschung Ev Hochaffine Nukleinsäuremoleküle mit funktionellen Gruppen zur spezifischen Erkennung von Zielmolekülen, ihre Herstellung und Verwendung
WO2002096417A1 (fr) 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Derives porphyrine et azaporphyrine substitues et utilisation en therapie photodynamique, radioimagerie, et diagnostic par irm

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US4962045A (en) * 1988-05-02 1990-10-09 The Perkin-Elmer Corporation Time-resolved fluorimetric detection of lanthanide labeled nucleotides
US5559207A (en) * 1989-03-06 1996-09-24 Board Of Regents, University Of Texas Texaphyrin metal complex mediated ester hydrolysis
KR960004931B1 (ko) * 1990-05-23 1996-04-18 아이시스 파마슈티칼스, 인코포레이티드 Rna의 5' 캡 구조의 변형을 통하여 rna 활성을 조절하는 조성물 및 방법
DE69221404T2 (de) * 1991-02-14 1998-02-05 Dade Microscan Inc Neue oligonukleotide konjugiert zu lanthanide-chelaten
WO1993012234A1 (fr) * 1991-12-13 1993-06-24 Sri International Reactifs antiviraux a base de proteines de liaison de l'arn
FR2697254A1 (fr) * 1992-10-22 1994-04-29 Genset Sa Conjugués constitués par un oligonucléotide lié à des dérivés de métalloporphyrine cationique, leur préparation et leur utilisation.

Also Published As

Publication number Publication date
IL114235A0 (en) 1995-10-31
JPH10511842A (ja) 1998-11-17
EP0770146A1 (fr) 1997-05-02
WO1996002669A1 (fr) 1996-02-01

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